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ALLIANCE – Study on asthma subtypes

little girl doing inhlation using her inhaler

Today we differentiate between two basic forms of asthma, allergic and non-allergic asthma. In allergic asthma, an excessive reaction of the immune system leads to chronic allergic inflammation of the respiratory tract. Patients often suffer from other allergic symptoms, such as allergic rhinitis or conjunctivitis (inflammation of the conjunctiva of the eye). In some cases, the symptoms occur only at certain times of the year, e.g. in the case of an allergy to pollen. House dust mite allergy sufferers often have symptoms all year round. Many patients also suffer from non-allergic asthma which is related to non-allergic airway inflammation. It seems however likely that many more subtypes of asthma exist and which differ between children and adults. Yet, reasons for this heterogeneity are not understood.

Alliance_Logo_IAP

In Munich the ALLIANCE study visits are carried out in the Christiane Herzog Outpatient Clinic of the Dr. von Hauner Children's Hospital of the Ludwig-Maximilian University Munich. The ALLIANCE team measures children's lung function, takes blood samples, performs sweat tests and nasal swabs, and measures exhaled air using an electronic nose, the "e-nose".  After a first comprehensive basic examination, the patients come again for a further visit every 12 months. Healthy children are also enrolled as a comparison group.

Health counseling.

The aim of the ALLIANCE study is to be able to offer asthma patients more individualized treatment in the future. The researchers are focusing on finding biomarkers (measurable indicators) that make the respective subtypes of asthma definable. Pediatricians and physicians should be able to clearly diagnose these subtypes: What prognosis does this child have – a good one or a progressive course of the disease? To which subtype does it belong? In contrast to the current state of diagnosis and therapy, the physicians want to treat children with asthma more specifically, earlier and more individually.

Scientists

Sabina_Illi_IAP_Portrait
Dr. rer. med. Sabina Illi

Statistician, Deputy Director, Group Leader

Porträt Jimmy Omony_freigestellt
Dr. Jimmy Omony

Biostatistician

Portrait Nicole Maison_freigestellt_A
Dr. med. Nicole Maison

Physician Scientist

Networks and Partners

Logo ARCN DZL

DZL Standort ARCN, Airway Research Center North

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Logo BREATH Hannover

DZL Standort BREATH, Biomedical Research in Endstage & Obstructive Lung Disease

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Logo UGMLC

DZL Standort UGMLC, Universities of Giessen and Marburg Lung Center

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Selected Publications

2024 Pediatr Allergy Immunol

Omony, J. ; Thölken, C. ; Salimi, A. ; Laubhahn, K. ; Illi, S. ; Weckmann, M. ; Grychtol, R. ; Rabe, KF. ; Thiele, D. ; Foth, S. ; Weber, S. ; Brinkmann, F. ; Kopp, M.V. ; Hansen, G. ; Renz, H. ; von Mutius, E. ; Schaub, B. ; Skevaki, C. ; ALLIANCE Study Group.

Urinary eosinophil-derived neurotoxin is associated with reduced lung function in pediatric asthma
2024 Am J Respir Crit Care Med

Jakwerth, CA. ; Weckmann, M. ; Illi, S. ; Charles, H. ; Zissler, U.M. ; Oelsner, M. ; Guerth, F. ; Omony, J. ; Nemani, S.S.P. ; Grychtol, R. ; Dittrich, A.M. ; Skevaki, C. ; Foth, S. ; Weber, S. ; Alejandre Alcazar, M.A. ; van Koningsbruggen-Rietschel, S. ; Brock, R. ; Blau, S. ; Hansen, G. ; Bahmer, T. ; Rabe, K.F. ; Brinkmann, F. ; Kopp, M.V. ; Chaker, A.M. ; Schaub, B. ; von Mutius, E. ; Schmidt-Weber, C.B. ; ALLIANCE Study Group as part of the German Center for Lung Research.

17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma
2024 Lancet Digit Health

Nahum, U. ; Gorlanova, O. ; Decrue, F. ; Oller, H. ; Delgado-Eckert, E. ; Böck, A. ; Schulzke, S. ; Latzin, P. ; Schaub, B. ; Karvonen, A.M. ; Lauener, R. ; Divaret-Chauveau, A. ; Illi, S. ; Roduit, C. ; von Mutius, E. ; Frey, U. ; BILD study group; PASTURE study group.

Symptom trajectories in infancy for the prediction of subsequent wheeze and asthma in the BILD and PASTURE cohorts: a dynamic network analysis
2024 Allergy

Risha, M.A. ; Reddy, K.D. ; Nemani, S.S.P. ; Jakwerth, C. ; Schmidt-Weber, C. ; Bahmer, T. ; Hansen, G. ; von Mutius, E. ; Rabe, K.F. ; Dittrich, A.M. ; Grychtol, R. ; Maison, N. ; Schaub, B. ; Kopp, M.V. ; Brinkmann, F. ; Meiners, S. ; Jappe, U. ; Weckmann, M. ; ALLIANCE Study Group as part of the German Centre for Lung Research (DZL).

Epigenetic training of human bronchial epithelium cells by repeated rhinovirus infections
2023 J Allergy Clin Immunol

Grychtol, R. ; Riemann, L. ; Gaedcke, S. ; Liu, B. ; DeLuca, D. ; Förster, R. ; Maison, N. ; Thiele, D. ; Jakobs, N. ; Bahmer, T. ; Meyer, M. ; Foth, S. ; Weber, S. ; Rietschel, E. ; Rabe, K.F. ; Kopp, M.V. ; von Mutius, E. ; Dittrich, A.M. ; Hansen, G. ; ALLIANCE Study Group as part of the German Center for Lung Research (DZL).

Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort
2022 Eur Respir J

Maison, N. ; Omony, J. ; Illi, S. ; Thiele, D. ; Skevaki, C. ; Dittrich, A.M. ; Bahmer, T. ; Rabe, K.F. ; Weckmann, M. ; Happle, C. ; Schaub, B. ; Meyer, M. ; Foth, S. ; Rietschel, E. ; Renz, H. ; Hansen, G. ; Kopp, M.V. ; von Mutius, E. ; Grychtol, R. ; ALLIANCE Study Group.

T2-high asthma phenotypes across lifespan
2022 Infection

Maison, N. ; Peck, A. ; Illi, S. ; Meyer-Buehn, M. ; von Mutius, E. ; Hübner, J. ; von Both U.

The rising of old foes: impact of lockdown periods on "non-SARS-CoV-2" viral respiratory and gastrointestinal infections
2022 Am J Respir Crit Care Med

Illi, S. ; Depner, M. ; Pfefferle, PI. ; Renz, H. ; Roduit, C. ; Taft, D.H. ; Kalanetra, K.M. ; Mills, D.A. ; Farquharson, F.M. ; Louis, P. ; Schmausser-Hechfellner, E. ; Divaret-Chauveau, A. ; Lauener, R. ; Karvonen, A.M. ; Pekkanen, J. ; Kirjavainen, P.V. ; Roponen, M. ; Riedler, J. ; Kabesch, M. ; Schaub, B. ; von Mutius, E. ; PASTURE Study Group.

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers

Contact

Sabina_Illi_IAP_Portrait
Dr. rer. med. Sabina Illi

Statistician, Deputy Director, Group Leader