2023 Lancet Reg Health Eur

Hammel MC, Stein R, Kratzsch J, Vogel M, Eckert AJ, Triatin RD, Colombo M, Meigen C, Bager R, Stanik J, Spielau U, Stoltze A, Wirkner K, Tönjes A, Snieder H, Holl RW, Stumvoll M, Blüher M, Kiess W, Körner A

Fasting indices of glucose-insulin-metabolism across life span and prediction of glycemic deterioration in children from new references

Evidence for superiority of age specific insulin-based cut-offs for prediction of metabolic failure

2022 Nat Metab

Kempf E, Landgraf K, Stein R, Hanschkow M, Hilbert A, Abou Jamra R, Boczki P, Herberth G, Kühnapfel A, Tseng YH, Stäubert C, Schöneberg T, Kühnen P, Rayner NW, Zeggini E, Kiess W, Blüher M, Körner A

Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity

Identification and characterization of a new monogenic obesity trait

2022 Nat Metab

Yang CH, Fagnocchi L, Apostle S, Wegert V, Casaní-Galdón S, Landgraf K, Panzeri I, Dror E, Heyne S, Wörpel T, Chandler DP, Lu D, Yang T, Gibbons E, Guerreiro R, Bras J, Thomasen M, Grunnet LG, Vaag AA, Gillberg L, Grundberg E, Conesa A, Körner A, PERMUTE & Pospisilik A

Independent phenotypic plasticity axes define distinct obesity sub-types

Translation of molecular determinants for obesity-overgrowth subtypes from mice to human

2022 Nat Metab

Hoang AC, Sasi-Szabó L, Pál T, Szabó T, Diedrich V, Herwig A, Landgraf K, Körner A, Röszer T

Mitochondrial RNA stimulates beige adipocyte development in young mice.

2021 EClinicalMedicine

Kempf E, Vogel M, Vogel T, Kratzsch J, Landgraf K, Kühnapfel A, Gausche R, Gräfe D, Sergeyev E, Pfäffle R, Kiess W, Stanik J, Körner A

Dynamic alterations in linear growth and endocrine parameters in children with obesity and height reference values.

2020 Cell Rep

Landgraf K, Klöting N, Gericke M, Maixner N, Guiu-Jurado E, Scholz M, Witte AV, Beyer F, Schwartze JT, Lacher M, Villringer A, Kovacs P, Rudich A, Blüher M, Kiess W, Körner A

The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG

Functional evidence on obesity gene TMEM18 driving healthy adipogenesis in humans

2020 Metabolism

Voigtmann F, Wolf P, Landgraf K, Stein R, Kratzsch J, Schmitz S, Jamra RA, Blüher M, Meiler J, Beck-Sickinger AG, Kiess W, Körner A

Identification of a novel leptin receptor (LEPR) variant and proof of functional relevance directing treatment decisions in patients with morbid obesity.

2019 N Engl J Med

Körner A, Kiess W, Vogel M

Persistence of Obesity from Early Childhood Onward

Letter with original data how endogenous and life-style factors interact on childhood obesity risk

2018 N Engl J Med

Geserick M, Vogel M, Gausche R, Lipek T, Spielau U, Keller E, Pfäffle R, Kiess W, Körner A

Acceleration of BMI in early childhood and risk of sustained obesity

Major study showing that obesity manifests in early childhood in >50,000 children, > 450 citations

2016 Cell

Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Lu TT, Casas E, Teperino R, Surani MA, Zvetkova I, Rimmington D, Tung YC, Lam B, Larder R, Yeo GS, O'Rahilly S, Vavouri T, Whitelaw E, Penninger JM, Jenuwein T, Cheung CL, Ferguson-Smith AC, Coll AP, Körner A, Pospisilik JA

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity

First evidence on obesity polyphenism in children triggered by epigenetic mechanisms. >125 citations

2015 Diabetes

Landgraf K, Rockstroh D, Wagner IV, Weise S, Tauscher R, Schwartze JT, Löffler D, Bühligen U, Wojan M, Till H, Kratzsch J, Kiess W, Blüher M, Körner A

Evidence of early alterations in adipose tissue biology and function and its association with obesity-related inflammation and insulin resistance in children

First study providing evidence of adipose tissue dysfunction developing already in childhood. >125 citations

2009 Nat Genet

Meyre D, Delplanque J, Chevre JC, Lecoeur C, Lobbens S, Gallina S, Durand E, Vatin V, Degraeve F, Proenca C, Gaget S, Körner A, Kovacs P, Kiess W, Tichet J, Marre M, Hartikainen AL, Horber F, Potoczna N, Herberg S, Levy-Marchal C, Pattou F, Heude B, Tauber M, McCarthy MI, Blakemore Al, Montpetit A, Polychronakos C, Weill J, Coin LJ, Asher J, Elliott P, Jarvelin MR, Visvikis-Siest S, Balkau B, Sladek R, Balding D, Walley A, Dina C, Froguel P

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

> 490 citations

2007 Cell Metab.

Revollo JR, Körner A*, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR, Milbrandt J, Kiess W, Imai S

Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.

Functional evidence for Nampt being important for insulin secretion. >700 citations

2007 Nat Genet.

Dina C, Meyre D, Gallina S, Durand E, Körner A, Jacobson P, Carlsson LM, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, Bougnères P, Kovacs P, Marre M, Balkau B, Cauchi S, Chèvre JC, Froguel P

Variation in FTO contributes to childhood obesity and severe adult obesity.

One of the two papers that initially found FTO as the strongest genetic candidate for obesity. >1,500 citations