Principal Investigator Helmholtz Pioneer Campus
Dr. Janna Nawroth
Forschungsbereich
Janna Nawroth promovierte in Biologie am California Institute of Technology. Dort untersuchte sie die Struktur-Funktions-Beziehungen der Fortbewegung von Quallen und nutzte diese Erkenntnisse zur Entwicklung muskelbetriebener Pumpen für die biomedizinische Forschung. Für ihre Postdoc-Ausbildung erhielt sie das Technology Development Fellowship am Wyss Institute der Harvard University. Zusammen mit Don Ingber und Kit Parker entwickelte sie Organ-Chips und fortschrittliche Bildgebungstechnologien zur Untersuchung der Mechanik von Herz-, Lungen- und Lebergewebe des Menschen. Anschließend setzte sie diese Arbeit bei der Organ-Chip-Firma Emulate und später an der University of Southern California fort. Im Jahr 2020 erhielt sie einen ERC Starting Grant für die Erforschung der Rolle mechanischer Kräfte und defekter mukoziliärer Clearance bei chronischen Atemwegserkrankungen. 2021 trat sie dem Helmholtz PioneerCampus bei.
Professional Background
Principal Investigator at Helmholtz Pioneer Campus, Helmholtz Munich
Junior Fellow at Technical University Munich (TUM), Germany
Senior Research Associate at USC Keck School of Medicine and USC Viterbi School of Engineering, Los Angeles, CA, USA
Associate Director, Research & Development Lead at Emulate Inc., Boston, MA
Principal Investigator at Emulate Inc., Boston, MA, USA
Postdoctoral Fellow & Technology Development Fellow, Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA
Postdoctoral Fellow, Graduate Aerospace Laboratories, Division of Engineering & Applied Science, California Institute of Technology, Pasadena, CA, USA
Ph.D. Graduate Student, Division of Biology, California Institute of Technology,Pasadena, CA, USA
Research Associate in Neurobiology, Yale School of Medicine, New Haven, CT, USA
Honors and Awards
- 2023 Whitman Center Fellowship, Marine Biology Laboratory (MBL), Woods Hole, USA
- 2020 W2 Professorship offer at Saarland University (in conjunction with Leibniz Programme for Women Professors Award)
- 2020 Invited to interview for W3 Professorship in Organ-on-a-Chip Systems at University of Tübingen, Germany
- 2020 Shortlisted (2nd or 3rd place) for W3 Professorship at TU Berlin, Germany
- 2017 Shortlisted (3rd place) for W3 Professorship at B CUBE Institute at TU Dresden, Germany
- 2014-2016 2-Year Wyss Technology Development Fellowship at the Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA
- 2014 Invited participation at workshop “Active Matter: Cytoskeleton, Cells, Tissues and Flocks”. Kavli Institute for Theoretical Physics, Santa Barbara, CA
- 2013 Demetriades–Tsafka–Kokkalis price for best Ph.D. thesis in Nanotechnology and related fields, California Institute of Technology, Pasadena, CA
- 2013 Invited attendance at 8th annual Science Foo Camp by Google, O'Reilly Media & Nature Journal
- 2012 Everhart Lecture Award, California Institute of Technology, Pasadena, CA
- 2009 PENS-Hertie Neuroscience Winter School Scholar, Hertie Foundation, Germany
- 2008-2012 4-Year Gordon and Betty Moore Fellowship for Graduate Studies, California Institute of Technology, Pasadena, CA
- 2008 2-Month Fellowship for “Neural Systems & Behavior” Graduate Level Research Course, Marine Biology Laboratory, Woods Hole, MA
- 2005 6-Month Scholarship for research semester at Yale University, German Academic Exchange Service (DAAD)
- 2003 6-Month Erasmus Mundus Scholarship Exchange Study Program at Montpellier University, France
- 2001-2007 6-Year Scholarship for Bachelor and Master Studies, German National Merit Foundation (Studienstiftung des Deutschen Volkes)
- 1999 1-Month travel stipend and book award for independent field studies on “Dragonflies in Southern France”, ZIS Foundation, Salem, Germany
Publications
Klassen, M.C. ; Balázs, A. ; Zöllner, J. ; Cleve, N. ; Czichon, L. ; von Schledorn, L. ; Hegermann, J. ; Nawroth, J. ; Roth, D. ; Mielenz, M. ; Hedtfeld, S. ; Stanke, F. ; Rubil, T. ; Ius, F. ; Jonigk, D. ; Hanrahan, J.W. ; Ruhparwar, A. ; Olmer, R. ; Mall, M.A. ; Merkert, S. ; Martin, U.
Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease.Korkmaz, R.Ü. ; Omony, J. ; Tan, X. ; Klotz, M. ; Dragunas, G. ; Chen, S. ; Shankhwar, S. ; Ertüz, Z. ; Müller, C. ; Ragab, M. ; Jeridi, A. ; Augustin, R. ; Nawroth, J. ; Kapellos, T. ; Rankl, B. ; Yildirim, A.Ö. ; von Mutius, E.
The therapeutic potential of farm dust extracts in a mouse model of eosinophilic inflammation.Roth, D. ; Zampa, B. ; Augustin, R. ; Payandehjoo, D. ; Porcella, G. ; Sahin, A.T. ; van der Does, A.M. ; Nawroth, J.
Release, transfer, fold: Using a silicone adhesive for on-demand 3D tissue engineering.Roth, D. ; Sahin, A.T. ; Ling, F. ; Tepho, N. ; Senger, C.N. ; Quiroz, E.J. ; Calvert, B.A. ; van der Does, A.M. ; Güney, T.G. ; Glasl, S. ; van Schadewijk, A. ; von Schledorn, L. ; Olmer, R. ; Kanso, E. ; Nawroth, J. ; Ryan, A.L.
Structure and function relationships of mucociliary clearance in human and rat airways.Koc-Gunel, S. ; Liu, E.C. ; Gautam, L.K. ; Calvert, B.A. ; Murthy, S. ; Harriott, N.C. ; Nawroth, J. ; Zhou, B. ; Krymskaya, V.P. ; Ryan, A.L.
Targeting fibroblast-endothelial interactions in LAM pathogenesis using 3D spheroid models and spatial transcriptomics.Funk, M.C. ; Nawroth, J. ; Lehmann, M.
A breath of the future: A novel human model for COPD and beyond.Roth, D. ; Sahin, A.T. ; Ling, F. ; Senger, C.N. ; Quiroz, E.J. ; Calvert, B.A. ; van der Does, A.M. ; Güney, T.G. ; Tepho, N. ; Glasl, S. ; van Schadewijk, A. ; von Schledorn, L. ; Olmer, R. ; Kanso, E. ; Nawroth, J. ; Ryan, A.L.
Structure-function relationships of mucociliary clearance in human airways.Ling, F. ; Essock-Burns, T. ; McFall-Ngai, M. ; Katija, K. ; Nawroth, J. ; Kanso, E.
Flow physics guides morphology of ciliated organs.Nawroth, J. ; Giez, C. ; Klimovich, A. ; Kanso, E. ; Bosch, T.C.G.
Spontaneous body wall contractions stabilize the fluid microenvironment that shapes host-microbe associations.von Schledorn, L. ; Puertollano Martín, D. ; Cleve, N. ; Zöllner, J. ; Roth, D. ; Staar, B.O. ; Hegermann, J. ; Ringshausen, F.C. ; Nawroth, J. ; Martin, U. ; Olmer, R.
Primary ciliary dyskinesia patient-specific hiPSC-derived airway epithelium in air-liquid interface culture recapitulates disease specific phenotypes in vitro.
