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Career

Prof. Dr. García-Cáceres was originally recruited to the Helmholtz Munich in 2012 from the Universidad Autónoma de Madrid as a Postdoctoral Scientist, and in 2015 was promoted to lead the Astrocyte-Neuron Network Unit at the Institute for Diabetes and Obesity. Since then, she has established and consolidated her own research group focused on studying the properties and physiological consequences of the communication between neurons and astrocytes, aiming to understand the role of those glial cells in physiological and pathological aspects of brain function in the neuroendocrine control of metabolism. Her work was awarded by the prestigious ERC Starting Grant and has already resulted in a paradigm shift in how glucose gets into the brain and how hypothalamic astrocytes tune sympathetic outflow towards cardiovascular target organs for controlling blood pressure.

Fields of Work and Expertise

Obesity  neuroendocrinology hypothalamus glia astrocytes

Professional Background

2021

W2 Professor

W2 Professor of Neuroendocrinology of Systems Metabolism at the Faculty of Medicine of Ludwig-Maximilians-Universität München (LMU) and the Helmholtz Munich.

2018

Deputy Director at the Institute

Deputy Director at the Institute for Diabetes and Obesity at Helmholtz Munich, Munich, Germany.

2018

Co-leadership and coordinator

Co-leadership and coordinator of the Brain Academy at the German Center for Diabetes Research (DZD) and Associate Investigator of Munich Cluster For Systems Neurology (Synergy).

2015

Head of the Astrocyte-Neuron Networks

Head of the Astrocyte-Neuron Networks Unit at the Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Munich, Munich, Germany.

Honors and Awards

icon award fill
2022
DAG Research Award
2021
Awarded by Helmholtz Association of German Research Centres for the establishment of W2 professorship
2018
ERC Starting Grant (ERC-ST2017) by European Research Council. Project: Astrocyte-Neuronal Crosstalk in Obesity and Diabetes (Project number: 757393)
2017
Awarded by ERA-NET NEURON for Excellent Paper in Neuroscience (EPNA) 2017. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell. 2016 Aug 11;166(4):867-80

Highlight Publications

1. González-García I, García-Clavé E, Cebrian-Serrano A, Contreras R, Le Thuc O, Xu Y, Gruber G, Legutko B, Lintelmann J, Adamski J, Wurst W, Müller TD, Woods SC, Pfluger P, Tschöp MH, Fisette A, García-Cáceres C.

Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1

Zani F, Blagih J, Gruber T, Buck MD, Jones N, Hennequart M, Newell CL, Pilley SE, Soro-Barrio P, Kelly G, Legrave NM, Cheung EC, Gilmore IS, Gould AP, Garcia-Caceres C, Vousden KH.

The dietary sweetener sucralose is a negative modulator of T cell-mediated responses
2022 Glia

Lutomska LM, Miok V, Krahmer N, González García I, Gruber T, Le Thuc O, Murat CD, Legutko B, Sterr M, Saher G, Lickert H, Müller TD, Ussar S, Tschöp MH, Lutter D, García-Cáceres C.

Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner

Gruber T, Pan C, Contreras-Cardone R., Le Thuc O., Legutko B., Ruiz-Ojeda FJ, Fuente-Fernández M., García-Villalón AL., González-Hedström D., Houben AJHM., Müller TD., Ussar S., Pfluger PT., Woods SC., Joris PJ., Ertürk A., Granado M., Horvath TL., Tschöp MH., García-Cáceres C

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension

García-Cáceres C., Balland E., Prevot V., Luquet S., Woods S.C., Koch M., Horvath T.L., Yi CX., Chowen J.A., Verkhratsky A., Araque A., Bechmann I., Tschöp M.H.

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism
2016 Cell.

García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, Fernandez AM, Luquet S, Woods SC, Torres-Alemán I, Kahn CR, Götz M, Horvath TL, Tschöp MH.

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

Networks and Affiliations

Logo LMU - Ludwig-Maximilians-Universität München

Ludwig-Maximilians-Universität München

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European Research Council

European Research Council

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SyNerg - Munich Cluster for Systems Neurology

SyNergy

Logo Deutsches Zentrum für Diabetesforschung;

German Center for Diabetes Research

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Helmholtz Association

Glia Vascular System of Mouse Brain

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