Metabolomics
2019
- tDeelen J, Kettunen J, Fischer K, van der Spek A, Trompet S, Kastenmüller G, Boyd A, Zierer J, van den Akker EB, Ala-Korpela M, Amin N, Demirkan A, Ghanbari M, van Heemst D, Ikram MA, van Klinken JB, Mooijaart SP, Peters A, Salomaa V, Sattar N, Spector TD, Tiemeier H, Verhoeven A, Waldenberger M, Würtz P, Davey Smith G, Metspalu A, Perola M, Menni C, Geleijnse JM, Drenos F, Beekman M, Jukema JW, van Duijn CM, Slagboom PE. A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals. Nat Commun. (Aug 2019)
- Wildberg C, Masuch A, Budde K, Kastenmüller G, Artati A, Rathmann W, Adamski J, Kocher T, Völzke H, Nauck M, Friedrich N, Pietzner M. Plasma Metabolomics to Identify and Stratify Patients with Impaired Glucose Tolerance. J Clin Endocrinol Metab. (Aug 2019)
- Nho K, Kueider-Paisley A, Ahmad S, MahmoudianDehkordi S, Arnold M, Risacher SL, Louie G, Blach C, Baillie R, Han X, Kastenmüller G, Trojanowski JQ, Shaw LM, Weiner MW, Doraiswamy PM, van Duijn C, Saykin AJ, Kaddurah-Daouk R; Alzheimer’s Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium. Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers. JAMA Netw Open. (Jul 2019)
- Masuch A, Budde K, Kastenmüller G, Artati A, Adamski J, Völzke H, Nauck M, Pietzner M. Metabolic signature associated with parameters of the complete blood count in apparently healthy individuals. J Cell Mol Med. (Jun 2019)
- Quell JD, Römisch-Margl W, Haid M, Krumsiek J, Skurk T, Halama A, Stephan N, Adamski J, Hauner H, Mook-Kanamori D, Mohney RP, Daniel H, Suhre K, Kastenmüller G. Characterization of Bulk Phosphatidylcholine Compositions in Human Plasma Using Side-Chain Resolving Lipidomics. Metabolites. (Jun 2019)
- Matejka K, Stückler F, Salomon M, Ensenauer R, Reischl E, Hoerburger L, Grallert H, Kastenmüller G, Peters A, Daniel H, Krumsiek J, Theis FJ, Hauner H, Laumen H. Dynamic modelling of an ACADS genotype in fatty acid oxidation - Application of cellular models for the analysis of common genetic variants. PLoS One. (May 2019)
- Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmüller G, Artati A, Suhre K, Adamski J, Nauck M, Völzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M. The Saliva Metabolome in Association to Oral Health Status. J Dent Res. (Jun 2019)
- Yu B, Flexeder C, McGarrah RW 3rd, Wyss A, Morrison AC, North KE, Boerwinkle E, Kastenmüller G, Gieger C, Suhre K, Karrasch S, Peters A, Wagner GR, Michelotti GA, Mohney RP, Schulz H, London SJ. Metabolomics Identifies Novel Blood Biomarkers of Pulmonary Function and COPD in the General Population. Metabolites. (Apr 2019)
2018
- Do KT, Wahl S, Raffler J, Molnos S, Laimighofer M, Adamski J, Suhre K, Strauch K, Peters A, Gieger C, Langenberg C, Stewart ID, Theis FJ, Grallert H. Kastenmüller G, Krumsiek J. Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies. Metabolomics. (Sep 2018)
- Ward-Caviness CK, Agha G, Chen BH, Pfeiffer L, Wilson R, Wolf P, Gieger C, Schwartz J, Vokonas PS, Hou L, Just AC, Bandinelli S, Hernandez DG, Singleton AB, Prokisch H, Meitinger T, Kastenmüller G, Ferrucci L, Baccarelli AA, Waldenberger M, Peters A. Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction. Clin Epigenetics. (Dec 2018)
- Halama A, Kahal H, Bhagwat AM, Zierer J, Sathyapalan T, Graumann J, Suhre K, Atkin SL. Metabolic and proteomic signatures of hypoglycaemia in type 2 diabetes. Diabetes Obes Metab. (Dec 2018)
- Tsepilov YA, Sharapov SZ, Zaytseva OO, Krumsek J, Prehn C, Adamski J, Kastenmüller G, Wang-Sattler R, Strauch K, Gieger C, Aulchenko YS. A network-based conditional genetic association analysis of the human metabolome. Gigascience. (Nov 2018)
- Kaul A, Masuch A, Budde K, Kastenmüller G, Artati A, Adamski J, Völzke H, Nauck M, Friedrich N, Pietzner M. Molecular Fingerprints of Iron Parameters among a Population-Based Sample. Nutrients. (Nov 2018)
- di Giuseppe R, Koch M, Nöthlings U, Kastenmüller G, Artati A, Adamski J, Jacobs G, Lieb W. Metabolomics signature associated with circulating serum selenoprotein P levels. Endocrine. (Nov 2018)
- Nho K, Kueider-Paisley A, MahmoudianDehkordi S, Arnold M, Risacher SL, Louie G, Blach C, Baillie R, Han X, Kastenmüller G, Jia W, Xie G, Ahmad S, Hankemeier T, van Duijn CM, Trojanowski JQ, Shaw LM, Weiner MW, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R; Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium. Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers. (Oct 2018)
- MahmoudianDehkordi S, Arnold M, Nho K, Ahmad S, Jia W, Xie G, Louie G, Kueider-Paisley A, Moseley MA, Thompson JW, St John Williams L, Tenenbaum JD, Blach C, Baillie R, Han X, Bhattacharyya S, Toledo JB, Schafferer S, Klein S, Koal T, Risacher SL, Kling MA, Motsinger-Reif A, Rotroff DM, Jack J, Hankemeier T, Bennett DA, De Jager PL, Trojanowski JQ, Shaw LM, Weiner MW, Doraiswamy PM, van Duijn CM, Saykin AJ, Kastenmüller G, Kaddurah-Daouk R; Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium. Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome. Alzheimers Dement. (Oct 2018)
- Barrios C, Zierer J, Würtz P, Haller T, Metspalu A, Gieger C, Thorand B, Meisinger C, Waldenberger M, Raitakari O, Lehtimäki T, Otero S, Rodríguez E, Pedro-Botet J, Kähönen M, Ala-Korpela M, Kastenmüller G, Spector TD, Pascual J, Menni C. Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations. Sci Rep. (Oct 2018)
- Masuch A, Pietzner M, Bahls M, Budde K, Kastenmüller G, Zylla S, Artati A, Adamski J, Völzke H, Dörr M, Felix SB, Nauck M, Friedrich N. Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP. Cardiovasc Diabetol. (Aug 2018)
- Hamad S, Adornetto G, Naveja J, Ravindranath AC, Raffler J, Campillos M. HitPickV2: a Web Server to predict targets of chemical compounds. Bioinformatics (Aug 2018)
- Sedlmeier A, Kluttig A, Giegling I, Prehn C, Adamski J, Kastenmüller G, Lacruz ME. The human metabolic profile reflects macro- and micronutrient intake distinctly according to fasting time. Sci Rep. (Aug 2018)
- Pietzner M, Budde K, Homuth G, Kastenmüller G, Henning AK, Artati A, Krumsiek J, Völzke H, Adamski J, Lerch MM, Kühn JP, Nauck M, Friedrich N. Hepatic steatosis associates with adverse molecular signatures in subjects without diabetes. J Clin Endocrinol Metab. (Jul 2018)
- Saulnier-Blache JS, Wilson R, Klavins K, Graham D, Alesutan I, Kastenmüller G, Wang-Sattler R, Adamski J, Roden M, Rathmann W, Seissler J, Meisinger C, Koenig W, Thiery J, Suhre K, Peters A, Kuro-O M, Lang F, Dallmann G, Delles C, Voelkl J, Waldenberger M, Bascands JL, Klein J, Schanstra JPLdlr-/- and ApoE-/- mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease. Atherosclerosis. (Jul 2018)
- Do KT, Rasp DJN, Kastenmüller G, Suhre K, Krumsiek J. MoDentify: phenotype-driven module identification in metabolomics networks at different resolutions. Bioinformatics. (Jul 2018)
- Pitchika A, Jolink M, Winkler C, Hummel S, Hummel N, Krumsiek J, Kastenmüller G, Raab J, Kordonouri O, Ziegler AG, Beyerlein A. Associations of maternal type 1 diabetes with childhood adiposity and metabolic health in the offspring: a prospective cohort study. Diabetologia. (Jul 2018)
- Jackson MA, Verdi S, Maxan ME, Shin CM, Zierer J, Bowyer RCE, Martin T, Williams FMK, Menni C, Bell JT, Spector TD, Steves CJ. Gut microbiota associations with common diseases and prescription medications in a population-based cohort. Nat Commun. (Jul 2018)
- Lacruz ME, Kluttig A, Tiller D, Medenwald D, Giegling I, Rujescu D, Prehn C, Adamski J, Greiser KH, Kastenmüller G. Instability of personal human metabotype is linked to all-cause mortality. Sci Rep. (Jun 2018)
- Zierer J, Jackson MA, Kastenmüller G, Mangino M, Long T, Telenti A, Mohney RP, Small KS, Bell JT, Steves CJ, Valdes AM, Spector TD, Menni C. The fecal metabolome as a functional readout of the gut microbiome. Nat Genet. (Jun 2018)
- Halama A, Kulinski M, Dib SS, Zaghlool SB, Siveen KS, Iskandarani A, Zierer J, Prabhu KS, Satheesh NJ, Bhagwat AM, Uddin S, Kastenmüller G, Elemento O, Gross SS, Suhre K. Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis. Cancer Lett. (May 2018)
- Menni C, Gudelj I, Macdonald-Dunlop E, Mangino M, Zierer J, Bešić E, Joshi PK, Trbojević-Akmačić I, Chowienczyk PJ, Spector TD, Wilson JF, Lauc G, Valdes AM. Glycosylation Profile of Immunoglobulin G Is Cross-Sectionally Associated With Cardiovascular Disease Risk Score and Subclinical Atherosclerosis in Two Independent Cohorts. Circ Res. (May 2018)
- Köttgen A, Raffler J, Sekula P, Kastenmüller G. Genome-Wide Association Studies of Metabolite Concentrations (mGWAS): Relevance for Nephrology. Semin Nephrol. (Mar 2018)
- Lange T, Budde K, Homuth G, Kastenmüller G, Artati A, Krumsiek J, Völzke H, Adamski J, Petersmann A, Völker U, Nauck M, Friedrich N, Pietzner M. Comprehensive Metabolic Profiling Reveals a Lipid-rich Fingerprint of Free Thyroxine Far Beyond Classical Parameters. J Clin Endocrinol Metab. (Mar 2018)
- Jackson MA, Bonder MJ, Kuncheva Z, Zierer J, Fu J, Kurilshikov A, Wijmenga C, Zhernakova A, Bell JT, Spector TD, Steves CJ. Detection of stable community structures within gut microbiota co-occurrence networks from different human populations. PeerJ. (Feb 2018)
- Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Legido-Quigley C, Thambisetty M. Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study. PLoS Med. (Jan 2018)
- Zaghlool SB, Mook-Kanamori DO, Kader S, Stephan N, Halama A, Engelke R, Sarwath H, Al-Dous EK, Mohamoud YA, Roemisch-Margl W, Adamski J, Kastenmüller G, Friedrich N, Visconti A, Tsai PC, Spector T, Bell J, Falchi M, Wahl A, Waldenberger M, Peters A, Gieger C, Pezer M, Lauc G, Graumann J, Malek JA, Suhre K. Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation. Hum Mol Genet. (Jan 2018)
2017
- Sekula P, Dettmer K, Vogl FC, Gronwald W, Ellmann L, Mohney RP, Eckardt KU, Suhre K, Kastenmüller G, Oefner PJ, Köttgen A. From Discovery to Translation: Characterization of C-Mannosyltryptophan and Pseudouridine as Markers of Kidney Function. Sci Rep. (Dec 2017)
- Rueedi R, Mallol R, Raffler J, Lamparter D, Friedrich N, Vollenweider P, Waeber G, Kastenmüller G, Kutalik Z, Bergmann S. Metabomatching: Using genetic association to identify metabolites in proton NMR spectroscopy. PLoS Comput Biol. (Dec 2017)
- Pietzner M, Kaul A, Henning AK, Kastenmüller G, Artati A, Lerch MM, Adamski J, Nauck M, Friedrich N. Comprehensive metabolic profiling of chronic low-grade inflammation among generally healthy individuals.
BMC Med. (Nov 2017) - Kim HI, Raffler J, Lu W, Lee JJ, Abbey D, Saleheen D, Rabinowitz JD, Bennett MJ, Hand NJ, Brown C, Rader D. Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. Am J Hum Genet. (Oct 2017)
- Hertel J, König J, Homuth G, Van der Auwera S, Wittfeld K, Pietzner M, Kacprowski T, Pfeiffer L, Kretschmer A, Waldenberger M, Kastenmüller G, Artati A, Suhre K, Adamski J, Langner S, Völker U, Völzke H, Nauck M, Friedrich N, Grabe HJ. Evidence for Stress-like Alterations in the HPA-Axis in Women Taking Oral Contraceptives. Sci Rep. (Oct 2017)
- Haid M, Muschet C, Wahl S, Römisch-Margl W, Prehn C, Möller G, Adamski J. Long-term stability of human plasma metabolites during storage at -80 °C. J Proteome Res. (Oct 2017)
- Pallister T, Jackson MA, Martin TC, Zierer J, Jennings A, Mohney RP, MacGregor A, Steves CJ, Cassidy A, Spector TD, Menni C. Hippurate as a metabolomic marker of gut microbiome diversity: Modulation by diet and relationship to metabolic syndrome. Sci Rep. (Oct 2017)
- St John-Williams L, Blach C, Toledo JB, Rotroff DM, Kim S, Klavins K, Baillie R, Han X, Mahmoudiandehkordi S, Jack J, Massaro TJ, Lucas JE, Louie G, Motsinger-Reif AA, Risacher SL; Alzheimer’s Disease Neuroimaging Initiative; Alzheimer’s Disease Metabolomics Consortium, Saykin AJ, Kastenmüller G, Arnold M, Koal T, Moseley MA, Mangravite LM, Peters MA, Tenenbaum JD, Thompson JW, Kaddurah-Daouk R. Targeted metabolomics and medication classification data from participants in the ADNI1 cohort. Sci Data. (Oct 2017)
- Keuper M, Sachs S, Walheim E, Berti L, Raedle B, Tews D, Fischer-Posovszky P, Wabitsch M, Hrabě de Angelis M, Kastenmüller G, Tschöp MH, Jastroch M, Staiger H, Hofmann SM. Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors. Mol Metab. (Oct 2017)
- Molnos S, Baumbach C, Wahl S, Müller-Nurasyid M, Strauch K, Wang-Sattler R, Waldenberger M, Meitinger T, Adamski J, Kastenmüller G, Suhre K, Peters A, Grallert H, Theis FJ, Gieger C. pulver: an R package for parallel ultra-rapid p-value computation for linear regression interaction terms. BMC Bioinformatics. (Sep. 2017)
- Do KT, Pietzner M, Rasp DJ, Friedrich N, Nauck M, Kocher T, Suhre K, Mook-Kanamori DO, Kastenmüller G, Krumsiek J. Phenotype-driven identification of modules in a hierarchical map of multifluid metabolic correlations. NPJ Syst Biol Appl. (Sep 2017)
- Entenmann L, Pietzner M, Artati A, Hannemann A, Henning AK, Kastenmüller G, Völzke H, Nauck M, Adamski J, Wallaschofski H, Friedrich N. Comprehensive metabolic characterization of serum osteocalcin action in a large non-diabetic sample. PLoS One. (Sep 2017)
- Menni C, Zierer J, Pallister T, Jackson MA, Long T, Mohney RP, Steves CJ, Spector TD, Valdes AM. Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women. Sci Rep. (Sep 2017)
- Menni C, Migaud M, Kastenmüller G, Pallister T, Zierer J, Peters A, Mohney RP, Spector TD, Bagnardi V, Gieger C, Moore SC, Valdes AM Metabolomic Profiling of Long-Term Weight Change: Role of Oxidative Stress and Urate Levels in Weight Gain. Obesity (Silver Spring). (Jul 2017)
- Kremer LS, Bader DM, Mertes C, Kopajtich R, Pichler G, Iuso A, Haack TB, Graf E, Schwarzmayr T, Terrile C, Koňaříková E, Repp B, Kastenmüller G, Adamski J, Lichtner P, Leonhardt C, Funalot B, Donati A, Tiranti V, Lombes A, Jardel C, Gläser D, Taylor RW, Ghezzi D, Mayr JA, Rötig A, Freisinger P, Distelmaier F, Strom TM, Meitinger T, Gagneur J, Prokisch H. Genetic diagnosis of Mendelian disorders via RNA sequencing. Nat Commun. (Jun 2017)
- Piontek U, Wallaschofski H, Kastenmüller G, Suhre K, Völzke H, Do KT, Artati A, Nauck M, Adamski J, Friedrich N, Pietzner M. Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes. Sci Rep. (May 2017)
- Adam J, Brandmaier S, Troll M, Rotter M, Mohney RP, Heier M, Adamski J, Li Y, Neschen S, Kastenmüller G, Suhre K, Ankerst D, Meitinger T, Wang-Sattler R. Response to Comment on Adam et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues. Diabetes 2016;65:3776-3785. Diabetes. (May 2017)
- Quell JD, Römisch-Margl W, Colombo M, Krumsiek J, Evans AM, Mohney R, Salomaa V, de Faire U, Groop LC, Agakov F, Looker HC, McKeigue P, Colhoun HM, Kastenmüller G. Automated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies. J Chromatogr B Analyt Technol Biomed Life Sci. (Apr 2017)
- Koch M, Freitag-Wolf S, Schlesinger S, Borggrefe J, Hov JR, Jensen MK, Pick J, Markus MR, Höpfner T, Jacobs G, Siegert S, Artati A, Kastenmüller G, Römisch-Margl W, Adamski J, Illig T, Nothnagel M, Karlsen TH, Schreiber S, Franke A, Krawczak M, Nöthlings U, Lieb W. Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample. Eur J Clin Nutr. (Apr 2017)
- Long T, Hicks M, Yu HC, Biggs WH, Kirkness EF, Menni C, Zierer J, Small KS, Mangino M, Messier H, Brewerton S, Turpaz Y, Perkins BA, Evans AM, Miller LA, Guo L, Caskey CT, Schork NJ, Garner C, Spector TD, Venter JC, Telenti A. Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites. Nat Genet. (Apr 2017)
- Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, Thambisetty M, Tenenbaum JD, Suhre K, Thompson JW, John-Williams LS, MahmoudianDehkordi S, Rotroff DM, Jack JR, Motsinger-Reif A, Risacher SL, Blach C, Lucas JE, Massaro T, Louie G, Zhu H, Dallmann G, Klavins K, Koal T, Kim S, Nho K, Shen L, Casanova R, Varma S, Legido-Quigley C, Moseley MA, Zhu K, Henrion MY, van der Lee SJ, Harms AC, Demirkan A, Hankemeier T, van Duijn CM, Trojanowski JQ, Shaw LM, Saykin AJ, Weiner MW, Doraiswamy PM, Kaddurah-Daouk R; Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium. Alzheimers Dement. (Mar 2017)
- Keser T, Vučković F, Barrios C, Zierer J, Wahl A, Akinkuolie AO, Štambuk J, Nakić N, Pavić T, Periša J, Mora S, Gieger C, Menni C, Spector TD, Gornik O, Lauc G. Effects of statins on the immunoglobulin G glycome. Biochim Biophys Acta. Mar 2017)
- Menni C, Zierer J, Valdes AM, Spector TD. Mixing omics: combining genetics and metabolomics to study rheumatic diseases. Nat Rev Rheumatol. Mar 2017)
- Suhre K, Arnold M, Bhagwat AM, Cotton RJ, Engelke R, Raffler J, Sarwath H, Thareja G, Wahl A, DeLisle RK, Gold L, Pezer M, Lauc G, El-Din Selim MA, Mook-Kanamori DO, Al-Dous EK, Mohamoud YA, Malek J, Strauch K, Grallert H, Peters A, Kastenmüller G, Gieger C, Graumann J. Connecting genetic risk to disease end points through the human blood plasma proteome. Nature Communications (Feb 2017)
- Siskos AP, Jain P, Römisch-Margl W, Bennett M, Achaintre D, Asad Y, Marney L, Richardson L, Koulman A, Griffin JL, Raynaud F, Scalbert A, Adamski J, Prehn C, Keun HC. Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma. Anal Chem. (Jan 2017)
2016
- Ward-Caviness CK, Breitner S, Wolf K, Cyrys J, Kastenmüller G, Wang-Sattler R, Schneider A, Peters A. Short-term NO2 exposure is associated with long-chain fatty acids in prospective cohorts from Augsburg, Germany: results from an analysis of 138 metabolites and three exposures. Int J Epidemiol. (2016)
- Zierer J, Pallister T, Tsai PC, Krumsiek J, Bell JT, Lauc G, Spector TD, Menni C, Kastenmüller G. Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model. Sci Rep. (2016)
- Lacruz ME, Kluttig A, Tiller D, Medenwald D, Giegling I, Rujescu D, Prehn C, Adamski J, Frantz S, Greiser KH, Emeny RT, Kastenmüller G, Haerting J. Cardiovascular Risk Factors Associated with Blood Metabolite Concentrations and Their Alterations over a 4-Year Period in a Population-Based Cohort. Circ Cardiovasc Genet. (2016)
- Siskos AP, Jain P, Römisch-Margl W, Bennett M, Achaintre D, Asad Y, Marney L, Richardson L, Koulman A, Griffin JL, Raynaud F, Scalbert A, Adamski J, Prehn C, Keun HC. Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma. Anal Chem. (2016)
- Suhre K, Arnold M, Bhagwat A, Cotton RJ, Engelke R, Laser A, Raffler J, Sarwath H, Thareja G, DeLisle RK, Gold L, Pezer M, Lauc G, El-Din Selim MA, Mook-Kanamori DO, Al-Dous EK, Mohamoud YA, Malek J, Strauch K, Grallert H, Peters A, Kastenmüller G, Gieger C, Graumann J. Connecting genetic risk to disease endpoints through the human blood plasma proteome. Preprint on bioRxiv (2016)
- Knacke H, Pietzner M, Do KT, Römisch-Margl W, Kastenmüller G, Völker U, Völzke H, Krumsiek J, Artati A, Wallaschofski H, Nauck M, Suhre K, Adamski J, Friedrich N. Metabolic fingerprints of circulating IGF-I and the IGF-I/IGFBP-3 ratio: a multi-fluid metabolomics study. J Clin Endocrinol Metab. (2016)
- Beger RD, Dunn W, Schmidt MA, Gross SS, Kirwan JA, Cascante M, Brennan L, Wishart DS, Oresic M, Hankemeier T, Broadhurst DI, Lane AN, Suhre K, Kastenmüller G, Sumner SJ, Thiele I, Fiehn O, Kaddurah-Daouk R; for “Precision Medicine and Pharmacometabolomics Task Group”-Metabolomics Society Initiative. Metabolomics enables precision medicine: "A White Paper, Community Perspective". Metabolomics (2016)
- Adam J, Brandmaier S, Leonhardt J, Scheerer MF, Mohney RP, Xu T, Bi J, Rotter M, Troll M, Chi S, Heier M, Herder C, Rathmann W, Giani G, Adamski J, Illig T, Strauch K, Li Y, Gieger C, Peters A, Suhre K, Ankerst D, Meitinger T, Hrabe de Angelis M, Roden M, Neschen S, Kastenmüller G, Wang-Sattler R. Metformin Effect on Non-Targeted Metabolite Profiles in Patients with Type 2 Diabetes and Multiple Murine Tissues. Diabetes (2016)
- Pallister T, Haller T, Thorand B, Altmaier E, Cassidy A, Martin T, Jennings A, Mohney RP, Gieger C, MacGregor A, Kastenmüller G, Metspalu A, Spector TD, Menni C. Metabolites of milk intake: a metabolomic approach in UK twins with findings replicated in two European cohorts. Eur J Nutr. (2016)
- Vogt S, Wahl S, Kettunen J, Breitner S, Kastenmüller G, Gieger C, Suhre K, Waldenberger M, Kratzsch J, Perola M, Salomaa V, Blankenberg S, Zeller T, Soininen P, Kangas AJ, Peters A, Grallert H, Ala-Korpela M, Thorand B. Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data. Int J Epidemiol. (2016)
- Much D, Beyerlein A, Kindt A, Krumsiek J, Stückler F, Rossbauer M, Hofelich A, Wiesenäcker D, Hivner S, Herbst M, Römisch-Margl W, Prehn C, Adamski J, Kastenmüller G, Theis F, Ziegler AG, Hummel S. Lactation is associated with altered metabolomic signatures in women with gestational diabetes. Diabetologia (2016)
- Fall T, Salihovic S, Brandmaier S, Nowak C, Ganna A, Gustafsson S, Broeckling CD, Prenni JE, Kastenmüller G, Peters A, Magnusson PK, Wang-Sattler R, Giedraitis V, Berne C, Gieger C, Pedersen NL, Ingelsson E, Lind L. Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes. Diabetologia (2016)
- Altmaier E, Menni C, Heier M, Meisinger C, Thorand B, Quell J, Kobl M, Römisch-Margl W, Valdes AM, Mangino M, Waldenberger M, Strauch K, Illig T, Adamski J, Spector T, Gieger C, Suhre K, Kastenmüller G. The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study. PLoS One (2016)
- Yet I, Menni C, Shin SY, Mangino M, Soranzo N, Adamski J, Suhre K, Spector TD, Kastenmüller G, Bell JT. Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms. PLoS One (2016)
- Fard D, Läer K, Rothämel T, Schürmann P, Arnold M, Cohen M, Vennemann M, Pfeiffer H, Bajanowski T, Pfeufer A, Dörk T, Klintschar M. Candidate gene variants of the immune system and sudden infant death syndrome. Int J Legal Med (2016)
- Schulte EC, Altmaier E, Berger HS, Do KT, Kastenmüller G, Wahl S, Adamski J, Peters A, Krumsiek J, Suhre K, Haslinger B, Ceballos-Baumann A, Gieger C, Winkelmann J. Alterations in Lipid and Inositol Metabolisms in Two Dopaminergic Disorders. PLoS One (2016)
- Zierer J, Kastenmüller G, Suhre K, Gieger C, Codd V, Tsai PC, Bell J, Peters A, Strauch K, Schulz H, Weidinger S, Mohney RP, Samani NJ, Spector T, Mangino M, Menni C. Metabolomics profiling reveals novel markers for leukocyte telomere length. Aging (2016)
- Vehmas AP, Adam M, Laajala TD, Kastenmüller G, Prehn C, Rozman J, Ohlsson C, Fuchs H, Hrabě de Angelis M, Gailus-Durner V, Elo LL, Aittokallio T, Adamski J, Corthals G, Poutanen M, Strauss L. Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse. J Proteomics (2016)
- Yousri NA, Kastenmüller G, AlHaq WG, Holle R, Kaab S, Mohney RP, Gieger C, Peters A, Adamski J, Suhre K, Arayssi T. Diagnostic and Prognostic Metabolites identified for Joint Symptoms in the KORA population. J Proteome Res (2016)
- Sekula, P., Goek, O.N., Quaye, L., Barrios, C., Levey, A.S., Römisch-Margl, W., Menni, C., Yet, I., Gieger, C., Inker, L.A., Adamski, J., Gronwald, W., Illig, T., Dettmer, K., Krumsiek, J., Oefner, P.J., Valdes, A.M., Meisinger, C., Coresh, J., Spector, T.D., Mohney, R.P., Suhre, K., Kastenmüller, G., Köttgen, A. A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population. J Am Soc Nephrol (2016)
- Suhre, K., Raffler, J., Kastenmüller, G. Biochemical Insights from Population Studies with Genetics and Metabolomics. Arch Biochem Biophys (2016)
- Halama, A., Horsch, M., Kastenmüller, G., Möller, G., Kumar, P., Prehn, C., Laumen, H., Hauner, H., Hrabĕ de Angelis, M., Beckers, J., Suhre, K., Adamski, J. Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis. Arch Biochem Biophys (2016)
- Suhre, K., Schwartz, J.E., Sharma, V.K., Chen, Q., Lee, J.R., Muthukumar, T., Dadhania, D.M., Ding, R., Mohney, R.P., Abecassis, M., Friedewald, J., Knechtle, S.J., Becker, Y.T., Ikle, D.N., Bridges, N.D., Williams, N.M., Kastenmüller, G., Karoly, E.D., Samstein, B., Shaked, A., Gross, S.S., Suthanthiran, M. Urine metabolite profiles predictive of human kidney allograft status. Journal of the American Society of Nephrology (2016)
2015
- Raffler, J., Friedrich, N., Arnold, M., Kacprowski, T., Rueedi, R., Altmaier, E., Bergmann, S., Budde, K., Gieger, C., Homuth, G., Pietzner, M., Römisch-Margl, W., Strauch, K., Völzke, H., Waldenberger, M., Wallaschofski, H., Nauck, M., Völker, U., Kastenmüller, G., Suhre, K. Genome-wide association study with targeted and non-targeted NMR metabolomics identifies 15 novel loci of urinary human metabolic individuality. PLoS Genetics (2015)
- Zierer, J., Menni, C., Kastenmüller, G., Spector, T.D. Integration of 'omics' data in aging research: from biomarkers to systems biology. Aging Cell (2015)
- Krumsiek, J., Mittelstrass, K., Do, K.T., Stückler, F., Ried, J., Adamski, J., Peters, A., Illig, T., Kronenberg, F., Friedrich, N., Nauck, M., Pietzner, M., Mook-Kanamori, D.O., Suhre, K., Gieger, C., Grallert, H., Theis, F.J., Kastenmüller, G. Gender-specific pathway differences in the human serum metabolome. Metabolomics (2015)
- Barrios, C., Zierer, J., Gudelj, I., Štambuk, J., Ugrina, I., Rodríguez, E., Soler, M.J., Pavić, T., Šimurina, M., Keser, T., Pučić-Baković, M., Mangino, M., Pascual, J., Spector, T.D., Lauc, G., Menni, C. Glycosylation Profile of IgG in Moderate Kidney Dysfunction. J Am Soc Nephrol (2015)
- Xu, T., Brandmaier, S., Messias, A.C., Herder, C., Draisma, H.H., Demirkan, A., Yu, Z., Ried, J., Haller, T., Heier, M., Campillos, M., Fobo, G., Stark, R., Holzapfel, C., Adam, J., Chi, S., Rotter, M., Panni, T., Quante, A.S., He, Y., Prehn, C., Römisch-Margl, W., Kastenmüller, G., Willemsen, G., Pool, R., Kasa, K., van Dijk, K.W., Hankemeier, T., Meisinger, C., Thorand, B., Ruepp, A., Hrabé de Angelis, M., Li, Y., Wichmann, H.-E., Stratmann, B., Strauch, K., Metspalu, A., Gieger, C., Suhre, K., Adamski, J., Illig, T., Rathmann, W., Roden, M., Peters, A., van Duijn, C.M., Boomsma, D.I., Meitinger, T., Wang-Sattler, R. Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes. Diabetes Care (2015)
- Kastenmüller, G., Raffler, J., Gieger, C., Suhre, K. Genetics of human metabolism: an update. Human Molecular Genetics (2015)
- Bartel, J., Krumsiek, J., Schramm, K., Adamski, J., Gieger, C., Herder, C., Carstensen, M., Peters, A., Rathmann, W., Roden, M., Strauch, K., Suhre, K., Kastenmüller, G., Prokisch, H., Theis, F.J. The Human Blood Metabolome-Transcriptome Interface. PLoS Genet. (2015)
- Tsepilov, Y.A., Shin, S.-Y., Soranzo, N., Spector, T.D., Prehn, C., Adamski, J., Kastenmüller, G., Wang-Sattler, R., Strauch, K., Gieger, C., Aulchenko, Y.S., Ried, J.S. Non-Additive Effects of Genes in Human Metabolomics. Genetics (2015)
- Menni, C., Graham, D., Kastenmüller, G., Alharbi, N., Alsanosi, S., McBride, M., Mangino, M., Titcombe, P., Shin, S.-Y., Psatha, M., Geisendorfer, T., Huber, A., Peters A., Wang-Sattler, R., Xu, T., Brosnan, M.J., Trimmer, J., Reichel, C., Mohney, R., Soranzo, N., Edwards, M., Cooper, C., Church, A., Suhre, K., Gieger, C., Dominiczak, A., Spector, T., Padmanabhan, S., Valdes, A. Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension (2015)
- Yousri, N., Mook-Kanamori, D., El-Din Selim, M., Takiddin, A., Al-Homsi, H., Al-Mahmoud, K., Karoly, E., Krumsiek, J., Do, K., Neumaier, U., Mook-Kanamori, M., Rowe, G., Chidiac, O., McKeon, C., Al Muftah, W., Kader, S., Kastenmüller, G., Suhre, K. A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different time-scales of glycemic control. Diabetologia (2015)
- Livshits, G., Macgregor, A.J., Gieger, C., Malkin, I., Moayyeri, A., Grallert, H., Emeny, R.T., Spector, T., Kastenmüller, G., Williams, F.M. An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker. Pain (2015)
- Schwab, S., Zierer, A., Schneider, A., Heier, M., Koenig, W., Kastenmüller, G., Waldenberger, M., Peters, A., Thorand, B. Vitamin E supplementation is associated with lower levels of C-reactive protein only in higher dosages and combined with other antioxidants: The Cooperative Health Research in the Region of Augsburg (KORA) F4 study. Br J Nutr (2015)
- Anton, G., Wilson, R., Yu, Z.-H., Prehn, C., Zukunft, S., Adamski, J., Heier, M., Meisinger, C., Römisch-Margl, W., Wang-Sattler, R., Hveem, K., Wolfenbuttel, B., Peters, A., Kastenmüller, G., Waldenberger, M. Pre-analytical sample quality: metabolite ratios as an intrinsic marker for prolonged room temperature exposure of serum samples. PLoS One (2015)
- Wahl, S., Vogt, S., Stückler, F., Krumsiek, J., Bartel, J., Kacprowski, T., Schramm, K., Carstensen, M., Rathmann, W., Roden, M., Jourdan, C., Kangas, A.J., Soininen, P., Ala-Korpela, M., Nöthlings, U., Boeing, H., Theis, F.J., Meisinger, C., Waldenberger, M., Suhre, K., Homuth, G., Gieger, C., Kastenmüller, G., Illig, T., Linseisen, J., Peters, A., Prokisch, H., Herder, C., Thorand, B., Grallert, H. Multi-omic signature of body weight change: results from a population-based cohort study. BMC Medicine (2015)
- Diakopoulos, K.N., Lesina, M., Wörmann, S., Song, L., Aichler, M., Schild, L., Artati, A., Römisch-Margl, W., Wartmann, T., Fischer, R., Kabiri, Y., Zischka, H., Halangk, W., Demir, I.E., Pilsak, C., Walch, A., Mantzoros, C.S., Steiner, J.M., Erkan, M., Schmid, R.M., Witt, H., Adamski, J., Algül, H. Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes. Gastroenterology (2015)
- Witting, M., Lucio, M., Tziotis, D., Wägele, B., Suhre, K., Voulhoux, R., Garvis, S., Schmitt-Kopplin, P. DI-ICR-FT-MS-based high-throughput deep metabotyping: a case study of the Caenorhabditis elegans-Pseudomonas aeruginosa infection model. Anal Bioanal Chem. (2015)
- Do, K., Kastenmüller, G., Mook-Kanamori, D.O., Yousri, N.A., Theis, F.J., Suhre, K., Krumsiek, J. Network-Based Approach for Analyzing Intra- and Interfluid Metabolite Associations in Human Blood, Urine, and Saliva. J Proteome Res (2015)
- Arnold, M.+, Raffler, J.+, Pfeufer, A., Suhre, K., Kastenmüller, G. SNiPA: an interactive, genetic variant-centered annotation browser. Bioinformatics (2015)
2014
- Ellwanger, D., Leonhardt, J., Mewes, H.-W. Large-scale modeling of condition-specific gene regulatory networks by information integration and inference. Nucleic Acids Res (2014)
- Mook-Kanamori, D.O., Römisch-Margl, W., Kastenmüller, G., Prehn, C., Petersen, A.-K., Illig, T., Gieger, C., Wang-Sattler, R., Meisinger, C., Peters, A., Adamski, J., Suhre K. Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up. J Endocrinol Invest (2014)
- Mathew, S., Krug, S., Skurk, T., Halama, A., Stank, A., Artati, A., Prehn, C., Malek, J.A., Kastenmüller, G., Römisch-Margl, W., Adamski, J., Hauner H, Suhre, K. Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake. J Transl Med (2014)
- Shin, S.-Y., Fauman, E., Petersen, A.K., Krumsiek, J., Santos, R., Huang, J., Arnold, M., Erte, I., Forgetta, V., Yang, T.-P., Walter, K., Menni, C., Chen, L., Vasquez, L., Valdes, A.M., Hyde, C.L., Wang, V., Ziemek, D., Roberts, P., Xi, L., Grundberg, E., The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Waldenberger, M., Richards, J.B., Mohney, R.P., Milburn, M.V., John, S.L., Trimmer, J., Theis, F.J., Overington, J.P., Suhre, K., Brosnan, J., Gieger, C., Kastenmüller, G., Spector, T.D., Soranzo, N. An atlas of genetic influences on human blood metabolites. Nature Genetics (2014) List of associations
- Altmaier, E., Fobo, G., Heier, M., Thorand, B., Meisinger, C., Römisch-Margl, W., Waldenberger, M., Gieger, C., Illig, T., Adamski, J., Suhre, K., Kastenmüller, G. Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism. European Journal of Epidemiology (2014)
- Shin, S.-Y., Petersen, A.-K., Wahl, S., Zhai, G., Römisch-Margl, W., Small, K.S., Döring, A., Kato, B.S., Peters, A., Grundberg, E., Prehn, C., Wang-Sattler, R., Wichmann, H.-E., de Angelis. M.H., Illig, T., Adamski, J., Deloukas, P., Spector, T.D., Suhre, K., Gieger, C., Soranzo, N. Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids. Genome Medicine (2014)
- Schramm, K., Marzi, C., Schurmann, C., Carstensen, M., Reinmaa, E., Biffar, R., Eckstein, G., Gieger, C., Grabe, H.J., Homuth, G., Kastenmüller, G., Mägi, R., Metspalu, A., Mihailov, E., Peters, A., Petersmann, A., Roden, M., Strauch, K., Suhre, K., Teumer, A., Völker, U., Völzke, H., Wang-Sattler, R., Waldenberger, M., Meitinger, T., Illig, T., Herder, C., Grallert, H., Prokisch, H. Mapping the genetic architecture of gene regulation in whole blood. PLoS One (2014)
- Yousri, N., Kastenmüller, G., Gieger, C., Shin, S.-Y., Erte, I., Menni, C., Peters, A., Meisinger, C., Mohney, R.P., Illig, T., Adamski, J., Soranzo, N., Spector, T.D., Suhre, K. Long term conservation of human metabolic phenotypes and link to heritability. Metabolomics (2014)
- Jourdan C., Linseisen J., Meisinger C., Petersen A.-K., Gieger C., Rawal R., Illig T., Heier M., Peters A., Wallaschofski H., Nauck M., Kastenmüller G., Suhre K., Prehn C., Adamski J., Koenig W., Roden M., Wichmann H.-E., Völzke H. Associations between thyroid hormones and serum metabolite profiles in an euthyroid population. Metabolomics (2014)
- Then, C., Wahl, S., Kirchhofer, A., Grallert, H., Krug, S., Kastenmüller, G., Römisch-Margl, W., Claussnitzer, M., Illig, T., Heier, M., Meisinger, C., Adamski, J., Thorand, B., Huth, C., Peters, A., Prehn, C., Heukamp, I., Laumen, H., Lechner, A., Hauner, H., Seissler J. Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146. PLoS One. 2013 Oct 24;8(10):e78430.
- Albrecht, E., Waldenberger, M., Krumsiek, J., Evans, A.M., Jeratsch, U., Breier, M., Adamski, J., Koenig, W., Zeilinger, S., Fuchs, C., Klopp, N., Theis, F.J., Wichmann, H.-E., Suhre, K., Illig, T., Strauch, K., Peters, A., Gieger, C., Kastenmüller, G., Doering, A., Meisinger, C. Metabolite profiling reveals new insights into the regulation of serum urate in humans. Metabolomics 10, 141-151 (2014)
- Petersen A.K., Zeilinger S., Kastenmüller G., Römisch-Margl W., Brugger M., Peters A., Meisinger C., Strauch K., Hengstenberg C., Pagel P., Huber F., Mohney R.P., Grallert H., Illig T., Adamski J., Waldenberger M., Gieger C., Suhre K. Epigenetics meets metabolomics: An epigenome-wide association study with blood serum metabolic traits. Hum Mol Genet. (2014)
2013
- Menni C., Fauman E., Erte I., Perry J.R., Kastenmüller G., Shin S.Y., Petersen A.K., Hyde C., Psatha M., Ward K.J., Yuan W., Milburn M., Palmer C.N., Frayling T.M., Trimmer J., Bell J.T., Gieger C., Mohney R., Brosnan M.J., Suhre K., Soranzo N., Spector T.D. Biomarkers for type 2 diabetes and impaired fasting glucose using a non-targeted metabolomics approach. Diabetes. 2013 Jul 24.
- Menni C., Kastenmüller G., Petersen A.K., Bell J.T., Psatha M., Tsai P.C., Gieger C., Schulz H., Erte I., John S., Brosnan M.J., Wilson S.G., Tsaprouni L., Lim E.M., Stuckey B., Deloukas P., Mohney R., Suhre K., Spector T.D., Valdes A.M. Metabolomic markers reveal novel pathways of ageing and early development in human populations. Int J Epidemiol. 2013 Jul 8.
- Menni C., Zhai G., MacGregor A., Prehn C., Römisch-Margl W., Suhre K., Adamski J., Cassidy A., Illig T., Spector T.D., Valdes A.M. Targeted metabolomics profiles are strongly correlated with nutritional patterns in women. Metabolomics 9, 506-514 (2013)
- Ferrannini E., Natalai A., Camastra S., Nannipieri M., Mari A., Adam K.-P., Milburn M.V., Kastenmüller G., Adamski J., Tuomi T., Lyssenko V., Groop L., Gall W.E. Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance. Diabetes 62. 1730-1737 (2013)
- Goek O.-N., Prehn C., Sekula P., Römisch-Margl W., Döring A, Gieger C., Heier M., Koenig W., Wang-Sattler R., Illig T., Suhre K., Adamski J., Köttgen A., Meisinger C. Metabolites associate with kidney function decline and incident chronic kidney disease in the general population. Nephrol. Dial. Transplant., DOI:10.1093/ndt/gft217 (2013)
- Xu T., Holzapfel C., Dong X., Bader E., Yu Z., Prehn C., Perstorfer K., Jaremek M., Römisch-Margl W., Rathmann W., Li Y., Wichmann H.-E., Wallaschofski H., Ladwig K.H., Theis F., Suhre K., Adamski J., Illig T., Peters A., Wang-Sattler R., Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study. BMC Med 2013 Mar 4;11:60.
- Raffler J., Römisch-Margl W., Petersen AK., Pagel P., Blöchl F., Hengstenberg C., Illig T., Meisinger C., Stark K., Wichmann HE., Adamski J., Gieger C., Kastenmüller G., Suhre K. Identification and MS assisted interpretation of genetically influenced NMR signals in human plasma. Genome Med. 2013 Feb 15;5(2):13.
2012
- Altmaier E., Emeny RT., Krumsiek J., Lacruz ME., Lukaschek K., Häfner S., Kastenmüller G., Römisch-Margl W., Prehn C., Mohney RP., Evans AM., Milburn MV., Illig T., Adamski J., Theis F., Suhre K., Ladwig KH. Metabolomic profiles in individuals with negative affectivity and social inhibition: A population-based study of Type D personality. Psychoneuroendocrinology. 2012 Dec 10.
- Yu Z., Zhai G., Singmann P., He Y., Xu T., Prehn C., Römisch-Margl W., Lattka E., Gieger C., Soranzo N., Heinrich J., Standl M., Thiering E., Mittelstraß K., Wichmann HE., Peters A., Suhre K., Li Y., Adamski J., Spector TD., Illig T., Wang-Sattler R. Human serum metabolic profiles are age dependent. Aging Cell. 2012 Dec;11(6):960-7.
- Ferrannini E., Natali A., Camastra S., Nannipieri M., Mari A., Adam KP., Milburn MV., Kastenmüller G., Adamski J., Tuomi T., Lyssenko V., Groop L., Gall WE. Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance. Diabetes. 2012 Nov 16.
- Wahl S., Yu Z., Kleber M., Singmann P., Holzapfel C., He Y., Mittelstrass K., Polonikov A., Prehn C., Römisch-Margl W., Adamski J., Suhre K., Grallert H., Illig T., Wang-Sattler R., Reinehr T. Childhood obesity is associated with changes in the serum metabolite profile. Obes Facts. 2012;5(5):660-70.
- Krumsiek J., Suhre K., Evans AM., Mitchell MW., Mohney RP., Milburn MV., Wägele B., Römisch-Margl W., Illig T., Adamski J., Gieger C., Theis FJ., Kastenmüller G. Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information. PLoS Genet. 2012 Oct;8(10):e1003005. Supplementary data
- Wang-Sattler R., Yu Z., Herder C., Messias AC., Floegel A., He Y., Heim K., Campillos M., Holzapfel C., Thorand B., Grallert H., Xu T., Bader E., Huth C., Mittelstrass K., Döring A., Meisinger C., Gieger C., Prehn C., Römisch-Margl W., Carstensen M., Xie L., Yamanaka-Okumura H., Xing G., Ceglarek U., Thiery J., Giani G., Lickert H., Lin X., Li Y., Boeing H., Joost HG., de Angelis MH., Rathmann W., Suhre K., Prokisch H., Peters A., Meitinger T., Roden M., Wichmann HE., Pischon T., Adamski J., Illig T. Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol. 2012;8:615.
- Lechner M., Höhn V., Brauner B., Dunger I., Fobo G., Frishman G., Montrone C., Kastenmüller G., Wägele B., Ruepp A. CIDeR: multifactorial interaction networks in human diseases. Genome Biol. 2012 Jul 18;13(7):R62.
- Wägele B., Witting M., Schmitt-Kopplin P., Suhre K. MassTRIX reloaded: combined analysis and visualization of transcriptome and metabolome data. PLoS One. 2012;7(7):e39860.
- Jourdan C., Petersen AK., Gieger C., Döring A., Illig T., Wang-Sattler R., Meisinger C., Peters A., Adamski J., Prehn C., Suhre K., Altmaier E., Kastenmüller G., Römisch-Margl W., Theis FJ., Krumsiek J., Wichmann HE., Linseisen J. Body fat free mass is associated with the serum metabolite profile in a population-based study. PLoS One. 2012;7(6):e40009.
- Krug S., Kastenmüller G., Stückler F., Rist M.J., Skurk T., Sailer M., Raffler J., Römisch-Margl W., Adamski J., Prehn C., Frank T., Engel K.H., Hofmann T., Luy B., Zimmermann R., Moritz F., Schmitt-Kopplin P., Krumsiek J., Kremer W., Huber F., Oeh U., Theis F.J., Szymczak W., Hauner H., Suhre K., Daniel H. The dynamic range of the human metabolome revealed by challenges. FASEB J. 2012 Jun;26(6):2607-19.
- Petersen AK., Krumsiek J., Wägele B., Theis FJ., Wichmann HE., Gieger C., Suhre K. On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies. BMC Bioinformatics. 2012 Jun 6;13:120.
- Renner S., Römisch-Margl W., Prehn C., Krebs S., Adamski J., Göke B., Blum H., Suhre K., Roscher A.A., Wolf E. Changing Metabolic Signatures of Amino Acids and Lipids During the Prediabetic Period in a Pig Model With Impaired Incretin Function and Reduced ß-Cell Mass. Diabetes. 2012 Apr 9.
- Goek O.N., Döring A., Gieger C., Heier M., Koenig W., Prehn C., Römisch-Margl W., Wang-Sattler R., Illig T., Suhre K., Sekula P., Zhai G., Adamski J., Köttgen A., Meisinger C. Serum Metabolite Concentrations and Decreased GFR in the General Population. Am J Kidney Dis. 2012 Mar 29.
- Petersen A.K., Stark K., Musameh M.D., Nelson C.P., Römisch-Margl W., Kremer W., Raffler J., Krug S., Skurk T., Rist M.J., Daniel H., Hauner H., Adamski J., Tomaszewski M., Döring A., Peters A., Wichmann H.E., Kaess B.M., Kalbitzer H.R., Huber F., Pfahlert V., Samani N.J., Kronenberg F., Dieplinger H., Illig T., Hengstenberg C., Suhre K., Gieger C., Kastenmüller G. Genetic associations with lipoprotein subfractions provide information on their biological nature. Hum Mol Genet. 2012 Mar 15;21(6):1433-43.
2011
- Suhre K., Shin SY., Petersen AK., Mohney RP., Meredith D., Wägele B., Altmaier E; CARDIoGRAM., Deloukas P., Erdmann J., Grundberg E., Hammond CJ., de Angelis MH., Kastenmüller G., Köttgen A., Kronenberg F., Mangino M., Meisinger C., Meitinger T., Mewes HW., Milburn MV., Prehn C., Raffler J., Ried JS., Römisch-Margl W., Samani NJ., Small KS., Wichmann HE., Zhai G., Illig T., Spector TD., Adamski J., Soranzo N., Gieger C., Human metabolic individuality in biomedical and pharmaceutical research. Nature, 477(7362):54-60, 2011.
- Suhre K., Wallaschofski H., Raffler J., Friedrich N., Haring R., Michael K., Wasner C., Krebs A., Kronenberg F., Chang D., Meisinger C., Wichmann H.-E., Hoffmann W., Völzke H., Völker U., Teumer A., Biffar R., Kocher T., Felix S.B., Illig T., Kroemer H.K., Gieger C., Römisch-Margl W., Nauck M., A genome-wide association study of metabolic traits in human urine Nature Genetics, 43:565-569, 2011.
- Yu Z., Kastenmüller G., He Y., Belcredi P., Möller G., Prehn C., Mendes J., Wahl S., Roemisch-Margl W., Ceglarek U., Polonikov A., Dahmen N., Prokisch H., Xie L., Li Y., Wichmann H.-E., Peters A., Kronenberg F., Suhre K., Adamski J., Illig T., Wang-Sattler R., Differences between human plasma and serum metabolite profiles. PLoS One. 6(7):e21230, 2011.
- Römisch-Margl W., Prehn C., Bogumil R., Röhring C., Suhre K., Adamski J., A procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics, Metabolomics, forthcoming.
- Suhre K., Römisch-Margl W., Hrabé de Angelis M., Adamski J., Luippold G., Augustin R., Identification of a potential biomarker for FABP4 inhibition: the power of lipidomics in pre-clinical drug testing, Journal of Biomolecular Screening, Epub 4 May 2011.
- Krumsiek J., Suhre K., Illig T., Adamski J., Theis F.J., Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data, BMC Systems Biology, 5:21, 2011.
- Mewes H.W., Ruepp A., Theis F., Rattei T., Walter M., Frishman D., Suhre K., Spannagl M., Mayer K.F., Stümpflen V., Antonov A.. MIPS: curated databases and comprehensive secondary data resources in 2010, Nucleic Acids Res., 39(Database issue):D220-224, 2011.
- Kastenmüller G., Römisch-Margl W., Wägele B., Altmaier E., Suhre K., metaP-Server: a web-based metabolomics data analysis tool, J. Biomedicine & Biotechnology, pii:839862, 2011.
- Altmaier E., Kastenmüller G., Römisch-Margl W., Thorand B., Weinberger K.M., Illig T., Adamski J., Döring A., Suhre K., Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics, European Journal of Epidemiology. 2011 Feb;26(2):145-56.
- Fuchs H., Gailus-Durner V., Adler T., Aguilar-Pimentel J.A., Becker L., Calzada-Wack J., Da Silva-Buttkus P., Neff F., Götz A., Hans W., Hölter S.M., Horsch M., Kastenmüller G., Kemter E., Lengger C., Maier H., Matloka M., Möller G., Naton B., Prehn C., Puk O., Rácz I., Rathkolb B., Römisch-Margl W., Rozman J., Wang-Sattler R., Schrewe A., Stöger C., Tost M., Adamski J., Aigner B., Beckers J., Behrendt H., Busch D.H., Esposito I., Graw J., Illig T., Ivandic B., Klingenspor M., Klopstock T., Kremmer E., Mempel M., Neschen S., Ollert M., Schulz H., Suhre K., Wolf E., Wurst W., Zimmer A., Hrabe de Angelis M., Mouse phenotyping, Methods, 2011 Feb;53(2):120-35.
- Mittelstrass K, Ried JS, Yu Z, Krumsiek J, Gieger C, Prehn C, Roemisch-Margl W, Polonikov A, Peters A, Theis FJ, Meitinger T, Kronenberg F, Weidinger S, Wichmann HE, Suhre K, Wang-Sattler R, Adamski J, Illig T. Differences between human plasma and serum metabolite profiles. PLoS Genet. 2011 Aug;7(8):e1002215.
2010
- Suhre K., Meisinger C., Döring A., Altmaier E., Belcredi P., Gieger C., Chang D., Milburn M.V., Gall W.E., Weinberger K.M., Mewes H.-W., Hrabé de AngelisM., Wichmann H.E., Kronenberg F., Adamski J., Illig T., Metabolic Footprint of Diabetes: A Multiplatform Metabolomics Study in an Epidemiological Setting, PLoS ONE, 5:e13953, 2010.
- Weikard R., Altmaier E., Suhre K., Weinberger K.M., Hammon H.M., Albrecht E., Setoguchi K., Takasuga A., Kuehn C., Metabolomic profiles indicate distinct physiological pathways affected by two loci with major divergent effect on Bos taurus growth and lipid deposition, Physiol Genomics, 42A:79-88, 2010.
- Illig, T, Gieger, C, Zhai, G, Römisch-Margl, W, Wang-Sattler, R, Prehn, C, Altmaier, E, Kastenmüller, G, Kato, BS , Mewes, HW, Meitinger, T, Hrabé de Angelis, M, Kronenberg, F, Soranzo, N , Wichmann, HE, Spector, TD, Adamski, J, Suhre, K, A genome-wide perspective of genetic variation in human metabolism, Nature Genetics, 42:137-141, 2010, doi:10.1038/ng.507.
2009
- Altmaier, E, Kastenmüller, G, Römisch-Margl, W, Thorand, B, Weinberger, KM, Adamski, J, Illig, T, Döring, A, Suhre K, Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics, Mol. Nutr. Food Res., 53:1357-1365, 2009 [PDF].
- Sigurdardottir, AG, Arnorsdottir, A, Thorbjarnardottir, SH, Eggertsson, G, Suhre K, Kristjansson, M, Characteristics of mutants designed to incorporate a new ion pair into the structure of a cold adapted subtilisin-like serine proteinase, Biochim. Biophys. Acta 1794:512-518, 2009.
- Suhre K, Gieger C, Eine genomweite Assoziationsstudie mit Stoffwechselprodukten, BioSpektrum 03.09, 263-265, 2009.
- Walter MC, Rattei T, Arnold R, Güldener U, Münsterkötter M, Nenova K, Kastenmüller G, Tischler P, Wölling A, Volz A, Pongratz N, Jost R, Mewes HW, Frishman D. PEDANT covers all complete RefSeq genomes. Nucleic Acids Res. 2009 Jan;37(Database issue):D408-11.
- Kastenmüller G, Schenk ME, Gasteiger J, Mewes HW. Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes. Genome Biol. 2009;10(3):R28.
2008
- Gieger, C, Geistlinger, L, Altmaier, E, Hrabé de Angelis, M, Kronenberg, F, Meitinger, T, Mewes, HW, Wichmann, HE, Weinberger, KM, Adamski, J, Illig, T, Suhre K, Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum, PLoS Genetics, 4(11):e1000282, 2008.
- Wang-Sattler, R, Yu, Y, Mittelstrass, K, Lattka, E, Altmaier, E, Gieger, C, Ladwig, KH, Dahmen, N, Weinberger, KM, Hao, P, Lui, L, Li, Y, Wichmann, HE, Adamski, J, Suhre K, Illig, T, Metabolic profiling reveals distinct variations linked to nicotine consumption in humans - first results from the KORA Study, PLoS One, 3(12):e3863, 2008.
- Fitzgerald LA, Boucher PT, Yanai-Balser G, Suhre K, Graves MV, and Van Etten JL, Putative gene promoter sequences in the chlorella viruses, Virology, 380:388-393, 2008.
- Altmaier E, Ramsay SL, Graber A, Mewes HW, Weinberger KM, Suhre K, Bioinformatics analysis of targeted metabolomics - uncovering old and new tales of diabetic mice under medication, Endocrinology, 149:3478-3489, 2008 [PDF].
- Suhre K and Schmitt-Kopplin P, MassTRIX: Mass TRanslator Into Pathways, Nucleic Acids Research, Volume 36, Web Server issue, W481-W484, 2008 [link to MassTRIX web-server].
- Kastenmüller G, Gasteiger J, Mewes HW. An environmental perspective on large-scale genome clustering based on metabolic capabilities. Bioinformatics. 2008 Aug 15;24(16):i56-62.
