Source: HMGU

Dr. Maria Colomé-Tatché
Research Group Leader

Phone: +49 89 3187-49402
Building/Room: 58a / 004

Google Scholar Profile

ResearchGate Profile


Short CV

I did my Bachelor’s and Master’s in Physics at the Autonomus University of Barcelona (2005). I also obtained a Master’s degree in Theoretical Physics at the Ecole Normale Superieure in Paris (2005) and a PhD in Physics at the Laboratory of Theoretical Physics and Statistical Models (University of Paris Sud) (2008). After a short postdoctoral stay at the Theoretical Quantum Optics Group (Institute for Theoretical Physics, University of Hannover), I moved to the Groningen Bioinformatics Centre where I transitioned into the field of quantitative biology, being involved in some of the first large scale population epigenetic studies in model organisms.

Since 2013 I am a Rosalind Franklin Fellow at the Department of the Biology of Ageing (European Research Institute for the Biology of Ageing – ERIBA, University of Groningen and University Medical Centre Groningen), and since 2016 I am also a Helmholtz Young Investigator's Group Leader at the Institute of Computational Biology (Helmholtz Zentrum München). 

Selected publications

Danese A, Richter ML, Fischer DS, Theis FJ* and Colomé-Tatché M*. (*corresponding authors). EpiScanpy: integrated single-cell epigenomic analysis. biorxiv, doi:

Colomé-Tatché M* and Theis FJ* (*corresponding authors). Statistical single cell multi-omics integration. Current Opinion in Systems Biology, (2018).

Hanna CW, Taudt A, Huang J, Gahurova L, Kranz A, Andrews S, Dean W, Stewart AF, Colomé-Tatché M, Kelsey G. MLL2 conveys transcription-independent H3K4 trimethylation in oocytes. Nat Struct Mol Biol., 25(1):73-82 (2018).

Taudt A, Roquis D, Vidalis A, Wardenaar R, Johannes F and Colomé-Tatché M* (*corresponding author). METHimpute: Imputation-guided construction of complete methylomes from WGBS data. BMC Genomics 19:444 (2018).

Bakker B, Taudt A, Belderbos ME, Porubsky D, Spierings DC, de Jong TV, Halsema N, Kazemier HG, Hoekstra-Wakker K, Bradley A, de Bont ES, van den Berg A, Guryev V, Lansdorp PM, Colomé-Tatché M*, Foijer F* (*corresponding authors). Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies. Genome Biology, 17:115. (2016).

vd Graaf A, Wardenaar R, Neumann DA, Taudt A, Shaw RG, Jansen RC, Schmitz RJ*, Colomé-Tatché M* and Johannes F* (*corresponding authors). Rate, spectrum and evolutionary dynamics of spontaneous epimutations. Proc. Natl. Acad. Sci. USA, 112:6676-81 (2015).

Cortijo S*, Wardenaar R*, Colomé-Tatché M*, Gilly A, Etcheverry M, Labadie K, Caillieux E, Hospital F, Aury J-M, Wincker P, Roudier F, Jansen RC, Colot V, Johannes F (*equal contributions). Mapping the epigenetic basis of complex traits. Science, 343:1145-48 (2014).

Colomé-Tatché M, Cortijo S, Wardenaar R, Lahouze B, Etcheverry M, Martin A, Feng S, Duvernois-Berthet E, Labadie K, Wincker P, Jacobsen SE, Jansen RC, V Colot and Johannes F. Features of the Arabidopsis recombination landscape resulting from the combined loss of sequence variation and DNA methylation. Proc. Natl. Acad. Sci. USA, doi: 10.1073/pnas.1212955109 (2012).

Roux F*, Colomé-Tatché M*, Edelist C, Wardenaar R, Guerche P, Hospital F, Colot V, Jansen RC, Johannes F (*equal contributions). Genome-wide epigenetic perturbation jump-starts patterns of heritable variation found in nature. Genetics, 188, 1015 (2011).

Johannes F and Colomé-Tatché M. Quantitative Epigenetics Through Epigenomic Perturbation of Isogenic Lines. Genetics, 188, 215 (2011).