DFG renews SFB1064 chromatin dynamics funding

In the framework of the now extended project “Chromatin Dynamics”, the researchers are pursuing the processes around the DNA: Our cells store their genetic information within the cell nucleus in a structure known as “chromatin”. The focus is particularly on the histone proteins around which the DNA is wound. Certain chemical changes of the histones can determine whether or not the genes are transcribed. The project’s objective is to understand this interaction and discover new relevant changes.

To this end: numerous disciplines are cooperating: Epigenetics, developmental biology, endocrinology, virology and molecular physiology. This is not surprising given that modifications of the histones can be influenced by numerous processes, such as ageing, metabolic processes, and diet. Conversely, changed chromatin can support inflammatory or metabolic diseases such as diabetes, obesity and cancer. Therefore, the participating scientists hope to understand these molecular processes in order to allow selective intervention in the future. Moreover, there will be research projects on embryogenesis and human fertility, as well as the therapeutically interesting field of targeted stem cell production.

Prof. Dr. Peter Becker (LMU) is coordinating the project. Participating from the Helmholtz Zentrum München are Prof. Dr. Maria Elena Torres-Padilla (IES), Dr. Nina Henriette Uhlenhaut (IDO), Prof. Dr. Dirk Eick (MEG), Prof. Dr. Wolfgang Hammerschmidt (AGV) and Prof. Dr. Robert Schneider (IFE). These epigenetics @HMGU community members will be receiving a total of approximately 2.8 million euros for their work. More...