Selected Publication


Deploying Mathematics to Explain Variability in Gene Regulation

Cellular heterogeneity has been reported to originate from non-genetic transcriptional variability. Recent studies have suggested that rare and large fluctuations in single cells, such as cancer, can result from temporary non-genetic variability in otherwise genetically identical cells.  Lea Schuch has demonstrated that a combinatorial minimal model of transcriptional bursting and gene interactions can give rise to rare coordinated high expression states which explains the new class of variability.

For more information read the press release of Helmholtz Zentrum München or click here for the original publication.