Publications
2025 Wissenschaftlicher Artikel in Cell Death and Differentiation Cell Death Differ., DOI: 10.1038/s41418-025-01445-3 (2025)
ARID1A mutations protect follicular lymphoma from FAS-dependent immune surveillance by reducing RUNX3/ETS1-driven FAS-expression.
2025 Wissenschaftlicher Artikel in Nature Nature 638, 1065–1075 (2025)
Mapping cells through time and space with moscot.
2025 Wissenschaftlicher Artikel in Nature Nature, DOI: 10.1038/s41586-024-08451-4 (2025)
Precursors of exhausted T cells are preemptively formed in acute infection.
2025 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 16:505 (2025)
Predicting cell morphological responses to perturbations using generative modeling.
2025 Wissenschaftlicher Artikel in microPublication biology MicroPubl. Biol. 2025, DOI: 10.17912/micropub.biology.001472 (2025)
Localization and expression dynamics of an RNA Pol I core subunit in response to fasting in C. elegans.
2025 Wissenschaftlicher Artikel in Genes and Development Genes Dev., DOI: 10.1101/gad.352270.124 (2025)
The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation.
2025 Wissenschaftlicher Artikel in Cell Cell 188, 1156-1174.e20 (2025)
An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development.
2025 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 53:gkaf109 (2025)
Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
2025 Wissenschaftlicher Artikel in Cardiovascular Diabetology Cardiovasc. Diabetol. 24:19 (2025)
Longitudinal association between DNA methylation and type 2 diabetes: Findings from the KORA F4/FF4 study.
2025 Nature Aging Nature Aging, DOI: 10.1038/s43587-025-00837-x (2025)
Author Correction: Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells.
2025 Wissenschaftlicher Artikel in Diabetes, Obesity and Metabolism Diabetes Obes. Metab. 27, 338–347 (2025)
Subphenotypes of adult-onset diabetes: Data-driven clustering in the population-based KORA cohort.
2024 Review in The Journal of Open Source Software JOSS 9:4371 (2024)
anndata: Access and store annotated data matrices.
2024 Wissenschaftlicher Artikel in Research Square Research Square, DOI: 10.21203/rs.3.rs-5046381/v1 (2024)
Topographic atlas of cell states identifies regional gene expression in the adult human lung.
2024 Meeting abstract in Neuroscience Applied Neurosci. App. 3, 1:104036 (2024)
Molecular mechanisms underlying the onset of metabolic deficits in sporadic Parkinson’s disease.
2024Vortrag: ICLR 2024 Workshops (2024)
Machine learning for genomics explorations.
2024 Wissenschaftlicher Artikel in Nature machine intelligence Nat. Mach. Intell., DOI: 10.1038/s42256-024-00934-3 (2024)
Delineating the effective use of self-supervised learning in single-cell genomics.
2024 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 25:319 (2024)
Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy.
2024 Review in Nature Nature 633, 47-57 (2024)
Deciphering the impact of genomic variation on function.
2024 Nature Neuroscience Nat. Neurosci., DOI: 10.1038/s41593-024-01858-2 (2024)
Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery.
2024 Wissenschaftlicher Artikel in Communications Medicine Commun. Med. 4:265 (2024)
Interpretable multimodal machine learning (IMML) framework reveals pathological signatures of distal sensorimotor polyneuropathy.
2024 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res., DOI: 10.1093/nar/gkae1203 (2024)
SLAM-seq reveals independent contributions of RNA processing and stability to gene expression in African trypanosomes.
2024 Review in Cell Cell 187, 7045-7063 (2024)
How to build the virtual cell with artificial intelligence: Priorities and opportunities.
2024 Review in Nature Methods Nat. Methods, DOI: 10.1038/s41592-024-02532-y (2024)
Considerations for building and using integrated single-cell atlases.
2024 Nature Nature, DOI: 10.1038/s41586-024-08482-x (2024)
Publisher Correction: An integrated transcriptomic cell atlas of human neural organoids.
2024 Wissenschaftlicher Artikel in Nature biomedical engineering Nat. Bio. Eng., DOI: 10.1038/s41551-024-01273-9 (2024)
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma.
2024 Review in Breathe Breathe 20:240056 (2024)
Artificial intelligence in tuberculosis: A new ally in disease control.
2024 Wissenschaftlicher Artikel in Nature Methods Nat. Methods, DOI: 10.1038/s41592-024-02555-5 (2024)
Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single-cell resolution.
2024 Wissenschaftlicher Artikel in Cancer Research Cancer Res., DOI: 10.1158/0008-5472.CAN-24-0456 (2024)
HBV remodels PP2A complexes to rewire kinase signaling in hepatocellular carcinoma.
2024 Wissenschaftlicher Artikel in Cell Reports Medicine Cell Rep. Med. 5:101846 (2024)
Modulation of TCR stimulation and pifithrin-α improves the genomic safety profile of CRISPR-engineered human T cells.
2024 Review in Nature Neuroscience Nat. Neurosci. 27, 2292-2309 (2024)
Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery.
2024 Wissenschaftlicher Artikel in Glia Glia, 22 (2024)
Single cell deletion of the transcription factors Trps1 and Sox9 in astrocytes reveals novel functions in the adult cerebral cortex.
2024 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 21, 2260–2270 (2024)
Probe set selection for targeted spatial transcriptomics.
2024 Wissenschaftlicher Artikel in Nature Nature 627, 347-357 (2024)
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
2024 Meeting abstract in Experimental Hematology Exp. Hematol. 137:104561 (2024)
A single-cell proteomics by mass spectrometry based map of the human CD34+hematopoie tic stem and progenitor cell compartment.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:10061 (2024)
Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline.
2024 Wissenschaftlicher Artikel in Nature Nature 635, 690-698 (2024)
An integrated transcriptomic cell atlas of human neural organoids.
2024 Wissenschaftlicher Artikel in Journal of Visualized Experiments J. Vis. Exp., DOI: 10.3791/66659:211 (2024)
Application of unsupervised multi-omic factor analysis to uncover patterns of variation and molecular processes linked to cardiovascular disease.
2024 Editorial in Cell Research Cell Res., DOI: 10.1038/s41422-024-01045-9 (2024)
A cross-species foundation model for single cells.
2024 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 25:277 (2024)
Mapping lineage-traced cells across time points with moslin.
2024 Wissenschaftlicher Artikel in Clinical Epigenetics Clin. Epigenet. 16:149 (2024)
Association analysis between an epigenetic alcohol risk score and blood pressure.
2024 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J., DOI: 10.1038/s44318-024-00227-w (2024)
Decoupled transcript and protein concentrations ensure histone homeostasis in different nutrients.
2024 Wissenschaftlicher Artikel in Cells Cells 13:408 (2024)
Comparing viral vectors and fate mapping approaches for astrocyte-to-neuron reprogramming in the injured mouse cerebral cortex.
2024 Wissenschaftlicher Artikel in Nature medicine Nat. Med., DOI: 10.1038/s41591-024-03214-0 (2024)
An open-source framework for end-to-end analysis of electronic health record data.
2024 Editorial in Epigenomics Epigenomics 16, 1061-1065 (2024)
Breaking the epigenetic code with MARCS: The Modification Atlas of Regulation by Chromatin States.
2024 EMBO Reports EMBO Rep., 3202–3220 (2024)
Publisher Correction: Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins.
2024 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 10:eadl4374 (2024)
Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity.
2024 Wissenschaftlicher Artikel in BMC Medicine BMC Med. 22:420 (2024)
Association of plasma proteomics with mortality in individuals with and without type 2 diabetes: Results from two population-based KORA cohort studies.
2024 Review in Nature Methods Nat. Methods 21, 1597-1602 (2024)
Small data methods in omics: The power of one.
2024 Wissenschaftlicher Artikel in Frontiers in bioengineering and biotechnology Front. Bioeng. Biotechnol. 12:1422235 (2024)
A multiparametric analysis including single-cell and subcellular feature assessment reveals differential behavior of spheroid cultures on distinct ultra-low attachment plate types.
Methods in Molecular Biology In: Chromatin Immunoprecipitation. 2024. 1-16 (Methods Mol. Biol. ; 2846)
Native ChIP: Studying the genome-wide distribution of histone modifications in cells and tissue.
Methods in Molecular Biology In: Chromatin Immunoprecipitation. 2024. 63-89 (Methods Mol. Biol. ; 2846)
Differential analysis of protein-DNA binding using ChIP-seq data.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:6611 (2024)
scTab: Scaling cross-tissue single-cell annotation models.
2024 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol., DOI: 10.1038/s41556-024-01512-w (2024)
Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:7611 (2024)
Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development.
2024 Review in Nature Methods Nat. Methods 21, 1430-1443 (2024)
Transformers in single-cell omics: A review and new perspectives.
2024 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J., DOI: 10.1038/s44318-024-00183-5 (2024)
Real-time assessment of mitochondrial DNA heteroplasmy dynamics at the single-cell level.
2024 Review in EMBO Reports EMBO Rep. 25, 3202-3220 (2024)
Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins.
2024 Wissenschaftlicher Artikel in Lancet, The Lancet 403, 1027-1050 (2024)
Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.
2024 Wissenschaftlicher Artikel in Kidney international reports Kidney Int. Rep. 9, 1849-1859 (2024)
Prioritization of kidney cell types highlights myofibroblast cells in regulating human blood pressure.
2024 Editorial in Developmental Cell Dev. Cell 59, 1623-1627 (2024)
Understanding how cells and organisms keep time during development.
2024 Wissenschaftlicher Artikel in Eye Eye, DOI: 10.1038/s41433-024-03264-1 (2024)
Evaluation of OCT biomarker changes in treatment-naive neovascular AMD using a deep semantic segmentation algorithm.
2024 Wissenschaftlicher Artikel in Nature Computational Science Nat. Comput. Sci. 4, 367–378 (2024)
MISATO: Machine learning dataset of protein-ligand complexes for structure-based drug discovery.
2024 Wissenschaftlicher Artikel in Cell Cell 187, 4637-4655.e26 (2024)
Innate immune memory after brain injury drives inflammatory cardiac dysfunction.
2024 Nature Communications Nat. Commun. 15:6190 (2024)
Author Correction: IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling.
2024 Wissenschaftlicher Artikel in Genes Genes 15:806 (2024)
Leveraging integrated RNA sequencing to decipher adrenomedullin's protective mechanisms in experimental bronchopulmonary dysplasia.
2024 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 40, i548-i557 (2024)
GraphCompass: Spatial metrics for differential analyses of cell organization across conditions.
2024 Nature Genetics Nat. Genet. 56, 1763-1764 (2024)
Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
2024 Wissenschaftlicher Artikel in Nature Nature 631, 645-653 (2024)
Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis.
2024 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 25:181 (2024)
Panpipes: A pipeline for multiomic single-cell and spatial transcriptomic data analysis.
2024 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 27, 1260–1273 (2024)
Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1.
2024 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 56, 1397–1411 (2024)
Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:5577 (2024)
Multi-modal generative modeling for joint analysis of single-cell T cell receptor and gene expression data.
2024 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 25:109 (2024)
hadge: A comprehensive pipeline for donor deconvolution in single-cell studies.
2024 Wissenschaftlicher Artikel in Diabetes/Metabolism Research and Reviews Diabetes Metab. Res. Rev. 40:e3834 (2024)
Association of transketolase polymorphisms with diabetic polyneuropathy in the general population: The KORA F4 study.
2024 Wissenschaftlicher Artikel in Metabolites Metabolites 14:258 (2024)
Prediction of myocardial infarction using a combined generative adversarial network model and feature-enhanced loss function.
2024 Wissenschaftlicher Artikel in Biomolecules Biomolecules 14:662 (2024)
Smoking-induced DNA hydroxymethylation signature is less pronounced than true DNA methylation: The population-based KORA Fit cohort
In: (Proceedings of Machine Learning Research). 2024. 3664-3672 ( ; 238)
Mixed models with multiple instance learning.
2024 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-024-01341-3 (2024)
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase.
2024 Review in Redox Biology Redox Biol. 75:103211 (2024)
Ferroptosis in health and disease.
2024 Wissenschaftlicher Artikel in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 17:e004374 (2024)
Single-cell dissection of the immune response after acute myocardial infarction.
2024 Review in Physiological Reviews Physiol. Rev. 104, 1679-1717 (2024)
Eukaryotic cell size regulation and its implications for cellular function and dysfunction.
2024 Wissenschaftlicher Artikel in Developmental Cell Dev. Cell 59, 2347-2363.e9 (2024)
An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration.
2024 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 26, 962-974 (2024)
Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators.
2024 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 56, 1090-1099 (2024)
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.
2024 Wissenschaftlicher Artikel in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:199 (2024)
Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i.
2024 Review in Genome Medicine Genome Med. 16:80 (2024)
Machine learning integrative approaches to advance computational immunology.
2024 Wissenschaftlicher Artikel in Nature Methods Nat. Methods, DOI: 10.1038/s41592-024-02303-9 (2024)
CellRank 2: Unified fate mapping in multiview single-cell data.
2024 Wissenschaftlicher Artikel in Genome Medicine Genome Med. 16:70 (2024)
Analysis of 3760 hematologic malignancies reveals rare transcriptomic aberrations of driver genes.
2024 Wissenschaftlicher Artikel in Nature medicine Nat. Med. 30, 1696-1710 (2024)
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes.
2024 Wissenschaftlicher Artikel in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:181 (2024)
Plasma proteome association with coronary heart disease and carotid intima media thickness: Results from the KORA F4 study.
2024 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 52, 6129-6144 (2024)
asteRIa enables robust interaction modeling between chromatin modifications and epigenetic readers.
2024 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 56, 778-791 (2024)
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.
2024 Review in Cell Cell 187, 2343-2358 (2024)
The future of rapid and automated single-cell data analysis using reference mapping.
2024 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 40:btae267 (2024)
Topological benchmarking of algorithms to infer Gene Regulatory Networks from Single-Cell RNA-seq Data.
2024 Wissenschaftlicher Artikel in Journal of Cell Biology, The J. Cell Biol. 223:e202309027 (2024)
Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells.
2024 Nature Genetics Nat. Genet. 56, 1032-1033 (2024)
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
2024 Nature Nature 628:E6 (2024)
Publisher Correction: Decoding chromatin states by proteomic profiling of nucleosome readers.
2024 Editorial in Cellular Reprogramming Cell. Reprogramm. 26, 37-42 (2024)
Reprogramming Stars #15: Colliding Cellular Reprogramming Paths- An Interview with Dr. Stefan Stricker.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:2960 (2024)
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells.
2024 Wissenschaftlicher Artikel in Journal of Hepatology J. Hepatol. 81, 289-302 (2024)
Polyploidisation pleiotropically buffers ageing in hepatocytes.
2024 Review in EMBO Reports EMBO Rep. 25, 1721-1733 (2024)
Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo.
2024 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 10:eadn9998 (2024)
Multiple parallel cell lineages in the developing mammalian cerebral cortex.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:2866 (2024)
Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex.
2024 Wissenschaftlicher Artikel in Nature Methods Nat. Methods, DOI: 10.1038/s41592-024-02212-x (2024)
SpatialData: An open and universal data framework for spatial omics.
2024 Review in Genes and Development Genes Dev. 38, 98-114 (2024)
Pan-cellular organelles and suborganelles-from common functions to cellular diversity?
2024 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 40:btae137 (2024)
longmixr: A tool for robust clustering of high-dimensional cross-sectional and longitudinal variables of mixed data types.
2024 Wissenschaftlicher Artikel in Nature Nature 627, 671-679 (2024)
Decoding chromatin states by proteomic profiling of nucleosome readers.
2024 Review in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 85:102173 (2024)
The influencers' era: How the environment shapes chromatin in 3D.
2024 Wissenschaftlicher Artikel in Neuron Neuron 112, 1117-1132.e9 (2024)
Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle.
2024 Wissenschaftlicher Artikel in EBioMedicine EBioMedicine 101:105007 (2024)
Phenotypic and genome-wide studies on dicarbonyls: Major associations to glomerular filtration rate and gamma-glutamyltransferase activity.
2024 Wissenschaftlicher Artikel in Nature Nature 628, 130-138 (2024)
Genome-wide characterization of circulating metabolic biomarkers.
2024 Wissenschaftlicher Artikel in Biology of Sex Differences Biol. Sex Differ. 15:26 (2024)
Sex and statin-related genetic associations at the PCSK9 gene locus: Results of genome-wide association meta-analysis.
2024 Wissenschaftlicher Artikel in Clinical Epigenetics Clin. Epigenet. 16:29 (2024)
Epigenome-wide association study of dietary fatty acid intake.
2024 Wissenschaftlicher Artikel in Liver International Liver Int. 44, 838-847 (2024)
Penetrance, cancer incidence and survival in HFE haemochromatosis-A population-based cohort study.
2024 Wissenschaftlicher Artikel in Thorax Thorax 79, 524-537 (2024)
COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:888 (2024)
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.
2024 Wissenschaftlicher Artikel in Journal of Neuroinflammation J. Neuroinflamm. 21:33 (2024)
The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice.
2024 Editorial in Molecular Cell Mol. Cell 84, 186-188 (2024)
A quick restart: RNA polymerase jumping onto post-replicative chromatin.
2024 Wissenschaftlicher Artikel in Respiratory Research Respir. Res. 25:49 (2024)
Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air-liquid interface.
2024 Wissenschaftlicher Artikel in European Respiratory Journal Eur. Respir. J. 63:2301326 (2024)
Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts.
2024 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 300:105648 (2024)
Ribosome inactivation regulates translation elongation in neurons.
2024 Wissenschaftlicher Artikel in Cell Cell 187, 149-165.e23 (2024)
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma.
2024 Wissenschaftlicher Artikel in Physiological reports Physiol. Rep. 12:e15901 (2024)
LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.
2024 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 21, 28–31 (2024)
Modeling fragment counts improves single-cell ATAC-seq analysis.
2024 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 21, 50-59 (2024)
Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells.
In: (Advances in Neural Information Processing Systems, 10-16 December 2023, New Orleans). 10010 North Torrey Pines Rd, La Jolla, California 92037 Usa: Neural Information Processing Systems (nips), 2023. 14
Training transitive and commutative multimodal transformers with LoReTTa.
2023 Letter to the Editor in Chest Chest 164, 85-89 (2023)
Longitudinal effects of 1-year smoking cessation on human bronchial epithelial transcriptome.
2023 Editorial in Cell Systems Cell Syst. 14, 423-427 (2023)
What do you most hope spatial molecular profiling will help us understand? Part 1.
2023Poster: NeurIPS 2023 AI for Science Workshop (2023)
SpatialSSL: Whole-Brain Spatial Transcriptomics in the Mouse Brain with Self-Supervised Learning.
2023 Meeting abstract in Neuroscience Applied Neurosci. App. 2:101038 (2023)
Effects of glucocorticoid exposure on gene expression and cell fate specification in cerebral organoids.
2023 Wissenschaftlicher Artikel in Neuroscience Applied Neurosci. App. 2:101126 (2023)
GPR101 loss promotes insulin resistance and diet-induced obesity risk.
2023 Wissenschaftlicher Artikel in Atherosclerosis Atherosclerosis 386:117384 (2023)
Meta-GWAS on PCSK9 concentrations reveals associations of novel loci outside the PCSK9 locus in White populations.
2023 Wissenschaftlicher Artikel in Gastroenterology Gastroenterology 165, 946-962.e13 (2023)
HLA-DP on epithelial cells enables tissue damage by NKp44+ natural killer cells in ulcerative colitis.
2023 Wissenschaftlicher Artikel in Stroke Stroke 54, 810-818 (2023)
Genetic risk Score for intracranial aneurysms: Prediction of subarachnoid hemorrhage and role in clinical heterogeneity.
2023 Wissenschaftlicher Artikel in The Lancet Public Health Lancet Public Health 8, e453-e462 (2023)
Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: A population-based cohort study using electronic health records.
2023 Wissenschaftlicher Artikel in Thorax Thorax 78, 496-503 (2023)
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease.
2023 Wissenschaftlicher Artikel in Gut (eGut) Gut 72, 2068-2080 (2023)
Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
2023 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-023-01179-1 (2023)
Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
2023 Letter to the Editor in Nature medicine Nat. Med. 29, 3018-3019 (2023)
Injury-specific signals elicit plasticity in glial cells from patients with brain injury.
2023 Meeting abstract in European Respiratory Journal Eur. Respir. J. 62:OA2624 (2023)
Spatiotemporal analysis of inflammaging and senescence programs in lung fibrosis using time-resolved single-cell transcriptomics and multiplexed immunofluorescence.
2023 Meeting abstract in European Respiratory Journal Eur. Respir. J. 62:2 (2023)
Evolution of epithelial-mesenchymal cell circuits in the progression of pulmonary fibrosis.
2023 Meeting abstract in European Respiratory Journal Eur. Respir. J. 62:3 (2023)
A spatially resolved extracellular matrix proteome atlas of the distal human lung.
2023 Wissenschaftlicher Artikel in Nature Nature 625, 401–409 (2023)
Emergence of replication timing during early mammalian development.
2023 Wissenschaftlicher Artikel in Nature human behaviour Nat. Hum. Behav. 7, 790-801 (2023)
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.
2023 Meeting abstract in Leukemia Research Leuk. Res. 128:2 (2023)
Multiomic analysis of chip bone marrow hematopoietic stem/progenitor cells reveals potential early stage of malignancy.
2023 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 64:4 (2023)
Single cell atlas of the human retina.
2023 Meeting abstract in Multiple Sclerosis Journal Mult. Scler. J. 29, 1097-1098 (2023)
A genetic association study identifying cis protein quantitative trait loci in patients with MS.
2023 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 64:332 (2023)
Predicting OCT-morphological anti-VEGF treatment response in patients with neovascular age-related degeneration using artificial intelligence.
2023 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 64:330 (2023)
New OCT based definition of treatment response to anti-VEGF in treatment naive neovascular AMD patients using an Deep Learning Algorithm.
2023 Wissenschaftlicher Artikel in Aging Aging 15, 14509-14552 (2023)
Mapping of the gene network that regulates glycan clock of ageing.
2023 Wissenschaftlicher Artikel in Science Translational Medicine Sci. Transl. Med. 15, 19:eadh0908 (2023)
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis.
2023 Wissenschaftlicher Artikel in Klinische Monatsblätter für Augenheilkunde Klin. Monatsbl. Augenheilkd., DOI: 10.1055/a-2227-3742 (2023)
Deep Learning based retinal layer segmentation in optical coherence tomography scans of patients with inherited retinal diseases.
2023 Wissenschaftlicher Artikel in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 109, 1318-1327 (2023)
Skeletal muscle gene expression signatures of obese high- and low- responders to endurance exercise training.
2023 Wissenschaftlicher Artikel in Nature Nature 615, 874-883 (2023)
Diminishing benefits of urban living for children and adolescents’ growth and development.
2023 Wissenschaftlicher Artikel in Nature medicine Nat. Med. 29, 3149–3161 (2023)
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain.
2023 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 9:eadj3793 (2023)
Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus.
2023 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 14:7888 (2023)
Explainable machine learning for profiling the immunological synapse and functional characterization of therapeutic antibodies.
2023 Editorial in Nature machine intelligence Nat. Mach. Intell. 5, 1176-1178 (2023)
Reporting electricity consumption is essential for sustainable AI.
2023 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 12, 1873-1883 (2023)
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids.
2023 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 14:7674 (2023)
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease.
2023 Wissenschaftlicher Artikel in BioSpektrum BioSpektrum 29, 378-380 (2023)
Zugängliche KI-Algorithmen für bessere Zellmikroskopie.
2023 Sonstiges: Meinungsartikel in Molecular Cell Mol. Cell 83, 3946-3947 (2023)
Too big not to fail: Different paths lead to senescence of enlarged cells.
2023 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 51, 12303-12324 (2023)
Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency.
2023 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 37, 901-912 (2023)
Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity.
2023 Wissenschaftlicher Artikel in Journal of Visualized Experiments J. Vis. Exp. 2023:16 (2023)
Single-copy gene locus chromatin purification in Saccharomyces cerevisiae.
2023 Wissenschaftlicher Artikel in American Journal of Physiology - Cell Physiology Am. J. Physiol.-Cell Physiol. 325, C1131-C1143 (2023)
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes.
2023 Wissenschaftlicher Artikel in ACS Nano ACS Nano 17, 21056-21072 (2023)
Nanoparticle-exposure-triggered virus reactivation induces lung emphysema in mice.
2023 Wissenschaftlicher Artikel in Diabetes Diabetes 72, 1870-1880 (2023)
A faecal metabolite signature of impaired fasting glucose: Results from twoindependent population-based cohorts.
2023 Wissenschaftlicher Artikel in Cardiovascular Research Cardiovasc. Res. 119, 2743-2754 (2023)
Predictive metabolites for incident myocardial infarction: A two-step meta-analysis of individual patient data from six cohorts comprising 7,897 individuals from the the COnsortium of METabolomic Studies.
2023 Wissenschaftlicher Artikel in Clinical Epigenetics Clin. Epigenet. 15:166 (2023)
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome.
2023 Wissenschaftlicher Artikel in Frontiers in Genetics Front. Genet. 14:1235337 (2023)
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.
2023 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 24:234 (2023)
Single-cell metabolic profiling reveals subgroups of primary human hepatocytes with heterogeneous responses to drug challenge.
2023 Wissenschaftlicher Artikel in Hemasphere Hemasphere 7:e958 (2023)
CSF3R T618I collaborates With RUNX1-RUNX1T1 to expand hematopoietic progenitors and sensitizes to GLI inhibition.
2023 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 14:7206 (2023)
Speos: An ensemble graph representation learning framework to predict core gene candidates for complex diseases.
2023 Review in Genes and Development Genes Dev. 37, 779-780 (2023)
Folding makes an imprint.
2023 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 20, 1683-1692 (2023)
Population-level integration of single-cell datasets enables multi-scale analysis across samples.
2023 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 14:6840 (2023)
Reconstructing disease dynamics for mechanistic insights and clinical benefit.
2023 Wissenschaftlicher Artikel in iScience iScience 26:108205 (2023)
Human pluripotent stem cell fate trajectories toward lung and hepatocyte progenitors.
Lecture Notes in Computer Science In: (26th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), Vancouver, CANADA, 8-12 October 2023). Gewerbestrasse 11, Cham, Ch-6330, Switzerland: Springer International Publishing Ag, 2023. 514-524 (Lect. Notes Comput. Sc. ; 14227 LNCS)
B-Cos Aligned Transformers Learn Human-Interpretable Features.
2023 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 30, 1628-1639 (2023)
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
2023 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 30, 1549-1560 (2023)
Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth.
2023 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 20, 1037-1047 (2023)
Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.
Methods in Cell Biology In:. 525 B Street, Suite 1900, San Diego, Ca 92101-4495 Usa: Elsevier Academic Press Inc, 2023. 199-219 (Methods Cell Biol. ; 182)
An automated image analysis pipeline to quantify the coordination and overlap of transcription and replication activity in mammalian genomes.
2023 Review in AoB Plants AoB Plants 15:plad032 (2023)
Plant environmental memory: Implications, mechanisms and opportunities for plant scientists and beyond.
2023 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 32, 2717-2734 (2023)
Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria.
2023 Wissenschaftlicher Artikel in Annals of the American Thoracic Society Ann. Am. Thorac. Soc. 20, 1124-1135 (2023)
Systemic markers of lung function and forced expiratory volume in 1 second decline across diverse cohorts.
2023 Nature Immunology Nat. Immunol. 24:1960 (2023)
Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets (Nature Immunology, (2023), 24, 9, (1540-1551), 10.1038/s41590-023-01588-w).
2023 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 55, 1448-1461 (2023)
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
2023 Nature Genetics Nat. Genet. 55, 1778-1779 (2023)
Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk (Nature Genetics, (2023), 55, 3, (410-422), 10.1038/s41588-023-01314-0).
2023 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 14:5846 (2023)
epiAneufinder identifies copy number alterations from single-cell ATAC-seq data.
2023 Microbiome Microbiome 11:206 (2023)
Correction: Darier’s disease exhibits a unique cutaneous microbial dysbiosis associated with inflammation and body malodour (Microbiome, (2023), 11, 1, (162), 10.1186/s40168-023-01587-x).
2023 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 14:5391 (2023)
The Oncology Biomarker Discovery framework reveals cetuximab and bevacizumab response patterns in metastatic colorectal cancer.
2023 Wissenschaftlicher Artikel in Frontiers in Plant Science Front. Plant Sci. 14:1124899 (2023)
Arabidopsis histone deacetylase HD2A and HD2B regulate seed dormancy by repressing DELAY OF GERMINATION 1.
2023 Wissenschaftlicher Artikel in Genes Genes 14:27 (2023)
Histone deacetylases HD2A and HD2B undergo feedback regulation by ABA and modulate drought tolerance via mediating ABA-induced transcriptional repression.
2023 Wissenschaftlicher Artikel in Nature metabolism Nat. Metab. 5, 1615-1637 (2023)
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas.
2023 Wissenschaftlicher Artikel in Briefings in Bioinformatics Brief. Bioinform. 24:13 (2023)
Multi-omics regulatory network inference in the presence of missing data.
2023 Wissenschaftlicher Artikel in Stem Cell Reports Stem Cell Rep. 18, 1972-1986 (2023)
Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment.
2023 Editorial in Molecular Systems Biology Mol. Syst. Biol. 19:e11799 (2023)
Single-cell biology: What does the future hold?
2023 Wissenschaftlicher Artikel in Life Science Alliance Life Sci. All. 6:19 (2023)
A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler.
2023 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 37, 336-350 (2023)
A change in biophysical properties accompanies heterochromatin formation in mouse embryos.
2023 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 74:101748 (2023)
Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis.
2023 Editorial in Nucleic Acids Research Nucleic Acids Res. 51, 7709-7713 (2023)
Editorial: Colyn Crane-Robinson (1935-2023).
2023 Wissenschaftlicher Artikel in Development / Company of Biologists Development 150:12 (2023)
CIARA: A cluster-independent algorithm for identifying markers of rare cell types from single-cell sequencing data.
2023 Wissenschaftlicher Artikel in Physical Review E Phys. Rev. E 107:044403 (2023)
Emergent statistical laws in single-cell transcriptomic data.
2023 Editorial in Nature Reviews - Molecular Cell Biology Nat. Rev. Mol. Cell Biol. 24, 691-694 (2023)
Heterochromatin definition and function.
2023 Sonstiges: Meinungsartikel in Genes and Development Genes Dev. 37, 56-57 (2023)
Totipotency, development, and chromatin.
2023 Review in Developmental Cell Dev. Cell 58, 435-449 (2023)
Dynamics of nuclear architecture during early embryonic development and lessons from liveimaging.
2023 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 42:112380 (2023)
Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures.
2023 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep. 24:e56194 (2023)
Hyperosmotic stress induces 2-cell-like cells through ROS and ATR signaling.
2023 Review in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 81:102083 (2023)
Regulation of mammalian totipotency: A molecular perspective from in vivo and in vitro studies.
2023 Review in Nucleus Nucleus 14:2229642 (2023)
Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes.
2023 Wissenschaftlicher Artikel in Blood Blood 142, 90-105 (2023)
A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML.
2023 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 75:101774 (2023)
Differences in DNA methylation of HAMP in blood cells predicts the development of type 2 diabetes.
2023 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 13:4805 (2023)
A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study.
2023 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 55, 410-422 (2023)
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.
2023 Wissenschaftlicher Artikel in Nature Aging Nature Aging 3, 450-458 (2023)
Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes.
2023 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 55, 973-983 (2023)
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.
2023 Wissenschaftlicher Artikel in BMC Genomic Data BMC Genom Data 24:28 (2023)
Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly - comparative results from the KORA and AugUR study.
2023 Wissenschaftlicher Artikel in Movement Disorders Mov. Disord. 38, 1410-1418 (2023)
Epigenetic association analyses and risk prediction of RLS.
2023 Wissenschaftlicher Artikel in Nature Immunology Nat. Immunol. 24, 1540-1551 (2023)
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.
2023 Wissenschaftlicher Artikel in Molecular Psychiatry Mol. Psychiatry 28, 3874-3887 (2023)
Circulating metabolites modulated by diet are associated with depression.
2023 Wissenschaftlicher Artikel in eLife eLife 12:29 (2023)
Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals.
2023 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 24:80 (2023)
Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data.
2023 Wissenschaftlicher Artikel in Journal of Translational Medicine J. Transl. Med. 21:566 (2023)
An arrhythmogenic metabolite in atrial fibrillation.
2023 Wissenschaftlicher Artikel in Microbiome Microbiome 11:162 (2023)
Darier's disease exhibits a unique cutaneous microbial dysbiosis associated with inflammation and body malodour.
2023 Wissenschaftlicher Artikel in Antioxidants Antioxidants 12:16 (2023)
L-aminoguanidine induces imbalance of ROS/RNS homeostasis and polyamine catabolism of tomato roots after short-term salt exposure.
2023 Wissenschaftlicher Artikel in PLOS Digit Health PLOS Digit Health 2:e0000187 (2023)
Explainable AI identifies diagnostic cells of genetic AML subtypes.
2023 Wissenschaftlicher Artikel in iScience iScience 26:107328 (2023)
Progressive disruption of hematopoietic architecture from clonal hematopoiesis to MDS.
2023 Review in Nature Biotechnology Nat. Biotechnol. 41, 604-606 (2023)
The scverse project provides a computational ecosystem for single-cell omics data analysis.
2023 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol. 41, 1787-1800 (2023)
Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease.
2023 Wissenschaftlicher Artikel in Nature Reviews - Genetics Nat. Rev. Genet. 24, 550-572 (2023)
Best practices for single-cell analysis across modalities.
2023 Review in Nature Cancer Nat. Cancer 4, 454-467 (2023)
Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy.
2023 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 9:eadd8564 (2023)
Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy.
2023 Wissenschaftlicher Artikel in Journal of Investigative Dermatology, The J. Invest. Dermatol. 143, 1461-1469.e5 (2023)
Gene expression-based molecular test as diagnostic aid for the differential diagnosis of psoriasis and eczema in formalin-fixed and paraffin-embedded tissue, microbiopsies, and tape strips.
2023 Wissenschaftlicher Artikel in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 152, 408-419 (2023)
The neglected twin: Nummular eczema is a variant of atopic dermatitis with codominant TH2/TH17 immune response.
2023 Wissenschaftlicher Artikel in Nature medicine Nat. Med. 29, 1563-1577 (2023)
An integrated cell atlas of the lung in health and disease.
2023 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 20, 1058-1069 (2023)
Learning consistent subcellular landmarks to quantify changes in multiplexed protein maps.
2023 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 42:112525 (2023)
Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.
2023 Wissenschaftlicher Artikel in Molecular Systems Biology Mol. Syst. Biol. 19:e11503 (2023)
Robust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel.
2023 Wissenschaftlicher Artikel in Cell Cell 186, 3706-3725.e29 (2023)
Distinct molecular profiles of skull bone marrow in health and neurological disorders.
2023 Wissenschaftlicher Artikel in NAR: Genomics and Bioinformatics NAR Gen. Bioinfo. 5:lqad070 (2023)
Single-cell reference mapping to construct and extend cell-type hierarchies.
2023 Wissenschaftlicher Artikel in Cell Death & Disease Cell Death Dis. 14:414 (2023)
Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation.
2023 Wissenschaftlicher Artikel in Histochemistry and Cell Biology Histochem. Cell Biol. 160, 223-251 (2023)
OME-Zarr: A cloud-optimized bioimaging file format with international community support.
2023 Wissenschaftlicher Artikel in Molecular Systems Biology Mol. Syst. Biol. 19:e11517 (2023)
Predicting cellular responses to complex perturbations in high-throughput screens.
2023 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 51, 4252-4265 (2023)
Linker histone H1 modulates defense priming and immunity in plants.
2023 Wissenschaftlicher Artikel in Metabolites Metabolites 13:227 (2023)
Metabolic signatures elucidate the effect of body mass index on type 2 diabetes.
2023 Wissenschaftlicher Artikel in Plants Plants 12:17 (2023)
ROP2 GTPase participates in nitric oxide (NO)-induced root shortening in arabidopsis.
2023 Wissenschaftlicher Artikel in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 21, 1697-1710 (2023)
Machine learning reveals STAT motifs as predictors for GR-mediated gene repression.
2023 Wissenschaftlicher Artikel in Neuron Neuron 111, 1241-1263.e16 (2023)
Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain.
2023 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 51, 1608-1624 (2023)
Predictive model of transcriptional elongation control identifies trans regulatory factors from chromatin signatures.
2023 Wissenschaftlicher Artikel in International Journal of Obesity Int. J. Obes. 47, 313-324 (2023)
Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: A matched transcriptomics approach after 8-week training-intervention.
2023 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 25, 337-350 (2023)
Biologically informed deep learning to query gene programs in single-cell atlases.
2023 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 42:112045 (2023)
Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control.
2023 Wissenschaftlicher Artikel in Thyroid Thyroid 33, 301-311 (2023)
Epigenome-wide association study reveals CpG sites associated with thyroid function and regulatory effects on KLF9.
2023 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 39:9 (2023)
DeepSom: A CNN-based approach to somatic variant calling in WGS samples without a matched normal.
2023 Wissenschaftlicher Artikel in JCI insight JCI insight 8:e155968 (2023)
A20 and the non-canonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny.
2023 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 32, 907–916 (2023)
Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.
2023 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol. 41, 140–149 (2023)
A proteome-scale map of the SARS-CoV-2-human contactome.
2022 Wissenschaftlicher Artikel in Nature Nature 610, 704-712 (2022)
A saturated map of common genetic variants associated with human height.
In: (Advances in Neural Information Processing Systems). 2022. ( ; 35)
Sparsity in Continuous-Depth Neural Networks.
In: (Advances in Neural Information Processing Systems). 2022. ( ; 35)
Predicting Cellular Responses to Novel Drug Perturbations at a Single-Cell Resolution.
In: (Proceedings of Machine Learning Research). 2022. 162-176 ( ; 176)
Multimodal single cell data integration challenge: Results and lessons learned.
2022 Letter to the Editor in Cell Cell 185, 2623-2625 (2022)
The challenges in finding your home as a multidisciplinary scientist.
2022 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 23:268 (2022)
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Informatik aktuell In: (Bildverarbeitung für die Medizin). 2022. 159 (Inf. aktuell ; 923)
Abstract: A database and neural network for highly accurate classification of single bone marrow cells.
2022 Meeting abstract in Oncology Research and Treatment Oncol. Res. Treat. 45, 264-265 (2022)
Single-cell MultiOmic analysis of CHIP bone marrow stem and progenitor cells provides evidence of early-stage malignant transformation.
2022 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 41:111865 (2022)
Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation.
2022 Meeting abstract in Experimental Hematology Exp. Hematol. 111, S150-S150 (2022)
Multiomic analysis of bone marrow hematopoietic stem/progenitor cells revals a potential early stage of malignancy of clonal hematopoiesis of indeterminate potential.
2022 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 41:111867 (2022)
Met/HGFR triggers detrimental reactive microglia in TBI.
2022Vortrag: European Islet Study Group Workshop 2022, June 13-15, 2022, Strasbourg, France. (2022)
Single-cell multiomics cross-species comparison of pancreas development.
2022 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 13:7729 (2022)
Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseases.
2022 Wissenschaftlicher Artikel in eLife eLife 11:e82031 (2022)
T cells modulate the microglial response to brain ischemia.
2022 Wissenschaftlicher Artikel in Nature Nature 612, 720–724 (2022)
Genetic diversity fuels gene discovery for tobacco and alcohol use.
2022 Wissenschaftlicher Artikel in ACR Open Rheumatology ACR Open Rheumatol. 4, 528-533 (2022)
47XXY and 47XXX in scleroderma and myositis.
2022 Letter to the Editor in Development / Company of Biologists Development 149:dev201404 (2022)
In preprints: Improving and interrogating embryo models.
2022 Wissenschaftlicher Artikel in Environmental Science & Technology Environ. Sci. Technol. 56, 17815-17824 (2022)
Higher daily air temperature is associated with shorter leukocyte telomere length: KORA F3 and KORA F4.
2022 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 25, 1608-1625 (2022)
TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury.
2022 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 41:111656 (2022)
Quantitative RNA imaging in single live cells reveals age-dependent asymmetric inheritance.
2022 Nature Nature 612:E7 (2022)
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries.
2022 Wissenschaftlicher Artikel in Journal of Lipid Research J. Lipid Res. 63, 11:100306 (2022)
The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat.
2022 Wissenschaftlicher Artikel in Genome Medicine Genome Med. 14:125 (2022)
Network reconstruction for trans acting genetic loci using multi-omics data and prior information.
2022 Wissenschaftlicher Artikel in Biophysical Journal Biophys. J. 121, 4702-4713 (2022)
Single-molecule experiments reveal the elbow as an essential folding guide in SMC coiled coil arms.
2022 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 18:e1010640 (2022)
Altered expression response upon repeated gene repression in single yeast cells.
2022 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol., DOI: 10.1038/s41587-022-01467-z (2022)
Modeling intercellular communication in tissues using spatial graphs of cells.
2022 Wissenschaftlicher Artikel in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 20, 5622-5638 (2022)
Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes.
2022 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 13432 LNCS, 699-708 (2022)
Noise transfer for unsupervised domain adaptation of retinal OCT images.
2022 Wissenschaftlicher Artikel in Nature Cardiovascular Research Nat. Cardio. Res. 1, 727–731 (2022)
Triggering of myocardial infarction by heat exposure is modified by medication intake.
2022 Wissenschaftlicher Artikel in Clinical and Translational Allergy Clin. Transl. Allergy 12:e12173 (2022)
Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response.
2022 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 109, 1366-1387 (2022)
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
2022 Wissenschaftlicher Artikel in BMC Biology BMC Biol. 20:174 (2022)
Segmentation, tracking and cell cycle analysis of live-cell imaging data with Cell-ACDC.
2022 Wissenschaftlicher Artikel in Diabetes Care Diabetes Care 45, 2892–2899 (2022)
Diabetes and obesity in down syndrome across the lifespan: A retrospective cohort study using U.K. electronic health records.
2022 Wissenschaftlicher Artikel in Molecular Systems Biology Mol. Syst. Biol. 18:e11129 (2022)
Probing cell identity hierarchies by fate titration and collision during direct reprogramming.
2022 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 12:16396 (2022)
Insight into the pulmonary molecular toxicity of heated tobacco products using human bronchial and alveolar mucosa models at air-liquid interface.
2022 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 119:e2200512119 (2022)
EBNA2-EBF1 complexes promote MYC expression and metabolic processes driving S-phase progression of Epstein-Barr virus-infected B cells.
2022 Wissenschaftlicher Artikel in Cells Cells 11:3289 (2022)
Dendritic cells or macrophages? The microenvironment of human clear cell renal cell carcinoma imprints a mosaic myeloid subtype associated with patient survival.
2022 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 54, 1227-1237 (2022)
Origin and function of activated fibroblast states during zebrafish heart regeneration.
2022 Wissenschaftlicher Artikel in Diabetes Diabetes 71, 1962-1978 (2022)
Heterogeneous development of β-cell populations In diabetes-resistant and -susceptible mice.
2022 Wissenschaftlicher Artikel in Neurology Neurology 99, E1738-E1754 (2022)
Contribution of common genetic variants to risk of early onset ischemic stroke.
2022 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 13:6204 (2022)
Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.
2022 Wissenschaftlicher Artikel in Immunity Immunity 55, 2285-2299.e7 (2022)
Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease.
2022 Wissenschaftlicher Artikel in Science Science 377:eabo1984 (2022)
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
2022 Wissenschaftlicher Artikel in Nature Nature 611, 115-123 (2022)
Stroke genetics informs drug discovery and risk prediction across ancestries.
2022 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 54, 1332–1344 (2022)
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.
2022 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 66:101595 (2022)
A transcriptional cross species map of pancreatic islet cells.
2022 Wissenschaftlicher Artikel in Life Science Alliance Life Sci. All. 5:e202201572 (2022)
The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program.
Methods in Molecular Biology In: Histone Methyltransferases. 2022. 327-403 (Methods Mol. Biol. ; 2529)
Identifying specific protein interactors of nucleosomes carrying methylated histones using quantitative mass spectrometry.
2022 Wissenschaftlicher Artikel in Cell Reports Medicine Cell Rep. Med. 3:100652 (2022)
Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19.
2022 Wissenschaftlicher Artikel in Molecular Biology of the Cell Mol. Biol. Cell 33:lt1 (2022)
Whi5 is diluted and protein synthesis does not dramatically increase in pre-Start G1.
2022 Wissenschaftlicher Artikel in Sleep Sleep 45:zsac098 (2022)
Reassessment of candidate gene studies for idiopathic restless legs syndrome in a large GWAS dataset of European ancestry.
2022 Wissenschaftlicher Artikel in Respiratory Research Respir. Res. 23:227 (2022)
Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa.
2022 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 13:5198 (2022)
Identification of risk loci for primary aldosteronism in genome-wide association studies.
2022 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 13:4819 (2022)
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.
2022 Wissenschaftlicher Artikel in Brain: A Journal of Neurology Brain 145, 3859-3871 (2022)
Interpretable surface-based detection of focal cortical dysplasias: A Multi-centre Epilepsy Lesion Detection study.
2022 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 50, 8491-8511 (2022)
TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation.
2022 Wissenschaftlicher Artikel in Frontiers in Immunology Front. Immunol. 13:917232 (2022)
Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation.
2022 Wissenschaftlicher Artikel in Cancers Cancers 14:3363 (2022)
Uncovering the contribution of moderate-penetrance susceptibility genes to breast cancer by whole-exome sequencing and targeted enrichment sequencing of candidate genes in women of European ancestry.
2022 Wissenschaftlicher Artikel in Aging Aging 14, 5620-5627 (2022)
Common electrocardiogram measures are not associated with telomere length.
2022 Wissenschaftlicher Artikel in Stroke Stroke 53, 2331-2339 (2022)
A family and a genome-wide polygenic risk score are independentlyassociated with stroke in a population-based study.
2022 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 13:4540 (2022)
Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis.
2022 Editorial in Frontiers in Plant Science Front. Plant Sci. 13:877438 (2022)
Editorial: Functions of nitric oxide in photosynthetic organisms.
2022 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep.:e54078 (2022)
A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis.
2022 Wissenschaftlicher Artikel in Pancreatology Pancreatol. 22, 449-456 (2022)
Colocalization analysis of pancreas eQTLs with risk loci from alcoholic and novel non-alcoholic chronic pancreatitis GWAS suggests potential disease causing mechanisms.
2022 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 18:e1009552 (2022)
The role of cell geometry and cell-cell communication in gradient sensing.
2022 Wissenschaftlicher Artikel in Atherosclerosis Atherosclerosis 349, 151-159 (2022)
The effect of LPA Thr3888Pro on lipoprotein(a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G>A.
2022 Wissenschaftlicher Artikel in Kidney International Kidney Int. 102, 624-639 (2022)
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
2022 Wissenschaftlicher Artikel in Science Science 376:eabf9088 (2022)
Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.
2022 Wissenschaftlicher Artikel in Environment International Environ. Int. 166:107366 (2022)
Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells.
2022 Wissenschaftlicher Artikel in Neuron Neuron 110, 2283-2298.e9 (2022)
Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
2022 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 39:110910 (2022)
ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity.
2022 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 8:eabg9287 (2022)
Excessive local host-graft connectivity in aging and amyloid-loaded brain.
2022 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 8:eabg9445 (2022)
Brain injury environment critically influences the connectivity of transplanted neurons.
2022 Review in Trends in Cell Biology Trends Cell Biol. 32, 707-719 (2022)
Centrosome heterogeneity in stem cells regulates cell diversity.
2022 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 54, 560-572 (2022)
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
2022 Wissenschaftlicher Artikel in JCI insight JCI insight 7:e157035 (2022)
Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases.
2022 Wissenschaftlicher Artikel in Communications Biology Comm. Biol. 5:580 (2022)
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
2022 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 13:3456 (2022)
Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage.
2022 Wissenschaftlicher Artikel in Virology Virology 569, 37-43 (2022)
The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 – Results from a prospective cohort of outpatient COVID-19 cases.
2022 Review in FEBS Letters FEBS Lett. 596, 2596-2616 (2022)
How to tame your genes: Mechanisms of inflammatory gene repression by glucocorticoids.
2022 Wissenschaftlicher Artikel in Atherosclerosis Atherosclerosis 352, 10-17 (2022)
Association between a polygenic and family risk score on the prevalence and incidence of myocardial infarction in the KORA-F3 study.
2022 Wissenschaftlicher Artikel in Aging Cell Aging Cell:e13608 (2022)
Integrative analysis of clinical and epigenetic biomarkers of mortality.
2022 Wissenschaftlicher Artikel in Cells Cells 11:520 (2022)
Innate immune pathways promote oligodendrocyte progenitor cell recruitment to the injury site in adult Zebrafish brain.
2022 Wissenschaftlicher Artikel in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 15:e003489 (2022)
Genome-wide characterization of a highly penetrant form of hyperlipoproteinemia associated with genetically elevated cardiovascular Risk.
2022 Wissenschaftlicher Artikel in eLife eLife 11:e71802 (2022)
Epigenetic scores for the circulating proteome as tools for disease prediction.
2022 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 54, 437-449 (2022)
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals.
2022 Scientific Reports Sci. Rep. 12:6793 (2022)
Author Correction: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin (Scientific Reports, (2018), 8, 1, (1366), 10.1038/s41598-018-19200-9).
2022 Review in Frontiers in psychiatry Front. Psychiatr. 13:815718 (2022)
Concept of the Munich/Augsburg Consortium Precision in Mental Health for the German Center of Mental Health.
2022 Wissenschaftlicher Artikel in Diagnostics Diagnostics 12:965 (2022)
Validation of the 30-year Framingham Risk Score in a German population-based cohort.
2022 Wissenschaftlicher Artikel in Biomedicines Biomedicines 10:616 (2022)
Bezafibrate reduces elevated hepatic fumarate in insulin-deficient mice.
2022 Wissenschaftlicher Artikel in New Biotechnology New Biotech. 68, 37-47 (2022)
Impact of the pre-examination phase on multicenter metabolomic studies.
2022 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 38:110547 (2022)
A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell.
2022 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 13:1303 (2022)
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
2022 Wissenschaftlicher Artikel in EMBO Molecular Medicine EMBO Mol. Med.:e14797 (2022)
Parkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons.
2022 Wissenschaftlicher Artikel in Molecular Systems Biology Mol. Syst. Biol. 18:e10798 (2022)
Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation.
2022 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 119:e2200083119 (2022)
Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease.
2022 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 29:282 (2022)
Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development.
2022 Wissenschaftlicher Artikel in Advanced science Adv. Sci.:e2104979 (2022)
Molecular signature of astrocytes for gene delivery by the synthetic adeno-associated viral vector rAAV9P1.
2022 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 25, 154-167 (2022)
Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler.
2022 Wissenschaftlicher Artikel in Diabetologia Diabetologia 65, 763-776 (2022)
Epigenome-wide association study of incident type 2 diabetes: A meta-analysis of five prospective European cohorts.
2022 Review in New Phytologist New Phytol. 234, 1119-1125 (2022)
Nitric oxide-releasing nanomaterials: From basic research to potential biotechnological applications in agriculture.
2022 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 54, 318–327 (2022)
DNA replication fork speed underlies cell fate changes and promotes reprogramming.
2022 Nature Genetics Nat. Genet. 54, 358-360 (2022)
EMPReSS: Standardized phenotype screens for functional annotation of the mouse genome (vol 37, pg 1155, 2005).
2022 Review in Nature Reviews - Genetics Nat. Rev. Genet. 23, 563-580 (2022)
Histone post-translational modifications - cause and consequence of genome function.
2022 Wissenschaftlicher Artikel in Cellular and Molecular Life Sciences - CMLS Cell. Mol. Life Sci. 79:244 (2022)
The extracellular matrix molecule tenascin-C modulates cell cycle progression and motility of adult neural stem/progenitor cells from the subependymal zone.
2022 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol. 40, 163-166 (2022)
A Python library for probabilistic analysis of single-cell omics data.
2022 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 19, 171–178 (2022)
Squidpy: A scalable framework for spatial omics analysis.
2022 Nature Communications Nat. Commun. 13:1122 (2022)
Author Correction: Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis (Nature Communications, (2022), 13, 1, (143), 10.1038/s41467-021-27706-6).
2022 Wissenschaftlicher Artikel in Environmental Health Perspectives Environ. Health Perspect. 130:27003 (2022)
Effect of atmospheric aging on soot particle toxicity in lung cell models at the air-liquid interface: Differential toxicological impacts of biogenic and anthropogenic Secondary Organic Aerosols (SOAs).
2022 Review in Nature Biotechnology Nat. Biotechnol. 40, 308–318 (2022)
Spatial components of molecular tissue biology.
2022 Review in European Respiratory Journal Eur. Respir. J. 59:2102057 (2022)
The discovAIR project: A roadmap towards the Human Lung Cell Atlas.
2022 Wissenschaftlicher Artikel in Briefings in Bioinformatics Brief. Bioinform. 23:bbab535 (2022)
TIGER: Technical variation elimination for metabolomics data using ensemble learning architecture.
2022 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 54, 18–29 (2022)
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
2022 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 109, 81-96 (2022)
Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes.
2022 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 13:441 (2022)
Tissue-specific multi-omics analysis of atrial fibrillation.
2022 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 19, 159–170 (2022)
CellRank for directed single-cell fate mapping.
2022 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 13:457 (2022)
Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development.
2022 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 13:143 (2022)
Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.
2022 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 19, 41-50 (2022)
Benchmarking atlas-level data integration in single-cell genomics.
2022 Review in Neuron Neuron 110, 366-393 (2022)
Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches.
2022 Review in Molecular Metabolism Mol. Metab. 57:101396 (2022)
Toward modeling metabolic state from single-cell transcriptomics
2022 Wissenschaftlicher Artikel in Cells Cells 11:28 (2022)
Enhancer RNA expression in response to glucocorticoid treatment in murine macrophages.
2022 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 31, 3367-3376 (2022)
First mitochondrial genome wide association study with metabolomics.
2022 Wissenschaftlicher Artikel in Allergy Allergy 77, 690-694 (2022)
Determinants of expression of SARS-CoV-2 entry-related genes in upper and lower airways.
2022 Wissenschaftlicher Artikel in Cardiovascular Research Cardiovasc. Res. 118, 1088–1102 (2022)
Cis-epistasis at the LPA locus and risk of cardiovascular diseases.
2022 Wissenschaftlicher Artikel in International Journal of Nonlinear Science Int. J. Nonlinear Sci. 23, 565–577 (2022)
Parameter inference with analytical propagators for stochastic models of autoregulated gene expression.
2021Vortrag: XV European Meeting on Glial Cells in Health and Disease, 07-10 July 2021, online. (2021)
Unravelling the fate determinants of astrocytic identity and their impact in direct neuronal reprogramming.
2021 Review in Current Opinion in Systems Biology Curr. Opin. Syst. Biol. 28:100347 (2021)
Graph representation learning for single cell biology.
2021 Wissenschaftlicher Artikel in Cell Cell 184, 6243-6261.e27 (2021)
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:7173 (2021)
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:7174 (2021)
Meta-analyses identify DNA methylation associated with kidney function and damage.
2021 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 118:e2105192118 (2021)
N6-methyladenosine (m6A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells.
2021 Wissenschaftlicher Artikel in Frontiers in Cardiovascular Medicine Front. Cardiovasc. Med. 8:779807 (2021)
Histopathology-based deep-learning predicts atherosclerotic lesions in intravascular imaging.
2021 Wissenschaftlicher Artikel in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:747667 (2021)
TUNAR lncRNA encodes a microprotein that regulates neural differentiation and neurite formation by modulating calcium dynamics.
2021 Wissenschaftlicher Artikel in Nature Nature 600, 675-679 (2021)
The power of genetic diversity in genome-wide association studies of lipids.
2021 Wissenschaftlicher Artikel in BMC Cardiovascular Disorders BMC Cardiovasc. Disord. 21:586 (2021)
Polygenic risk for coronary artery disease in the Scottish and English population.
2021 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 7:eabb3673 (2021)
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.
2021 Wissenschaftlicher Artikel in Viruses Viruses 13:2537 (2021)
Differential effect of SARS-CoV-2 spike glycoprotein 1 on human bronchial and alveolar lung mucosa models: Implications for pathogenicity.
2021 Editorial in Nature Cell Biology Nat. Cell Biol. 23, 1221-1223 (2021)
Retrotransposing a promoter for development.
2021 Wissenschaftlicher Artikel in Cells Cells 10:3443 (2021)
Tgf-β induction of mir-143/145 is associated to exercise response by influencing differentiation and insulin signaling molecules in human skeletal muscle.
2021 Wissenschaftlicher Artikel in Nature Nature 600, 285-289 (2021)
Single-cell transcriptomic characterization of a gastrulating human embryo.
2021 Wissenschaftlicher Artikel in International Journal of Molecular Sciences Int. J. Mol. Sci. 22:12695 (2021)
Cardioprotective effects of palmitoleic acid (C16:1n7) in a mouse model of catecholamine-induced cardiac damage are mediated by PPAR activation.
2021 Letter to the Editor in Trends in Neurosciences Trends Neurosci. 45, 3-5 (2021)
Evolutionary conservation and cell type specificity of nuclear compartments in the brain.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:6876 (2021)
scCODA is a Bayesian model for compositional single-cell data analysis.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:6883 (2021)
Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α.
2021 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 54:101359 (2021)
Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:6233 (2021)
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:6625 (2021)
scPower accelerates and optimizes the design of multi-sample single cell transcriptomic studies.
2021 Wissenschaftlicher Artikel in American Journal of Psychiatry, The Am. J. Psychiatry 179, 375-387 (2021)
Cell-type-specific impact of glucocorticoid receptor activation on the developing brain: A cerebral organoid study.
2021 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 81, 4861-4875.e7 (2021)
Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size.
2021 Wissenschaftlicher Artikel in American Journal of Respiratory Cell and Molecular Biology Am. J. Respir. Cell Mol. Biol. 65, 366-377 (2021)
Current smoking alters gene expression and DNA methylation in the nasal epithelium of patients with asthma.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:6618 (2021)
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
2021 Review in PLoS Biology PLoS Biol. 19:e3001419 (2021)
A field guide to cultivating computational biology.
Lecture Notes in Computer Science In: (3rd MICCAI Workshop on Domain Adaptation and Representation Transfer, DART 2021, 27 September-01 October 2021, Virtual, Online). 2021. 216-225 (Lect. Notes Comput. Sc. ; 12968 LNCS)
Sickle cell disease severity prediction from percoll gradient images using graph convolutional networks.
Lecture Notes in Computer Science In: (24th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2021, 27 September-01 October 2021, Virtual, Online). 2021. 257-266 (Lect. Notes Comput. Sc. ; 12908 LNCS)
Structure-preserving multi-domain stain color augmentation using style-transfer with disentangled representations.
2021 Review in Diabetologie, Die Diabetologie 17, 788–798 (2021)
Künstliche Intelligenz und maschinelles Lernen in der Diabetesforschung.
2021 Wissenschaftlicher Artikel in Brain: A Journal of Neurology Brain, DOI: 10.1093/brain/awab360 (2021)
Blood DNA methylation provides an accurate biomarker of KMT2B-related dystonia and predicts onset.
2021 Wissenschaftlicher Artikel in Journal of Visualized Experiments J. Vis. Exp., DOI: 10.3791/63047 (2021)
Cryo-section dissection of the adult subependymal zone for accurate and deep quantitative proteome analysis.
2021 Review in Genome Biology Genome Biol. 22:301 (2021)
Over 1000 tools reveal trends in the single-cell RNA-seq analysis landscape.
2021 Review in Cell and Tissue Research Cell Tissue Res., DOI: 10.1007/s00441-021-03539-z (2021)
P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke.
2021 Review in International Journal of Molecular Sciences Int. J. Mol. Sci. 22:10291 (2021)
Risk prediction of cardiovascular events by exploration of molecular data with explainable artificial intelligence.
2021 Wissenschaftlicher Artikel in Immunity Immunity 54, 2497-2513.e9 (2021)
Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling.
2021 Wissenschaftlicher Artikel in Nature human behaviour Nat. Hum. Behav. 5, 1717-1730 (2021)
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.
2021 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 11:19365 (2021)
Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function.
2021 Wissenschaftlicher Artikel in Epilepsia Epilepsia 62, 1518-1527 (2021)
Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations.
2021 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J.:e107532 (2021)
Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad4.
2021 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 54:101330 (2021)
Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes.
2021 Wissenschaftlicher Artikel in Frontiers in Public Health Front. Publ. Health 9:583377 (2021)
Group testing for SARS-CoV-2 allows for up to 10-fold efficiency increase across realistic scenarios and testing strategies.
2021 Wissenschaftlicher Artikel in Lancet, The Lancet 398, 957-980 (2021)
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: A pooled analysis of 1201 population-representative studies with 104 million participants.
2021 Review in Plant Physiology and Biochemistry Plant Physiol. Biochem. 167, 851-861 (2021)
Computational prediction of NO-dependent posttranslational modifications in plants: Current status and perspectives.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:5228 (2021)
EpiScanpy: Integrated single-cell epigenomic analysis.
2021 Review in Molecular Systems Biology Mol. Syst. Biol. 17:e10282 (2021)
RNA velocity-current challenges and future perspectives.
2021 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 22:248 (2021)
Sfaira accelerates data and model reuse in single cell genomics.
2021 Wissenschaftlicher Artikel in Nature metabolism Nat. Metab. 3, 1202-1216 (2021)
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice.
2021 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol., DOI: 10.1038/s41587-021-01001-7 (2021)
Mapping single-cell data to reference atlases by transfer learning.
2021 Review in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:698002 (2021)
Non-codon optimized PiggyBac transposase induces developmental brain aberrations: A call for in vivo analysis.
2021 Wissenschaftlicher Artikel in Acta Horticulturae Acta Hortic. 1315, 105-112 (2021)
Transient expression of HDA19 recombinant protein in Nicotiana benthamiana.
2021 Wissenschaftlicher Artikel in Nature Nature 596, 393-397 (2021)
Genetic insights into biological mechanisms governing human ovarian ageing.
2021 Sonstiges: Meinungsartikel in Nature Cell Biology Nat. Cell Biol. 23, 814-816 (2021)
Deconfining heterochromatin for expression.
2021 Wissenschaftlicher Artikel in Journal of Hypertension J. Hypertens. 39, 2527-2533 (2021)
N-glycosylation of immunoglobulin G predicts incident hypertension.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:4515 (2021)
Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.
2021 Editorial in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 70, III-V (2021)
Editorial overview: Fluidity of cell fates - from reprogramming to repair.
2021 Review in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:699771 (2021)
Single-molecule techniques to study chromatin.
2021 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 36:109409 (2021)
Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.
2021 Wissenschaftlicher Artikel in Blood Blood 138, 1917-1927 (2021)
Highly accurate differentiation of bone marrow cell morphologies using deep neuralnetworks on a large image dataset
2021 Nature Cell Biology Nat. Cell Biol., DOI: 10.1038/s41556-021-00735-5 (2021)
Publisher Correction: Epithelial cell plasticity drives endoderm formation during gastrulation.
2021 Wissenschaftlicher Artikel in Antioxidants Antioxidants 10:1128 (2021)
Gsnor contributes to demethylation and expression of transposable elements and stress-responsive genes.
2021 Wissenschaftlicher Artikel in Cell Systems Cell Syst. 12, 706-715.e4 (2021)
AutoGeneS: Automatic gene selection using multi-objective optimization for RNA-seq deconvolution.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:4202 (2021)
Transcription coordinates histone amounts and genome content.
2021 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 35, 1142-1160 (2021)
ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation.
2021 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 22:194 (2021)
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
2021 Wissenschaftlicher Artikel in ERJ Open Research ERJ Open Res. 7:00104-2021 (2021)
Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: Does it provide new insights?
2021 Wissenschaftlicher Artikel in Clinical Chemistry Clin. Chem. 67, 1153-1155 (2021)
Metabolomic fingerprints in large population cohorts: Impact of preanalytical heterogeneity.
2021 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 81, 2944-2959.e10 (2021)
Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin.
2021 Wissenschaftlicher Artikel in Nature metabolism Nat. Metab. 3, 1091-1108 (2021)
Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development.
2021 Review in Life Life 11:637 (2021)
Consequences and resolution of transcription-replication conflicts.
2021 Nature Communications Nat. Commun. 12:4256 (2021)
Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:4264 (2021)
Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy.
2021 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 22:191 (2021)
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
2021 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 53, 101295 (2021)
Correlation guided Network Integration (CoNI) reveals novel genes affecting hepatic metabolism.
2021 Wissenschaftlicher Artikel in Cardiovascular Research Cardiovasc. Res. 118:1742–1757 (2021)
Chronically elevated branched chain amino acid levels are pro-arrhythmic.
2021 Review in Cell Systems Cell Syst. 12, 522-537 (2021)
Machine learning for perturbational single-cell omics.
2021 Wissenschaftlicher Artikel in Nature biomedical engineering Nat. Bio. Eng. 5, 1246-1260 (2021)
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
2021 Review in Current Opinion in Systems Biology Curr. Opin. Syst. Biol. 28, 100355 (2021)
Mechanistic models of blood cell fate decisions in the era of single-cell data.
2021 Wissenschaftlicher Artikel in Clinical Epigenetics Clin. Epigenet. 13:121 (2021)
DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.
2021 Wissenschaftlicher Artikel in Genetic Epidemiology Genet. Epidemiol. 45, 633-650 (2021)
Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:3505 (2021)
Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes.
2021 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 7:eabi5781 (2021)
Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:3987 (2021)
A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
2021 Wissenschaftlicher Artikel in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 32, 1747-1763 (2021)
Plasma proteomics of renal function: A trans-ethnic metaanalysis and Mendelian randomization study.
2021 Wissenschaftlicher Artikel in Blood Blood 138, 1727-1732 (2021)
CHIP & HIPs: Clonal hematopoiesis is common in hip arthroplasty patients and associates with autoimmune disease.
2021 Review in EMBO Reports EMBO Rep. 22:e52774 (2021)
Histone acylations and chromatin dynamics: Concepts, challenges, and links to metabolism.
2021 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 23, 692-703 (2021)
Epithelial cell plasticity drives endoderm formation during gastrulation.
2021 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 28, 521-532 (2021)
Retinoic acid signaling is critical during the totipotency window in early mammalian development.
2021 Wissenschaftlicher Artikel in Molecular Psychiatry Mol. Psychiatry 26, 7372–7383 (2021)
A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression.
2021 Wissenschaftlicher Artikel in Nature Nature (2021)
Swarm Learning for decentralized and confidential clinical machine learning.
2021 Wissenschaftlicher Artikel in Plant Physiology Plant Physiol. 187, 336-360 (2021)
Nitric oxide coordinates growth, development, and stress response via histone modification and gene expression.
2021 Wissenschaftlicher Artikel in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:662056 (2021)
NG2-glia transiently overcome their homeostatic network and contribute to wound closure after brain injury.
2021 Review in Epigenomics Epigenomics 13, 981-984 (2021)
Epigenomics in the single cell era, an important read out for genome function and cell identity.
2021 Wissenschaftlicher Artikel in Cardiovascular Diabetology Cardiovasc. Diabetol. 20:111 (2021)
Metabolic syndrome and the plasma proteome: From association to causation.
2021 Wissenschaftlicher Artikel in STAR Protocols STAR Protoc. 2:100609 (2021)
Protocol for using heterologous spike-ins to normalize for technical variation in chromatin immunoprecipitation.
2021 Wissenschaftlicher Artikel in Heredity Heredity 127, 190–202 (2021)
Region-level epimutation rates in Arabidopsis thaliana.
2021 Review in Current Opinion in Neurobiology Curr. Opin. Neurobiol. 69, 185-192 (2021)
Neuronal replacement: Concepts, achievements, and call for caution.
2021 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 81, 2793-2807.e8 (2021)
Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication.
2021 Review in Developmental Cell Dev. Cell 56, 1562-1573 (2021)
Decoding the organization, dynamics, and function of the 4D genome.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:2785 (2021)
Cellular connectomes as arbiters of local circuit models in the cerebral cortex.
2021 Review in BioSpektrum BioSpektrum 27, 246-249 (2021)
Dem Anfang auf der Spur — die Suche nach DNA-Replikationsursprüngen.
2021Vortrag: Cell Bio Virtual 2020, 2-16 December 2020, Virtual. (2021)
Coordination of mitochondrial homeostasis with cell size.
2021 Wissenschaftlicher Artikel in Diabetes Aktuell Diabetes akt. 19, 62-65 (2021)
Einfluss von Genetik und Epigenetik auf die Entstehung von Diabetes.
2021 Wissenschaftlicher Artikel in Diabetologia Diabetologia 64, 1850-1865 (2021)
HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling.
2021 Wissenschaftlicher Artikel in Molecular Psychiatry Mol. Psychiatry 26, 6293-6304 (2021)
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
2021 Nature Cell Biology Nat. Cell Biol. 23, 566-576 (2021)
Author Correction: Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates.
2021 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 11:7995 (2021)
Tens of images can suffice to train neural networks for malignant leukocyte detection.
2021 Wissenschaftlicher Artikel in British Journal of Dermatology - BJD Br. J. Dermatol. 185, 573-584 (2021)
Host traits, lifestyle and environment are associated with the human skin bacteria.
2021 Wissenschaftlicher Artikel in Molecular Systems Biology Mol. Syst. Biol. 17:e9923 (2021)
Integrated intra- and intercellular signaling knowledge for multicellular omics analysis.
2021 Wissenschaftlicher Artikel in Plant Science Plant Sci. 307:110860 (2021)
Cyanobacterial NOS expression improves nitrogen use efficiency, nitrogen-deficiency tolerance and yield in Arabidopsis.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:1588 (2021)
Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population.
2021 Nature Nature 592:E1 (2021)
Author Correction: Inceptor counteracts insulin signalling in β-cells to control glycaemia.
2021 Wissenschaftlicher Artikel in Epidemiology Epidemiology 32, 378-388 (2021)
Deep learning-based propensity scores for confounding control in comparative effectiveness research: A large-scale, real-world data study.
2021 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 49:101188 (2021)
CD81 marks immature and dedifferentiated pancreatic β-cells.
2021 Wissenschaftlicher Artikel in Human Genetics and Genomics Advances HGG Advances 2:100013 (2021)
Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits.
2021 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 22:103 (2021)
InstantDL: An easy-to-use deep learning pipeline for image segmentation and classification.
2021 Wissenschaftlicher Artikel in EMBO Molecular Medicine EMBO Mol. Med. 13:e12871 (2021)
Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers.
2021 Nature Nature 589, E6 (2021)
Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung (Nature, (2020), 588, 7836, (151-156), 10.1038/s41586-020-2882-8).
2021 Nature Nature 592:E8 (2021)
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (Nature, (2020), 587, 7834, (377-386), 10.1038/s41586-020-2715-9).
2021 Wissenschaftlicher Artikel in iScience iScience 24:102120 (2021)
Computational modeling of stem and progenitor cell kinetics identifies plausible hematopoietic lineage hierarchies.
2021 Nature Communications Nat. Commun. 12:995 (2021)
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
2021 PLoS Biology PLoS Biol. 19:e3001132 (2021)
Correction: Reoccuring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatio-temporal patterns.
2021 Wissenschaftlicher Artikel in Clinical Epigenetics Clin. Epigenet. 13:60 (2021)
Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases.
2021 Review in Journal of Experimental Botany J. Exp. Bot. 72, 777-780 (2021)
The role of nitric oxide in plant biology: Current insights and future perspectives.
2021 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 34:108742 (2021)
The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers.
2021 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 7:eabe4497 (2021)
Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation.
2021 Wissenschaftlicher Artikel in Journal of human genetics J. Hum. Genet. 66, 625–636 (2021)
Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:24 (2021)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
2021 Wissenschaftlicher Artikel in Nature Nature 590, 326–331 (2021)
Inceptor counteracts insulin signalling in β-cells to control glycaemia.
2021 Review in Nature Neuroscience Nat. Neurosci. 24, 312-325 (2021)
Reactive astrocyte nomenclature, definitions, and future directions.
Methods in Molecular Biology In: Epigenetic Reprogramming During Mouse Embryogenesis. 2021. 265-282 (Methods Mol. Biol. ; 2214)
DamID to map genome-protein interactions in preimplantation mouse embryos.
In: (2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI), 13-16 April 2021, Nice, France). 2021. 966-970
Fourier transform of percol gradients boosts CNN classification ofhereditary hemolytic anemias.
2021 Wissenschaftlicher Artikel in Research Square Research Square, in press (2021)
DABC-Net for robust pneumonia segmentation and prediction of COVID-19 progression on chest CT scans.
2021 Wissenschaftlicher Artikel in EMBO Molecular Medicine EMBO Mol. Med.:e12461 (2021)
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:1279 (2021)
Revealing the role of the human blood plasma proteome in obesity using genetic drivers.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:1185 (2021)
Deep learning the collisional cross sections of the peptide universe from a million experimental values.
2021 Wissenschaftlicher Artikel in Journal of Investigative Dermatology, The J. Invest. Dermatol. 141, 681-685.e6 (2021)
CD23 levels on B cells determine long-term therapeutic response in patients with atopic eczema treated with selective IgE immune apheresis.
2021 Editorial in Frontiers in Plant Science Front. Plant Sci. 12:639262 (2021)
Editorial: Highlights of POG 2019 - Plant Oxygen Group Conference.
2021 Wissenschaftlicher Artikel in Metabolites Metabolites 11:89 (2021)
Validation of candidate phospholipid biomarkers of chronic kidney disease in hyperglycemic individuals and their organ-specific exploration in leptin receptor-deficient db/db mouse.
2021 Wissenschaftlicher Artikel in Clinical Epigenetics Clin. Epigenet. 13:7 (2021)
DNA methylation and lipid metabolism: An EWAS of 226 metabolic measures.
2021 Wissenschaftlicher Artikel in International Journal of Radiation Biology Int. J. Radiat. Biol. 97, 529-540 (2021)
Posterior subcapsular cataracts are a late effect after acute exposure to 0.5 Gy ionizing radiation in mice.
2021 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 34:108748 (2021)
Dynamic adoption of anergy by antigen-exhausted CD4+ T cells.
2021 Wissenschaftlicher Artikel in Kidney International Kidney Int. 99, 926-939 (2021)
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.
2021 Review in Journal of Experimental Botany J. Exp. Bot. 72, 808-818 (2021)
Nitric oxide signaling in the plant nucleus: The function of nitric oxide in chromatin modulation and transcription.
2021 Wissenschaftlicher Artikel in Science Science 371:eabb2986 (2021)
Characterization of a common progenitor pool of the epicardium and myocardium.
2021 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 23, 23-31 (2021)
Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates.
2021 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 108, 284-294 (2021)
Genome-wide association study identifies novel susceptibility loci for KIT D816V positive mastocytosis.
2021 Wissenschaftlicher Artikel in Cell Cell 184, 709-722.e13 (2021)
Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics.
2021 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 16:e1009190 (2021)
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
2021 Review in Genes and Development Genes Dev. 35, 22-39 (2021)
TFs for TEs: The transcription factor repertoire of mammalian transposable elements.
2021 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep. 22:e51009 (2021)
Succinylation of H3K122 destabilizes nucleosomes and enhances transcription.
2021 Review in Nucleic Acids Research Nucleic Acids Res. 49, 3020–3032 (2021)
Staying true to yourself: Mechanisms of DNA methylation maintenance in mammals
2021 Wissenschaftlicher Artikel in Life Science Alliance Life Sci. All. 4:e202000924 (2021)
Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice.
2021 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 28, 524-534.e7 (2021)
CRISPR-mediated induction of neuron-enriched mitochondrial proteins boosts direct glia-to-neuron conversion.
2021 Wissenschaftlicher Artikel in Movement Disorders Mov. Disord. 36, 449-459 (2021)
Shared genetics of multiple system atrophy and inflammatory bowel disease.
2021 Review in Neurobiology of Disease Neurobiol. Dis. 148:105174 (2021)
Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming.
2021 Wissenschaftlicher Artikel in Nature human behaviour Nat. Hum. Behav. 5, 59–70 (2021)
Genome-wide association study identifies 48 common genetic variants associated with handedness.
2021 Wissenschaftlicher Artikel in Pediatric Allergy and Immunology Pediatr. Allergy Immunol. 32, 295-304 (2021)
Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors.
2021 Wissenschaftlicher Artikel in Methods in Molecular Biology Methods Mol. Biol. 2214, 175-187 (2021)
Mapping of chromosome territories by 3D-chromosome painting during early mouse development.
2021 Wissenschaftlicher Artikel in Glia Glia 69, 165-181 (2021)
Repetitive injury and absence of monocytes promote astrocyte self-renewal and neurological recovery.
2021 Review in Physiological Reviews Physiol. Rev. 101, 177-211 (2021)
CRISPR-tools for physiology & cell state changes - potential of transcriptional engineering and epigenome editing.
2021 Wissenschaftlicher Artikel in Glycobiology Glycobiology 31, 82-88 (2021)
Replication of fifteen loci involved in human plasma protein N-glycosylation in 4,802 samples from four cohorts.
2021 Wissenschaftlicher Artikel in Molecular Psychiatry Mol. Psychiatry 26, 2111–2125 (2021)
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
2021 Wissenschaftlicher Artikel in Addiction Biology Addict. Biol. 26:e12855 (2021)
Alcohol consumption is associated with widespread changes in blood DNA methylation: Analysis of cross-sectional and longitudinal data.
2020 Review in EMBO Journal, The EMBO J. 39:e105725 (2020)
Thinking "ethical" when designing an international, cross-disciplinary biomedical research consortium.
2020 Review in Current Topics in Developmental Biology Curr. Top. Dev. Biol. 142, 1-66 (2020)
The regulation of cortical neurogenesis.
2020 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 201:A5527 (2020)
Systemic biomarkers of lung function and FEV1 decline across multiple cohorts.
2020 BMC Public Health BMC Public Health 20:1335 (2020)
Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19) (vol 20, 1036, 2020).
Lecture Notes in Computer Science In:. 2020. 246-256 (Lect. Notes Comput. Sc. ; 12265 LNCS)
Attention based multiple instance learning for classification of blood cell disorders.
2020 Wissenschaftlicher Artikel in STAR Protocols STAR Protoc. 1:100228 (2020)
Microfluidics for single-cell lineage tracking over time to characterize transmission of phenotypes in Saccharomyces cerevisiae.
2020 Wissenschaftlicher Artikel in Cell Systems Cell Syst. 11, 653-662.e8 (2020)
H4K20 methylation is differently regulated by dilution and demethylation in proliferating and cell-cycle-arrested xenopus embryos.
Lecture Notes in Computer Science In:. 2020. 174-183 (Lect. Notes Comput. Sc. ; 12265 LNCS)
Background and illumination correction for time-lapse microscopy data with correlated foreground.
2020 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 48, 11335-11346 (2020)
Predicting single-cell gene expression profiles of imaging flow cytometry data with machine learning.
2020 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 36, 2, i610-i617 (2020)
Conditional out-of-distribution generation for unpaired data using transfer VAE.
2020 Wissenschaftlicher Artikel in Frontiers in Immunology Front. Immunol. 11:606338 (2020)
Specific induction of double negative B cells during protective and pathogenic immune responses.
Acta Horticulturae In:. 2020. 455-462 (Acta Hortic. ; 1297)
Transformation of Nicotiana tabacum using the herbicide resistance bar gene as a selectable marker.
2020 Review in Annual Review of Genetics Annu. Rev. Genet. 54, 167-187 (2020)
Measuring and modeling single-cell heterogeneity and fate decision in mouse embryos.
2020 Wissenschaftlicher Artikel in Nature Nature 588, 466-472 (2020)
Cells of the adult human heart.
2020 Review in Tumor Diagnostik und Therapie Tumordiagnos. Ther. 41, 666-668 (2020)
Zytomorphologische Diagnostik mithilfe von künstlicher Intelligenz (KI).
2020 Wissenschaftlicher Artikel in Journal of extracellular vesicles J. Extra. Vesicles 9:1792683 (2020)
In vivo identification of apoptotic and extracellular vesicle-bound live cells using image-based deep learning.
2020 Wissenschaftlicher Artikel in PLoS Biology PLoS Biol. 18:e3000708 (2020)
Reoccurring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatiotemporal patterns.
2020 Wissenschaftlicher Artikel in Photoacoustics Photoacoustics 20:100203 (2020)
A sparse deep learning approach for automatic segmentation of human vasculature in multispectral optoacoustic tomography.
2020 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 12396 LNCS, 105-114 (2020)
Learning Tn5 sequence bias from ATAC-seq on naked chromatin.
2020 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 48, 11394-11407 (2020)
The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances.
2020 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 21:259 (2020)
A genome assembly and the somatic genetic and epigenetic mutation rate in a wild long-lived perennial Populus trichocarpa.
2020 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 21:33023650 (2020)
AlphaBeta: Computational inference of epimutation rates and spectra from high-throughput DNA methylation data in plants.
2020 Wissenschaftlicher Artikel in iScience iScience 23:101601 (2020)
MitoSegNet: Easy-to-use deep learning segmentation for analyzing mitochondrial morphology.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:5653 (2020)
Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin.
2020 Wissenschaftlicher Artikel in Nature machine intelligence Nat. Mach. Intell. 2, 719-726 (2020)
Self-supervised retinal thickness prediction enables deep learning from unlabelled data to boost classification of diabetic retinopathy.
2020 Wissenschaftlicher Artikel in Nature Nature 588, 151–156 (2020)
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
2020 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 52, 1151-1157 (2020)
Regulation of single-cell genome organization into TADs and chromatin nanodomains.
2020 Wissenschaftlicher Artikel in Advanced materials Adv. Mater. 32:e2003913 (2020)
Prediction of chronic inflammation for inhaled particles: The impact of material cycling and quarantining in the lung epithelium.
2020 Wissenschaftlicher Artikel in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 8:587778 (2020)
Dose-dependent and subset-specific regulation of midbrain dopaminergic neuron differentiation by LEF1-mediated WNT1/b-catenin signaling.
2020 Wissenschaftlicher Artikel in Communications Biology Comm. Biol. 3:628 (2020)
PAX6 mutation alters circadian rhythm and beta cell function in mice without affecting glucose tolerance.
2020 Wissenschaftlicher Artikel in Frontiers in Plant Science Front. Plant Sci. 11:549913 (2020)
Improving air quality by nitric oxide consumption of climate-resilient trees suitable for urban greening.
2020 Review in Nature Nature 587, 377–386 (2020)
LifeTime and improving European healthcare through cell-based interceptive medicine.
2020 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 6:eaaz4551 (2020)
METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth.
2020 Wissenschaftlicher Artikel in International Journal of Cancer Int. J. Cancer 147, 3523-3538 (2020)
miR-34a is upregulated in AIP-mutated somatotropinomas and promotes octreotide resistance.
2020 Review in Development / Company of Biologists Development 147:dev189688 (2020)
The molecular and cellular features of 2-cell-like cells: a reference guide.
2020 Wissenschaftlicher Artikel in Glia Glia 69, 346-361 (2020)
Heterogeneity of astrocytes: Electrophysiological properties of juxtavascular astrocytes before and after brain injury.
2020 Wissenschaftlicher Artikel in Molecular Systems Biology Mol. Syst. Biol. 16:e9416 (2020)
Predicting antigen specificity of single T cells based on TCR CDR3 regions.
2020 Wissenschaftlicher Artikel in Diabetes Diabetes 69, 2756-2765 (2020)
Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes.
2020 Wissenschaftlicher Artikel in Royal Society Open Science R. Soc. Open Sci. 7:200701 (2020)
Ectopic fat accumulation in human astrocytes impairs insulin action.
2020 Wissenschaftlicher Artikel in Diabetes Diabetes 69, 2766-2778 (2020)
Deciphering the plasma proteome of type 2 diabetes.
2020 Review in Current Genetics Curr. Genet. 66, 1029–1035 (2020)
The past determines the future: Sugar source history and transcriptional memory.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:3559 (2020)
Alveolar regeneration through a Krt8+transitional stem cell state that persists in human lung fibrosis.
2020 Wissenschaftlicher Artikel in Annals of Neurology Ann. Neurol. 88, 736-746 (2020)
Circulating metabolites differentiate acute ischemic stroke from stroke mimics.
2020 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol. 38, 1408–1414 (2020)
Generalizing RNA velocity to transient cell states through dynamical modeling.
2020 Review in Trends in Molecular Medicine Trends Mol. Med. 26, 890-892 (2020)
Neuronal reprogramming for brain repair: Challenges and perspectives.
2020 Wissenschaftlicher Artikel in Aging Aging 12, 15222-15259 (2020)
Global variability of the human IgG glycome.
2020 Wissenschaftlicher Artikel in Lancet Respiratory Medicine, The Lancet Resp. Med. 8, 696-708 (2020)
Chronic obstructive pulmonary disease and related phenotypes: Polygenic risk scores in population-based and case-control cohorts.
2020 Wissenschaftlicher Artikel in Journal of Clinical Investigation J. Clin. Invest. 130, 6093-6108 (2020)
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
2020 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 22, 767-778 (2020)
Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3.
2020 Editorial in Mammalian Genome Mamm. Genome, DOI: 10.1007/s00335-020-09843-3 (2020)
Introduction to mammalian genome special issue: Epigenetics.
2020 Review in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 64, 26-30 (2020)
A cell in hand is worth two in the embryo: Recent advances in 2-cell like cell reprogramming.
2020 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J.:e103373 (2020)
Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells.
2020 Wissenschaftlicher Artikel in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 147, 587-599 (2020)
Inflammatory macrophage memory in nonsteroidal anti-inflammatory drug–exacerbated respiratory disease.
2020 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 48, 8393-8407 (2020)
Anti-inflammatory functions of the glucocorticoid receptor require DNA binding.
2020 Wissenschaftlicher Artikel in BMC Public Health BMC Public Health 20:1036 (2020)
Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19).
2020 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 40:101038 (2020)
Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting.
2020 Review in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 18, 1330-1341 (2020)
Seq-ing answers: Current data integration approaches to uncover mechanisms of transcriptional regulation.
2020 Wissenschaftlicher Artikel in Nature Nature 582, 592–596 (2020)
The proteome landscape of the kingdoms of life.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:3068 (2020)
Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces.
2020 Wissenschaftlicher Artikel in Particle and Fibre Toxicology Part. Fibre Toxicol. 17:27 (2020)
Influence of wood species on toxicity of log-wood stove combustion aerosols: A parallel animal and air-liquid interface cell exposure study on spruce and pine smoke.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:2952 (2020)
Cell size sets the diameter of the budding yeast contractile ring.
2020 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 78, 915-925 (2020)
Single-cell tracing dissects regulation of maintenance and inheritance of transcriptional reinduction memory.
2020 Review in New Phytologist New Phytol. 227, 1319-1325 (2020)
Regulating the regulator: Nitric oxide control of post-translational modifications.
2020 Review in Frontiers in Genetics Front. Genet. 11:450 (2020)
Proximity labeling techniques to study chromatin.
Informatik aktuell In: Bildverarbeitung für die Medizin 2020. 2020. 53-54 (Inf. aktuell)
Abstract: Recognition of AML blast cells in a curated single-cell dataset of leukocyte morphologies using deep convolutional neural networks.
2020 Wissenschaftlicher Artikel in Cell Cell 181, 1016-1035 (2020)
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues.
2020 Review in Current opinion in pharmacology Curr. Opin. Pharmacol. 53, 35-44 (2020)
Anti-inflammatory glucocorticoid action: Genomic insights and emerging concepts.
2020 Review in Molecular Metabolism Mol. Metab. 38:100951 (2020)
Interactions between metabolism and chromatin in plant models.
2020 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 36, 4296-4300 (2020)
COMUNET: A tool to explore and visualize intercellular communication.
2020 Review in Cell Cell 181, 1189-1193 (2020)
Biomedical research goes viral: Dangers and opportunities.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:2306 (2020)
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.
2020 Wissenschaftlicher Artikel in Acta Physiologica Acta Physiol. 230:e13496 (2020)
Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling.
2020 Wissenschaftlicher Artikel in Cell Systems Cell Syst. 10, 363-378.e12 (2020)
Gene networks with transcriptional bursting recapitulate rare transient coordinated high expression states in cancer.
2020 Wissenschaftlicher Artikel in EMBO Molecular Medicine EMBO Mol. Med. 12:e11419 (2020)
Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy.
2020 Wissenschaftlicher Artikel in Nature medicine Nat. Med. 26, 681–687 (2020)
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
2020 Review in Molecular Metabolism Mol. Metab. 38:100987 (2020)
You are what you eat-How nutrition and metabolism shape the genome through epigenetics.
2020 Nature metabolism Nat. Metab. 2, 380 (2020)
Author Correction: Targeted pharmacological therapy restores β-cell function for diabetes remission (Nature Metabolism, (2020), 2, 2, (192-209), 10.1038/s42255-020-0171-3).
2020 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol. 38, 1061–1072 (2020)
Generation of pancreatic β cells from CD177+ anterior definitive endoderm.
2020 Meeting abstract in Wound repair and regeneration Wound Repair Regen. 28, A16-A16 (2020)
Scar formation is driven by N-cadherin dependent collective fibroblast migration.
2020 Review in Mammalian Genome Mamm. Genome 31, 119–133 (2020)
Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations.
2020 Wissenschaftlicher Artikel in Current Biology Curr. Biol. 30, 1142-1151 (2020)
Epithelial planar bipolarity emerges from Notch-mediated asymmetric inhibition of Emx2.
2020 Review in Genome Biology Genome Biol. 21:31 (2020)
Eleven grand challenges in single-cell data science.
2020 Meeting abstract in Wound repair and regeneration Wound Repair Regen. 28, A7-A7 (2020)
Fate trajectory modeling reveals convergence of airway derived progenitors and AT2 cells on transient KRT8+alveolar cell state during lung regeneration.
2020 Review in Philosophical Transactions of the Royal Society of London. Series B Philos. Trans. R. Soc. B - Biol. Sci. 375:20190339 (2020)
On transposons and totipotency.
2020 Wissenschaftlicher Artikel in eLife eLife 9:e52155 (2020)
The single-cell eQTLGen consortium.
2020 Wissenschaftlicher Artikel in Mammalian Genome Mamm. Genome 31, 30-48 (2020)
A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.
2020 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 36, 4291-4295 (2020)
Automatic identification of relevant genes from low-dimensional embeddings of single-cell RNA-seq data.
2020 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 34, 715-729 (2020)
The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.
2020 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 106, 389-404 (2020)
Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length.
2020 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 30, 1223-1234 (2020)
Domain model explains propagation dynamics and stability of histone H3K27 and H3K36 methylation landscapes.
2020 Review in Nature Nature 578, 522-524 (2020)
Turning connective tissue into neurons for 10 years.
2020 Review in Frontiers in Cellular Neuroscience Front. Cell. Neurosci. 14:32 (2020)
Filling the gaps - A call for comprehensive analysis of extracellular matrix of the glial scar in region- and injury-specific contexts.
2020 Wissenschaftlicher Artikel in Life Science Alliance Life Sci. All. 3:e201900499 (2020)
Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition.
2020 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 16:e1007147 (2020)
Model-based analysis of response and resistance factors of cetuximab treatment in gastric cancer cell lines.
2020 Wissenschaftlicher Artikel in Diabetes Care Diabetes Care 43, 875-884 (2020)
Epigenetic link between statin therapy and type 2 diabetes.
2020 Nature Plants Nat. Plants 6:328 (2020)
Author Correction: Widespread long-range cis-regulatory elements in the maize genome.
2020 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 16:e1007616 (2020)
DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning.
In: Beyond Our Genes. 2020. 175-208
The (not so) controversial role of DNA methylation in epigenetic inheritance across generations.
2020 Wissenschaftlicher Artikel in Nature metabolism Nat. Metab. 2, 192-209 (2020)
Targeted pharmacological therapy restores β-cell function for diabetes remission.
2020 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 15:e0227648 (2020)
Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:15 (2020)
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.
2020 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 26, 277-293.e8 (2020)
Defining the adult neural stem cell niche proteome identifies key regulators of adult neurogenesis.
2020 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 77, 294-309.e9 (2020)
MeCP2 represses the rate of transcriptional initiation of highly methylated long genes.
2020 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep. 21:e48354 (2020)
A distinct metabolic state arises during the emergence of 2-cell-like cells.
2020 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 36, 1260-1261 (2020)
breakpointR: An R/Bioconductor package to localize strand state changes in Strand-seq data.
2020 Wissenschaftlicher Artikel in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 145, 1208-1218 (2020)
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
2020 Wissenschaftlicher Artikel in Annals of Neurology Ann. Neurol. 87, 184-193 (2020)
Identification of restless legs syndrome genes by mutational load analysis.
2020 Wissenschaftlicher Artikel in Journal of the European Academy of Dermatology and Venereology J. Eur. Acad. Dermatol. Venereol. 34, 800-809 (2020)
IL-17C amplifies epithelial inflammation in human psoriasis and atopic eczema.
2020 Review in Biochimica et Biophysica Acta - Gene Regulatory Mechanisms Biochim. Biophys. Acta-Gene Regul. Mech. 1863:194444 (2020)
Gene networks in cancer are biased by aneuploidies and sample impurities.
2020 Review in New Phytologist New Phytol. 225, 1828-1834 (2020)
Recommendations on terminology and experimental best practice associated with plant nitric oxide research.
2020 Wissenschaftlicher Artikel in European Journal of Nutrition Eur. J. Nutr. 59, 1357-1369 (2020)
Modifying effect of metabotype on diet-diabetes associations.
2020 Wissenschaftlicher Artikel in Thorax Thorax 75, 184-187 (2020)
Altered relaxation times in MRI indicate bronchopulmonary dysplasia.
2020 Wissenschaftlicher Artikel in Briefings in Bioinformatics Brief. Bioinform. 21, 272-281 (2020)
Copy number aberrations from Affymetrix SNP 6.0 genotyping data-how accurate are commonly used prediction approaches?
In: Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. 2019. 309-347
Omics: Potential role in early phase drug development.
2019Poster: Intestinal organoids - from stem cells to metabolism and microbiome interactions, 29 September 2019, Kopenhagen. (2019)
Gradual pioneer factor expression resolves enteroendocrine lineage recruitment from intestinal stem cells.
2019 Meeting abstract in European Neuropsychopharmacology : ENP Eur. Neuropsychopharmacol. 29, S7-S8 (2019)
Brain organoids as models of the developing human brain: deciphering the molecular signature of prenatal stress.
2019 GigaScience GigaScience 8:giz162 (2019)
A network-based conditional genetic association analysis of the human metabolome (vol 7, gij137, 2018).
2019 Meeting abstract in Glia Glia 67, E689-E690 (2019)
Tlr2 and Cxcr3 pathways modulate scar formation after traumatic brain injury.
2019 Meeting abstract in Glia Glia 67, E693-E693 (2019)
Injury-induced plasticity of parenchymal astrocytes in the human cerebral cortex.
2019 Meeting abstract in Glia Glia 67, E758-E758 (2019)
Lrp1 loss in radial glia and their progeny - astrocytic dysfunctions contribute to spontaneous epileptogenesis.
2019 Journal of the European Academy of Dermatology and Venereology J. Eur. Acad. Dermatol. Venereol. 33, 2380-2380 (2019)
Is the humoral immunity dispensable for the pathogenesis of psoriasis? (vol 33, pg 115, 2019).
2019 Sonstiges: Meinungsartikel in Informatik-Spektrum Inf.-Spektrum, DOI: 10.1007/s00287-019-01220-y (2019)
Munich School for Data Science (MUDS) – Eine Graduiertenschule für Data Science in München.
2019 Wissenschaftlicher Artikel in Nature Plants Nat. Plants 5, 1237-1249 (2019)
Widespread long-range cis-regulatory elements in the maize genome.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:5121 (2019)
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.
2019 Wissenschaftlicher Artikel in Nature machine intelligence Nat. Mach. Intell. 1, 538-544 (2019)
Human-level recognition of blast cells in acute myeloid leukemia with convolutional neural networks.
2019 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11764 LNCS, 676-684 (2019)
Multi-task learning of a deep K-nearest neighbour network for histopathological image classification and retrieval.
2019 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11764 LNCS, 685-693 (2019)
Multiclass deep active learning for detecting red blood cell subtypes in brightfield microscopy.
2019 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-019-0341-8 (2019)
Author Correction: G-tract RNA removes Polycomb repressive complex 2 from genes (Nature Structural & Molecular Biology, (2019), 26, 10, (899-909), 10.1038/s41594-019-0293-z).
In: (Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2019, 23-27 June 2019, Munich, Germany). 2019.:8871546
Broadband IR-fingerprinting of human blood as a universal tool for diseases diagnostics.
2019 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep. 20:e47952 (2019)
Expression and phase separation potential of heterochromatin proteins during early mouse development.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:4957 (2019)
Associations of autozygosity with a broad range of human phenotypes.
2019 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 76, 531-545.e5 (2019)
Cistromic reprogramming of the diurnal glucocorticoid hormone response by high-fat diet.
2019 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 60 (2019)
Predicting retinal thickness from fundus images across modalities using deep learning.
2019 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 20:225 (2019)
Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues.
2019 Meeting abstract in Multiple Sclerosis Journal Mult. Scler. J. 25, 906-907 (2019)
Identification of functionally relevant genetic variants associated with multiple sclerosis using deep learning.
2019 Meeting abstract in Xenotransplantation Xenotransplantation 26 (2019)
Studying in vivo beta cell maturation in pigs by scRNAseq.
2019 Editorial in Development / Company of Biologists Development 146:dev185025 (2019)
Chromatin and epigenetics in development: A Special Issue.
2019 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 26, 899-909 (2019)
G-tract RNA removes Polycomb repressive complex 2 from genes.
Lecture Notes in Computer Science In:. 2019. 184-186 (Lect. Notes Comput. Sc. ; 11729 LNCS)
In-silico staining from bright-field and fluorescent images using deep learning.
2019 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11731 LNCS, 289-298 (2019)
Quantifying structural heterogeneity of healthy and cancerous mitochondria using a combined segmentation and classification USK-net.
2019 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11728 LNCS, 673-686 (2019)
Evaluation of domain adaptation approaches for robust classification of heterogeneous biological data sets.
2019 Editorial in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11731 LNCS, v-vii (2019)
Preface.
2019 Meeting abstract in European Journal of Immunology Eur. J. Immunol. 49, 48-48 (2019)
Identification of a DC precursor population with pDC and cDC potential responding to endosomal TLR stimulation with increased pDC output.
2019 Meeting abstract in European Journal of Immunology Eur. J. Immunol. 49, 88-88 (2019)
Analysis of EV-decorated CD8+T cells during viral infection.
2019 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 30, 16-29 (2019)
Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro.
2019 Editorial in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11729 LNCS, v-vii (2019)
Preface.
2019 Editorial in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11728 LNCS, v-vii (2019)
Preface.
2019 Editorial in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11727 LNCS, v-vii (2019)
Preface.
2019 Wissenschaftlicher Artikel in Neuron Neuron 103, 1086-1095.e5 (2019)
Inducing different neuronal subtypes from astrocytes in the injured mouse cerebral cortex.
2019 Review in Nitric oxide Nitric oxide 93, 53-70 (2019)
A forty year journey: The generation and roles of NO in plants.
2019 Wissenschaftlicher Artikel in mBio mBio 10:e01723-19 (2019)
First days in the life of naïve human B-lymphocytes infected with Epstein-Barr Virus.
2019 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 51, 1459-1474 (2019)
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
2019 Wissenschaftlicher Artikel in Haematologica - The Hematology Journal Haematologica 105, 2484-2495 (2019)
Murine tissue actor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality.
2019 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep. 20:e48552 (2019)
The glucocorticoid receptor in brown adipocytes is dispensable for control of energy homeostasis.
2019 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 116, 20679-20688 (2019)
Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.
2019 Wissenschaftlicher Artikel in Circulation Circulation 140, 645-657 (2019)
Blood leukocyte DNA methylation predicts risk of future myocardial infarction and coronary heart disease: A longitudinal study of 11,461 participants from population-based cohorts.
2019 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 20:183 (2019)
MPRAnalyze: Statistical framework for massively parallel reporter assays.
2019 Wissenschaftlicher Artikel in Fluids and barriers of the CNS Fluids barriers CNS 16:30 (2019)
Claudin-12 is not required for blood-brain barrier tight junction function.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:3858 (2019)
EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.
2019 Meeting abstract in European Neuropsychopharmacology : ENP Eur. Neuropsychopharmacol. 29, 1037-1037 (2019)
Genotype, prenatal environment or both-what shapes the newborn´s epigenome?
2019 Meeting abstract in European Neuropsychopharmacology : ENP Eur. Neuropsychopharmacol. 29, 1161-1161 (2019)
Polygenic risk score analysis of trajectories of cognitive performance in psychiatric patients.
2019 Meeting abstract in European Neuropsychopharmacology : ENP Eur. Neuropsychopharmacol. 29, 1257-1258 (2019)
Polygenic burden analysis of longitudinal clusters of psychopathological features in a cross-diagnostic group of individuals with severe mental illness.
2019 Meeting abstract in Pharmacoepidemiology and Drug Safety Pharmacoepidemiol. Drug Saf. 28, 585-586 (2019)
Deep learning-based propensity score computation: Cohort study in second line treated advanced non-small cell lung cancer (aNSCLC) patients.
2019 Review in Frontiers in Immunology Front. Immunol. 10:1859 (2019)
Fighting the fire: Mechanisms of inflammatory gene regulation by the glucocorticoid receptor.
2019 Editorial in Stem cell investigation Stem Cell Investig. 6:30 (2019)
Seeking fate-CRISPRa screens reveal new neural lineage and reprogramming factors.
2019 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 9:12367 (2019)
Pheno-seq - linking visual features and gene expression in 3D cell culture systems.
2019 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 16, 715-721 (2019)
scGen predicts single-cell perturbation responses.
2019 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 20:155 (2019)
BART-Seq: cost-effective massively parallelized targeted sequencing for genomics, transcriptomics, and single-cell analysis.
2019 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 116, 16046-16055 (2019)
Epstein-Barr virus reprograms human B lymphocytes immediately in the prelatent phase of infection.
2019 Wissenschaftlicher Artikel in Plant & cell physiology Plant Cell Physiol. 60, 2449-2463 (2019)
S-nitrosothiol signaling is involved in regulating hydrogen peroxide metabolism of zinc-stressed Arabidopsis.
2019 Wissenschaftlicher Artikel in Cytometry Part A Cytometry A 95, 952-965 (2019)
Evaluation of deep learning strategies for nucleus segmentation in fluorescence images.
2019 Wissenschaftlicher Artikel in Stem cell research & therapy Stem Cell Res. Ther. 10:218 (2019)
Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability.
2019 Review in Frontiers in Immunology Front. Immunol. 10:1515 (2019)
Meeting the challenges of high-dimensional single-cell data analysis in immunology.
2019 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J. 38:e100481 (2019)
Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain.
2019 Wissenschaftlicher Artikel in Nature Nature 571, 419-423 (2019)
scSLAM-seq reveals core features of transcription dynamics in single cells.
2019 Wissenschaftlicher Artikel in JAMA cardiology JAMA Cardiol. 4, 575-579 (2019)
Estimation of the required lipoprotein(a)-lowering therapeutic effect size for reduction in coronary heart disease outcomes a mendelian randomization analysis.
2019 Review in Frontiers in Genetics Front. Genet. 10:535 (2019)
Inferring interaction networks from multi-omics data.
2019 Wissenschaftlicher Artikel in Journal of Experimental Botany J. Exp. Bot. 70, 4521-4537 (2019)
Phytoglobin overexpression promotes barley growth in the presence of enhanced level of atmospheric nitric oxide.
2019 Review in Development / Company of Biologists Development 146:dev170506 (2019)
Concepts and limitations for learning developmental trajectories from single cell genomics.
2019 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 9:9299 (2019)
Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR.
2019 Review in Molecular Systems Biology Mol. Syst. Biol. 15:e8746 (2019)
Current best practices in single-cell RNA-seq analysis: A tutorial.
2019 Wissenschaftlicher Artikel in Nature medicine Nat. Med. 25, 1153-1163 (2019)
A cellular census of human lungs identifies novel cell states in health and in asthma.
2019 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 35, 4834-4836 (2019)
DEUS: An R package for accurate small RNA profiling based on differential expression of unique sequences.
2019 Review in Frontiers in Plant Science Front. Plant Sci. 10:625 (2019)
Redox-dependent chromatin remodeling: A new function of nitric oxide as architect of chromatin structure in plants.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:2548 (2019)
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.
2019 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 28, 2062-2077 (2019)
Defining the genetic control of human blood plasma N-glycome using genome-wide association study.
2019 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 51, 957-972 (2019)
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
2019 Wissenschaftlicher Artikel in American Journal of Epidemiology Am. J. Epidemiol. 188, 991-1012 (2019)
The consortium of metabolomics studies (COMETS): Metabolomics in 47 prospective cohort studies.
2019 Wissenschaftlicher Artikel in Development / Company of Biologists Development 146:dev173849 (2019)
Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis.
2019 Editorial in Nature Nature 569, 342-343 (2019)
A map of beta-cell differentiation.
2019 Review in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 55, 52-58 (2019)
Genome activation and architecture in the early mammalian embryo.
2019 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 28, 2615-2633 (2019)
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.
2019 Wissenschaftlicher Artikel in Nature Nature 569, 729-733 (2019)
Genome-lamina interactions are established de novo in the early mouse embryo.
2019 Wissenschaftlicher Artikel in Nature Nature 570, 71-76 (2019)
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
2019 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 14:e0216110 (2019)
Dynamic modelling of an ACADS genotype in fatty acid oxidation - Application of cellular models for the analysis of common genetic variants.
2019 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 166, 11370-11379 (2019)
Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk.
2019 Wissenschaftlicher Artikel in European Heart Journal Eur. Heart J. 40, 2883-2896 (2019)
Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:2119 (2019)
Targeted removal of epigenetic barriers during transcriptional reprogramming.
2019Poster: CSH meeting: mechanisms of metabolic signaling, 14 May 2019, Cold Spring Harbour, NY, USA. (2019)
Glucose starvation in Huh7 cells triggers a transcriptional memory.
2019Poster: RECOMB 2019, 4-8 May 2019, Washington D.C.. (2019)
Reconstructing regulatory networks from multi-omics data using prior information.
2019 Wissenschaftlicher Artikel in American Journal of Epidemiology Am. J. Epidemiol. 188, 1033-1054 (2019)
Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions.
2019 Sonstiges: Meinungsartikel in Molecular & Cellular Oncology Mol. Cell. Oncol. 6:1605820 (2019)
A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks.
2019 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 9:6584 (2019)
The interactome of a family of potential methyltransferases in HeLa cells.
2019 Review in American Journal of Respiratory Cell and Molecular Biology Am. J. Respir. Cell Mol. Biol. 61, 31-41 (2019)
The Human Lung Cell Atlas: A high-resolution reference map of the human lung in health and disease.
2019 Wissenschaftlicher Artikel in EBioMedicine EBioMedicine 43, 562-575 (2019)
The Notch ligand DNER regulates macrophage IFN gamma release in chronic obstructive pulmonary disease.
2019 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 9:6250 (2019)
Common patterns of gene regulation associated with Cesarean section and the development of islet autoimmunity - indications of immune cell activation.
2019 Review in Nature Reviews - Genetics Nat. Rev. Genet. 20, 389-403 (2019)
Deep learning: New computational modelling techniques for genomics.
2019 Wissenschaftlicher Artikel in Experimental Eye Research Exp. Eye Res. 188:107632 (2019)
Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.
2019 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 51, 636-648 (2019)
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
2019 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol. 37, 461-468 (2019)
Inferring population dynamics from single-cell RNA-sequencing time series data.
2019 Wissenschaftlicher Artikel in Metabolites Metabolites 9:61 (2019)
Metabolomics identifies novel blood biomarkers of pulmonary function and COPD in the general population.
2019 Wissenschaftlicher Artikel in Journal of the American College of Cardiology J. Am. Coll. Cardiol. 73, 58-66 (2019)
Association of the PHACTR1/EDN1 genetic locus with spontaneous coronary artery dissection.
2019 Wissenschaftlicher Artikel in Allergy Allergy 74, 1364-1373 (2019)
A strategy for high-dimensional multivariable analysis classifies childhood asthma phenotypes from genetic, immunological, and environmental factors.
2019 Meeting abstract in Experimental Dermatology Exp. Dermatol. 28, E13-E13 (2019)
Visualizing scar development in living tissues reveals the collective migration of fibroblasts mediated by N-cadherin.
2019 Meeting abstract in Experimental Dermatology Exp. Dermatol. 28, E29-E30 (2019)
CD23 is a biomarker of clinical response to IgE-specific immunoadsorption in patients with severe atopic eczema.
2019 Wissenschaftlicher Artikel in Human Genetics Hum. Genet. 138, 375–388 (2019)
The metabolic network coherence of human transcriptomes is associated with genetic variation at the cadherin 18 locus.
2019 Wissenschaftlicher Artikel in Nitric oxide Nitric oxide 88, 10-26 (2019)
Deciphering the nitric oxide, cyanide and iron-mediated actions of sodium nitroprusside in cotyledons of salt stressed sunflower seedlings.
2019 Wissenschaftlicher Artikel in Metabolites Metabolites 9:44 (2019)
Ageing investigation using two-time-point metabolomics data from KORA and CARLA studies.
2019 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 20:59 (2019)
PAGA: Graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells.
2019 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 24, 80-97 (2019)
Point mutations in the PDX1 transactivation domain impair human beta-cell development and function.
2019 Wissenschaftlicher Artikel in Nature medicine Nat. Med. 25, 561–568 (2019)
Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia.
2019 npj Systems biology and applications NPJ Syst. Biol. Appl. 5:11 (2019)
Publisher Correction: Multi-experiment nonlinear mixed effectmodeling of single-cell translation kinetics after transfection.
2019 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 51, 481-493 (2019)
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
2019 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 51, 494-505 (2019)
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
2019 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 21, 311-318 (2019)
H4K20meO recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.
2019 Wissenschaftlicher Artikel in Nature Nature 567, 113-117 (2019)
The centrosome protein AKNA regulates neurogenesis via microtubule organization.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:963 (2019)
An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:376 (2019)
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
2019 Wissenschaftlicher Artikel in American Journal of Clinical Nutrition Am. J. Clin. Nutr. 109, 276-287 (2019)
Disentangling the genetics of lean mass.
2019 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 51, 245-257 (2019)
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:323 (2019)
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling.
2019 Wissenschaftlicher Artikel in FASEB Journal FASEB J. 33, 5924-5941 (2019)
A miR-29a-driven negative feedback loop regulates peripheral glucocorticoid receptor signaling.
2019 Editorial in Epigenomics Epigenomics 11, 363-366 (2019)
Histone H1, the forgotten histone.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:390 (2019)
Single-cell RNA-seq denoising using a deep count autoencoder.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:306 (2019)
E47 modulates hepatic glucocorticoid action.
2019 Editorial in Frontiers in Plant Science Front. Plant Sci. 10, 104:104 (2019)
Editorial: Post-translational modifications in plant nuclear signaling: Novel insights into responses to environmental changes.
2019 Editorial in Frontiers in Microbiology Front. Microbiol. 9:3338 (2019)
Editorial: Integrative computational systems biology approaches in immunology and medicine.
2019 Editorial in Trends in cancer Trends Cancer 5, 5-7 (2019)
Glucose-regulated TET2 activity links cancer to diabetes.
2019 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 16, 43-49 (2019)
A test metric for assessing single-cell RNA-seq batch correction.
2019 Wissenschaftlicher Artikel in Methods in Molecular Biology Methods Mol. Biol. 1896, 159-190 (2019)
Quantification of aneuploidy in mammalian systems.
2019 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J. 38:e99518 (2019)
Metabolic regulation of pluripotency and germ cell fate through alpha-ketoglutarate.
2019 Wissenschaftlicher Artikel in Journal of the European Academy of Dermatology and Venereology J. Eur. Acad. Dermatol. Venereol. 33, 115-122 (2019)
Is the humoral immunity dispensable for the pathogenesis of psoriasis?
2018 Wissenschaftlicher Artikel in Science Science 362, 1182-1186 (2018)
A DNA methylation reader complex that enhances gene transcription.
In: Lecture Notes in Bioengineerin. 2018. 85-100
MicroRNA as an integral part of cell communication: Regularized target prediction and network prediction.
In: Lecture Notes in Bioengineering. 2018. 115-136
Information theoretic concepts to unravel cell–cell communication.
2018 Meeting abstract in European Heart Journal Eur. Heart J. 39, 998-998 (2018)
Using the plasma proteome to decipher metabolic syndrome pathophysiology and discover a diagnostic biomarker panel.
2018 Meeting abstract in Blood Blood 132 (2018)
Data driven computational modeling of hematopoiesis in myelodysplastic syndromes unveils differences in hematopoietic stem cell kinetics compared to age-matched healthy controls.
2018 Wissenschaftlicher Artikel in Journal of Visualized Experiments J. Vis. Exp. 142:e58556 (2018)
A customizable protocol for string assembly gRNA cloning (STAgR).
2018 Wissenschaftlicher Artikel in Interface : journal of the Royal Society J. R. Soc. Interface 15:20180600 (2018)
Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data.
2018 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 4:eaar8082 (2018)
TADs are 3D structural units of higher-order chromosome organization in Drosophila.
2018 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 8:18042 (2018)
A single-cell micro-trench platform for automatic monitoring of cell division and apoptosis after chemotherapeutic drug administration.
2018 Wissenschaftlicher Artikel in Clinical Epigenetics Clin. Epigenet. 10:161 (2018)
Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction.
2018 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 25, 3231-3240.e8 (2018)
Increasing neural stem cell division asymmetry and quiescence are predicted to contribute to the age-related decline in neurogenesis.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:5269 (2018)
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.
2018 Wissenschaftlicher Artikel in npj Systems biology and applications NPJ Syst. Biol. Appl. 5 (2018)
Multi-experiment nonlinear mixed effect modeling of single-cell translation kinetics after transfection.
2018 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 25, 3241-3251.e5 (2018)
The aryl hydrocarbon receptor pathway defines the time frame for restorative neurogenesis.
2018 Wissenschaftlicher Artikel in Chemical senses Chem. Senses 44, 7-9 (2018)
Interspecific variation of olfactory preferences in flies, mice, and humans.
2018 Wissenschaftlicher Artikel in Cell Systems Cell Syst. 7, 567-579 (2018)
Efficient parameter estimation enables the prediction of drug response using a mechanistic pan-cancer pathway model.
2018 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 197 (2018)
Proteomic profiling identifies novel circulating markers associated with lung function.
2018 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 197 (2018)
Quantitative MRI measurements to detect pulmonary hypertension in bronchopulomnary dysplasia.
2018 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 25, 2729-2741.e6 (2018)
A primate-specific isoform of PLEKHG6 regulates neurogenesis and neuronal migration.
2018 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 197 (2018)
The human lung cell atlas: A comprehensive reference map for all cell types in the healthy human lung.
2018 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 197 (2018)
Diagnosis of bronchopulmonary dysplasia using magnetic resonance imaging analysis.
2018 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 46:e119 (2018)
Impulse model-based differential expression analysis of time course sequencing data.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:4919 (2018)
Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests.
2018 Wissenschaftlicher Artikel in GigaScience GigaScience 7, DOI: 10.1093/gigascience/giy137 (2018)
A network-based conditional genetic association analysis of the human metabolome.
2018 Wissenschaftlicher Artikel in Journal of the American Heart Association J. Am. Heart Assoc. 7:e009243 (2018)
Systems genetics approaches in rat identify novel genes and gene networks associated with cardiac conduction.
2018 Wissenschaftlicher Artikel in EBioMedicine EBioMedicine 38, 206-216 (2018)
Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults.
2018 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 23, 742-757.e8 (2018)
SUMO safeguards somatic and pluripotent cell identities by enforcing distinct chromatin states.
2018 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 50, 1505-1513 (2018)
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.
2018 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 50, 1514-1523 (2018)
Genetics of blood lipids among similar to 300,000 multi-ethnic participants of the Million Veteran Program.
2018 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 72, 739-752 (2018)
Critical role of the UBL domain in stimulating the E3 ubiquitin ligase activity of UHRF1 toward chromatin.
2018 Wissenschaftlicher Artikel in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 126, 20-29 (2018)
Impact of brain fatty acid signaling on peripheral insulin action in mice.
2018 Meeting abstract in Genetic Epidemiology Genet. Epidemiol. 42, 719-720 (2018)
Pharmacogenetic effects in population-based metabolic profiles.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:4455 (2018)
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
2018 Wissenschaftlicher Artikel in Developmental Cell Dev. Cell 47, 205-221.e7 (2018)
Organellar proteomics and phospho-proteomics reveal subcellular teorganization in diet-induced hepatic steatosis.
2018Poster: 40 years Myc, 50 years Polymerase II, and 65 years Dirk Eick!, 9 November 2018, Planegg-Martinsried. (2018)
Regulation of transcription: RNA Pol II and Myc.
2018 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 8:15249 (2018)
Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations.
2018 Review in Nature Genetics Nat. Genet. 50, 1352-1358 (2018)
Challenges and guidelines toward 4D nucleome data and model standards.
2018 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 50, 1412-1425 (2018)
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
2018 Wissenschaftlicher Artikel in American Journal of Clinical Nutrition Am. J. Clin. Nutr. 108, 453-475 (2018)
Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies.
2018 Nature Communications Nat. Commun. 9:3853 (2018)
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease (vol 9, 3268, 2018).
2018 Wissenschaftlicher Artikel in Metabolomics Metabolomics 14:128 (2018)
Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies.
2018 Meeting abstract in Diabetologia Diabetologia 61, S259-S259 (2018)
Interindividual susceptibility to type 2 diabetes in mice: Hepatic transcriptome and DNA methylome profiling.
2018 Wissenschaftlicher Artikel in Nature Nature 561, 253-257 (2018)
An orthogonal proteomic survey uncovers novel Zika virus host factors.
In: Lecture Notes in Computer Science (16th International Conference on Computational Methods in Systems Biology, 12-14 September 2018, Brno; Czech Republic). 2018. 300-306 ( ; 11095 LNBI)
LNA++: Linear noise approximation with first and second order sensitivities.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:3268 (2018)
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.
2018 Meeting abstract in Allergy Allergy 73, 732-733 (2018)
The role of humoral immunity in the pathogenesis of psoriasis.
2018 Nature Genetics Nat. Genet. 50:1343 (2018)
Author correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
2018 Review in Diabetologie, Die Diabetologie 14, 486-492 (2018)
Mit Big Data zur personalisierten Diabetesprävention.
2018 Wissenschaftlicher Artikel in Molecular Nutrition and Food Research Mol. Nutr. Food Res. 62:1800117 (2018)
Identification of comprehensive metabotypes associated with cardiometabolic diseases in the population-based KORA study.
2018 Wissenschaftlicher Artikel in Cell Cell 174, 1571-1585.e11 (2018)
Atlas of circadian metabolism reveals system-wide coordination and communication between clocks.
2018 Wissenschaftlicher Artikel in PLoS Biology PLoS Biol. 16:e2005886 (2018)
Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock.
2018 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 52, 1112-1121 (2018)
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
2018 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 34, 494-501 (2018)
Bayesian parameter estimation for biochemical reaction networks using region-based adaptive parallel tempering.
2018 Review in Trends in Genetics Trends Genet. 34, 806-820 (2018)
Nimble and ready to mingle: Transposon outbursts of early development.
2018 Wissenschaftlicher Artikel in Diabetes Diabetes 67, 1414-1427 (2018)
A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes.
2018 Wissenschaftlicher Artikel in Blood Blood 132, 1842-1850 (2018)
DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis.
2018 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 50, 1072–1080 (2018)
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
2018 Wissenschaftlicher Artikel in Epilepsia Epilepsia 59, 1577-1582 (2018)
Unilateral temporal interictal epileptiform discharges correctly predict the epileptogenic zone in lesional temporal lobe epilepsy.
2018 Editorial in Neuron Neuron 98, 1069-1071 (2018)
Q&A Magdalena Götz
2018 Review in Current Opinion in Systems Biology Curr. Opin. Syst. Biol. 7, 54-59 (2018)
Statistical single cell multi-omics integration.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:2697 (2018)
Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:1653 (2018)
Global profiling of protein-DNA and protein-nucleosome binding affinities using quantitative mass spectrometry.
2018 Review in Molecular Systems Biology Mol. Syst. Biol. 14:e8046 (2018)
Using single-cell genomics to understand developmental processes and cell fate decisions.
2018 Wissenschaftlicher Artikel in BMC Genomics BMC Genomics 19:444 (2018)
METHimpute: Imputation-guided construction of complete methylomes from WGBS data.
2018 Wissenschaftlicher Artikel in JAMA cardiology JAMA Cardiol. 3, 463-472 (2018)
Association of methylation signals with incident coronary heart disease in an epigenome-wide assessment of circulating tumor necrosis factor.
2018 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 21, 932–940 (2018)
Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program.
2018 Review in Journal of Experimental Botany J. Exp. Bot. 69, 3507-3510 (2018)
Nitric oxide sensor proteins with revolutionary potential.
2018 Review in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 52, 65-69 (2018)
Understanding direct neuronal reprogramming - from pioneer factors to 3D chromatin.
2018 Wissenschaftlicher Artikel in GigaScience GigaScience 7, 1-8 (2018)
MetaMap: An atlas of metatranscriptomic reads in human disease-related RNA-seq data.
2018 Wissenschaftlicher Artikel in Stem Cell Reports Stem Cell Rep. 10, 58-69 (2018)
Inductive and selective effects of GSK3 and MEK inhibition on nanog heterogeneity in embryonic stem cells.
2018 Wissenschaftlicher Artikel in Circulation Circulation 138, 2007-2020 (2018)
Dicer in macrophages prevents atherosclerosis by promoting mitochondrial oxidative metabolism.
2018 Wissenschaftlicher Artikel in Science Science 360:eaaq1723 (2018)
Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics.
2018 Wissenschaftlicher Artikel in Methods in Molecular Biology Methods Mol. Biol. 1747, 205-221 (2018)
Detection of S-nitrosated nuclear proteins in pathogen-treated Arabidopsis cell cultures using biotin switch technique.
2018 Wissenschaftlicher Artikel in Methods in Molecular Biology Methods Mol. Biol. 1747, 183-203 (2018)
Identification of NO-sensitive cysteine residues using cysteine mutants of recombinant proteins.
2018 Wissenschaftlicher Artikel in eLife eLife 7:e30823 (2018)
Live cell-lineage tracing and machine learning reveal patterns of organ regeneration.
2018 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 50, 834-848 (2018)
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.
In: (Workshop on Bildverarbeitung fur die Medizin, 11-13 March 2018, Erlangen). 2018. 10-10
Digital cytomorphology: Deep learning on an image data set of cell morphologies in acute myeloid leukemia.
2018 Wissenschaftlicher Artikel in Frontiers in Cardiovascular Medicine Front. Cardiovasc. Med. 5:59 (2018)
Using gene expression to annotate cardiovascular GWAS loci.
2018 Review in Journal of Neurochemistry J. Neurochem. 146, 500-525 (2018)
Cortical progenitor biology: Key features mediating proliferation versus differentiation.
2018 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 22, 865-878.e8 (2018)
Epithelial sodium channel regulates adult neural stem cell proliferation in a flow-dependent manner.
2018 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 14:e1007329 (2018)
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.
2018 Review in Frontiers in Neuroscience Front. Neurosci. 12:5 (2018)
DNA-methylation: Master or slave of neural fate decisions?
2018 Wissenschaftlicher Artikel in Frontiers in Cellular Neuroscience Front. Cell. Neurosci. 12:57 (2018)
Mob2 insufficiency disrupts neuronal migration in the developing cortex.
2018 Review in Nature Nature 557, 329-334 (2018)
New approaches for brain repair-from rescue to reprogramming.
2018 Review in Experimental & molecular medicine Exp. Mol. Med. 50:e453 (2018)
Whither systems medicine?
2018 Wissenschaftlicher Artikel in Nutrients Nutrients 10:547 (2018)
A vitamin E-enriched antioxidant diet interferes with the acute adaptation of the liver to physical exercise in mice.
2018 Review in Molecular Metabolism Mol. Metab., DOI: 10.1016/j.molmet.2018.01.007 (2018)
Metabolic intermediates - Cellular messengers talking to chromatin modifiers.
2018 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 8:7547 (2018)
Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner.
2018 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 13:e0196015 (2018)
One step generation of customizable gRNA vectors for multiplex CRISPR approaches through string assembly gRNA cloning (STAgR).
2018 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep. 19:e45294 (2018)
Cross-talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury.
2018 Review in Open Biology Open Biol. 8:180013 (2018)
Entering the post-epigenomic age: Back to epigenetics.
2018 Wissenschaftlicher Artikel in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 38, 1230-1241 (2018)
Genetic factors explain a major fraction of the 50% lower lipoprotein(a) concentrations in Finns.
2018 Wissenschaftlicher Artikel in Glia Glia 66, 1644-1662 (2018)
Influence of white matter injury on gray matter reactive gliosis upon stab wound in the adult murine cerebral cortex.
2018 Wissenschaftlicher Artikel in EMBO Molecular Medicine EMBO Mol. Med. 10:e8349 (2018)
Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.
2018 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 9, 57-68 (2018)
Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.
2018 Wissenschaftlicher Artikel in Journal of Investigative Dermatology, The J. Invest. Dermatol. 138, 1785-1794 (2018)
Type I immune response induces keratinocyte necroptosis and is associated with interface dermatitis.
2018 Wissenschaftlicher Artikel in Frontiers in Immunology Front. Immunol. 9:277 (2018)
Genome-wide association study on immunoglobulin G glycosylation patterns.
2018 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 102, 375-400 (2018)
A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure.
2018 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 8:1801 (2018)
Spatiotemporal patterning of EpCAM is important for murine embryonic endo-And mesodermal differentiation.
2018 Nature Communications Nat. Commun. 9:706 (2018)
Erratum: Publisher Correction: Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway (Nature communications (2017) 8 1 (1483)).
2018 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 25, 73-82 (2018)
MLL2 conveys transcription-independent H3K4 trimethylation in oocytes.
2018 Review in Science Science 359, 639-640 (2018)
Revising concepts about adult stem cells.
2018 Meeting abstract in Oncology Research and Treatment Oncol. Res. Treat. 41, 197-197 (2018)
Computer-aided morphological classification of blood cells relevant in Acute Myeloid Leukemia.
2018 Review in Environment International Environ. Int. 114, 77-86 (2018)
Epigenetics as a mechanism linking developmental exposures to long-term toxicity.
2018 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 27, 1106-1121 (2018)
Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:288 (2018)
Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
2018 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 19:15 (2018)
SCANPY: Large-scale single-cell gene expression data analysis.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:260 (2018)
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
2018 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 8:1366 (2018)
Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin.
2018 Review in Nature Reviews - Endocrinology Nat. Rev. Endocrinol. 14, 140-162 (2018)
Animal models of obesity and diabetes mellitus.
2018 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 27, 546-558 (2018)
Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin.
2018 Scientific Data Sci. Data 5:180002 (2018)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
2018 Wissenschaftlicher Artikel in Molecular Cancer Research Mol. Cancer Res. 16, 390-402 (2018)
Epigenetically regulated chromosome 14q32 miRNA cluster induces metastasis and predicts poor prognosis in lung adenocarcinoma patients.
2018 Wissenschaftlicher Artikel in Radiation and Environmental Biophysics Radiat. Environ. Biophys. 57, 99-113 (2018)
Lifetime study in mice after acute low-dose ionizing radiation: A multifactorial study with special focus on cataract risk.
2018 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 8, 180-188 (2018)
Cadm2 regulates body weight and energy homeostasis in mice.
2018 Wissenschaftlicher Artikel in Endocrine-Related Cancer Endocr. Relat. Cancer 25, 145-162 (2018)
Characterization of neuroendocrine tumors in heterozygous mutant MENX rats: A novel model of invasive medullary thyroid carcinoma.
2018 Wissenschaftlicher Artikel in Biochimica et Biophysica Acta - General Subjects Biochim. Biophys. Acta-Gen. Subj. 1862, 637-648 (2018)
IgG glycosylation and DNA methylation are interconnected with smoking.
2018 Wissenschaftlicher Artikel in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 197, 1076-1080 (2018)
Early identification of bronchopulmonary dysplasia using novel biomarkers by proteomic screening.
2018 Wissenschaftlicher Artikel in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 141, 1320-1333.e11 (2018)
Toll-like receptor 7/8 agonists stimulate plasmacytoid dendritic cells to initiate T(H)17-deviated acute contact dermatitis in human subjects.
2018 Wissenschaftlicher Artikel in Journal of Investigative Dermatology, The J. Invest. Dermatol. 138, 141-149 (2018)
MSX1-induced neural crest-like reprogramming promotes melanoma progression.
2018 Wissenschaftlicher Artikel in International Journal of Obesity Int. J. Obes. 42, 507-517 (2018)
A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue.
2018 Wissenschaftlicher Artikel in Journal of Investigative Dermatology, The J. Invest. Dermatol. 138, 179-188 (2018)
The role of Fibroblast growth factor binding protein 1 in skin carcinogenesis and inflammation.
2018 Wissenschaftlicher Artikel in Pediatric Diabetes Pediatr. Diabetes 19, 277-283 (2018)
Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young.
2018 Wissenschaftlicher Artikel in Neuropsychopharmacology Neuropsychopharmacology 43, 342-353 (2018)
Anxiety associated increased CpG methylation in the promoter of Asb1: A translational approach evidenced by epidemiological and clinical studies and a murine model.
2017 Wissenschaftlicher Artikel in Cell Cell 171, 557-572.e24 (2017)
Multiscale 3D genome rewiring during mouse neural development.
2017 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 49, 876-886 (2017)
Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila.
2017 Meeting abstract in Molecular Biology of the Cell Mol. Biol. Cell 28 (2017)
Proteomics identifies organelle specific phosphorylation and reveals major subcellular reorganization in the progression of NAFLD.
2017 Editorial in Current Opinion in Cell Biology Curr. Opin. Cell Biol. 49, IV-V (2017)
Editorial overview: Cell differentiation and development: New kids in the block - new tools and concepts opening new doors in development.
2017 Wissenschaftlicher Artikel in European Journal of Human Genetics Eur. J. Hum. Genet. 25, 137-146 (2017)
Across-cohort QC analyses of GWAS summary statistics from complex traits.
2017 Wissenschaftlicher Artikel in Journal of Visualized Experiments J. Vis. Exp. 2017:e56264 (2017)
A universal protocol for large-scale gRNA library production from any DNA source.
2017 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 49, 1722–1730 (2017)
Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.
2017 Review in Current Opinion in Cell Biology Curr. Opin. Cell Biol. 49, 53-58 (2017)
The phenomenology of cell size control.
2017 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 50, 106-119 (2017)
A molecular roadmap for the emergence of early-embryonic-like cells in culture.
2017 Wissenschaftlicher Artikel in Scientific Data Sci. Data 4:170179 (2017)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
2017 Wissenschaftlicher Artikel in Nature Nature 552, 239-243 (2017)
Pluripotent state transitions coordinate morphogenesis in mouse and human embryos.
2017 Wissenschaftlicher Artikel in Journal of Mathematical Biology J. Math. Biol., 1-52 (2017)
Time-dependent propagators for stochastic models of gene expression: An analytical method.
2017 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 49, 1758-1766 (2017)
Exome-wide association study of plasma lipids in >300,000 individuals.
2017 Wissenschaftlicher Artikel in OncoTarget Oncotarget 8, 98623-98634 (2017)
Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.
2017 Wissenschaftlicher Artikel 122, 110-115 (2017)
Crosstalk between reactive oxygen species and nitric oxide in plants: Key role of S-nitrosoglutathione reductase.
2017 Wissenschaftlicher Artikel in eLife eLife 6:e27041 (2017)
The Human Cell Atlas.
2017 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 8:1483 (2017)
Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway.
2017 Review in Current Opinion in Neurobiology Curr. Opin. Neurobiol. 47, 188-195 (2017)
Glial control of neurogenesis.
2017 Wissenschaftlicher Artikel in Molecular Psychiatry Mol. Psychiatry 22, 1680-1690 (2017)
An epigenome-wide association study meta-analysis of educational attainment.
2017 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 49, 1752-1757 (2017)
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
2017 Nature Communications Nat. Commun. 8:1414 (2017)
Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:15453 (2017)
Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.
2017 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 12:e0182472 (2017)
Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.
2017 Wissenschaftlicher Artikel in Neurology Neurology 89, 1829-1839 (2017)
COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.
2017 Wissenschaftlicher Artikel in Cytometry Part A Cytometry A 93A, 314-322 (2017)
Image analysis of neural stem cell division patterns in the zebrafish brain.
2017 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 34, 896-898 (2017)
netReg: Network-regularized linear models for biological association studies.
2017 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 24, 1048–1056 (2017)
Histone propionylation is a mark of active chromatin.
2017 Wissenschaftlicher Artikel in Frontiers in Physiology Front. Physiol. 8:775 (2017)
Model based targeting of IL-6-induced inflammatory responses in cultured primary hepatocytes to improve application of the JAK inhibitor ruxolitinib.
2017 Wissenschaftlicher Artikel in BMC Genomics BMC Genomics 18:805 (2017)
The dynamics of smoking-related disturbed methylation: A two time-point study of methylation change in smokers, non-smokers and former smokers.
2017 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 114, E9579-E9588 (2017)
GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency.
2017 Wissenschaftlicher Artikel in Regenerative Medicine Regen. Med. 2:29 (2017)
Neuronal replacement therapy: Previous achievements and challenges ahead.
2017 Wissenschaftlicher Artikel in Current Opinion in Systems Biology Curr. Opin. Syst. Biol. 4, 85-91 (2017)
Single cells make big data: New challenges and opportunities in transcriptomics.
2017 Wissenschaftlicher Artikel in Ecology Letters Ecol. Lett. 20, 1576-1590 (2017)
Ecological plant epigenetics: Evidence from model and non-model species, and the way forward.
2017 Wissenschaftlicher Artikel in Genetics Genetics 207, 1275-1283 (2017)
RL-SKAT: An exact and efficient score Test for heritability and set tests.
2017 Wissenschaftlicher Artikel in Journal of Cell Biology, The J. Cell Biol. 216, 3017-3028 (2017)
Dynamic changes in H1 subtype composition during epigenetic reprogramming.
2017 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 8:886 (2017)
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
2017 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 45, 11121-11130 (2017)
DNA residence time is a regulatory factor of transcription repression.
2017 Wissenschaftlicher Artikel in Lancet Neurology, The Lancet Neurol. 16, 898–907 (2017)
Identification of novel risk loci for restless legs syndrome: A meta-analysis of genome-wide association studies in individuals of European ancestry: A meta-analysis.
2017 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 18:429 (2017)
pulver: An R package for parallel ultra-rapid p-value computation for linear regression interaction terms.
2017 Wissenschaftlicher Artikel in Behavioural Brain Research Behav. Brain Res. 352, 187-196 (2017)
Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.
2017 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 18:170 (2017)
Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.
2017 Wissenschaftlicher Artikel in Diabetologia Diabetologia 61, 117-129 (2017)
Metabolite ratios as potential biomarkers for type 2 diabetes: A DIRECT study.
2017 Wissenschaftlicher Artikel in Development / Company of Biologists Development 144, 3917-3931 (2017)
The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development.
2017 Meeting abstract in Allergy Allergy 72, 53-53 (2017)
Association of atopic dermatitis with cardiovascular risk factors and diseases.
2017 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 137, S275-S275 (2017)
TLR7/8 agonists stimulate plasmacytoid dendritic cells to initiate a Th17-deviated acute contact dermatitis in humans.
2017 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 137, S254-S254 (2017)
Interface Dermatitis is characterized by a type I immune response and an epidermal reaction to IFN-gamma and TNF-alpha.
2017 Wissenschaftlicher Artikel in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 28, 2311-2321 (2017)
NFAT5 and SLC4A10 loci associate with plasma osmolality.
2017 Wissenschaftlicher Artikel in Physiologia Plantarum Physiol. Plant. 162, 49-72 (2017)
S-nitrosylation/denitrosylation as a regulatory mechanism of salt stress sensing in sunflower seedlings.
2017 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 13:e1006959 (2017)
Loss of the chromatin modifier Kdm2aa causes BrafV-600E -independent spontaneous melanoma in zebrafish.
2017 Wissenschaftlicher Artikel in Journal of Lipid Research J. Lipid Res. 58, 1834-1844 (2017)
A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.
2017 Wissenschaftlicher Artikel in PLoS Medicine PLoS Med. 14:e1002383 (2017)
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
2017 Letter to the Editor in Annals of Oncology Ann. Oncol. 28, 1668-1670 (2017)
Copy number alterations assessed at the single-cell level revealed mono- and polyclonal seeding patterns of distant metastasis in a small-cell lung cancer patient.
2017 Wissenschaftlicher Artikel in Journal of Biomedical Science J. Biomed. Sci. 24:57 (2017)
Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1I27N mutant mice.
2017 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 12:e0181038 (2017)
Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation.
2017 Review in Development / Company of Biologists Development 144, 2714-2718 (2017)
Programming and reprogramming the brain: A meeting of minds in neural fate.
2017 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 49, 1502–1510 (2017)
LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo.
2017 Wissenschaftlicher Artikel in Respiratory Research Respir. Res. 18:152 (2017)
Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function.
2017 Wissenschaftlicher Artikel in Thorax Thorax 72, 1007-1020 (2017)
Pulmonary CCR2+CD4+ T cells are immune regulatory and attenuate lung fibrosis development.
2017 Wissenschaftlicher Artikel in Hypertension Hypertension 70, 713-750 (2017)
Transcriptome-wide analysis identifies novel associations with blood pressure.
2017 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 8:463 (2017)
Reconstructing cell cycle and disease progression using deep learning.
2017 Wissenschaftlicher Artikel in Obesity Obesity 25, 1618-1624 (2017)
Metabolomic profiling of long-term weight change: Role of oxidative stress and urate levels in weight gain.
2017 Wissenschaftlicher Artikel in Computational and Mathematical Methods in Medicine Comput. Math. Methods Med. 2017:7847531 (2017)
Correcting classifiers for sample selection bias in two-phase case-control studies.
2017 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 6, 974-990 (2017)
Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:8734 (2017)
Evaluating the causal relation of ApoA-IV with disease-related traits - A bidirectional two-sample mendelian randomization study.
2017 Wissenschaftlicher Artikel in European Neuropsychopharmacology : ENP Eur. Neuropsychopharmacol. 27, 3, S406 (2017)
Integrating polygenic allele burden information and phenomic data to characterize complex disease trajectories in severe mental illness.
2017 Wissenschaftlicher Artikel in European Neuropsychopharmacology : ENP Eur. Neuropsychopharmacol. 27, 3, S456-S457 (2017)
The Role of micrornas in the course of servere mental disorders.
2017 Wissenschaftlicher Artikel in European Neuropsychopharmacology : ENP Eur. Neuropsychopharmacol. 27, 3, S408-S409 (2017)
Polygenic burden analysis of longitudinal clusters of quality of life and functioning in patients with severe mental illness.
2017 Wissenschaftlicher Artikel in European Neuropsychopharmacology : ENP Eur. Neuropsychopharmacol. 27, 3, S401-S402 (2017)
Polygenic burden analysis of longitudinal clusters of psychopathological features in a cross-diagnostic group of individuals with severe mental illness.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:5418 (2017)
Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock.
2017 Wissenschaftlicher Artikel in Diabetes Aktuell Diabetes akt. 15, 104-107 (2017)
Ernährungsgewohnheiten schlagen sich im Erbgut nieder.
2017 Wissenschaftlicher Artikel in Hypertension Hypertension 70, e4-e19 (2017)
Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney.
2017 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 8:80 (2017)
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
2017 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 33, i293-i300 (2017)
A scalable moment-closure approximation for large-scale biochemical reaction networks.
2017 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 21, 18-34 (2017)
Direct neuronal reprogramming: Achievements, hurdles, and new roads to success.
2017 Wissenschaftlicher Artikel in British Journal of Nutrition Br. J. Nutr. 117, 1631-1644 (2017)
Metabotyping and its application in targeted nutrition: An overview.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:6037 (2017)
Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes.
2017 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 13:e1006812 (2017)
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.
2017 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 8:15475 (2017)
Prevalence of sexual dimorphism in mammalian phenotypic traits.
2017 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 20, 1096-1103 (2017)
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
2017 Wissenschaftlicher Artikel in Immunology Immunology 152, 402-413 (2017)
microRNA cluster 106a~363 is involved in T-Helper 17 (Th17) cell differentiation.
2017 Wissenschaftlicher Artikel in Journal of Theoretical Biology J. Theor. Biol. 430, 32-44 (2017)
Modeling coexistence of oscillation and Delta/Notch-mediated lateral inhibition in pancreas development and neurogenesis.
2017 Wissenschaftlicher Artikel in European Heart Journal Eur. Heart J. 38, 1823-1831 (2017)
A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction.
2017 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 8:14836 (2017)
A BaSiC tool for background and shading correction of optical microscopy images.
2017 Meeting abstract in Glia Glia 65, E401-E401 (2017)
Proliferation and neural stem cell potential of diencephalic astrocytes revealed by genome-wide expression analysis is Smad4-dependent.
2017 Wissenschaftlicher Artikel in Journal of Investigative Dermatology, The J. Invest. Dermatol. 137, 1945-1954 (2017)
miR-146b probably assists miRNA-146a in the suppression of keratinocyte proliferation and inflammatory responses in psoriasis.
2017 Meeting abstract in Glia Glia 65, E404-E405 (2017)
Differences of grey and white matter astrocytes in the intact and injured cerebral cortex.
2017 Meeting abstract in Glia Glia 65, E121-E121 (2017)
Self-renewal and differentiation potential of reactive astrocytes in vivo.
2017 Meeting abstract in Glia Glia 65, E520-E520 (2017)
Intrinsic changes in the proliferative program limit astrocyte homeostasis in the aged post-traumatic murine cerebral cortex.
2017 Wissenschaftlicher Artikel in Diabetes Diabetes 66, 2888-2902 (2017)
An expanded genome-wide association study of type 2 diabetes in Europeans.
2017 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 13:e1006755 (2017)
Identifying systematic heterogeneity patterns in genetic association meta-analysis studies.
2017 Wissenschaftlicher Artikel in BMC Systems Biology BMC Syst. Biol. 11:63 (2017)
Comprehensive benchmarking of Markov chain Monte Carlo methods for dynamical systems.
2017 Wissenschaftlicher Artikel in Allergy Allergy 72, 1962-1971 (2017)
Identification of a plasma miRNA biomarker-signature for allergic asthma: A translational approach.
2017 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 19, 643-654 (2017)
Rapid genome-wide recruitment of RNA polymerase II drives transcription, splicing, and translation events during T cell responses.
2017 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 195 (2017)
2d cross-omics integrated enrichment analysis of human and mice COPD lungs reveal novel pathological mechanisms of disease progression.
2017 Sonstiges: Nachrichtenmeldung in Nature Genetics Nat. Genet. 49, 820-821 (2017)
Starting embryonic transcription for the first time.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:46026 (2017)
Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma.
2017 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 33, 3211-3219 (2017)
Model-based branching point detection in single-cell data by K-Branches clustering.
2017 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 195 (2017)
Deficiency of immunoproteasome subunits increases alternative polarization of alveolar macrophages.
2017 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 195 (2017)
Discrimination of pulmonary changes in neonatal chronic lung disease by a new Mri score.
2017 Wissenschaftlicher Artikel in Biological Psychiatry Biol. Psychiatry 81, 325-335 (2017)
Genome-wide association for major depression through age at onset stratification: Major depressive disorder working group of the Psychiatric Genomics Consortium.
2017 Meeting abstract in Molecular and Cellular Pediatrics Mol. Cell. Pediatr. 4, 1:5 (2017)
Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.
2017 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 8:15466 (2017)
Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1.
2017 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 49, 834-841 (2017)
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
2017 Wissenschaftlicher Artikel in Molecular and Cellular Proteomics Mol. Cell. Proteomics 16, 1528-1546 (2017)
Proteome-wide identification of glycosylation-dependent interactors of Galectin-1 and Galectin-3 on mesenchymal retinal pigment epithelial cells.
2017 Meeting abstract in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 139, AB163-AB163 (2017)
Label free identification of peripheral blood eosinophils using high-throughput imaging flow cytometry.
2017 Wissenschaftlicher Artikel in Diabetes Diabetes 66, 2019-2032 (2017)
A low-frequency inactivating Akt2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:2397 (2017)
Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.
2017 Wissenschaftlicher Artikel in OncoTarget Oncotarget 8, 38239-38250 (2017)
Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene.
2017 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 13:e1006528 (2017)
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:45040 (2017)
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
2017 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 12:e0176372 (2017)
Validation of standard operating procedures in a multicenter retrospective study to identify -omics biomarkers for chronic low back pain.
2017 Wissenschaftlicher Artikel in Arthritis & Rheumatology Arthritis Rheum. 69, 1090-1099 (2017)
Immune-array analysis in sporadic inclusion body myositis reveals HLA-DRB1 amino acid heterogeneity across the myositis spectrum.
2017 Wissenschaftlicher Artikel in Neurogenesis Neurogenesis 4:e1285383 (2017)
Transient CREB-mediated transcription is key in direct neuronal reprogramming.
2017 Wissenschaftlicher Artikel in Cerebral Cortex Cereb. Cortex 27, 1-16 (2017)
Changes in the proliferative program limit astrocyte Hhmeostasis in the aged post-traumatic murine cerebral cortex.
2017 Wissenschaftlicher Artikel in OncoTarget Oncotarget 8, 22876-22893 (2017)
Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:45652 (2017)
Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci.
2017 Meeting abstract in Experimental Dermatology Exp. Dermatol. 26, E61-E61 (2017)
Interface dermatitis shows a distinctive molecular signature independent from individual disease background.
2017 Meeting abstract in Experimental Dermatology Exp. Dermatol. 26, E69-E70 (2017)
Characterization of multiple B cell subsets in peripheral blood and skin biopsies of psoriasis patients identifies a correlation of plasma and regulatory B cells and disease severity.
2017 Meeting abstract in Experimental Dermatology Exp. Dermatol. 26, E68-E68 (2017)
The imiquimod model as a model for psoriasis and/or eczema in humans?
2017 Wissenschaftlicher Artikel in Biochimica et Biophysica Acta - General Subjects Biochim. Biophys. Acta-Gen. Subj. 1861, 1152-1158 (2017)
Effects of statins on the immunoglobulin G glycome.
2017 Wissenschaftlicher Artikel in Physical Biology Phys. Biol. 14:036001 (2017)
CgCorrect: A method to correct for confounding cell-cell variation due to cell growth in single-cell transcriptomics.
2017 Wissenschaftlicher Artikel in Neuron Neuron 93, 777-791.e3 (2017)
Time-specific effects of spindle positioning on embryonic progenitor pool composition and adult neural stem cell seeding.
2017 Wissenschaftlicher Artikel in Journal of Neuroscience J. Neurosci. 37, 4231-4242 (2017)
Respiration-deficient astrocytes survive as glycolytic cells in vivo.
2017 Wissenschaftlicher Artikel in Progress in Brain Research Prog. Brain. Res. 230, 69-97 (2017)
Brain repair from intrinsic cell sources: Turning reactive glia into neurons.
2017 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 12:e0170458 (2017)
Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function.
2017 Wissenschaftlicher Artikel in Plant Physiology Plant Physiol. 173, 1434-1452 (2017)
Nitric oxide modulates histone acetylation at stress genes by inhibition of histone deacetylases.
2017 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 33, 2020-2028 (2017)
fastER: A user-friendly tool for ultrafast and robust cell segmentation in large-scale microscopy.
2017 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 8:14357 (2017)
Connecting genetic risk to disease end points through the human blood plasma proteome.
2017 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 49, 403-415 (2017)
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
2017 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 49, 416-425 (2017)
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
2017 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 14, 403–406 (2017)
Prospective identification of hematopoietic lineage choice by deep learning.
2017 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 12:e0169223 (2017)
Maternal pre-pregnancy obesity is associated with altered placental transcriptome.
2017 Wissenschaftlicher Artikel in Journal of Clinical Investigation J. Clin. Invest. 127, 695-708 (2017)
Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance.
2017 Wissenschaftlicher Artikel in Particle and Fibre Toxicology Part. Fibre Toxicol. 14:2 (2017)
Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection.
2017 Wissenschaftlicher Artikel in Disease Models and Mechanisms Dis. Model. Mech. 10, 163-171 (2017)
Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology.
2017 Wissenschaftlicher Artikel in Journal of Investigative Dermatology, The J. Invest. Dermatol. 137, 1074-1081 (2017)
Association of atopic dermatitis with cardiovascular risk factors and diseases.
2017 Wissenschaftlicher Artikel in Epigenetics & Chromatin Epigenetics Chromatin 10:1 (2017)
Genome-wide methylation data mirror ancestry information.
2017 Wissenschaftlicher Artikel in Nature Nature 541, 81-86 (2017)
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.
2017 Wissenschaftlicher Artikel in Methods in Molecular Biology Methods Mol. Biol. 1488, 217-237 (2017)
Epigenetics and control of RNAs.
2017 Wissenschaftlicher Artikel in Cell Systems Cell Syst. 4, 194–206.e9 (2017)
Parallelization and high-performance computing enables automated statistical inference of multi-scale models.
2017 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 33, 1049-1056 (2017)
Parameter estimation for dynamical systems with discrete events and logical operations.
2017 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 13:e1005331 (2017)
Scalable parameter estimation for genome-scale biochemical reaction networks.
2017 Wissenschaftlicher Artikel in Endocrine-Related Cancer Endocr. Relat. Cancer 24, 1-15 (2017)
Targeting PI3K/mTOR signaling exerts potent antitumor activity in pheochromocytoma in vivo.
2017 Review in Nature Reviews - Genetics Nat. Rev. Genet. 18, 51-66 (2017)
From profiles to function in epigenomics.
2017 Wissenschaftlicher Artikel in Nature Chemical Biology Nat. Chem. Biol. 13, 91-98 (2017)
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.
2017 Wissenschaftlicher Artikel in Diabetologia Diabetologia 60, 287-295 (2017)
Peptide serum markers in islet autoantibody-positive children.
2017 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 45:e3 (2017)
TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus.
2017 Wissenschaftlicher Artikel in Molecular Psychiatry Mol. Psychiatry 22, 192-201 (2017)
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.
2017 Wissenschaftlicher Artikel in Plant, Cell and Environment Plant Cell Environ. 40, 36-50 (2017)
Nitric oxide-fixation by non-symbiotic hemoglobin proteins in Arabidopsis thaliana under N-limited conditions.
2016 Wissenschaftlicher Artikel in Genetics Genetics 202, 825-841 (2016)
Signatures of Dobzhansky-Muller Incompatibilities in the genomes of recombinant inbred lines.
2016 Review in Nature Reviews - Genetics Nat. Rev. Genet. 17, 661-678 (2016)
Organization and function of the 3D genome.
2016 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 48, 1436-1442 (2016)
Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development.
2016 Meeting abstract in European Respiratory Journal Eur. Respir. J. 48, PP104 (2016)
LSC Abstract – Early biomarkers indicating the development of neonatal chronic lung disease defined by clinical and imaging parameters.
2016 Meeting abstract in Diabetologia Diabetologia 59, S47-S47 (2016)
miRNA signatures in maternal whole blood cells of women with gestational diabetes.
2016 Meeting abstract in Diabetologia Diabetologia 59, S259-S259 (2016)
Systemic metabolic effects exerted by a point mutation in the RED subdomain of PAX6.
2016 Meeting abstract in Diabetologia Diabetologia 59, S188-S188 (2016)
Dll1-and Dll4-mediated Notch signalling in adult pancreatic beta cells is essential for the structural integrity of islets and maintenance of glucose homeostasis.
2016 Meeting abstract in Diabetologia Diabetologia 59, S176-S177 (2016)
Genome wide meta-analysis identifies novel regulators of circulating serum progranulin.
2016 Meeting abstract in Diabetologia Diabetologia 59, S187-S187 (2016)
Lactation is associated with altered metabolomic signatures in women with gestational diabetes.
2016 Letter to the Editor in Obstetrical & gynecological survey Obstet. Gynecol. Surv. 71, 719-720 (2016)
Epigenetic germline inheritance of diet-induced obesity and insulin resistance.
2016 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 193 (2016)
Mouse lung developmental gene expression profiling study identifies novel candidate genes for pulmonary function.
2016 Wissenschaftlicher Artikel in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 9, 250-258 (2016)
Common and rare genetic variation in CCR2, CCR5, or CX3CR1 and risk of atherosclerotic coronary heart disease and glucometabolic traits.
2016 Meeting abstract in Atherosclerosis Atherosclerosis 252, E263-E263 (2016)
Associations between lipoprotein subfractions and genome-wide DNA methylation in KORA F4.
2016 Meeting abstract in Allergy Allergy 71, 431-431 (2016)
Genome-wide association study unravels genetic determinants of the atopic march.
2016 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 113, 14372-14377 (2016)
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.
2016 Sonstiges: Meinungsartikel in Cell Stem Cell Cell Stem Cell 19, 291-292 (2016)
Overcoming iPSC Obstacles.
2016 Meeting abstract in European Journal of Cancer Eur. J. Cancer 68, S44-S44 (2016)
Large-scale modeling of cancer signaling: Mechanistic modeling meets Big Data.
In: Gasotransmitters in Plants : The Rise of a New Paradigm in Cell Signaling. Springer International Publishing, 2016. 137-154 ( ; 3)
Growth-promoting effect of NO fumigation and hemoglobins.
2016 Meeting abstract in European Journal of Cancer Eur. J. Cancer 68, S135-S135 (2016)
Identification of predictive response and resistance factors to targeted therapy in gastric cancer using a systems medicine approach.
IFAC-PapersOnLine In: (Foundations of Systems Biology in Engineering - FOSBE 2016, 9—12 October 2016, Magdeburg). 2016. 264-269 (IFAC PapersOnline ; 49-26)
Quantitative comparison of competing PDE models for Pomlp dynamics in fission yeast.
2016 Meeting abstract in Pancreatology Pancreatol. 16, S. 11 (2016)
Oncogenic Kras promotes early pancreatic carcinogenesis by perpetuating elements of natural inflammatory response.
2016 Meeting abstract in Cancer Research Cancer Res. 76 (2016)
Abstract 1945: Identification of a miRNA/mRNA network driving non-small cell lung cancer (NSCLC) dissemination.
2016 Wissenschaftlicher Artikel in Labor-Praxis Laborpraxis, DOI: undefined (2016)
Einzigartige Zellen: Computerbasierte Methoden verbessern die Einzelzell-Analyse.
2016 https://www.bsse.ethz.ch/csd/software/ttt-and-qtfy.html (2016)
Big Data for small cells - neue Software zur Beobachtung einzelner Zellen.
2016 Wissenschaftlicher Artikel in Biomolecular detection and quantification Biomol. Detect. Quantif. 11, 31-44 (2016)
Inhibition of fat cell differentiation in 3T3-L1 pre-adipocytes by all-trans retinoic acid: Integrative analysis of transcriptomic and phenotypic data.
2016 Wissenschaftlicher Artikel in Frontiers in Plant Science Front. Plant Sci. 7:1669 (2016)
ROS-mediated inhibition of S-nitrosoglutathione reductase contributes to the activation of anti-oxidative mechanisms.
2016 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 30, 2513-2526 (2016)
SUV4-20 activity in the preimplantation mouse embryo controls timely replication.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:13357 (2016)
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.
2016 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 113, 13366-13371 (2016)
Genetic variants linked to education predict longevity.
2016 Wissenschaftlicher Artikel in Nature Nature 539, 248-253 (2016)
Transplanted embryonic neurons integrate into adult neocortical circuits.
2016 Wissenschaftlicher Artikel in Cell Systems Cell Syst. 3, 480-490 (2016)
Analysis of cell lineage trees by exact bayesian inference identifies negative autoregulation of nanog in mouse embryonic stem cells.
2016 Wissenschaftlicher Artikel in Clinical Epigenetics Clin. Epigenet. 8:124 (2016)
Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0166015 (2016)
Epigenetic signatures at AQP3 and SOCS3 engage in low-grade inflammation across different tissues.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0165548 (2016)
Are epigenetic factors implicated in chronic widespread pain?
2016 Wissenschaftlicher Artikel in Nature Nature 539, 248-253 (2016)
Transplanted embryonic neurons integrate into adult neocortical circuits.
2016 Wissenschaftlicher Artikel in BMC Genomics BMC Genomics 17:917 (2016)
CORALINA: A universal method for the generation of gRNA libraries for CRISPR-based screening.
2016 Wissenschaftlicher Artikel in Nature medicine Nat. Med. 22, 1428-1438 (2016)
Cardioprotection and lifespan extension by the natural polyamine spermidine.
2016 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 10019, 287-295 (2016)
Mitosis detection in intestinal crypt images with hough forest and conditional random fields.
2016 Wissenschaftlicher Artikel in BMJ Open BMJ Open 6:e012070 (2016)
'Omics' biomarkers associated with chronic low back pain: Protocol of a retrospective longitudinal study.
2016 Meeting abstract in Experimental Dermatology Exp. Dermatol. 25, 30-31 (2016)
A distinct molecular signature of interface dermatitis as determined by gene expression analysis combined with disease independent histological phenotyping.
2016 Meeting abstract in Experimental Dermatology Exp. Dermatol. 25, 27-28 (2016)
Characterization of multiple B cell subsets in peripheral blood of psoriasis patients identifies a correlation of plasma and regulatory B cells with disease severity.
2016 Wissenschaftlicher Artikel in Genes Genomes Genetics G3 Genes Genomes Genetics G3 6, 4035-4046 (2016)
The first Scube3 mutant mouse line with pleiotropic phenotypic alterations.
2016 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 12:e1006379 (2016)
Effect of insulin resistance on monounsaturated fatty acid levels: A multi-cohort non-targeted metabolomics and mendelian randomization study.
2016 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 48, 1462-1472 (2016)
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
2016 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 30, 2199-2212 (2016)
Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration.
2016 Wissenschaftlicher Artikel in OncoTarget Oncotarget 7, 74510-74525 (2016)
Long-term exposure to air pollution is associated with biological aging.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0164298 (2016)
Sphingomyelin synthase 1 is essential for male fertility in mice.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0164097 (2016)
Inducible expression of the De-Novo designed antimicrobial peptide SP1-1 in tomato confers resistance to Xanthomonas campestris pv. vesicatoria.
2016 Wissenschaftlicher Artikel in Aging Aging 8, 1844-1865 (2016)
DNA methylation-based measures of biological age: Meta-analysis predicting time to death.
2016 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 136, S217-S217 (2016)
Characterization of multiple B cell subsets in peripheral blood of psoriasis patients identifies a correlation of regulatory B cells and disease severity.
2016 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 136, S219-S219 (2016)
Interface dermatitis shows a distinctive molecular signature independent from individual disease background.
2016 Wissenschaftlicher Artikel in Nature Nature 537, 494-496 (2016)
Developmental biology: Panoramic views of the early epigenome.
2016 Wissenschaftlicher Artikel in Journal of the American College of Cardiology J. Am. Coll. Cardiol. 68, 1435-1448 (2016)
52 Genetic loci influencing myocardial mass.
2016 Wissenschaftlicher Artikel in Gut (eGut) Gut 67, 146-156 (2016)
Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy.
2016 Wissenschaftlicher Artikel in Diabetes Diabetes 65, 3776-3785 (2016)
Metformin effect on non-targeted metabolite profiles in patients with type 2 diabetes and multiple murine tissues.
2016 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 6:25853 (2016)
Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium.
2016 Wissenschaftlicher Artikel in Diabetologia Diabetologia 59, 1214-1221 (2016)
Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
2016 Wissenschaftlicher Artikel in Cancer Epidemiology, Biomarkers & Prevention Cancer Epidemiol. Biomarkers Prev. 25, 1043-1049 (2016)
Genetic variation associated with longer telomere length increases risk of chronic lymphocytic leukemia.
2016 Wissenschaftlicher Artikel in International Journal of Epidemiology Int. J. Epidemiol. 45, 1469-1481 (2016)
Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: A cross-sectional analysis in population-based data.
2016 Wissenschaftlicher Artikel in BMC Systems Biology BMC Syst. Biol. 10:80 (2016)
Tailored parameter optimization methods for ordinary differential equation models with steady-state constraints.
2016 Wissenschaftlicher Artikel in Cell Cell 166, 867-880 (2016)
Astrocytic insulin signaling couples brain glucose uptake with nutrient availability.
2016 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 13, 845-848 (2016)
Diffusion pseudotime robustly reconstructs lineage branching.
2016 Wissenschaftlicher Artikel in Archives of Physiology and Biochemistry Arch. Physiol. Biochem. 122, 281-288 (2016)
Impact of fibroblast growth factor 21 on the secretome of human perivascular preadipocytes and adipocytes: A targeted proteomics approach.
In: Proceedings (Proceedings / IEEE 13th International Symposium on Biomedical Imaging (ISBI), 13-16 April 2016, Prague, Czech Republic). IEEE, 2016.
Structure-based assessment of cancerous mitochondria using deep networks.
2016 Sonstiges: Meinungsartikel in Cell Systems Cell Syst. 3, 7-11 (2016)
What is the key best practice for collaborating with a computational biologist?
2016 MEDICA Magazin MEDICA Magazin, DOI: undefined (2016)
Zelle unter Beobachtung: "Mit der Software können wir die Entwicklung im Video studieren".
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:12397 (2016)
MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity.
2016 Wissenschaftlicher Artikel in Parkinsonism & Related Disorders Parkinsonism Relat. Disord. 31, 119-123 (2016)
Systematic TOR1A non-c.907_909delGAG variant analysis in isolated dystonia and controls.
2016 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 25, 4094-4106 (2016)
Analysis with the exome array identifies multiple new independent variants in lipid loci.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0158101 (2016)
Meta-analysis of genome-wide association studies and network analysis-based integration with gene expression data identify new suggestive loci and unravel a Wnt-centric network associated with Dupuytren's disease.
2016 Wissenschaftlicher Artikel in European Journal of Nutrition Eur. J. Nutr. 56, 2379-2391 (2016)
Metabolites of milk intake: A metabolomic approach in UK twins with findings replicated in two European cohorts.
2016 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 12:e1005030 (2016)
Inference for stochastic chemical kinetics using moment equations and system size expansion.
2016 Wissenschaftlicher Artikel in Arthritis Research & Therapy Arthritis Res. Ther. 18:156 (2016)
Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies.
2016 Laborjournal Laborjournal 7-8, 59-61 (2016)
Von lernfähigen Maschinen lernen.
2016 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 25, 3635-3646 (2016)
A genome-wide association meta-analysis on apolipoprotein A-IV concentrations.
2016 Review in Development / Company of Biologists Development 143, 2494-2510 (2016)
Direct neuronal reprogramming: Learning from and for development.
2016 Wissenschaftlicher Artikel in eLife eLife 5:e08711 (2016)
Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation.
2016 Editorial in Developmental Cell Dev. Cell 38, 3-5 (2016)
A pluripotency platform for Prdm14.
2016 Wissenschaftlicher Artikel in Nature Nature 535, 430-434 (2016)
Identification of proliferative and mature β-cells in the islets of Langerhans.
2016 Wissenschaftlicher Artikel in Nature Nature 536, 41-47 (2016)
The genetic architecture of type 2 diabetes.
2016 Wissenschaftlicher Artikel in Diabetologia Diabetologia 59, 2114-2124 (2016)
Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes.
2016 Wissenschaftlicher Artikel in Diabetologia Diabetologia 59, 2193-2202 (2016)
Lactation is associated with altered metabolomic signatures in women with gestational diabetes.
2016 Wissenschaftlicher Artikel in Nature Nature 535, 299-302 (2016)
Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.
2016 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol. 34, 703-706 (2016)
Software tools for single-cell tracking and quantification of cellular and molecular properties.
2016 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 2:e1501678 (2016)
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.
2016 Wissenschaftlicher Artikel in Carcinogenesis Carcinogenesis 37, 576-582 (2016)
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.
2016 Genome Biology Genome Biol. 17:143 (2016)
Erratum to: Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons [Genome Biol, (2016), 17, 116].
2016 Wissenschaftlicher Artikel in Nature Protocols Nat. Protoc. 11, 1360-1370 (2016)
Single-cell in vivo imaging of adult neural stem cells in the zebrafish telencephalon.
2016 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 17:116 (2016)
Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons.
2016 Wissenschaftlicher Artikel in Diabetes Diabetes 65, 2849-2861 (2016)
TGFβ contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:11812 (2016)
A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels.
2016 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 48, 681-686 (2016)
Histone H3 globular domain acetylation identifies a new class of enhancers.
2016 Meeting abstract in Cancer Research Cancer Res. 76:P1-06-02 (2016)
A force-sensitive organoid assay to quantify regenerative potential of single primary human mammary cells.
2016 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 17:115 (2016)
Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies.
2016 Wissenschaftlicher Artikel in Diabetes Diabetes 65, 2540-2552 (2016)
Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice.
2016 Nature Communications Nat. Commun. 7:11835 (2016)
Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
2016 Wissenschaftlicher Artikel in Advances in Botanical Research Adv. Bot. Res. 77, 15-39 (2016)
S-nitrosylation of nuclear proteins: New pathways in regulation of gene expression.
2016 Wissenschaftlicher Artikel in Genetics Genetics 203, 1629-1640 (2016)
Principles of microRNA regulation revealed through modeling microRNA expression quantitative trait loci.
2016 Wissenschaftlicher Artikel in Genomics, Proteomics & Bioinformatics Geno. Prot. Bioinfo. 14, 235-243 (2016)
Comparison of cox model methods in a low-dimensional setting with few events.
2016 Wissenschaftlicher Artikel in Nature Nature 533, 539-542 (2016)
Genome-wide association study identifies 74 loci associated with educational attainment.
2016 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 12:e1006034 (2016)
Discovery of genetic variation on chromosome 5q22 associated with mortality in heart failure.
2016 Wissenschaftlicher Artikel in Epigenetics Epigenetics 11, 389-397 (2016)
Characterization of non-canonical polycomb repressive complex 1 subunits during early mouse embryogenesis.
2016 Wissenschaftlicher Artikel in Experimental Dermatology Exp. Dermatol. 25, 767-774 (2016)
A novel molecular disease classifier for psoriasis and eczema.
2016 Review in Nature Reviews - Genetics Nat. Rev. Genet. 17, 319-332 (2016)
Genetic sources of population epigenomic variation.
2016 Wissenschaftlicher Artikel in Steroids Steroids 114, 7-15 (2016)
There goes the neighborhood: Assembly of transcriptional complexes during the regulation of metabolism and inflammation by the glucocorticoid receptor.
2016 Editorial in Current Opinion in Biotechnology Curr. Opin. Biotechnol. 39, IV-VI (2016)
Systems biology - the intersection of experiments and computation, underpinning biotechnology.
2016 Wissenschaftlicher Artikel in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 138, 1207-1210.e2 (2016)
A computational model to predict severity of atopic eczema from 30 serum proteins.
2016 Wissenschaftlicher Artikel in OncoTarget Oncotarget 7, 30396-30407 (2016)
Twist1 induces distinct cell states depending on TGFBR1-activation.
2016 Laborjournal Laborjournal 23, 22-25 (2016)
Das ist der Zyklus der Systembiologie.
2016 Wissenschaftlicher Artikel in Current Opinion in Biotechnology Curr. Opin. Biotechnol. 39, 207-214 (2016)
Single-cell gene expression profiling and cell state dynamics: Collecting data, correlating data points and connecting the dots.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:11317 (2016)
Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0152996 (2016)
CIP2A promotes T-cell activation and immune response to Listeria monocytogenes infection.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0153163 (2016)
The pharmacogenetic footprint of ACE inhibition: A population-based metabolomics study.
2016 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 32, 2464-2472 (2016)
MEMO - multi-experiment mixture model analysis of censored data.
2016 Wissenschaftlicher Artikel in Current Opinion in Biotechnology Curr. Opin. Biotechnol. 39, 198-206 (2016)
Computational approaches for systems metabolomics.
2016 Wissenschaftlicher Artikel in IET Systems Biology IET Syst. Biol. 10, 210-218 (2016)
Inferring catalysis in biological systems.
2016 Meeting abstract in Experimental Dermatology Exp. Dermatol. 25, E16 (2016)
Epidemiologic and genetic association between atopic dermatitis, rheumatoid arthritis, inflammatory bowel disease, and type-1 diabetes.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:11122 (2016)
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.
2016 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 48, 624-633 (2016)
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0152314 (2016)
Association between DNA methylation in whole blood and measures of glucose metabolism: Kora F4 study.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:11008 (2016)
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.
2016 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 15, 360-371 (2016)
An essential role for liver ERα in coupling hepatic metabolism to the reproductive cycle.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0150472 (2016)
Generation and standardized, systemic phenotypic analysis of Pou3f3L423P mutant mice.
2016 Wissenschaftlicher Artikel in Metabolomics Metabolomics 12:76 (2016)
Metabolomics reveals effects of maternal smoking on endogenous metabolites from lipid metabolism in cord blood of newborns.
2016 Wissenschaftlicher Artikel in Chromosoma Chromosoma 125, 29-39 (2016)
LINEs in mice: Features, families, and potential roles in early development.
2016 Review in Trends in Genetics Trends Genet. 32, 42-56 (2016)
Lateral thinking: How histone modifications regulate gene expression.
2016 Wissenschaftlicher Artikel in Biochimica et Biophysica Acta - Gene Regulatory Mechanisms Biochim. Biophys. Acta-Gene Regul. Mech. 1859, 486-495 (2016)
The role of linker histone H1 modifications in the regulation of gene expression and chromatin dynamics.
2016 Meeting abstract in Oncology Research and Treatment Oncol. Res. Treat. 39, 16-17 (2016)
Clinical validation of response and resistance factor candidates to targeted therapy in Gastric Cancer (GC).
2016 Wissenschaftlicher Artikel in Cell Death and Differentiation Cell Death Differ. 23, 1026-1037 (2016)
Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages.
2016 Wissenschaftlicher Artikel in Genome Medicine Genome Med. 8:28 (2016)
A roadmap of constitutive NF-κB activity in Hodgkin lymphoma: Dominant roles of p50 and p52 revealed by genome-wide analyses.
2016 Review in Genes and Development Genes Dev. 30, 611-621 (2016)
Building up the nucleus: Nuclear organization in the establishment of totipotency and pluripotency during mammalian development.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0151771 (2016)
miTALOS v2: Analyzing tissue specific microRNA function.
2016 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 48, 497-499 (2016)
Epigenetic germline inheritance of diet-induced obesity and insulin resistance.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0147388 (2016)
Association of forced vital capacity with the developmental gene NCOR2.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:10782 (2016)
Hypothalamic leptin action is mediated by histone deacetylase 5.
2016 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 25, 2082-2092 (2016)
Testing the role of predicted gene knockouts in human anthropometric trait variation.
2016 Wissenschaftlicher Artikel in Journal of Computational Biology J. Comput. Biol. 23, 279-290 (2016)
Unbiased prediction and feature selection in high-dimensional survival regression.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0146732 (2016)
CERENA: ChEmical REaction Network Analyzer - a toolbox for the simulation and analysis of stochastic chemical kinetics.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0149477 (2016)
Pitchfork and Gprasp2 target smoothened to the primary cilium for Hedgehog pathway activation.
2016 Wissenschaftlicher Artikel in OncoTarget Oncotarget 7, 12937-12950 (2016)
MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM.
2016 Wissenschaftlicher Artikel in Lancet Neurology, The Lancet Neurol. 15, 174-184 (2016)
Loci associated with ischaemic stroke and its subtypes (SiGN): A genome-wide association study.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:10494 (2016)
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
2016 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 17:8 (2016)
H1 gets the genome in shape.
2016 Wissenschaftlicher Artikel in Plant Physiology Plant Physiol. 170, 1945-1961 (2016)
Modulation of protein S-nitrosylation by isoprene emission in poplar.
2016 Wissenschaftlicher Artikel in Journal of Inherited Metabolic Disease J. Inherit. Metab. Dis. 39, 309-319 (2016)
Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:10495 (2016)
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:10023 (2016)
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
2016 Wissenschaftlicher Artikel in Aging Aging 8, 77-94 (2016)
Metabolomics profiling reveals novel markers for leukocyte telomere length.
2016 Wissenschaftlicher Artikel in Phytochemistry Phytochemistry 122, 76-80 (2016)
Expression of antimicrobial peptides under control of a camalexin-biosynthetic promoter confers enhanced resistance against Pseudomonas syringae.
2016 Wissenschaftlicher Artikel in Cell Systems Cell Syst. 2, 49-58 (2016)
Combinatorial histone acetylation patterns are generated by motif-specific reactions.
2016 Editorial in Cell Cell 164, 341-342 (2016)
Epigenetic ON/OFF switches for obesity.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0147129 (2016)
Alterations in lipid and inositol metabolisms in two dopaminergic disorders.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:10256 (2016)
Label-free cell cycle analysis for high-throughput imaging flow cytometry.
2016 Wissenschaftlicher Artikel in Stroke Stroke 47, 307-316 (2016)
Genome-wide association analysis of young onset stroke identifies a locus on chromosome 10q25 near HABP2.
Studies in Mechanobiology, Tissue Engineering and Biomaterials In: Geris, L.* ; Gomez-Cabrero, D.* [Eds.]: Uncertainty in Biology : A Computational Modeling Approach. Berlin; Heidelberg: Springer, 2016. 243-268 (Stud. Mechanobiol. Tiss. Engineering Biomater. ; 17)
Bayesian model selection methods and their application to biological ODE systems.
2016 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 32, 1241-1243 (2016)
Destiny: Diffusion maps for large-scale single-cell data in R.
2016 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 18, 396-409 (2016)
Identification and successful negotiation of a metabolic checkpoint in direct neuronal repogramming.
2016 Wissenschaftlicher Artikel in Journal of Proteome Research J. Proteome Res. 15, 554-562 (2016)
Diagnostic and prognostic metabolites identified for joint symptoms in the KORA population.
2016 Wissenschaftlicher Artikel in Diabetes Diabetes 65, 803-817 (2016)
Genome-wide association studies identify genetic loci associated with albuminuria in diabetes.
2016 Wissenschaftlicher Artikel in Mechanisms of Development Mech. Dev. 139, 51-64 (2016)
The global gene expression profile of the secondary transition during pancreatic development.
2016 Wissenschaftlicher Artikel in Proteomics Proteomics 16, 437-447 (2016)
In situ detection of histone variants and modifications in mouse brain using imaging mass spectrometry.
2016 Wissenschaftlicher Artikel in Mucosal Immunology Mucosal Immunol. 9, 917-926 (2016)
Interleukin-4 and interferon-γ orchestrate an epithelial polarization in the airways.
2016 Wissenschaftlicher Artikel in Clinical Science Clin. Sci. 130, 273-287 (2016)
Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema.
2016 Wissenschaftlicher Artikel in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 27, 1175-1188 (2016)
A metabolome-wide association study of kidney function and disease in the general population.
2016 Wissenschaftlicher Artikel in Journal of Time Series Analysis J. Time Ser. Anal. 37, 337-354 (2016)
Separation of uncorrelated stationary time series using autocovariance matrices.
2016 Wissenschaftlicher Artikel in Annals of the Rheumatic Diseases : ARD online Ann. Rheum. Dis. 75, 1558-1566 (2016)
Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.
2016 Wissenschaftlicher Artikel in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 137, 130–136 (2016)
Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes.
2016 Wissenschaftlicher Artikel in Developmental Biology Dev. Biol. 413, 86-103 (2016)
Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development.
2016 Wissenschaftlicher Artikel in Plant, Cell and Environment Plant Cell Environ. 39, 147-164 (2016)
Common ragweed (Ambrosia artemisiifolia L.): Allergenicity and molecular characterisation of pollen after plant exposure to elevated NO2.
2016 Wissenschaftlicher Artikel in Gut (eGut) Gut 65, 647-657 (2016)
A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling.
2015 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 112, 6676-6681 (2015)
Rate, spectrum, and evolutionary dynamics of spontaneous epimutations.
Pneumologe, Der In:. 2015. 69-A24 (Pneumologe)
SEC14-like 3 is decreased in airway ciliated cells in experimental and paediatric asthma.
2015 Wissenschaftlicher Artikel in Diabetes Diabetes 64, 4312-4321 (2015)
Genetic predisposition to weight loss and regain with lifestyle intervention: Analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials.
2015 Wissenschaftlicher Artikel in OncoTarget Oncotarget 6, 42468-42477 (2015)
Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.
2015 Wissenschaftlicher Artikel in Genetic Epidemiology Genet. Epidemiol. 39, 624-634 (2015)
A Bayesian approach to the overlap analysis of epidemiologically linked traits.
2015 Sonstiges: Meinungsartikel in Obstetrics & Gynecology Obstet. Gynecol. 70, 758-762 (2015)
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility, and BRCA1-mediated DNA repair.
2015 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep. 16, 1439-1453 (2015)
The H1 linker histones: Multifunctional proteins beyond the nucleosomal core particle.
2015 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 5:14756 (2015)
IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity.
2015 Wissenschaftlicher Artikel in FEBS Journal, The FEBS J. 282, 1658-1674 (2015)
Novel types and sites of histone modifications emerge as players in the transcriptional regulation contest.
2015 Wissenschaftlicher Artikel in Epigenetics Epigenetics, DOI: 10.1080/15592294.2015.1103424 (2015)
Dynamics of histone H3 acetylation in the nucleosome core during mouse pre-implantation development.
2015 Wissenschaftlicher Artikel in Cold Spring Harbor Symposia on Quantitative Biology Cold Spring Harb. Symp. Quant. Biol., DOI: 10.1101/sqb.2015.80.027458 (2015)
Regulation of reprogramming and cellular plasticity through histone exchange and histone variant incorporation.
2015 Wissenschaftlicher Artikel in Current Opinion in Cell Biology Curr. Opin. Cell Biol. 34, 9-15 (2015)
How cells build totipotency and pluripotency: Nuclear, chromatin and transcriptional architecture.
2015 Wissenschaftlicher Artikel in International Journal of Molecular Sciences Int. J. Mol. Sci. 16, 30204-30222 (2015)
MicroRNA-target network inference and local network enrichment analysis identify two microRNA clusters with distinct functions in head and neck squamous cell carcinoma.
2015 Wissenschaftlicher Artikel in Mammalian Genome Mamm. Genome 27, 17-28 (2015)
Dexamethasone treatment alters insulin, leptin, and adiponectin levels in male mice as observed in DIO but does not lead to alterations of metabolic phenotypes in the offspring.
2015 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 6:8658 (2015)
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.
2015 Wissenschaftlicher Artikel in Development / Company of Biologists Development 142, 3661-3674 (2015)
Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche.
2015 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 47, 1415-1425 (2015)
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
2015 Wissenschaftlicher Artikel in Genetic Epidemiology Genet. Epidemiol. 39, 499-508 (2015)
Evaluating the calibration and power of three gene-based association tests of rare variants for the X chromosome.
2015 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 97, 816-836 (2015)
Genome-wide association analysis of psoriatic arthritis and cutaneous psoriasis reveals differences in their genetic architecture.
In: Krentz, A.J.* ; Heinemann, L.* ; Hompesch, M.* [Eds.]: Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development. London: Springer, 2015. 189-222
Omics: Potential role in early-phase drug development.
2015 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 47, 1449-1456 (2015)
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
In: Proceedings (12th IEEE International Symposium on Biomedical Imaging, ISBI 2015, 16-19 April 2015, Brooklyn, United States). 2015. 1304-1307
Anatomic-landmark detection using graphical context modelling.
2015 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 9308, 52-63 (2015)
Approximate bayesian computation for stochastic single-cell time-lapse data using multivariate test statistics.
2015 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 6:8804 (2015)
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
2015 Wissenschaftlicher Artikel in BMC Medical Genomics BMC Med. Genomics 8:65 (2015)
Extensive alterations of the whole-blood transcriptome are associated with body mass index: Results of an mRNA profiling study involving two large population-based cohorts.
2015 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 47, 1294-1303 (2015)
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
2015 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 11, 1134-1146 (2015)
Quantitative interaction proteomics of neurodegenerative disease proteins.
2015 Meeting abstract in FEBS Journal, The FEBS J. 282, 306 (2015)
Study of protein S-nitrosylation and its role in plant development and pathogenesis.
2015 Wissenschaftlicher Artikel in Epigenetics & Chromatin Epigenetics Chromatin 8:43 (2015)
Characterization of whole-genome autosomal differences of DNA methylation between men and women.
2015 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 11:e1005378 (2015)
The influence of age and sex on genetic associations with adult body size and shape: A large-scale genome-wide interaction study.
2015 Systembiologie.de Systembiologie.de 9, 40-43 (2015)
Models and methods for systems biology and systems medicine: The Institute of Computational Biology at the Helmholtz Zentrum München.
2015 Wissenschaftlicher Artikel in Journal of Coupled Systems and Multiscale Dynamics J. Coupled Syst. Multiscale Dyn. 3, 164-173 (2015)
A case study on the use of scale separation-based analytical propagators for parameter inference in models of stochastic gene regulation.
2015 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 24, 6836-6848 (2015)
Integrative pathway genomics of lung function and airflow obstruction.
2015 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 47, 1121-1130 (2015)
A comprehensive 1000 genomes–based genome-wide association meta-analysis of coronary artery disease.
2015 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 47, 1282-1293 (2015)
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
2015 Wissenschaftlicher Artikel in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 618-627 (2015)
Effect of bile acid sequestrants on the risk of cardiovascular events: A mendelian randomization analysis.
2015 Wissenschaftlicher Artikel in RNA Biology RNA Biol. 12, 998-1009 (2015)
SimiRa: A tool to identify coregulation between microRNAs and RNA-binding proteins.
2015 Wissenschaftlicher Artikel in Journal of Neuroscience J. Neurosci. 35, 13385-13401 (2015)
Dickkopf3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse.
2015 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 17, 1235-1246 (2015)
Network plasticity of pluripotency transcription factors in embryonic stem cells.
2015 Wissenschaftlicher Artikel in Archives of Biochemistry and Biophysics Arch. Biochem. Biophys. 589, 93-107 (2015)
Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis.
2015 Wissenschaftlicher Artikel in BMC Systems Biology BMC Syst. Biol. 9:61 (2015)
Inference of spatiotemporal effects on cellular state transitions from time-lapse microscopy.
2015 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 11:e1005487 (2015)
Genome-wide association study with targeted and non-targeted NMR metabolomics identifies 15 novel loci of urinary human metabolic individuality.
2015 Wissenschaftlicher Artikel in European Journal of Neurology Eur. J. Neurol. 22, 1488-1491 (2015)
Heritability of young- and old-onset ischaemic stroke.
2015 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 9237, 328-335 (2015)
An affine equivariant robust second-order BSS method.
2015 Meeting abstract in International Journal of Stroke Int. J. Stroke 10, 250 (2015)
Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease.
2015 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 135, S63 (2015)
Epidemiologic and genetic association between atopic dermatitis, rheumatoid arthritis, inflammatory bowel disease, and type-1 diabetes.
2015 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 135, S1 (2015)
Molecular diagnostics of psoriasis and eczema-a novel approach to establish personalised therapy.
2015 Wissenschaftlicher Artikel in Parkinsonism & Related Disorders Parkinsonism Relat. Disord. 21, 1278-1281 (2015)
Large-scale TUBB4A mutational screening in isolated dystonia and controls.
2015 Wissenschaftlicher Artikel in European Journal of Human Genetics Eur. J. Hum. Genet. 24, 521-528 (2015)
Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research.
2015 Wissenschaftlicher Artikel in Cold Spring Harbor Perspectives in Biology Cold Spring Harbor Perspect. Biol. 8, DOI: 10.1101/cshperspect.a018853 (2015)
Neurogenesis in the developing and adult brain - similarities and key differences.
2015 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 10:e0135284 (2015)
Integrative analysis of MicroRNA and mRNA data reveals an orchestrated function of MicroRNAs in skeletal myocyte differentiation in response to TNF-α or IGF1.
2015 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 10:e0134503 (2015)
Cox4i2, Ifit2, and Prdm11 mutant mice: Effective selection of genes predisposing to an altered airway inflammatory response from a large compendium of mutant mouse lines.
2015 Wissenschaftlicher Artikel in Metabolomics Metabolomics 11, 1815-1833 (2015)
Gender-specific pathway differences in the human serum metabolome.
2015 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 11:e1005423 (2015)
SLIRP regulates the rate of mitochondrial protein synthesis and protects LRPPRC from degradation.
2015 Wissenschaftlicher Artikel in Glia Glia 63, 2340-2361 (2015)
Astrocyte reactivity after brain injury - the role of galectins 1 and 3.
2015 Genome Medicine Genome Med. 7:75 (2015)
Erratum to: Brave new epigenomes: The dawn of epigenetic engineering.
2015 Wissenschaftlicher Artikel in International Journal of Genomics Int. J. Genomics 2015:693193 (2015)
Genetic geostatistical framework for spatial analysis of fine-scale genetic heterogeneity in modern populations: Results from the KORA study.
2015 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 5:12673 (2015)
Validated prediction of pro-invasive growth factors using a transcriptome-wide invasion signature derived from a complex 3D invasion assay.
2015 Wissenschaftlicher Artikel in Diabetes Care Diabetes Care 38, 1858-1867 (2015)
Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes.
2015 Molecular Cancer Mol. Cancer 14:144 (2015)
Erratum to: Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer.
2015 Wissenschaftlicher Artikel in International Journal of Epidemiology Int. J. Epidemiol. 44, 662-672 (2015)
Mendelian randomization study of height and risk of colorectal cancer.
2015 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 6:7796 (2015)
Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1.
2015 Meeting abstract in Glia Glia 63, E64 (2015)
Identification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming.
2015 Meeting abstract in Glia Glia 63, E105-E106 (2015)
Genetic ablation of proliferating NG2-glia in the adult brain.
2015 Meeting abstract in Glia Glia 63, E297-E298 (2015)
Mitochondrial dysfunction mimics the impact of ageing on hippocampal neurogenesis.
2015 Wissenschaftlicher Artikel in Genome Research Genome Res. 25, 1295-1308 (2015)
Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers.
2015 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 47, 172-179 (2015)
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
2015 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 24, R93-R101 (2015)
Genetics of human metabolism: An update.
2015 Wissenschaftlicher Artikel in Methods Methods 85, 54-61 (2015)
Computational assignment of cell-cycle stage from single-cell transcriptome data.
2015 Wissenschaftlicher Artikel in Plant Science Plant Sci. 238, 115-126 (2015)
Identification of nuclear target proteins for S-nitrosylation in pathogen-treated Arabidopsis thaliana cell cultures.
2015 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 31, 3558-3560 (2015)
Data2Dynamics: A modeling environment tailored to parameter estimation in dynamical systems.
2015 Wissenschaftlicher Artikel in Nature Nature 523, 459-462 (2015)
Directional dominance on stature and cognition in diverse human populations.
2015 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 11:e1005230 (2015)
Discovery and fine-mapping of glycaemic and obesity-related trait loci using high-density imputation.
2015 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 17, 74-88 (2015)
Transcriptional mechanisms of proneural factors and REST in regulating neuronal reprogramming of astrocytes.
2015 Wissenschaftlicher Artikel in Journal of Coupled Systems and Multiscale Dynamics J. Coupled Syst. Multiscale Dyn. 3, 101-121 (2015)
Data-driven modelling of biological multi-scale processes.
2015 Wissenschaftlicher Artikel in Lancet Diabetes and Endocrinology Lancet Diabet. Endocrinol. 3, 526-534 (2015)
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control study.
2015 Wissenschaftlicher Artikel in Diabetic Medicine Diabetic Med. 32, 1479-1483 (2015)
Low serum omentin levels in the elderly population with type 2 diabetes and polyneuropathy.
2015 Wissenschaftlicher Artikel in New Phytologist New Phytol. 208, 860-872 (2015)
Crosstalk between nitric oxide and glutathione is required for NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1)-dependent defense signaling in Arabidopsis thaliana.
2015 Wissenschaftlicher Artikel in Tree Physiology Tree Physiol. 35, 910-920 (2015)
Effects of rhizopheric Nitric Oxide (NO) on N uptake in Fagus sylvatica seedlings depend on soil CO2 concentration, soil N availability and N source.
2015 Sonstiges: Meinungsartikel in Genome Medicine Genome Med. 7:59 (2015)
Brave new epigenomes: The dawn of epigenetic engineering.
2015 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 11:e1005274 (2015)
The human blood metabolome-transcriptome interface.
2015 Wissenschaftlicher Artikel in Molecular Psychiatry Mol. Psychiatry 20, 735-743 (2015)
The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects.
2015 Editorial in Glia Glia 63, 1288-1290 (2015)
Glial stem and progenitor cells shape the brain-in ontogeny, phylogeny, and disease.
2015 Wissenschaftlicher Artikel in Diabetologia Diabetologia 58, 1845-1854 (2015)
Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery.
2015 Wissenschaftlicher Artikel in Atherosclerosis Atherosclerosis 241, 419-426 (2015)
Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.
2015 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 31, i89-i96 (2015)
Reconstructing gene regulatory dynamics from high-dimensional single-cell snapshot data.
2015 Wissenschaftlicher Artikel in Development / Company of Biologists Development 142, 3239-3251 (2015)
Quantification of regenerative potential in primary human mammary epithelial cells.
2015 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 6:7208 (2015)
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.
2015 Wissenschaftlicher Artikel in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 192, 727-736 (2015)
Identification of immune-relevant factors conferring sarcoidosis genetic risk.
2015 Wissenschaftlicher Artikel in Hypertension Hypertension 66, 422-429 (2015)
Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate.
2015 Wissenschaftlicher Artikel in Proteomics Proteomics 15, 3030-3047 (2015)
Iron and FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT)-dependent regulation of proteins and genes in Arabidopsis thaliana roots.
2015 Wissenschaftlicher Artikel in International Journal of Epidemiology Int. J. Epidemiol. 44, 578-586 (2015)
Adiposity as a cause of cardiovascular disease: A Mendelian randomization study.
2015 Wissenschaftlicher Artikel in International Journal of Hygiene and Environmental Health Int. J. Hyg. Environ. Health 218, 535-542 (2015)
Associations between short-term exposure to particulate matter and ultrafine particles and myocardial infarction in Augsburg, Germany.
2015 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 96, 695-708 (2015)
Genome-wide analysis of body proportion classifies height-associated variants by mechanism of action and implicates genes important for skeletal development.
2015 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep. 16, 836-850 (2015)
Atrx promotes heterochromatin formation at retrotransposons.
2015 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 16:60 (2015)
histoneHMM: Differential analysis of histone modifications with broad genomic footprints.
2015 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 16, 712-724 (2015)
Combined single-cell functional and gene expression analysis resolves heterogeneity within stem cell populations.
2015 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 31, 2989-2998 (2015)
Diffusion maps for high-dimensional single-cell analysis of differentiation data.
2015 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 96, 883-893 (2015)
Recessive mutations in the α3 (VI) collagen gene COL6A3 cause early-onset isolated dystonia.
2015 Wissenschaftlicher Artikel in Genetics Genetics 200, 707-718 (2015)
Non-additive effects of genes in human metabolomics.
2015 Wissenschaftlicher Artikel in Science Science 348, 789-793 (2015)
Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain.
2015 Wissenschaftlicher Artikel in Diabetes Aktuell Diabetes akt. 13, 72-74 (2015)
Epigenetische Vererbung - ist die Zukunft diabetisch?
2015 Wissenschaftlicher Artikel in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 334-342 (2015)
DNA methylation of lipid-related genes affects blood lipid levels.
2015 Review in Glia Glia 63, 1452-1468 (2015)
Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and genome-wide expression analysis.
2015 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 47, 589-597 (2015)
The impact of low-frequency and rare variants on lipid levels.
2015 Wissenschaftlicher Artikel in Genome Research Genome Res. 25, 836-844 (2015)
Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo.
2015 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 11:e1005226 (2015)
Burden analysis of rare microdeletions suggests a strong impact of neurodevelopmental genes in genetic generalised epilepsies.
2015 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 135, S111 (2015)
MSX1-induced neural crest-like reprograming promotes melanoma progression.
2015 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 11:e1005165 (2015)
The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease.
2015 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 4, 519-527 (2015)
Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes.
2015 Wissenschaftlicher Artikel in IET Systems Biology IET Syst. Biol. 9, 193-203 (2015)
Identifying latent dynamic components in biological systems.
2015 Meeting abstract in Experimental Dermatology Exp. Dermatol. 24, E15 (2015)
Psoriasis and cardiometabolic risk: independent association but distinct genetic architectures.
2015 Wissenschaftlicher Artikel in Pain Pain 156, 1845-1851 (2015)
An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker.
2015 Wissenschaftlicher Artikel in Human Genome Variation Hum. Genome Var. 2:14028 (2015)
Excess of rare coding variants in PLD3 in late- but not early-onset Alzheimer’s disease.
2015 Wissenschaftlicher Artikel in Molecular Cancer Mol. Cancer 14:94 (2015)
Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer.
2015 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 6:6804 (2015)
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.
2015 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 10:e0123643 (2015)
A critical period for postnatal adaptive plasticity in a model of motor axon miswiring.
2015 Wissenschaftlicher Artikel in Philosophical Transactions of the Royal Society of London. Series B Philos. Trans. R. Soc. B - Biol. Sci. 370, DOI: 10.1098/rstb.2014.0108 (2015)
Opposing effects of allogrooming on disease transmission in ant societies.
2015 Wissenschaftlicher Artikel in European Journal of Epidemiology Eur. J. Epidemiol. 30, 305-315 (2015)
Prevalence of refractive error in Europe: The European Eye Epidemiology (E3) consortium.
2015 Nature Communications Nat. Commun. 6:6542 (2015)
Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
2015 Review in Human Molecular Genetics Hum. Mol. Genet. 24, 3582-3594 (2015)
Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: A systematic review and meta-analysis with evidence from up to 331 175 individuals.
2015 Wissenschaftlicher Artikel in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 136, 802-806 (2015)
A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.ϖ
2015 Wissenschaftlicher Artikel in Journal of Mathematical Biology J. Math. Biol. 72, 87-122 (2015)
A geometric analysis of fast-slow models for stochastic gene expression.
2015 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 10:e0119752 (2015)
Modulation of genetic associations with serum urate levels by body-mass-index in humans.
2015 Sonstiges: Meinungsartikel in Plant Physiology Plant Physiol. 167, 1209-1210 (2015)
Interplay of reactive oxygen species and nitric oxide: Nitric oxide coordinates reactive oxygen species homeostasis.
2015 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 6:5890 (2015)
Biological interpretation of genome-wide association studies using predicted gene functions.
2015 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 24, 1185-1199 (2015)
Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci.
2015 Wissenschaftlicher Artikel in BMC Medicine BMC Med. 13:48 (2015)
Multi-omic signature of body weight change: Results from a population-based cohort study.
2015 Wissenschaftlicher Artikel in Statistics and Computing Stat. Comp. 26, 663-677 (2015)
An adaptive scheduling scheme for calculating Bayes factors with thermodynamic integration using Simpson’s rule.
2015 Wissenschaftlicher Artikel in Diabetologia Diabetologia 58, 1118-1128 (2015)
Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: The KORA S4 survey.
2015 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 18, 490-492 (2015)
Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone.
2015 Wissenschaftlicher Artikel in Lancet, The Lancet 385, 351-361 (2015)
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: Evidence from genetic analysis and randomised trials.
2015 Wissenschaftlicher Artikel in Circulation Circulation 131, 1191-1201 (2015)
ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling via cleavage of thrombospondin-1.
2015 Wissenschaftlicher Artikel in Diabetes Diabetes 64, 1841-1852 (2015)
Age- and sex-specific causal effects of adiposity on cardiovascular risk factors.
2015 Editorial in BioSpektrum BioSpektrum 21, 20-21 (2015)
Vererbung von Merkmalen außerhalb der primären Sequenz der DNA.
2015 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 11:e1004876 (2015)
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
2015 Wissenschaftlicher Artikel in Nature Nature 518, 197-206 (2015)
Genetic studies of body mass index yield new insights for obesity biology.
2015 Wissenschaftlicher Artikel in Nature Nature 518, 187-196 (2015)
New genetic loci link adipose and insulin biology to body fat distribution.
2015 Wissenschaftlicher Artikel in Neuron Neuron 85, 710-717 (2015)
A critical period for experience-dependent remodeling of adult-born neuron connectivity.
2015 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol. 33, 269-276 (2015)
Decoding the regulatory network of early blood development from single-cell gene expression measurements.
2015 Wissenschaftlicher Artikel in Signal Processing Signal Process. 113, 95-103 (2015)
Model selection using limiting distributions of second-order blind source separation algorithms.
2015 Wissenschaftlicher Artikel in European Journal of Human Genetics Eur. J. Hum. Genet. 23, 1328-1333 (2015)
Rare variants in β-Amyloid Precursor Protein (APP) and Parkinson's disease.
2015 Wissenschaftlicher Artikel in International Journal of Surgery Int. J. Surg. 14, 67-74 (2015)
Metabolism gene signatures and surgical site infections in abdominal surgery.
2015 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol. 33, 155-160 (2015)
Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells.
2015 Wissenschaftlicher Artikel in Journal of Investigative Dermatology, The J. Invest. Dermatol. 135, 1283-1293 (2015)
Psoriasis and cardiometabolic traits: Modest association but distinct genetic architectures.
2015 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 10, 131-139 (2015)
Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation.
2015 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 96, 104-120 (2015)
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
2015 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 10:e1004854 (2015)
Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in the regulation of circulating serum chemerin.
In: Walter, J.* ; Meissner, A.* [Eds.]: Epigenetics and Human Health. Heidelberg: Springer, 2015. 43-68 ( ; 4)
Histone variants and reprogramming in early development.
2015 Wissenschaftlicher Artikel in Journal of Proteome Research J. Proteome Res. 14, 1183-1194 (2015)
Network-based approach for analyzing intra- and interfluid metabolite associations in human blood, urine, and saliva.
2015 Wissenschaftlicher Artikel in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 159-167 (2015)
Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis.
2015 Wissenschaftlicher Artikel in Journal of Experimental Botany J. Exp. Bot. 66, 989-999 (2015)
Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration.
2015 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 47, 78-83 (2015)
Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection.
2015 Wissenschaftlicher Artikel in Cell and Tissue Research Cell Tissue Res. 359, 5-16 (2015)
How to make neurons-thoughts on the molecular logic of neurogenesis in the central nervous system.
2015 Wissenschaftlicher Artikel in Stem Cells Stem Cells 33, 170-182 (2015)
Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells.
2015 Wissenschaftlicher Artikel in Human Genetics Hum. Genet. 134, 131-146 (2015)
Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: The CREAM consortium.
2015 Wissenschaftlicher Artikel in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 35, 229-236 (2015)
Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease.
2015 Wissenschaftlicher Artikel in Diabetologia Diabetologia 58, 374-383 (2015)
Nutritional strategy to prevent fatty liver and insulin resistance independent from obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice.
2015 Wissenschaftlicher Artikel in Mammalian Genome Mamm. Genome 26, 33-42 (2015)
Generation of mice lacking DUF1220 protein domains: Effects on fecundity and hyperactivity.
2015 Wissenschaftlicher Artikel in Molecular Psychiatry Mol. Psychiatry 20, 647-656 (2015)
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
2015 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 31, 128-130 (2015)
RAMONA: A web application for gene set analysis on multilevel omics data.
2015 Wissenschaftlicher Artikel in Diabetes Diabetes 64, 284-290 (2015)
Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice.
2015 Wissenschaftlicher Artikel in Neuropsychopharmacology Neuropsychopharmacology 40, 338-349 (2015)
Differential and converging molecular mechanisms of antidepressants' action in the hippocampal dentate gyrus.
2015 Wissenschaftlicher Artikel in Virchows Archiv Virchows Arch. 466, 503-515 (2015)
Aurora B expression and histone variant H1.4S27 phosphorylation are no longer coordinated during metaphase in aneuploid colorectal carcinomas.
2014 Wissenschaftlicher Artikel in Science Science 343, 1145-1148 (2014)
Mapping the epigenetic basis of complex traits.
2014 Wissenschaftlicher Artikel in Methods in Molecular Biology Methods Mol. Biol. 1112, 125-149 (2014)
Genome-wide analysis of DNA methylation in Arabidopsis using MeDIP-chip.
2014 Wissenschaftlicher Artikel in IFAC-PapersOnLine IFAC PapersOnline 19, 1729-1735 (2014)
Modeling of stochastic biological processes with non-polynomial propensities using non-central conditional moment equation.
2014 Meeting abstract in Molecular Biology of the Cell Mol. Biol. Cell 25:P537 (2014)
Morphodynamic analysis of T lymphocyte migration in confined microenvironments.
2014 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 23, 6944-6960 (2014)
Trans-ethnic meta-analysis of white blood cell phenotypes.
2014 Wissenschaftlicher Artikel in Annual Review of Cell and Developmental Biology Annu. Rev. Cell Dev. Biol. 30, 465-502 (2014)
The cell biology of neurogenesis: Toward an understanding of the development and evolution of the neocortex.
2014 Meeting abstract in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 122:OP4_11 (2014)
FGF21 inhibits adiponectin secretion in human adipocytes.
2014 Meeting abstract in British Journal of Dermatology - BJD Br. J. Dermatol. 171, E135 (2014)
Intraindividual genome expression analysis reveals opposing immune reaction in psoriasis and eczema.
2014 Meeting abstract in Diabetologia Diabetologia 57, S67-S68 (2014)
Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in regulation of circulating serum chemerin.
2014 Meeting abstract in Diabetologia Diabetologia 57, S66 (2014)
FOXA2 bound sites are enriched for type 2 diabetes risk variants.
2014 Meeting abstract in Diabetologia Diabetologia 57, S50-S51 (2014)
Fine-mapping type 2 diabetes susceptibility loci with high-density imputation.
2014 Wissenschaftlicher Artikel in eLife eLife 3:e01632 (2014)
Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription.
2014 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 4:6674 (2014)
Methylation of histone H4 at aspartate 24 by protein L-isoaspartate O-methyltransferase (PCMT1) links histone modifications with protein homeostasis.
2014 Wissenschaftlicher Artikel in Trends in Cell Biology Trends Cell Biol. 24, 712-723 (2014)
Epigenetics reloaded: The single-cell revolution.
2014 Wissenschaftlicher Artikel in Cell and Tissue Research Cell Tissue Res. 356, 457-466 (2014)
Histone variants: Key players of chromatin.
2014 Wissenschaftlicher Artikel in Nature Reviews - Molecular Cell Biology Nat. Rev. Mol. Cell Biol. 15, 723-734 (2014)
Chromatin dynamics in the regulation of cell fate allocation during early embryogenesis.
2014 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 56, 580-594 (2014)
Redundant mechanisms to form silent chromatin at pericentromeric regions rely on BEND3 and DNA methylation.
2014 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 28, 1381-1383 (2014)
LINEing germ and embryonic stem cells' silencing of retrotransposons.
2014 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 28, 1042-1047 (2014)
Higher chromatin mobility supports totipotency and precedes pluripotency in vivo.
2014 Wissenschaftlicher Artikel in Development / Company of Biologists Development 141, 2173-2181 (2014)
Transcription factor heterogeneity in pluripotent stem cells: A stochastic advantage.
2014 Wissenschaftlicher Artikel in Genome Research Genome Res. 24, 942-953 (2014)
Natural variation of histone modification and its impact on gene expression in the rat genome.
2014 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 8859, 61-72 (2014)
Uncertainty analysis for non-identifiable dynamical systems: Profile likelihoods, bootstrapping and more.
2014 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 8859, 73-85 (2014)
Radial basis function approximations of Bayesian parameter posterior densities for uncertainty analysis.
2014 Wissenschaftlicher Artikel in Clinical Endocrinology Clin. Endocrinol. 81, 702-710 (2014)
Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: A systematic meta-analysis.
2014 Wissenschaftlicher Artikel in Stem Cell Reports Stem Cell Rep. 3, 1000-1014 (2014)
Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex.
2014 Diabetologia Diabetologia 58, 206 (2014)
Erratum to: Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes.
2014 Wissenschaftlicher Artikel in Aging Aging 6, 856-878 (2014)
Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts.
2014 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 9:e113125 (2014)
Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: Renal transcriptome studies in mouse models of uromodulin-associated kidney disease.
2014 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 9, 1292-1305 (2014)
Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.
2014 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 8649, 15-29 (2014)
Centroid clustering of cellular lineage trees.
2014 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 5:4926 (2014)
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
2014 Wissenschaftlicher Artikel in International Journal of Cancer Int. J. Cancer 136, 2293-2303 (2014)
MiR-34a deficiency accelerates medulloblastoma formation in vivo.
2014 Wissenschaftlicher Artikel in European Journal of Human Genetics Eur. J. Hum. Genet. 22, 1217-1224 (2014)
Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R.
2014 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 9:e110232 (2014)
Computational prediction of candidate proteins for S-nitrosylation in Arabidopsis thaliana.
In: Gillli, M.* ; Gonzalez-Rodriguez, G.* ; Nieto-Reyes, A.* [Eds.]: Proccedings (21st International Conference on Computational Statistics (COMPSTAT2014), 19-22 August 2014, Geneva, Switzerland). 2014. 625-632
Bayesian blind source separation applied to the lymphocyte pathway.
2014 Wissenschaftlicher Artikel in Separation – Science & Applications Sep. Sci. Appl. 34, 24-26 (2014)
Single-cell analysis: Biology at high resolution.
2014 Wissenschaftlicher Artikel in GIT : Labor-Fachzeitschrift GIT Fachz. Lab. 9, 28-30 (2014)
Einzelzellanalysen: Biologie in Hochauflösung.
2014 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 10:e100451 (2014)
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.
2014 Meeting abstract in Journal of Human Hypertension J. Hum. Hypertens. 28, 638 (2014)
Circulating levels of a dicarboxylic acid associate with blood pressure, predict mortality and response to antihypertensive drugs. A multi-omics study.
2014 Wissenschaftlicher Artikel in Journal of Computational Biology J. Comput. Biol. 21, 855-865 (2014)
Bayesian blind source separation for data with network structure.
2014 Wissenschaftlicher Artikel in Journal of Clinical Periodontology J. Clin. Periodontol. 41, 1115-1121 (2014)
Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men.
2014 Wissenschaftlicher Artikel in Lancet Neurology, The Lancet Neurol. 13, 893-903 (2014)
Genetic determinants of common epilepsies: A meta-analysis of genome-wide association studies.
2014 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 46, 1173-1186 (2014)
Defining the role of common variation in the genomic and biological architecture of adult human height.
2014 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 10:e1003843 (2014)
Fast synchronization of ultradian oscillators controlled by Delta-Notch signaling with Cis-inhibition.
2014 Wissenschaftlicher Artikel in Journal of Investigative Dermatology, The J. Invest. Dermatol. 135, 369-377 (2014)
miR-23a-3p causes cellular senescence by targeting hyaluronan synthase2: Possible implication for skin aging.
2014 Meeting abstract in Allergy Allergy 69, 365 (2014)
In utero cigarette smoke exposure affects foetal pulmonary signalling networks in a murine model.
2014 Wissenschaftlicher Artikel in Molecular Genetics and Metabolism Mol. Genet. Metab. 112, 317-338 (2014)
Pleiotropic genes for metabolic syndrome and inflammation.
2014 Meeting abstract in Allergy Allergy 69, 40-41 (2014)
MicroRNA-based identification of epithelial SEC14L3 loss in experimental and human paediatric asthma.
2014 Wissenschaftlicher Artikel in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 7, 864-872 (2014)
Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.
2014 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 9:e107110 (2014)
Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci.
2014 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 9:e106886 (2014)
S-nitroso-proteome in poplar leaves in response to acute ozone stress.
2014 Wissenschaftlicher Artikel in Diabetologia Diabetologia 57, 2521-2529 (2014)
Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes.
2014 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 111, 13127-13132 (2014)
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.
2014 Wissenschaftlicher Artikel in Frontiers in Cellular Neuroscience Front. Cell. Neurosci. 8:215 (2014)
The role of α-E-catenin in cerebral cortex development: Radial glia specific effect on neuronal migration.
2014 Wissenschaftlicher Artikel in Database: The Journal of Biological Databases and Curation Database 2014:bau083 (2014)
Mouse IDGenes: A reference database for genetic interactions in the developing mouse brain.
2014 Wissenschaftlicher Artikel in Movement Disorders Mov. Disord. 29, 1504-1510 (2014)
DYT16 revisited: Exome sequencing identifies PRKRA mutations in a European dystonia family.
2014 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 23, 4738-4744 (2014)
Multi-ethnic fine-mapping of 14 central adiposity loci.
2014 Wissenschaftlicher Artikel in American Journal of Physiology - Lung Cellular and Molecular Physiology Am. J. Physiol. Lung Cell Mol. Physiol. 307, L692-L706 (2014)
Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD.
2014 Wissenschaftlicher Artikel in Nature Protocols Nat. Protoc. 9, 1192-1212 (2014)
Quality control and conduct of genome-wide association meta-analyses.
2014 Meeting abstract in Experimental Hematology Exp. Hematol. 42, S52 (2014)
Decoding the transcriptional program for blood development from whole tissue single-cell gene expression measurements.
2014 Meeting abstract in Experimental Hematology Exp. Hematol. 42, S57 (2014)
Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells.
2014 Wissenschaftlicher Artikel in Nature Nature 514, 92-97 (2014)
Parent-of-origin specific allelic associations among 106 genomic1 loci for age at menarche.
2014 Wissenschaftlicher Artikel in Journal of Neuroscience J. Neurosci. 34, 10659-10674 (2014)
Hypothalamic miR-103 protects from hyperphagic obesity in mice.
2014 Wissenschaftlicher Artikel in European Journal of Epidemiology Eur. J. Epidemiol. 29, 629-638 (2014)
Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants.
2014 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 10, 1-12:e1004508 (2014)
Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on Body Mass Index.
2014 Editorial in Developmental Cell Dev. Cell 30, 114-115 (2014)
A time and place for understanding neural stem cell specification.
2014 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 15:232 (2014)
On the potential of models for location and scale for genome-wide DNA methylation data.
2014 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 46, 731-735 (2014)
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
2014 Meeting abstract in British Journal of Dermatology - BJD Br. J. Dermatol. 170, E19 (2014)
Eczema ≠ eczema: The transcriptional heterogeneity of eczema.
2014 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 9:e101814 (2014)
Allergic contact dermatitis in psoriasis patients: Typical, delayed, and non-interacting.
2014 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 95, 49-65 (2014)
Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.
2014 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 9:e102113 (2014)
A systematic evaluation of short tandem repeats in lipid candidate genes: Riding on the SNP-wave.
2014 Wissenschaftlicher Artikel in American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics Am. J. Med. Genet. B 165, 283-293 (2014)
Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity.
2014 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 15:240 (2014)
MCA: Multiresolution Correlation Analysis, a graphical tool for subpopulation identification in single-cell gene expression data.
2014 Wissenschaftlicher Artikel in Science Translational Medicine Sci. Transl. Med. 6:244ra90 (2014)
Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema.
2014 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 134, S1 (2014)
Intra-individual genome expression analysis reveals a specific molecular signature of psoriasis and eczema.
2014 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 95, 85-95 (2014)
Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome.
2014 Review in Physiological Reviews Physiol. Rev. 94, 709-737 (2014)
Glial cells as progenitors and stem cells: New roles in the healthy and diseased brain.
2014 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 10:e1003686 (2014)
ODE constrained mixture modelling: A method for unraveling subpopulation structures and dynamics.
2014 Wissenschaftlicher Artikel in Diabetes Diabetes 63, 4343-4359 (2014)
Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits.
2014 Wissenschaftlicher Artikel in BMC Genomics BMC Genomics 15:487 (2014)
Relationship between genome and epigenome - challenges and requirements for future research.
2014 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 46, 826-836 (2014)
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
2014 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 95, 24-38 (2014)
Gene-age interactions in blood pressure regulation: A large-scale investigation with the CHARGE, Global BPgen, and ICBP consortia.
2014 Wissenschaftlicher Artikel in Stem Cell Reports Stem Cell Rep. 3, 34-43 (2014)
Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells.
2014 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 23, 6069-6080 (2014)
16p11.2 600 kb duplications confer risk for typical and atypical Rolandic epilepsy.
2014 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 46, 669-677 (2014)
Genome-wide association analysis identifies six new loci associated with forced vital capacity.
2014 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 23, 5847-5857 (2014)
Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses.
2014 Wissenschaftlicher Artikel in Journal of Proteomics J. Proteomics 109, 417-435 (2014)
Large-scale protein analysis of European beech trees following four vegetation periods of twice ambient ozone exposure.
2014 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 23, 5597-5614 (2014)
Peroxidasin is essential for eye development in the mouse.
2014 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 9:e98092 (2014)
Blood cis-eQTL analysis fails to identify novel association signals among sub-threshold candidates from genome-wide association studies in restless legs syndrome.
2014 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 94, 710-720 (2014)
Simulation of finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland.
2014 Wissenschaftlicher Artikel in Methods in Molecular Biology Methods Mol. Biol. 1160, 165-188 (2014)
Posttranscriptional regulatory networks: From expression profiling to integrative analysis of mRNA and microRNA data.
2014 Wissenschaftlicher Artikel in Journal of Immunology J. Immunol. 192, 3507-3517 (2014)
Differential kinetics of antigen dependency of CD4+ and CD8+ T cells.
2014 Wissenschaftlicher Artikel in European Journal of Epidemiology Eur. J. Epidemiol. 29, 325-336 (2014)
Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism.
2014 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 46, 543-550 (2014)
An atlas of genetic influences on human blood metabolites.
2014 Meeting abstract in Experimental Dermatology Exp. Dermatol. 23, E21 (2014)
Genome-wide comparative analysis of atopic eczema and psoriasis gives insight into disease mechanisms.
2014 Meeting abstract in Experimental Dermatology Exp. Dermatol. 23, E20 (2014)
Intra-individual genome expression analysis reveals a specific molecular signature of psoriasis and eczema.
2014 Wissenschaftlicher Artikel in Journal of Clinical Periodontology J. Clin. Periodontol. 41, 531-540 (2014)
SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis.
2014 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 9:e94882 (2014)
Mitochondrial DNA variants in obesity.
2014 Wissenschaftlicher Artikel in PLoS Pathogens PLoS Pathog. 10:e1004084 (2014)
JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants.
2014 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 9:e93844 (2014)
Mapping the genetic architecture of gene regulation in whole blood.
2014 Wissenschaftlicher Artikel in Journal of Investigative Dermatology, The J. Invest. Dermatol. 134, 1873-1883 (2014)
An integrated epigenetic and transcriptomic analysis reveals distinct tissue-specific patterns of DNA methylation associated with atopic dermatitis.
2014 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 94, 437-452 (2014)
An excess of risk-increasing low-frequency variants can be a signal of polygenic inheritance in complex diseases.
2014 Wissenschaftlicher Artikel in Genome Medicine Genome Med. 6:25 (2014)
Interrogating causal pathways linking genetic variants, small molecule metabolites and circulating lipids.
2014 Wissenschaftlicher Artikel in Journal of Endocrinological Investigation J. Endocrinol. Invest. 37, 369-374 (2014)
Increased amino acids levels and the risk of developing hypertriglyceridemia in a 7-year follow-up.
2014 Wissenschaftlicher Artikel in Molecular Biotechnology : MB Online Mol. Biotechnol. 56, 697-713 (2014)
Simple derivation of transgene-free iPS cells by a dual recombinase approach.
2014 Review in Current Opinion in Neurobiology Curr. Opin. Neurobiol. 27C, 39-46 (2014)
Role of radial glial cells in cerebral cortex folding.
2014 Sonstiges: Meinungsartikel in Molecular Metabolism Mol. Metab. 3, 92-93 (2014)
Mix 'n' match estrogens.
2014 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 30, 1867-1875 (2014)
Probabilistic PCA of censored data: Accounting for uncertainties in the visualisation of high-throughput single-cell qPCR data.
2014 Wissenschaftlicher Artikel in European Journal of Human Genetics Eur. J. Hum. Genet. 22, 317-321 (2014)
Data sharing in large research consortia: Experiences and recommendations from ENGAGE.
2014 Wissenschaftlicher Artikel in Journal of Integrated OMICS J. Integr. OMICS, DOI: 10.5584/jiomics.v4i1.157 (2014)
Subtoxic concentrations of benzo[a]pyrene induce metabolic changes and oxidative stress in non-activated and affect the mTOR pathway in activated Jurkat T cells.
2014 Wissenschaftlicher Artikel in Lancet, The Lancet 383, 1990-1998 (2014)
DNA methylation and body-mass index: A genome-wide analysis.
2014 Wissenschaftlicher Artikel in Genome Research Genome Res. 24, 592-603 (2014)
Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.
2014 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 46, 234-244 (2014)
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
2014 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 10:e1004123 (2014)
Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
2014 Wissenschaftlicher Artikel in Hypertension Hypertension 63, 1102-1109 (2014)
Diastrophic dysplasia sulfate transporter (SLC26A2) is expressed in the adrenal cortex and regulates aldosterone secretion.
2014 Wissenschaftlicher Artikel in Catalysis Letters Catal. Lett. 10, 1005-1017 (2014)
Long term conservation of human metabolic phenotypes and link to heritability.
2014 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 94, 349-360 (2014)
Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.
2014 Wissenschaftlicher Artikel in Stem Cell Reports Stem Cell Rep. 2, 153-162 (2014)
In vivo targeting of adult neural stem cells in the dentate gyrus by a split-cre approach.
2014 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 289, 10769-10784 (2014)
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
2014 Wissenschaftlicher Artikel in Development / Company of Biologists Development 141, 514-525 (2014)
miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm.
2014 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 111, E626-E635 (2014)
Parameterizing cell-to-cell regulatory heterogeneities via stochastic transcriptional profiles.
2014 Review in Cell Cell 156, 343-358 (2014)
Leveraging cross-species transcription factor binding site patterns: From diabetes risk loci to disease mechanisms.
2014 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 23, 2490-2497 (2014)
DNA mismatch repair gene MSH6 implicated in determining age at natural menopause.
2014 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 23, 2498-2510 (2014)
Gene-centric meta-analyses for central adiposity traits in up to 57412 individuals of European descent confirm known loci and reveal several novel associations.
2014 Wissenschaftlicher Artikel in Diabetes Diabetes 63, 1154-1165 (2014)
Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity.
2014 Wissenschaftlicher Artikel in European Respiratory Journal Eur. Respir. J. 43, 983-992 (2014)
Telomere length in circulating leukocytes is associated with lung function and disease.
2014 Wissenschaftlicher Artikel in Journal of Hepatology J. Hepatol. 60, 816-823 (2014)
Liver adapts mitochondrial function to insulin resistant and diabetic states in mice.
2014 Wissenschaftlicher Artikel in Neurogenetics Neurogenetics 15, 49-57 (2014)
Rare variants in LRRK1 and Parkinson's disease.
2014 Wissenschaftlicher Artikel in Acta Diabetologica Acta Diabetol. 51, 403-411 (2014)
A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion.
2014 Wissenschaftlicher Artikel in Movement Disorders Mov. Disord. 29, 143-147 (2014)
Rare sequence variants in ANO3 and GNAL in a primary torsion dystonia series and controls.
2014 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 23, 239-246 (2014)
Genome-wide association study identifies three novel loci for type 2 diabetes.
2014 Wissenschaftlicher Artikel in Catalysis Letters Catal. Lett. 10, 386-401 (2014)
Comparative analysis of plasma metabolomics response to metabolic challenge tests in healthy subjects and influence of the FTO obesity risk allele.
2014 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 23, 534-545 (2014)
Epigenetics meets metabolomics: An epigenome-wide association study with blood serum metabolic traits.
2014 Wissenschaftlicher Artikel in Journal of Mathematical Biology J. Math. Biol. 69, 687-735 (2014)
Method of conditional moments (MCM) for the chemical master equation: A unified framework for the method of moments and hybrid stochastic-deterministic models.
2014 Wissenschaftlicher Artikel in Metabolomics Metabolomics 10, 141-151 (2014)
Metabolite profiling reveals new insights into the regulation of serum urate in humans.
2014 Wissenschaftlicher Artikel in Catalysis Letters Catal. Lett. 10, 152-164 (2014)
Associations between thyroid hormones and serum metabolite profiles in an euthyroid population.
2013 Wissenschaftlicher Artikel in Methods in Molecular Biology Methods Mol. Biol. 1067, 203-224 (2013)
Evaluation of MeDIP-chip in the context of whole-genome bisulfite sequencing (WGBS-seq) in Arabidopsis.
2013 Wissenschaftlicher Artikel in eLife eLife 2:e01749 (2013)
Multiple knockout mouse models reveal lincRNAs are required for life and brain development.
2013 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 27, 2427-2432 (2013)
Heterochromatin establishment at pericentromeres depends on nuclear position.
2013 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 5, 687-701 (2013)
Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.
2013 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 45, 1418-1427 (2013)
Evaluating empirical bounds on complex disease genetic architecture.
2013 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 29, 2419-2426 (2013)
Assessing association between protein truncating variants and quantitative traits.
2013 Wissenschaftlicher Artikel in Genetic Epidemiology Genet. Epidemiol. 37, 539-550 (2013)
Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants.
2013 Meeting abstract in Human Heredity Hum. Hered. 76, 94-95 (2013)
Genome-wide environmental sensitivity analysis of human metabolomics data.
2013 Meeting abstract in Human Heredity Hum. Hered. 76, 94 (2013)
Genome-wide scan of metabolomics data using non-additive intra-locus models.
2013 Meeting abstract in Pancreas Pancreas 42, 1360-1361 (2013)
Identification and characterization of an Aldh1a3-positive subtype of pancreatic ductal adenocarcinoma mediated by oncogenic Krasg12d/Erk-Mtor axis.
2013 Meeting abstract in Pancreas Pancreas 42, 1360 (2013)
Pancreatic progenitor expansion, mesenchymal cell proliferation and inflammation are required during early carcinogenesis.
2013 Editorial in EURASIP Journal on Advances in Signal Processing EURASIP J. Adv. Signal Process. 2013:185 (2013)
Dependent component analysis.
2013 Meeting abstract in Diabetologia Diabetologia 56, S267 (2013)
High glycaemic index (GI) diet induced hepatic fat accumulation and insulin resistance is associated with high glucose-dependent insulinotropic polypeptide (GIP) secretion.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e82879 (2013)
Niemann-pick C disease gene mutations and age-related neurodegenerative disorders.
2013 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 14:S2 (2013)
iVUN: Interactive Visualization of Uncertain biochemical reaction Networks.
2013 Wissenschaftlicher Artikel in Cell Cell 152, 859-872 (2013)
Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer.
2013 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 3, 2142-2154 (2013)
The genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells.
2013 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 20, 657-661 (2013)
Scratching the (lateral) surface of chromatin regulation by histone modifications.
2013 Wissenschaftlicher Artikel in Briefings in Functional Genomics Brief. Funct. Genomic. Proteomic. 12, 231-243 (2013)
Cancers with wrong HATs: The impact of acetylation.
2013 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 110, E2191-E2198 (2013)
Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions.
2013 Wissenschaftlicher Artikel in Current Opinion in Cell Biology Curr. Opin. Cell Biol. 25, 184-189 (2013)
Targeting histone modifications - epigenetics in cancer.
2013 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 4:2233 (2013)
Dissecting the role of H3K64me3 in mouse pericentromeric heterochromatin.
2013 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 20, 1321-1324 (2013)
Live visualization of chromatin dynamics with fluorescent TALEs.
2013 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 27, 1635-1639 (2013)
How mammals pack their sperm: A variant matter.
2013 Wissenschaftlicher Artikel in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 23, 512-518 (2013)
Towards an understanding of the regulatory mechanisms of totipotency.
2013 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 20, 332-338 (2013)
Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 by RNA.
2013 Wissenschaftlicher Artikel in Development / Company of Biologists Development 140, 487-491 (2013)
A germline-centric view of cell fate commitment, reprogramming and immortality.
2013 Wissenschaftlicher Artikel in Current Topics in Developmental Biology Curr. Top. Dev. Biol. 104, 1-45 (2013)
Mechanisms and dynamics of heterochromatin formation during mammalian development: closed paths and open questions.
2013 Wissenschaftlicher Artikel in Genome Research Genome Res. 23, 1130-1141 (2013)
Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci.
2013 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 9:e1003919 (2013)
Mining the human phenome using allelic scores that index biological intermediates.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e60454 (2013)
Genetic variants from lipid-related pathways and risk for incident myocardial infarction.
2013 Wissenschaftlicher Artikel in Cell Metabolism Cell Metab. 18, 844-859 (2013)
Inflammation-induced alteration of astrocyte mitochondrial dynamics requires autophagy for mitochondrial network maintenance.
In: Sarwat, M.* ; Ahmad, A.* ; Abdin, M.Z.* [Eds.]: Stress Signaling in Plants: Genomics and Proteomics Perspective, Volume 1. New York: Springer, 2013. 123-148
Regulation and function of protein S-nitrosylation in plant stress.
2013 Wissenschaftlicher Artikel in BMC Genomics BMC Genomics 14:865 (2013)
Automated wokflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles.
2013 Wissenschaftlicher Artikel in International Journal of Developmental Biology Int. J. Dev. Biol. 57, 741-751 (2013)
Pitx3 directly regulates Foxe3 during early lens development.
2013 Wissenschaftlicher Artikel in Diabetes Diabetes 63, 2158-2171 (2013)
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.
2013 Wissenschaftlicher Artikel in Development / Company of Biologists Development 141, 28-38 (2013)
Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglomerular fate specification in the adult olfactory bulb.
2013 Meeting abstract in Allergy Allergy 68, 233-233 (2013)
SEC14L3 is de-regulated in murine experimental asthma via miRNA-mediated down-regulation of CREB.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e81833 (2013)
Prdm6 is essential for cardiovascular development in vivo.
2013 Wissenschaftlicher Artikel in Diabetes Diabetes 62, 4270-4276 (2013)
Biomarkers for type 2 diabetes and impaired fasting glucose using a non-targeted metabolomics approach.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e79145 (2013)
Rare variants in PLXNA4 and Parkinson's disease.
2013 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 45, 1353-1360 (2013)
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
2013 Review in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 4:e201301009 (2013)
Statistical methods for the analysis of high-throughput metabolomics data.
2013 Wissenschaftlicher Artikel in FASEB Journal FASEB J. 27, 4476-4488 (2013)
A de novo-designed antimicrobial peptide with activity against multiresistant Staphylococcus aureus acting on RsbW kinase.
2013 Review in Frontiers in Plant Science Front. Plant Sci. 4:137 (2013)
Nitric oxide-based protein modification: Formation and site-specificity of protein S-nitrosylation.
2013 Wissenschaftlicher Artikel in Frontiers in Plant Science Front. Plant Sci. 4:293 (2013)
Effect of nitric oxide on gene transcription - S-nitrosylation of nuclear proteins.
2013 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 4:2049 (2013)
α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors.
In: Autio, R.* ; Shmulevich, I.* ; Strimmer, K.* ; Wiuf, C.* ; Sarbu, S.* ; Yli-Harja, O.* [Eds.]: Proceedings of the WCSB 2013 (10th International Workshop on Computational Systems Biology, 10 - 12 June 2013, Tampere, Finland). Tampere: Tampere International Center for Signal Processing, 2013. 66-73 (TICSP Series ; 63)
Parameter estimation for stochastic biochemical processes: A comparison of moment equation and fintie state projection.
2013 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 41, 9622-9633 (2013)
A modular framework for gene set analysis integrating multilevel omics data.
2013 Wissenschaftlicher Artikel in Translational Psychiatry Transl. Psychiatry 3:e308 (2013)
A common biological basis of obesity and nicotine addiction.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e65804 (2013)
Genetic loci for retinal arteriolar microcirculation.
2013 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 22, 3597-3607 (2013)
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
2013 Wissenschaftlicher Artikel in Diabetologia Diabetologia 56, 1306-1316 (2013)
Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.
2013 Wissenschaftlicher Artikel in International Journal of Epidemiology Int. J. Epidemiol. 42, 1111-1119 (2013)
Metabolomic markers reveal novel pathways of ageing and early development in human populations.
2013 Wissenschaftlicher Artikel in Diabetologia Diabetologia 56, 1291-1305 (2013)
Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.
2013 Wissenschaftlicher Artikel in Diabetes Diabetes 62, 2141-2150 (2013)
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
2013 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 45, 1274-1283 (2013)
Discovery and refinement of loci associated with lipid levels.
2013 Wissenschaftlicher Artikel in Diabetes Diabetes 62, 1746-1755 (2013)
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e62378 (2013)
Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations.
2013 Wissenschaftlicher Artikel in Nutrition, Metabolism and Cardiovascular Diseases Nutr. Metab. Cardiovasc. Dis. 23, 1043-1049 (2013)
The SH2B1 obesity locus and abnormal glucose homeostasis: Lack of evidence for association from a meta-analysis in individuals of European ancestry.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e78337 (2013)
Standardized, systemic phenotypic analysis of UmodC93F and UmodA227T mutant mice.
2013 Wissenschaftlicher Artikel in American Journal of Physiology - Cell Physiology Am. J. Physiol.-Cell Physiol. 305, C877-C886 (2013)
Cytokine response of primary human myotubes in an in vitro exercise model.
2013 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 14:297 (2013)
An automatic method for robust and fast cell detection in bright field images from high-throughput microscopy.
2013 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 45, 1345-1352 (2013)
Common variants associated with plasma triglycerides and risk for coronary artery disease.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e74335 (2013)
Lessons learned from quantitative dynamical modeling in systems biology.
2013 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 9:e1003796 (2013)
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.
2013 Wissenschaftlicher Artikel in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 132, 1121-1129 (2013)
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.
2013 Meeting abstract in European Respiratory Journal Eur. Respir. J. 42 (2013)
Telomere length in circulating leukocytes is associated with lung function and disease.
2013 Meeting abstract in European Respiratory Journal Eur. Respir. J. 42 (2013)
miRNA-based identification of SEC14L3 deregulation in murine experimental asthma.
2013 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 14:S7 (2013)
Modeling of 2D diffusion processes based on microscopy data: Parameter estimation and practical identifiability analysis.
2013 Wissenschaftlicher Artikel in Circulation Circulation 128, 1310-1324 (2013)
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
2013 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 45, 1300-1308 (2013)
Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development.
2013 Wissenschaftlicher Artikel in Pain Pain 154, 2216-2226 (2013)
Wound-healing growth factor, basic FGF, induces Erk1/2-dependent mechanical hyperalgesia.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e71687 (2013)
De-novo design of antimicrobial peptides for plant protection.
2013 Wissenschaftlicher Artikel in Biochimica et Biophysica Acta - Proteins and Proteomics Biochim. Biophys. Acta-Proteins Proteom. 1844, 1011-1017 (2013)
Secretome profiling of primary human skeletal muscle cells.
2013 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 16, 1370-1372 (2013)
Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain.
2013 Wissenschaftlicher Artikel in American Journal of Epidemiology Am. J. Epidemiol. 178, 451-460 (2013)
Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.
2013 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 2, 435-446 (2013)
Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis.
2013 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 13, 403-418 (2013)
The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network.
2013 Wissenschaftlicher Artikel in RNA Biology RNA Biol. 10, 1125-1135 (2013)
The human transcriptome is enriched for miRNA-binding sites located in cooperativity-permitting distance.
2013 Wissenschaftlicher Artikel in BMC Systems Biology BMC Syst. Biol. 7:48 (2013)
Sharpening of expression domains induced by transcription and microRNA regulation within a spatio-temporal model of mid-hindbrain boundary formation.
2013 Wissenschaftlicher Artikel in PLoS Medicine PLoS Med. 10:e1001474 (2013)
The role of adiposity in cardiometabolic traits: A mendelian randomization analysis.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e64762 (2013)
Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: Findings from 3,000 participants in the population-based KORA F4 study.
2013 Wissenschaftlicher Artikel in Hepatology Hepatology 58, 1074-1083 (2013)
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
2013 Wissenschaftlicher Artikel in Mathematical Biosciences Math. Biosci. 246, 293-304 (2013)
High-dimensional Bayesian parameter estimation: Case study for a model of JAK2/STAT5 signaling.
2013 Wissenschaftlicher Artikel in Journal of Clinical Investigation J. Clin. Invest. 123, 3272-3291 (2013)
Rapamycin extends murine lifespan but has limited effects on aging.
2013 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 4:2125 (2013)
Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type.
2013 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 9:e1003500 (2013)
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
2013 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 22, 2754-2764 (2013)
Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error.
2013 Wissenschaftlicher Artikel in Psychiatric Genetics Psychiatr. Genet. 23, 143-152 (2013)
A genomewide association study of smoking relapse in four European population-based samples.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e64544 (2013)
Identification of C/EBPβ target genes in ALK+ Anaplastic Large Cell Lymphoma (ALCL) by gene expression profiling and chromatin immunoprecipitation.
2013 Wissenschaftlicher Artikel in Science Science 340, 1467-1471 (2013)
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.
2013 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 45, 621-631 (2013)
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
2013 Wissenschaftlicher Artikel in Acta Neuropathologica Acta Neuropathol. 126, 137-150 (2013)
Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas.
2013 Wissenschaftlicher Artikel in Nephrology Dialysis Transplantation Nephrol. Dial. Transplant. 28, 2131-2138 (2013)
Metabolites associate with kidney function decline and incident chronic kidney disease in the general population.
2013 Wissenschaftlicher Artikel in Arthritis & Rheumatology Arthritis Rheum. 65, 1224-1231 (2013)
Variants in RUNX3 contribute to susceptibility to psoriatic arthritis, exhibiting further common ground with ankylosing spondylitis.
2013 Wissenschaftlicher Artikel in Hippocampus Hippocampus 23, 708-719 (2013)
In vivo contribution of nestin- and GLAST-lineage cells to adult hippocampal neurogenesis.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e63812 (2013)
Tobacco smoking leads to extensive genome-wide changes in DNA methylation.
2013 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 12, 426-439 (2013)
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog.
2013 Wissenschaftlicher Artikel in EMBO Molecular Medicine EMBO Mol. Med. 5, 919-934 (2013)
The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival.
2013 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 45, 501-512 (2013)
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
2013 Wissenschaftlicher Artikel in PLoS Medicine PLoS Med. 10:e1001383 (2013)
Causal relationship between obesity and vitamin D status: Bi-directional Mendelian randomization analysis of multiple cohorts.
2013 Wissenschaftlicher Artikel in Movement Disorders Mov. Disord. 28, 538-540 (2013)
The role of SCARB2 as susceptibility factor in Parkinson's disease.
2013 Wissenschaftlicher Artikel in Bayesian Analysis Bayesian Anal. 8, 1-22 (2013)
A vine-copula based adaptive MCMC sampler for efficient inference of dynamical systems.
2013 Wissenschaftlicher Artikel in Bayesian Analysis Bayesian Anal. 8, 33-42 (2013)
Rejoinder on "A vine-copula based adaptive MCMC sampler for efficient inference of dynamical systems".
2013 Wissenschaftlicher Artikel in SIAM Journal on Applied Dynamical Systems SIAM J. Appl. Dyn. Syst. 12, 315-351 (2013)
Truth-content and phase transitions of random boolean networks with generic logics.
In: Lavrik, I.N.* [Eds.]: Systems Biology of Apoptosis. New York: Springer, 2013. 57-84
Systematic complexity reduction of signaling models and application to a CD95 signaling model for apoptosis.
2013 Wissenschaftlicher Artikel in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 98, E1137-E1142 (2013)
Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors.
2013 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 15, 363-372 (2013)
Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis.
2013 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 288, 16690-16703 (2013)
High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.
2013 Wissenschaftlicher Artikel in Cell Cell 153, 535-549 (2013)
Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e60542 (2013)
The molecular genetic architecture of self-employment.
2013 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 22, 1663-1678 (2013)
Loci influencing blood pressure identified using a cardiovascular gene-centric array.
2013 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 16, 580-586 (2013)
Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation.
In: Proceedings of the 6th IEEE Pacific Visualization Symposium (IEEE PacificVis 2013 : 27.02.-01.03.2013, Sydney, Australia). Sydney, Australia: Univ. Sydney, 2013. 201-208
Visualizing edge-edge relations in graphs.
2013 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 45, 433-439 (2013)
Seven new loci associated with age-related macular degeneration.
2013 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 45, 422-427 (2013)
Identification of seven loci affecting mean telomere length and their association with disease.
2013 Wissenschaftlicher Artikel in Translational Psychiatry Transl. Psychiatry 3:e229 (2013)
A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults.
2013 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 9:e1003270 (2013)
ImmunoChip study implicates antigen presentation to T cells in narcolepsy.
2013 Wissenschaftlicher Artikel in Systembiologie.de Systembiologie.de 6, 16-19 (2013)
Wer hat an der Uhr gedreht? Regulationsmechanismen der Segmentierung im Wirbeltierembryo.
2013 Wissenschaftlicher Artikel in DNA Repair DNA Repair 12, 356-366 (2013)
SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.
2013 Wissenschaftlicher Artikel in Allergy Allergy 68, 629-636 (2013)
Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma.
2013 Wissenschaftlicher Artikel in BMC Medicine BMC Med. 11:60 (2013)
Effects of smoking and smoking cessation on human serum metabolite profile: Results from the KORA cohort study.
2013 Review in BioEssays Bioessays 35, 242-252 (2013)
Fate specification in the adult brain lessons for eliciting neurogenesis from glial cells.
2013 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 110, 1152-1161 (2013)
Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e54507 (2013)
Pax6 Interactions with chromatin and identification of its novel direct target genes in lens and forebrain.
2013 Wissenschaftlicher Artikel in Diabetologia Diabetologia 56, 298-310 (2013)
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.
2013 Wissenschaftlicher Artikel in Diabetes Diabetes 62, 977-986 (2013)
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
2013 Wissenschaftlicher Artikel in Annals of Neurology Ann. Neurol. 73, 86-94 (2013)
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.
2013 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 8:e55884 (2013)
Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity.
2013 Wissenschaftlicher Artikel in Plant Molecular Biology Plant Mol. Biol. 81, 259-272 (2013)
Production of a de-novo designed antimicrobial peptide in Nicotiana benthamiana.
2013 Wissenschaftlicher Artikel in Genome Medicine Genome Med. 5:13 (2013)
Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma.
2013 Wissenschaftlicher Artikel in Development / Company of Biologists Development 140, 1123-1136 (2013)
Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation.
2013 Wissenschaftlicher Artikel in Cellular and Molecular Life Sciences - CMLS Cell. Mol. Life Sci. 70, 1637-1651 (2013)
Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells.
2013 Wissenschaftlicher Artikel in Development / Company of Biologists Development 140, 1055-1066 (2013)
The transcription factor Otx2 regulates choroid plexus development and function.
2013 Wissenschaftlicher Artikel in Development / Company of Biologists Development 140, 483-486 (2013)
Radial glia - from boring cables to stem cell stars.
2013 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 22, 184-201 (2013)
Gene-centric meta-analyses of 108912 individuals confirm known body mass index loci and reveal three novel signals.
2013 Wissenschaftlicher Artikel in Diabetes Diabetes 62, 291-298 (2013)
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
2013 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 45, 76-82 (2013)
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
2013 Wissenschaftlicher Artikel in European Journal of Human Genetics Eur. J. Hum. Genet. 21, 410-414 (2013)
Dilution of candidates: The case of iron-related genes in restless legs syndrome.
2013 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 45, 145-154 (2013)
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
2013 Wissenschaftlicher Artikel in Psychoneuroendocrinology Psychoneuroendocrinology 38, 1299-1309 (2013)
Metabolomic profiles in individuals with negative affectivity and social inhibition: A population-based study of Type D personality.
2013 Wissenschaftlicher Artikel in Glia Glia 61, 273-286 (2013)
Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men.
2013 Wissenschaftlicher Artikel in European Journal of Human Genetics Eur. J. Hum. Genet. 21, 48-54 (2013)
Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood.
2013 Wissenschaftlicher Artikel in Philosophical Transactions of the Royal Society of London, Series A Philos. Trans. R. Soc. A - Math. Phys. Eng. Sci. 371:20110544 (2013)
Joining forces of Bayesian and frequentist methodology: A study for inference in the presence of non-identiability.
2013 Wissenschaftlicher Artikel in Cerebral Cortex Cereb. Cortex 23, 2552-2567 (2013)
The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals.
2012 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 109, 16240-16245 (2012)
Features of the Arabidopsis recombination landscape resulting from the combined loss of sequence variation and DNA methylation.
2012 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 28, 2930-2939 (2012)
MeDIP-HMM: Genome-wide identification of distinct DNA methylation states from high-density tiling arrays.
2012 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 2, 10-18 (2012)
MicroRNA-9 Modulates Hes1 ultradian oscillations by forming a double-negative feedback loop.
2012 Letter to the Editor in Nature Neuroscience Nat. Neurosci. 15, 697-699 (2012)
microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons.
2012 Wissenschaftlicher Artikel in Methods in Molecular Biology Methods Mol. Biol. 917, 445-459 (2012)
Methods to analyze microRNA expression and function during Xenopus development.
2012 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 8:e1002505 (2012)
Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 302-306 (2012)
Common variants at CDKAL1 and KLF9 are associated with body mass index in East Asian populations.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 307-311 (2012)
Meta-analysis identifies common variants associated with body mass index in east Asians.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 1015-1019 (2012)
Evidence of widespread selection on standing variation in Europe at height-associated SNPs.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 297-301 (2012)
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.
2012 Meeting abstract in Journal of Psychosomatic Research J. Psychosomat. Res. 72, 491 (2012)
PTSD is associated with attrition of leukocyte telomere length. Findings from the KORA F4 Study.
2012 Editorial in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 7191, V-VII (2012)
Preface.
2012 Wissenschaftlicher Artikel in Signal Processing Signal Process. 92, 1796-1808 (2012)
ICA over finite fields - separability and algorithms.
2012 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 26, 797-802 (2012)
A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation.
2012 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 419, 183-197 (2012)
Linker histone subtypes differ in their effect on nucleosomal spacing in vivo.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 1104-1110 (2012)
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
2012 Wissenschaftlicher Artikel in Epigenetics & Chromatin Epigenetics Chromatin 5:7 (2012)
A unified phylogeny-based nomenclature for histone variants.
2012 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 26, 2580-2589 (2012)
The role of PR-Set7 in replication licensing depends on Suv4-20h.
2012 Wissenschaftlicher Artikel in Epigenetics Epigenetics 7, 747-757 (2012)
Analysis of active chromatin modifications in early mammalian embryos reveals uncoupling of H2A.Z acetylation and H3K36 trimethylation from embryonic genome activation.
2012 Wissenschaftlicher Artikel in Nature Nature 483, 470-473 (2012)
Control of ground-state pluripotency by allelic regulation of Nanog.
2012 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 21, 5359-5372 (2012)
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.
2012 Wissenschaftlicher Artikel in Atherosclerosis Atherosclerosis 225, 363-369 (2012)
Evaluation of gene-obesity interaction effects on cholesterol levels: A genetic predisposition score on HDL-cholesterol is modified by obesity.
2012 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 8:e1003046 (2012)
Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.
2012 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 7:e50938 (2012)
Analyzing illumina gene expression microarray data from different tissues: Methodological aspects of data analysis in the MetaXpress consortium.
2012 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 21, 5329-5343 (2012)
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.
2012 Wissenschaftlicher Artikel in Nature Nature 491, 119-124 (2012)
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
2012 Wissenschaftlicher Artikel in Blood Blood 120, 4873-4881 (2012)
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
In: Suhre, K.* [Eds.]: Genetics Meets Metabolomics: From Experiment to Systems Biology. New York: Springer, 2012. 39-56
Statistical methods in genetic and molecular epidemiology and their application in studies with metabolic phenotypes.
2012 Wissenschaftlicher Artikel in Nature Nature 492, 369-375 (2012)
Seventy-five genetic loci influencing the human red blood cell.
2012 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 287, 43708-43719 (2012)
An emerging role of sonic hedgehog shedding as a modulator of heparan sulfate interactions.
2012 Wissenschaftlicher Artikel in Plant Physiology Plant Physiol. 160, 2285-2299 (2012)
Deciphering systemic wound responses of the pumpkin extrafascicular phloem by metabolomics and stable isotope-coded protein labeling.
2012 Review in International Journal of Molecular Sciences Int. J. Mol. Sci. 13, 15193-15208 (2012)
Nitric oxide-dependent posttranslational modification in plants: An update.
2012 Wissenschaftlicher Artikel in Methods in Molecular Biology Methods Mol. Biol. 822, 249-260 (2012)
PhenomiR: MicroRNAs in human diseases and biological processes.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 1341-1348 (2012)
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
2012 Wissenschaftlicher Artikel in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 186, 877-885 (2012)
A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1.
2012 Wissenschaftlicher Artikel in Metabolites Metabolites 2, 632-647 (2012)
A topological characterization of medium-dependent essential metabolic reactions.
In: Theis, F.J. ; Cichocki, A.* ; Yeredor, A* ; Zibulevsky, M.* [Eds.]: Proceedings (10th international conference on Latent Variable Analysis and Signal Separation). Heidelberg: Springer, 2012. 172-179 (Lecture Notes in Computer Science ; 7191)
Joint diagonalization of several scatter matrices for ICA.
2012 Wissenschaftlicher Artikel in RNA Biology RNA Biol. 9, 1266-1274 (2012)
Specific temperature-induced perturbations of secondary mRNA structures are associated with the cold-adapted temperature-sensitive phenotype of influenza A virus.
2012 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 21, 4805-4815 (2012)
Genome-wide meta-analysis of common variant differences between men and women.
2012 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 7:e32670 (2012)
Circadian gene variants and susceptibility to type 2 diabetes: A pilot study.
2012 Wissenschaftlicher Artikel in International Journal of Epidemiology Int. J. Epidemiol. 41, 1376-1382 (2012)
Sex-specific differences in effect size estimates at established complex trait loci.
2012 Wissenschaftlicher Artikel in Journal of natural medicines J. Nat. Med. 18, 1847-1856 (2012)
Targeted estrogen delivery reverses the metabolic syndrome.
Lecture Notes in Computer Science In: Theis, F.J. ; Cichocki, A.* ; Yeredor, A* ; Zibulevsky, M.* [Eds.]: Proceedings (10th International Conference, LVA/ICA 2012, 12-15 March 2012, Tel Aviv, Israel). Heidelberg: Springer, 2012. 180-187 (Lect. Notes Comput. Sc. ; 7191)
To infinity and beyond: On ICA over Hilbert Spaces.
2012 Wissenschaftlicher Artikel in Advances in Artificial Neural Systems Adv. Artif. Neural Syst. 2012:962105 (2012)
Measuring non-Gaussianity by phi-transformed and fuzzy histograms.
2012 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 91, 744-753 (2012)
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
2012 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 21, 3042-3049 (2012)
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.
In: Suhre, K.* [Eds.]: Genetics Meets Metabolomics: from Experiment to Systems Biology. New York: Springer, 2012. 281-313
Systems biology meets metabolism.
2012 Wissenschaftlicher Artikel in FASEB Journal FASEB J. 26, 5081-5091 (2012)
The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis.
2012 Wissenschaftlicher Artikel in Mammalian Genome Mamm. Genome 23, 611-622 (2012)
Innovations in phenotyping of mouse models in the German Mouse Clinic.
2012 Review in Nature Reviews - Genetics Nat. Rev. Genet. 13, 759-769 (2012)
Genetic variation in metabolic phenotypes: Study designs and applications.
2012 Wissenschaftlicher Artikel in Neurobiology of Disease Neurobiol. Dis. 48, 454-463 (2012)
Long-term genetic fate mapping of adult generated neurons in a mouse temporal lobe epilepsy model.
2012 Wissenschaftlicher Artikel in Genes and Immunity Genes Immun. 13, 549-555 (2012)
A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes.
2012 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 7:e44609 (2012)
In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis.
2012 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 8:e1003005 (2012)
Mining the unknown: A systems approach to metabolite identification combining genetic and metabolic information.
Lecture Notes in Computer Science In: Theis, F.J. ; Cichocki, A.* ; Yeredor, A* ; Zibulevsky, M.* [Eds.]: Proceedings (10th international conference on Latent Variable Analysis and Signal Separation). Heidelberg: Springer, 2012. 528-535 (Lect. Notes Comput. Sc. ; 7191)
Bayesian fuzzy clustering of colored graphs.
Proceedings on Work on Computational Systems Biology In: Larjo, A.* ; Schober, S.* ; Farhan, M.* ; Bossert, M.* ; Yli-Harja, O.* [Eds.]: Proceedings (Ninth International Workshop on Computational Systems Biology, WCSB 2012, June 4-6, 2012, Ulm, Germany). Tampere, Finnland: Tampere International Center for Signal Processing, 2012. 43-46 (Proc. WCSB ; 61)
Blind source separation using latent gaussian graphical models.
Lecture Notes in Computer Science In: Theis, F.J. ; Cichocki, A.* ; Yeredor, A* ; Zibulevsky, M.* [Eds.]: Proceedings (10th international conference on Latent Variable Analysis and Signal Separation). Heidelberg: Springer, 2012. 520-527 (Lect. Notes Comput. Sc. ; 7191)
Bayesian inference of latent causes in gene regulatory dynamics.
2012 Wissenschaftlicher Artikel in FEBS Journal, The FEBS J. 279, 3488-3500 (2012)
Multi-scale modeling of GMP differentiation based on single-cell genealogies.
2012 Wissenschaftlicher Artikel in Journal of Multivariate Analysis J. Multivar. Anal. 112, 48-62 (2012)
Uniqueness of linear factorizations into independent subspaces.
2012 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 3:1076 (2012)
Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle.
2012 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 13:120 (2012)
On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies.
2012 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 11, 471-476 (2012)
Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells.
2012 Wissenschaftlicher Artikel in BMC Systems Biology BMC Syst. Biol. 6:95 (2012)
Bayesian model selection validates a biokinetic model for zirconium processing in humans.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 981-990 (2012)
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 991-1005 (2012)
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
2012 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 28, i626-i632 (2012)
A novel approach for resolving differences in single-cell gene expression patterns from zygote to blastocyst.
2012 Wissenschaftlicher Artikel in Aging Cell Aging Cell 11, 960-967 (2012)
Human serum metabolic profiles are age dependent.
2012 Wissenschaftlicher Artikel in Molecular Systems Biology Mol. Syst. Biol. 8:615 (2012)
Novel biomarkers for pre-diabetes identified by metabolomics.
2012 Editorial in Nature Neuroscience Nat. Neurosci. 15, 1176-1178 (2012)
Shaping barrels: Activity moves NG2+ glia.
2012 Wissenschaftlicher Artikel in Neurogenetics Neurogenetics 13, 281-285 (2012)
Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson's disease.
2012 Wissenschaftlicher Artikel in Journal of Hepatology J. Hepatol. 57, 366-375 (2012)
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.
2012 Wissenschaftlicher Artikel in American Journal of Kidney Diseases Am. J. Kidney Dis. 60, 197-206 (2012)
Serum metabolite concentrations and decreased GFR in the general population.
2012 Wissenschaftlicher Artikel in Chemical Research in Toxicology Chem. Res. Toxicol. 25, 1565-1567 (2012)
Identification and quantification of 1-hydroxybutene-2-yl mercapturic acid in human urine by UPLC- HILIC-MS/MS as a novel biomarker for 1,3-butadiene exposure.
2012 Wissenschaftlicher Artikel in Journal of Neuroscience J. Neurosci. 32, 13292-13308 (2012)
A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation.
2012 Wissenschaftlicher Artikel in Science Science 337, 749-753 (2012)
Bergmann glial AMPA receptors are required for fine motor coordination.
2012 Wissenschaftlicher Artikel in Diabetes Diabetes 61, 2176-2186 (2012)
Impact of common variation in bone-related genes on type 2 diabetes and related traits.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 659-669 (2012)
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
2012 Wissenschaftlicher Artikel in Journal of Proteome Research J. Proteome Res. 11, 4120-4131 (2012)
Bayesian independent component analysis recovers pathway signatures from blood metabolomics data.
In: Suhre, K.* [Eds.]: Genetics Meets Metabolomics: from Experiment to Systems Biology. Springer, 2012. 85-106
Mouse genetics and metabolic mouse phenotyping.
2012 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 21, 3535-3545 (2012)
Cardiopulmonary dysfunction in the osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms.
2012 Wissenschaftlicher Artikel in Acta Neuropathologica Acta Neuropathol. 124, 187-197 (2012)
Long-term proteasomal inhibition in transgenic mice by UBB+1 expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients.
2012 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 21, 3275-3282 (2012)
Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function.
2012 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 7:e40009 (2012)
Body fat free mass is associated with the serum metabolite profile in a population-based study.
2012 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 8:e1002695 (2012)
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
2012 Wissenschaftlicher Artikel in Plant Physiology Plant Physiol. 159, 902-914 (2012)
Looking deep inside: Detection of low-abundance proteins in leaf extracts of arabidopsis and phloem exudates of pumpkin.
2012 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 8:e1002586 (2012)
From dynamic expression patterns to boundary formation in the presomitic mesoderm.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 369-375 (2012)
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits.
2012 Wissenschaftlicher Artikel in Journal of Investigative Dermatology, The J. Invest. Dermatol. 132, 1133-1140 (2012)
Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL.
2012 Wissenschaftlicher Artikel in Neurogenetics Neurogenetics 13, 181-187 (2012)
Replication study of Multiple Sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients.
2012 Wissenschaftlicher Artikel in PLoS Biology PLoS Biol. 10:e1001300 (2012)
Social transfer of pathogenic fungus promotes active immunisation in ant colonies.
2012 Wissenschaftlicher Artikel in Biophysical Journal Biophys. J. 102, 19-29 (2012)
Stability and multiattractor dynamics of a toggle switch based on a two-stage model of stochastic gene expression.
2012 Wissenschaftlicher Artikel in Genetic Epidemiology Genet. Epidemiol. 36, 244-252 (2012)
PSEA: Phenotype Set Enrichment Analysis - a new method for analysis of multiple phenotypes.
2012 Wissenschaftlicher Artikel in Schizophrenia Research Schizophr. Res. 138, 69-73 (2012)
Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder.
2012 Wissenschaftlicher Artikel in Entropy Entropy 14, 993-1010 (2012)
Cellular automata on graphs: Topological properties of ER graphs evolved towards low-entropy dynamics.
2012 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 7:e35502 (2012)
Ethylene supports colonization of plant roots by the mutualistic fungus Piriformospora indica.
2012 Wissenschaftlicher Artikel in Cancer Genetics Cancer Genet. 205, 212-219 (2012)
MicroRNA profiling with correlation to gene expression revealed the oncogenic miR-17-92 cluster to be up-regulated in osteosarcoma.
2012 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 8:e1002741 (2012)
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
2012 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 90, 636-647 (2012)
Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 483-489 (2012)
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.
2012 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 8:e1002607 (2012)
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals.
2012 Wissenschaftlicher Artikel in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 129, 840-845 (2012)
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
2012 Wissenschaftlicher Artikel in Diabetes Diabetes 61, 524-530 (2012)
Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk.
2012 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 7:e29202 (2012)
A genome-wide association search for type 2 diabetes genes in African Americans.
2012 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 90, 410-425 (2012)
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
2012 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 7:e31369 (2012)
Genome-wide association study to identify common variants associated with brachial circumference: A meta-analysis of 14 cohorts.
2012 Wissenschaftlicher Artikel in Neuron Neuron 73, 911-924 (2012)
A radial glia-specific role of RhoA in double cortex formation.
2012 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 21, 1433-1443 (2012)
Genetic associations with lipoprotein subfractions provide information on their biological nature.
2012 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 8:e1002490 (2012)
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 260-268 (2012)
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
2012 Wissenschaftlicher Artikel in FASEB Journal FASEB J. 26, 2607-2619 (2012)
The dynamic range of the human metabolome revealed by challenges.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 67-72 (2012)
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
2012 Wissenschaftlicher Artikel in Obesity Obesity 20, 466-470 (2012)
SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents.
2012 Wissenschaftlicher Artikel in European Heart Journal Eur. Heart J. 33, 238-251 (2012)
Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: Meta-analysis of genome-wide association studies from five community-based studies.
In: Arabnia, H.R.* ; Tran, Q.-N.* [Eds.]: Proceedings (2011 International Conference on Bioinformatics & Computational Biology (BIOCOMP '11), 18-21 July 2011, Las Vegas, USA). Athens, GA, USA: CSREA Press, 2012. 751-759
Uncertain gene regulatory networks simplified by gramian-based approach.
2012 Wissenschaftlicher Artikel in Parkinsonism & Related Disorders Parkinsonism Relat. Disord. 18, 104-106 (2012)
Mutational screening of THAP1 in a German population with primary dystonia.
Advances in Experimental Medicine and Biology In: Goryanin, I.I.* ; Goryachev, A.B.* [Eds.]: Advances in Systems Biology. New York: Springer, 2012. 247-260 (Adv. Exp. Med. Biol. ; 736)
An ensemble approach for inferring semi-quantitative regulatory dynamics for the differentiation of mouse embryonic stem cells using prior knowledge.
In: Thai, M.T.* ; Pardalos, P.M.* [Eds.]: Handbook of Optimization in Complex Networks. Theory and Applications. New York, NJ: Springer, 2012. 169-208 (Optimization and Its Applications ; 57)
Modularity maximization and tree clustering: Novel ways to determine effective geographic borders.
2012 Wissenschaftlicher Artikel in Cellular Reprogramming Cell. Reprogramm. 14, 68-78 (2012)
Comparative analysis of nuclear transfer embryo-derived mouse embryonic stem cells. Part II: Gene regulation.
2012 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 44, 187-192 (2012)
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
2012 Wissenschaftlicher Artikel in Glia Glia 60, 343-357 (2012)
Stab wound injury of the zebrafish telencephalon: A model for comparative analysis of reactive gliosis.
2012 Wissenschaftlicher Artikel in Genesis : The Journal of Genetics and Development Genesis 50, 506-515 (2012)
Sox10-iCreERT2 : A mouse line to inducibly trace the neural crest and oligodendrocyte lineage.
2012 Wissenschaftlicher Artikel in Genesis : The Journal of Genetics and Development Genesis 50, 496-505 (2012)
The Sox17-mCherry fusion mouse line allows visualization of endoderm and vascular endothelial development.
2011 Letter to the Editor in Nature Reviews - Genetics Nat. Rev. Genet. 12, 376 (2011)
Concerning epigenetics and inbreeding.
2011 Sonstiges: Meinungsartikel in Genetics Genetics 188, 1015-1017 (2011)
Genome-wide epigenetic perturbation jump-starts patterns of heritable variation found in nature.
2011 Wissenschaftlicher Artikel in Genetics Genetics 188, 215-227 (2011)
Quantitative epigenetics through epigenomic perturbation of isogenic lines.
2011 Wissenschaftlicher Artikel in New Journal of Physics New J. Phys. 13:113021 (2011)
Adiabatic spin cooling using high-spin Fermi gases.
2011 Wissenschaftlicher Artikel in Physical Review Letters Phys. Rev. Lett. 106:125302 (2011)
Parametric excitation of a 1D gas in integrable and nonintegrable cases.
2011 Wissenschaftlicher Artikel in Developmental Cell Dev. Cell 20, 19-32 (2011)
MicroRNA-9 reveals regional diversity of neural progenitors along the anterior-posterior axis.
2011 Wissenschaftlicher Artikel in BMC Developmental Biology BMC Dev. Biol. 11:70 (2011)
Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration.
2011 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 89, 688-700 (2011)
Blood pressure loci identified with a gene-centric array.
2011 Wissenschaftlicher Artikel in Signal Processing Signal Process. 92, 1928-1936 (2011)
The signal separation evaluation campaign (2007-2010): Achievements and remaining challenges.
2011 Wissenschaftlicher Artikel in Journal of Cell Science J. Cell Sci. 124, 1623-1628 (2011)
Isoform-specific phosphorylation of human linker histone H1.4 in mitosis by the kinase Aurora B.
2011 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 25, 673-678 (2011)
The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.
2011 Wissenschaftlicher Artikel in Genes and Cancer Genes Cancer 2, 631-647 (2011)
Histone modifiers in cancer: Friends or foes?
2011 Wissenschaftlicher Artikel in Epigenetics & Chromatin Epigenetics Chromatin 4:11 (2011)
Methylation of H2AR29 is a novel repressive PRMT6 target.
2011 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 43, 117-120 (2011)
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
2011 Wissenschaftlicher Artikel in Diabetes Diabetes 60, 2407-2416 (2011)
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: A 14-cohort meta-analysis.
2011 Wissenschaftlicher Artikel in British Journal of Nutrition Br. J. Nutr. 106, 1263-1272 (2011)
Gene-PUFA interactions and obesity risk.
2011 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 89, 619-627 (2011)
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.
2011 Wissenschaftlicher Artikel in Diabetologia Diabetologia 54, 1052-1056 (2011)
Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.
2011 Wissenschaftlicher Artikel in Diabetes Diabetes 60, 345-354 (2011)
Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.
2011 Wissenschaftlicher Artikel in Diabetologia Diabetologia 54, 2038-2046 (2011)
Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
2011 Wissenschaftlicher Artikel in Nature Nature 480, 201-208 (2011)
New gene functions in megakaryopoiesis and platelet formation.
In: Arabnia, H.R.* ; Tran, Q.-N.* [Eds.]: Proceedings (The 2011 International Conference on Bioinformatics and Computational Biology). Elsevier, 2011. ( ; Proceedings of BIOCOMP'11)
Stability analysis of hybrid stochastic gene regulatory networks.
In: Górriz, J.M.* ; Lang, E.W.* ; Ramirez, J.* [Eds.]: Recent Advances in Biomedical Signal Processing. Sharjah: Bentham Science, 2011. 26-47
Exploratory matrix factorization techniques for large scale biomedical data sets.
2011 Wissenschaftlicher Artikel in Nature Protocols Nat. Protoc. 6, 1981-1989 (2011)
Prospective isolation of adult neural stem cells from the mouse subependymal zone.
2011 Wissenschaftlicher Artikel in IEEE Transactions on Signal Processing IEEE Trans. Signal Process. 59, 4478 - 4482 (2011)
Uniqueness of non-Gaussianity-based dimension reduction.
2011 Wissenschaftlicher Artikel in International Journal of Robust and Nonlinear Control Int. J. Robust Nonlin. 21, 1742-1758 (2011)
Steady-state robustness of qualitative gene regulation networks.
2011 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 43, 1131-1138 (2011)
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
2011 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 6:e15813 (2011)
Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans.
2011 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 7:e1002333 (2011)
A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.
In: Proceedings (Microscopic Image Analysis with Applications in Biology, 2nd September 2011, Heidelberg, Germany). Heidelberg: MIAAB, 2011. http://www.miaab.org/miaab-2011-
Efficient fluorescence image normalization for time lapse movies.
2011 Wissenschaftlicher Artikel in Physical Review E Phys. Rev. E 83:046127 (2011)
Vertex centralities in input-output networks reveal the structure of modern economies.
Applications of MATLAB in Science and Engineering. Rijeka: InTech, 2011. 35-60
From discrete to continuous gene regulation models - a tutorial using the odefy toolbox.
2011 Wissenschaftlicher Artikel in Proceedings of SPIE Proc. SPIE 8058:805819 (2011)
Gaussian graphical modeling reveals specific lipid correlations in glioblastoma cells.
2011 Wissenschaftlicher Artikel in Diabetes Diabetes 60, 2624-2634 (2011)
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
2011 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 43, 561-564 (2011)
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.
2011 Wissenschaftlicher Artikel in Cell Cell 147, 81-94 (2011)
The Lin28/let-7 axis regulates glucose metabolism.
2011 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 7:e1002260 (2011)
Large-scale gene-centric analysis identifies novel variants for coronary artery disease.
2011 Wissenschaftlicher Artikel in Journal of Neuroscience J. Neurosci. 31, 12471-12482 (2011)
Genetic deletion of Cdc42 reveals a crucial role for astrocyte recruitment to the injury site in vitro and in vivo.
2011 Wissenschaftlicher Artikel in Plant Science Plant Sci. 181, 527-533 (2011)
S-nitrosylation: An emerging post-translational protein modification in plants.
2011 Wissenschaftlicher Artikel in Development / Company of Biologists Development 138, 5067-5078 (2011)
The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex.
2011 Wissenschaftlicher Artikel in Nature Protocols Nat. Protoc. 6, 1847-1859 (2011)
Using an adherent cell culture of the mouse subependymal zone to study the behavior of adult neural stem cells on a single-cell level.
2011 Wissenschaftlicher Artikel in BMC Neurology BMC Neurology 11:134 (2011)
Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features.
2011 Wissenschaftlicher Artikel in Nature Nature 478, 97-102 (2011)
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.
2011 Wissenschaftlicher Artikel in Nature Nature 478, 103-109 (2011)
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
2011 Wissenschaftlicher Artikel in RNA RNA 17, 809-819 (2011)
miTALOS: Analyzing the tissue-specific regulation of signaling pathways by human and mouse microRNAs.
2011 Wissenschaftlicher Artikel in New Journal of Physics New J. Phys. 13:013041 (2011)
Dynamic regimes of random fuzzy logic networks.
2011 Wissenschaftlicher Artikel in Molecular Biology and Evolution Mol. Biol. Evol. 28, 2501-2512 (2011)
Complex principal component and correlation structure of 16 yeast genomic variables.
In: Eur. Signal Process. Conf (19th European Signal Processing Conference, 29 August - 2 September 2011, Barcelona). Barcelona: EUSIPCO, 2011. 1733-1737
An ISA algorithm with unknown group sizes successfully identifies biologically meaningful clusters in metabolomics data.
2011 Wissenschaftlicher Artikel in BMC Systems Biology BMC Syst. Biol. 5:136 (2011)
MicroRNAs coordinately regulate protein complexes.
2011 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 43, 1005-1011 (2011)
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
2011 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 6:e26457 (2011)
The nature and perception of fluctuations in human musical rhythms.
2011 Wissenschaftlicher Artikel in Plant Physiology and Biochemistry Plant Physiol. Biochem. 49, 946-957 (2011)
Regulation of plant cytosolic aldolase functions by redox-modifications.
2011 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 43, 1082-1090 (2011)
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
2011 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 6:e22649 (2011)
Hierarchical differentiation of myeloid progenitors is encoded in the transcription factor network.
2011 Wissenschaftlicher Artikel in BMC Genetics BMC Genet. 12:67 (2011)
Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays.
2011 Wissenschaftlicher Artikel in Neurology Neurology 76, 1106-1108 (2011)
Variant screening of the coding regions of MEIS1 in patients with restless legs syndrome.
2011 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 6:e22070 (2011)
The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits.
2011 Wissenschaftlicher Artikel in Nature Nature 477, 54-60 (2011)
Human metabolic individuality in biomedical and pharmaceutical research.
2011 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 7:e1002171 (2011)
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
2011 Wissenschaftlicher Artikel in Journal of Proteomics J. Proteomics 74, 1182-1189 (2011)
Deep insights into the plant proteome by pretreatment with combinatorial hexapeptide ligand libraries.
2011 Wissenschaftlicher Artikel in Proteomics Proteomics 11, 1664-1683 (2011)
Proteomic analysis of defense response of wildtype Arabidopsis thaliana and plants with impaired NO-homeostasis.
2011 Wissenschaftlicher Artikel in Respiratory Research Respir. Res. 12, 94 (2011)
Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation.
2011 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 7:e1001324 (2011)
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
2011 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 88, 664-673 (2011)
Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk.
2011 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 7:e1002215 (2011)
Discovery of sexual dimorphisms in metabolic and genetic biomarkers.
2011 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 43, 753-760 (2011)
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
2011 Wissenschaftlicher Artikel in Acta Physiologiae Plantarum Acta Physiol. Plant. 33, 1493-1514 (2011)
Proteomic analysis of Arabidopsis protein S-nitrosylation in response to inoculation with Pseudomonas syringae.
2011 Wissenschaftlicher Artikel in European Journal of Human Genetics Eur. J. Hum. Genet. 19, 813-819 (2011)
Genetic architecture of circulating lipid levels.
2011 Wissenschaftlicher Artikel in Diabetes Diabetes 60, 1340-1348 (2011)
Updated genetic score based on 34 confirmed type 2 diabetes loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program.
2011 Wissenschaftlicher Artikel in International Journal of Molecular Epidemiology and Genetics Int. J. Mol. Epidemiol. Genet. 2, 163-177 (2011)
Effect of genome-wide simultaneous hypotheses tests on the discovery rate.
2011 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 7:e1002113 (2011)
Multiple loci are associated with white blood cell phenotypes.
2011 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 43, 565-571 (2011)
A genome-wide association study of metabolic traits in human urine.
2011 Wissenschaftlicher Artikel in Journal of Medical Genetics J. Med. Genet. 48, 462-466 (2011)
MEIS1 and BTBD9: Genetic association with restless leg syndrome in end stage renal disease.
2011 Wissenschaftlicher Artikel in Neural Development Neural Dev. 6:12 (2011)
Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells.
2011 Wissenschaftlicher Artikel in European Journal of Neuroscience Eur. J. Neurosci. 33, 1045-1054 (2011)
Restrictions in time and space - new insights into generation of specific neuronal subtypes in the adult mammalian brain.
2011 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 20, 1241-1251 (2011)
A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
2011 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 88, 6-18 (2011)
Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height.
2011 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 43, 333-340 (2011)
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
2011 Wissenschaftlicher Artikel in Diabetologia Diabetologia 54, 111-119 (2011)
A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.
2011 Wissenschaftlicher Artikel in Circulation Circulation 123, 1864-1872 (2011)
Genetic predictors of fibrin D-dimer levels in healthy adults.
2011 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 286, 18614-18622 (2011)
Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice.
2011 Wissenschaftlicher Artikel in Circulation Circulation 123, 731-738 (2011)
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
2011 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 20, 1042-1047 (2011)
Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.
2011 Wissenschaftlicher Artikel in iForest : Biogeosciences and Forestry iForest 4, 69-76 (2011)
Changes in the proteome of juvenile European beech following three years exposure to free-air elevated ozone.
2011 Wissenschaftlicher Artikel in Diabetes Care Diabetes Care 34, 121-125 (2011)
Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
2011 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 43, 17-19 (2011)
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
2011 Wissenschaftlicher Artikel in European Heart Journal Eur. Heart J. 32, 1121-1133 (2011)
Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy.
2011 Wissenschaftlicher Artikel in Development / Company of Biologists Development 138, 1459-1469 (2011)
Clonal analysis by distinct viral vectors identifies bona fide neural stem cells in the adult zebrafish telencephalon and characterizes their division properties and fate.
2011 Wissenschaftlicher Artikel in Brain Research Brain Res. 1376, 31-41 (2011)
EGF induces CREB and ERK activation at the wall of the mouse lateral ventricles.
2011 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 6:e18195 (2011)
Integration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner ear.
2011 Wissenschaftlicher Artikel in Glia Glia 59, 869-881 (2011)
Progenitors in the adult cerebral cortex: Cell cycle properties and regulation by physiological stimuli and injury.
2011 Wissenschaftlicher Artikel in Development / Company of Biologists Development 138, 1057-1068 (2011)
Continuous live imaging of adult neural stem cell division and lineage progression in vitro.
2011 Wissenschaftlicher Artikel in FASEB Journal FASEB J. 25, 937-947 (2011)
Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling.
2011 Wissenschaftlicher Artikel in OMICS OMICS 15, 141-154 (2011)
Huge splicing frequency in human Y chromosomal UTY gene.
2011 Wissenschaftlicher Artikel in Glia Glia 59, 821-832 (2011)
GDNF-induced osteopontin from Müller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration.
2011 Review in Nature Reviews - Neuroscience Nat. Rev. Neurosci. 12, 88-104 (2011)
The stem cell potential of glia: Lessons from reactive gliosis.
2011 Wissenschaftlicher Artikel in Nature Protocols Nat. Protoc. 6, 214-228 (2011)
Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex.
2011 Wissenschaftlicher Artikel in BMC Systems Biology BMC Syst. Biol. 5:21 (2011)
Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data.
2011 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 43, 66-71 (2011)
Common variants in P2RY11 are associated with narcolepsy.
2011 Wissenschaftlicher Artikel in European Heart Journal Eur. Heart J. 32, 158-168 (2011)
Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23.
2011 Wissenschaftlicher Artikel in Blood Blood 117, 519-529 (2011)
Immune modulation by Fas ligand reverse signaling: Lymphocyte proliferation is attenuated by the intracellular Fas ligand domain.
2011 Review in Methods Methods 53, 120-135 (2011)
Mouse phenotyping.
In: Górriz, J.M.* ; Lang, E.W.* ; Ramirez, J.* [Eds.]: Recent Advances in Biomedical Signal Processing. Oak Park, IL: Bentham Science Publishers, 2011. 26-47
Exploratory matrix factorization techniques for large scale biomedical data sets.
2011 Wissenschaftlicher Artikel in Cancer Research Cancer Res. 71, 693-704 (2011)
Dynamic mathematical modeling of IL13-induced signaling in Hodgkin and primary mediastinal B-Cell lymphoma allows prediction of therapeutic targets.
2011 Wissenschaftlicher Artikel in Bulletin of Mathematical Biology Bull. Math. Biol. 73, 978-1003 (2011)
Theoretical analysis of time-to-peak responses in biological reaction networks.
2011 Wissenschaftlicher Artikel in International Review of Economics and Finance Int. Rev. Econom. Finance 20, 135-145 (2011)
The Heckscher-Ohlin model and the network structure of international trade.
2011 Wissenschaftlicher Artikel in Bulletin of Mathematical Biology Bull. Math. Biol. 73, 706-725 (2011)
Effective parameters determining the information flow in hierarchical biological systems.
In: Górriz, J.M.* ; Lang, E.W.* ; Ramirez, J.* [Eds.]: Recent Advances in Biomedical Signal Processing. Hilversum: Bentham Science Publishers, 2011. 157-170
Are we to integrate previous information into microarray analyses? Interpretation of a Lmx1b-knockout experiment.
2011 Wissenschaftlicher Artikel in Cerebral Cortex Cereb. Cortex 21, 413-424 (2011)
Neuronal network formation from reprogrammed early postnatal rat cortical glial cells.
2010 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 26, 1000-1006 (2010)
Comparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq.
2010 Wissenschaftlicher Artikel in Physical Review Letters Phys. Rev. Lett. 105:050402 (2010)
Mott-insulator phases of spin-3/2 fermions in the presence of quadratic zeeman coupling.
2010 Wissenschaftlicher Artikel in Physical Review A Phys. Rev. A 81:013611 (2010)
Finite-size effects for the gap in the excitation spectrum of the one-dimensional Hubbard model.
2010 Wissenschaftlicher Artikel in Development / Company of Biologists Development 137, 1553-1562 (2010)
FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation.
2010 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 6:e1001184 (2010)
Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.
In: Biomedical Signal Analysis - Contemporary Methods and Applications. Cambridge, MA: MIT Press, 2010. 1-28
Foundations of medical imaging and signal recording.
2010 Wissenschaftlicher Artikel in Epigenetics & Chromatin Epigenetics Chromatin 3:7 (2010)
Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D.
2010 Wissenschaftlicher Artikel in Journal of Experimental Medicine J. Exp. Med. 207, 711-719 (2010)
Arginine methylation of the B cell antigen receptor promotes differentiation.
2010 Wissenschaftlicher Artikel in BioEssays Bioessays 32, 659-668 (2010)
What an epigenome remembers.
2010 Wissenschaftlicher Artikel in Briefings in Functional Genomics Brief. Funct. Genomic. Proteomic. 9, 429-443 (2010)
Chatting histone modifications in mammals.
2010 Wissenschaftlicher Artikel in Molecular BioSystems Mol. Biosyst. 6, 1719-1729 (2010)
Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown.
2010 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 6:e1001234 (2010)
Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 binding.
2010 Wissenschaftlicher Artikel in Epigenetics Epigenetics 5, 112-117 (2010)
Going global: novel histone modifications in the globular domain of H3.
2010 Wissenschaftlicher Artikel in Briefings in Functional Genomics Brief. Funct. Genomic. Proteomic. 9, 444-454 (2010)
Epigenetic reprogramming and development: A unique heterochromatin organization in the preimplantation mouse embryo.
2010 Wissenschaftlicher Artikel in Current Opinion in Endocrinology, Diabetes and Obesity Curr. Opin. Endocrinol. Diabetes Obes. 17, 500-506 (2010)
Epigenetic regulation of reprogramming factors towards pluripotency in mouse preimplantation development.
2010 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 12, 853-862 (2010)
Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3.
2010Vortrag: 8th ERS Lung Science Conference 2010, 26-28 March 2010, Estoril, Portugal. (2010)
Comparison of pulmonary response among two mouse strains with divergent lung function following carbon nanoparticle instillation.
2010 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 42, 1077-1085 (2010)
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
2010 Wissenschaftlicher Artikel in American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics Am. J. Med. Genet. B 158B, 1448-1458 (2010)
Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance.
2010 Wissenschaftlicher Artikel in Diabetes Diabetes 59, 3229-3239 (2010)
Common variants at 10 genomic loci influence hemoglobin A₁C levels via glycemic and nonglycemic pathways.
2010 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 6:e1001058 (2010)
Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.
2010 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 6:e1001213 (2010)
Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.
2010 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 42, 996-999 (2010)
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.
2010 Wissenschaftlicher Artikel in Nature Nature 467, 460-464 (2010)
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
2010 Wissenschaftlicher Artikel in Human Mutation Hum. Mutat. 31, 477-483 (2010)
Quantifying the effect of sequence variation on regulatory interactions.
2010 Wissenschaftlicher Artikel in Journal of Theoretical Biology J. Theor. Biol. 266, 436-448 (2010)
Biologically meaningful update rules increase the critical connectivity of generalized Kauffman networks.
In: Das, S.* ; Caragea, D.* ; Welch, S.* ; Hsu, W.H.* [Eds.]: Handbook of Research on Computational Methodologies in Gene Regulatory Networks. IGI Global, 2010. 405-428
Determining the properties of gene regulatory networks from expression data.
2010 Wissenschaftlicher Artikel in BMC Genomics BMC Genomics 11:224 (2010)
Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects.
2010 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 5:e11154 (2010)
Tissue-specific target analysis of disease-associated microRNAs in human signaling pathways.
2010 Wissenschaftlicher Artikel in Advances in Experimental Medicine and Biology Adv. Exp. Med. Biol. 680, 189-197 (2010)
Robust stability analysis and design under consideration of multiple feedback loops of the tryptophan regulatory network of Escherichia coli.
2010 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 11, 1-10:233 (2010)
Odefy - from discrete to continuous models.
In: Vigneron, V.* ; Zarzoso, V.* ; Moreau, E.* [Eds.]: Proceedings (Latent variable analysis and signal separation : 9th international conference, 27-30 September 2010, St. Malo, France). Berlin: Springer, 2010. 370-377 ( ; 6365)
Second order subspace analysis and simple decompositions.
Lecture Notes in Computer Science In: Vigneron, V.* ; Zarzoso, V.* ; Moreau, E.* [Eds.]: Latent variable analysis and signal separation (Latent variable analysis and signal separation 9th international conference, 27-30 September 2010, St. Malo, France). Berlin: Springer, 2010. 114-122 (Lect. Notes Comput. Sc. ; 6365)
The 2010 signal separation evaluation campaign (SiSEC2010): Audio source separation.
In: Vigneron, V.* [Eds.]: Proceedings (Latent variable analysis and signal separation : 9th international conference, 27-30 September 2010, St. Malo, France). Heidelberg: Springer, 2010. 466-473 (LNCS; 6365)
Robust second-order source separation identifies experimental responses in biomedical imaging.
In: Vigneron, V.* ; Zarzoso, V.* ; Moreau, E.* [Eds.]: Proceedings (Latent variable analysis and signal separation : 9th international conference, 27-30 September 2010, St. Malo, France). Berlin: Springer, 2010. 645-652 ( ; 6365)
ICA over finite fields.
Lecture Notes in Computer Science In: Vigneron, V.* ; Zarzoso, V.* ; Moreau, E.* [Eds.]: Proceedings (Latent variable analysis and signal separation : 9th international conference, 27-30 September 2010, St. Malo, France). Berlin: Springer, 2010. 434-441 (Lect. Notes Comput. Sc. ; 6365)
Second-order source separation based on prior knowledge realized in a graph model.
2010 Wissenschaftlicher Artikel in IEEE Transactions on Circuits and Systems, Part I: Regular Papers IEEE Trans. Circuits Syst. I-Regul. Pap. 57, 1463-1474 (2010)
Colored subspace analysis: Dimension reduction based on a signal's autocorrelation structure.
2010 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 11:522 (2010)
Structuring heterogeneous biological information using fuzzy clustering of k-partite graphs.
2010 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 11:R6 (2010)
PhenomiR: A knowledgebase for microRNA expression in diseases and biological processes.
2010 Wissenschaftlicher Artikel in Journal of Neuroscience J. Neurosci. 30, 14835-14842 (2010)
MicroRNA loss enhances learning and memory in mice.
Lecture Notes in Computer Science In: Vigneron, V.* ; Zarzoso, V.* ; Moreau, E.* [Eds.]: Proceedings (Latent variable analysis and signal separation : 9th international conference, 27-30 September 2010, St. Malo, France). Berlin: Springer, 2010. 254-262 (Lect. Notes Comput. Sc. ; 6365)
Information-theoretic model selection for independent components.
In: Empirical and theoretical methods. München: ifo Institut für Wirtschaftsforschung e.V., 2010. 1-20 (CESifo working paper series ; 3175)
Which sectors of a modern economy are most central?
2010 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 39, 1, D220-D224 (2010)
MIPS: Curated databases and comprehensive secondary data resources in 2010.
Lecture Notes in Computer Science In: Vigneron, V.* ; Zarzoso, V.* ; Moreau, E.* [Eds.]: Proceedings (Latent variable analysis and signal separation : 9th international conference, 27-30 September 2010, St. Malo, France). Berlin: Springer, 2010. 123-130 (Lect. Notes Comput. Sc. ; 6365)
The 2010 signal separation evaluation campaign (SiSEC2010): Biomedical source separation.
Cambridge, Mass.: MIT Press, 2010. 432 S.
Biomedical signal analysis: Contemporary methods and applications.
In: Proceedings (BIOCOMP'10 - The 2010 International Conference on Bioinformatics & Computational Biology). Las Vegas (Nevada): CSREA Press, 2010.
Robust stability analysis of multi-time scale genetic regulatory networks under parametric uncertainties.
In: Schomburg, D.* ; Grote, A.* [Eds.]: Proceedings (German Conference on Bioinformatics 2010). Bonn: Ges. f. Inform., 2010. 31-40 ( ; P-173)
Uncovering the structure of heterogeneus biological data: Fuzzy graph partitioning in the k-partite setting.
2010 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 5:e15422 (2010)
The structure of borders in a small world.
2010 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 11:585 (2010)
Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation.
2010 Wissenschaftlicher Artikel in British Journal of Mathematical and Statistical Psychology Br. J. Math. Stat. Psychol. 63, 341-360 (2010)
The ad coefficient as a descriptive measure of the within-group agreement of ratings.
2010 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 42, 937-948 (2010)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
2010 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 7, 744-758 (2010)
In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells.
2010 Wissenschaftlicher Artikel in Nature Nature 467, 832-838 (2010)
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
2010 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 5:e13953 (2010)
Metabolic footprint of diabetes: A multiplatform metabolomics study in an epidemiological setting.
2010 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 107, 18493-18498 (2010)
Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma.
2010 Wissenschaftlicher Artikel in Neuron Neuron 68, 682-694 (2010)
The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA.
2010 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 42, 991-995 (2010)
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
2010 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 13, 1308-1309 (2010)
Making glutamatergic neurons from GABAergic progenitors.
2010 Wissenschaftlicher Artikel in Stroke Stroke 41, 2944-2999 (2010)
Modulation of fate determinants Olig2 and Pax6 in resident glia evokes spiking neuroblasts in a model of mild brain ischemia.
2010 Wissenschaftlicher Artikel in The Plant cell Plant Cell 22, 2894-2907 (2010)
Redox regulation of the NPR1-TGA1 system of Arabidopsis thaliana by nitric oxide.
2010 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 7, 78-89 (2010)
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus.
2010 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 19, 3885-3894 (2010)
Genome-wide association analysis identifies multiple loci related to resting heart rate.
2010 Wissenschaftlicher Artikel in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 3, 331-339 (2010)
Genetic regulation of serum phytosterol levels and risk of coronary artery disease.
2010 Wissenschaftlicher Artikel in Neurobiology of Aging Neurobiol. Aging 31, 167-168 (2010)
Polymorphisms in the receptor for GDNF (RET) are not associated with Parkinson's disease in Southern Germany.
2010 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 6, 31:e1000836 (2010)
Patterns of subnet usage reveal distinct scales of regulation in the transcriptional regulatory network of Escherichia coli.
2010 Wissenschaftlicher Artikel in BMC Developmental Biology BMC Dev. Biol. 10:39 (2010)
Relative roles of the different Pax6 domains for pancreatic alpha cell development.
2010 Wissenschaftlicher Artikel in Brain Research Reviews Brain Res. Rev. 63, 47-59 (2010)
What determines neurogenic competence in glia?
2010 Wissenschaftlicher Artikel in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 21, 1223-1232 (2010)
Common genetic variants associate with serum phosphorus concentration.
2010 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 6:e1001045 (2010)
Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six loci influencing serum magnesium levels.
2010 Wissenschaftlicher Artikel in International Journal of Biomathematics and Biostatatistics Int. J. Biomath. Biostat. 1, 9-21 (2010)
Gene regulation at the Mid-Hindbrain Boundary: Study of a mathematical model in the stationary limit.
2010 Wissenschaftlicher Artikel in Nature Nature 466, 707-713 (2010)
Biological, clinical and population relevance of 95 loci for blood lipids.
2010 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 42, 579-589 (2010)
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
2010 Wissenschaftlicher Artikel in Statistics in Medicine Stat. Med. 29, 2347-2358 (2010)
How to link call rate and p-values for Hardy-Weinberg equilibrium as measures of genome-wide SNP data quality.
2010 Wissenschaftlicher Artikel in Current Opinion in Neurobiology Curr. Opin. Neurobiol. 20, 400-407 (2010)
Stem cells niches during development - lessons from the cerebral cortex.
2010 Wissenschaftlicher Artikel in Genes and Immunity Genes Immun. 11, 397-405 (2010)
IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci.
2010 Wissenschaftlicher Artikel in Blood Blood 115, 5289-5299 (2010)
Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators.
2010 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 11:318 (2010)
CONAN: Copy number variation analysis software for genome-wide association studies.
2010 Wissenschaftlicher Artikel in Journal of Cell Science J. Cell Sci. 123, 1922-1930 (2010)
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.
2010 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 6, 445-456 (2010)
Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging.
2010 Wissenschaftlicher Artikel in Gene Expression Patterns Gene Expr. Patterns 10, 265-273 (2010)
Combination of in silico and in situ hybridisation approaches to identify potential Dll1 associated miRNAs during mouse embryogenesis.
2010 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 42, 448-453 (2010)
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
2010 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 19, 1129-1136 (2010)
European lactase persistence genotype shows evidence of association with increase in body mass index.
2010 Wissenschaftlicher Artikel in American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics Am. J. Med. Genet. B 153B, 684-690 (2010)
Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction.
2010 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 42, 292-294 (2010)
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
2010 Wissenschaftlicher Artikel in Molecular Pharmaceutics Mol. Pharm. 7, 727-737 (2010)
Toxicity pathway focused gene expression profiling of PEI-based polymers for pulmonary applications.
2010 Wissenschaftlicher Artikel in PLoS Biology PLoS Biol. 8:e1000373 (2010)
Directing astroglia from the cerebral cortex into subtype specific functional neurons.
2010 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 42, 153-159 (2010)
Genome-wide association study of PR interval.
2010 Wissenschaftlicher Artikel in Neuron Glia Biology Neuron Glia Biol. 6, 93-107 (2010)
The specific role of histone deacetylase 2 in adult neurogenesis.
2010 Wissenschaftlicher Artikel in European Journal of Neuroscience Eur. J. Neurosci. 31, 1173-1184 (2010)
PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering.
2010 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 5:e9468 (2010)
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
2010 Wissenschaftlicher Artikel in Plant Physiology Plant Physiol. 152, 1514-1528 (2010)
Regulation of plant glycine decarboxylase by s-nitrosylation and glutathionylation.
2010 Review in Physiologia Plantarum Physiol. Plant. 138, 372-383 (2010)
NO synthesis and signaling in plant: Where do we stand?
2010 Wissenschaftlicher Artikel in Molecular and Cellular Biology Mol. Cell. Biol. 30, 764-780 (2010)
Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis.
2010 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 42, 105-116 (2010)
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
2010 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 42, 24-26 (2010)
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.
2010 Wissenschaftlicher Artikel in Stem Cells Stem Cells 28, 775-787 (2010)
Chondroitin sulfates are required for fibroblast growth factor-2-dependent proliferation and maintenance in neural stem cells and for epidermal growth factor-dependent migration of their progeny.
2010 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 42, 137-141 (2010)
A genome-wide perspective of genetic variation in human metabolism.
2010 Wissenschaftlicher Artikel in Journal of Integrative Bioinformatics J. Integr. Bioinform. 7:151 (2010)
From binary to multivalued to continuous models: The lac operon as a case study.
2010 Wissenschaftlicher Artikel in Mammalian Genome Mamm. Genome 21, 13-27 (2010)
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3(416insG ) mice.
2010 Wissenschaftlicher Artikel in Protoplasma Protoplasma 243, 95-103 (2010)
PAR modulation of the UV-dependent levels of flavonoid metabolites in Arabidopsis thaliana (L.) Heynh. leaf rosettes: Cumulative effects after a whole vegetative growth period.
2010 Wissenschaftlicher Artikel in Atherosclerosis Atherosclerosis 208, 183-189 (2010)
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
2009 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 16, 777-781 (2009)
H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming.
2009 Wissenschaftlicher Artikel in Chemistry and Biology Chem. Biol. 16, 1027-1029 (2009)
Tools to tackle protein acetylation.
2009 Wissenschaftlicher Artikel in Molecular and Cellular Biology Mol. Cell. Biol. 29, 2278-2295 (2009)
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development.
2009 Wissenschaftlicher Artikel in International Journal of Developmental Biology Int. J. Dev. Biol. 53, 1003-1011 (2009)
Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage.
2009 Wissenschaftlicher Artikel in Epigenetics Epigenetics 4, 80-84 (2009)
Epigenetic reprogramming in mammalian reproduction: Contribution from histone variants.
In: Electroporation and Sonoporation in Developmental Biology. Tokyo: Springer, 2009. 179-200
Temporal and tissue-specific control of gene expression in the peri-implantation mouse embryo through electroporation of dsRNA.
In: Proceedings (Strengthening Radiation Protection Worldwide, IRPA 12 - 12th International Congress of the International Radiation Protection Association; 19-24 October 2008; Buenos Aires). Vienna: International Atomic Energy Agency, 2009. 1-10
Organ doses from environmental exposures calculated using the ICRP Reference Male and Reference Female voxel phantoms.
2009 Wissenschaftlicher Artikel in Molecular and Cellular Endocrinology Mol. Cell. Endocrinol. 301, (Sp. Iss. SI), 109-116 (2009)
Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms.
2009 Wissenschaftlicher Artikel in Particle and Fibre Toxicology Part. Fibre Toxicol. 6:31 (2009)
Pathway focused protein profiling indicates differential function for IL-1B,-18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice.
2009Vortrag: Herbsttagung der Sektion Zellbiologie, 06-07 November 2009, Borstel, Germany. (2009)
Indications of IL1B, IL18 and VEGF cascade in maintenance of homeostasis following transient pulmonary inflammation due to carbon nanoparticle (CNP) challenge in mice .
2009 Wissenschaftlicher Artikel in Nature Nature 462, 868-874 (2009)
Parental origin of sequence variants associated with complex diseases.
2009 Wissenschaftlicher Artikel in BioSpektrum BioSpektrum 15, 263-265 (2009)
Eine genomweite Assoziationsstudie mit Stoffwechselprodukten.
2009 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 41, 1308-1314 (2009)
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
2009 Wissenschaftlicher Artikel in Molecular Nutrition and Food Research Mol. Nutr. Food Res. 53, 681-685 (2009)
Association between functional FABP2 promoter haplotypes and body mass index: Analyses of 8072 participants of the KORA cohort study.
2009 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 41, 1191-1198 (2009)
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
2009 Wissenschaftlicher Artikel in European Journal of Human Genetics Eur. J. Hum. Genet. 17, 967-975 (2009)
An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population.
2009 Wissenschaftlicher Artikel in Journal of Neuroscience J. Neurosci. 29, 4172-4188 (2009)
Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling.
2009 Wissenschaftlicher Artikel in Glia Glia 57, 1630-1647 (2009)
Conditional deletion of β1-integrin in astroglia causes partial reactive gliosis.
2009 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 12, 1524-1533 (2009)
Adult generation of glutamatergic olfactory bulb interneurons.
2009 Wissenschaftlicher Artikel in Journal of Proteomics J. Proteomics 73, 1-9 (2009)
S-Nitrosylation in plants: Pattern and function.
2009 Wissenschaftlicher Artikel in Physics Letters A Phys. Lett. A 373, 546-549 (2009)
Outer-totalistic cellular automata on graphs.
Lecture Notes in Computer Science In: Adali, T.* [Eds.]: Independent Component Analysis and Signal Separation. Berlin: Springer, 2009. 387-394 (Lect. Notes Comput. Sc. ; 5441)
Estimating hidden influences in metabolic and gene regulatory networks.
Lecture Notes in Computer Science In: Adali, T.* [Eds.]: Independent Component Analysis and Signal Separation. Berlin: Springer, 2009. 354-361 (Lect. Notes Comput. Sc. ; 5441)
Soft dimension reduction for ICA by joint diagonalization on the Stiefel manifold.
2009 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 5:e1000569 (2009)
Spatial analysis of expression patterns predicts genetic interactions at the mid-hindbrain boundary.
2009 Wissenschaftlicher Artikel in Theoretical Computer Science Theor. Comput. Sci. 410, 3826-3838 (2009)
Reconstruction of graphs based on random walks.
2009 Editorial in PLoS Computational Biology PLoS Comput. Biol. 5:e1000385 (2009)
Hypergraphs and cellular networks.
2009 Wissenschaftlicher Artikel in Biophysical Journal Biophys. J. 96, 3791-3800 (2009)
Blind source separation techniques for the decomposition of multiply labeled fluorescence images.
2009 Wissenschaftlicher Artikel in BMC Systems Biology BMC Syst. Biol. 3, 98:98 (2009)
Transforming Boolean models to continuous models: Methodology and application to T-cell receptor signaling.
Lecture Notes in Computer Science In: Adali, T.* [Eds.]: Independent Component Analysis and Signal Separation. Berlin: Springer, 2009. 259-266 (Lect. Notes Comput. Sc. ; 5441)
Hierarchical extraction of independent subspaces of unknown dimensions.
In: Romejin, H.E.* ; Pardalos, P.M.* [Eds.]: Handbook of Optimization in Medicine. New York: Springer, 2009. 1-38 (Springer Optimization and Its Applications ; 26)
Optimization techniques for data representions with biomedical applications.
In: Adali, T.* [Eds.]: Proceedings (Independent Component Analysis and Signal Separation). Berlin: Springer, 2009. 548-556 (Lecture Notes in Computer Science ; 5441)
Blind decomposition of spectral imaging microscopy: A study on artificial and real test data.
In: Pardalos, P.M.* ; Romejin, H.E.* [Eds.]: Handbook of Optimization in Medicine. New York: Springer Science + Business Media B.V., 2009. 253-290
Optimization techniques for data representations with biomedical applications.
2009 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 41, 876-878 (2009)
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
2009 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 41, 666-676 (2009)
Genome-wide association study identifies eight loci associated with blood pressure.
2009 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 41, 1182-1190 (2009)
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
2009 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 284, 31260-31269 (2009)
Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells.
2009 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 4:e6034 (2009)
Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array.
2009 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 12, 1229-1237 (2009)
AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.
2009 Review in Genome Biology Genome Biol. 10:R81 (2009)
Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine.
2009 Wissenschaftlicher Artikel in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 2, 125-133 (2009)
Association of novel genetic Loci with circulating fibrinogen levels: A genome-wide association study in 6 population-based cohorts.
2009 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 4:e6054 (2009)
Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.
2009 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 10, Suppl.1:S56 (2009)
Human gene expression sensitivity according to large scale meta-analysis.
2009 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 5:e1000508 (2009)
Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution.
2009 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 5:e1000504 (2009)
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
2009 Wissenschaftlicher Artikel in Cerebral Cortex Cereb. Cortex 19, (Suppl.1), i35-i143 (2009)
Late origin of glia-restricted progenitors in the developing mouse cerebral cortex.
2009 Wissenschaftlicher Artikel in Cellular Physiology and Biochemistry Cell. Physiol. Biochem. 24, 317-324 (2009)
Mesenchymal stem cells promote oligodendroglial differentiation in hippocampal slice cultures.
2009 Wissenschaftlicher Artikel in British Journal of Cancer BJC Br. J. Cancer 100, 656-662 (2009)
Overexpressed vs mutated Kras in murine fibroblasts: A molecular phenotyping study.
2009 Review in Nature Reviews - Genetics Nat. Rev. Genet. 10, 371-380 (2009)
Towards better mouse models: Enhanced genotypes, systemic phenotyping and envirotype modelling.
2009 Review in Current Pharmaceutical Biotechnology Curr. Pharm. Biotechnol. 10, 236-243 (2009)
The German Mouse Clinic: A platform for systemic phenotype analysis of mouse models.
2009 Wissenschaftlicher Artikel in Journal of Medical Genetics J. Med. Genet. 46, 315-318 (2009)
Replication of restless legs syndrome loci in three European populations.
2009 Wissenschaftlicher Artikel in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 29, 774-780 (2009)
Large scale association analysis of novel genetic loci for coronary artery disease.
2009 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 41, 407-414 (2009)
Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
2009 Wissenschaftlicher Artikel in Genetic Testing and Molecular Biomarkers Genet. Test. Mol. Biomark. 13, 223-226 (2009)
Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort.
2009 Wissenschaftlicher Artikel in Blood Blood 113, 3831-3837 (2009)
A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function.
2009 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 18, 1524-1532 (2009)
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.
2009 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 84, 66-71 (2009)
A genome-wide association study identifies three loci associated with mean platelet volume.
2009 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 18, 2288-2296 (2009)
Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations.
2009 Wissenschaftlicher Artikel in Annals of Medicine Ann. Med. 41, 128-138 (2009)
Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.
2009 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 41, 25-34 (2009)
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
2009 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 41, 47-55 (2009)
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
2009 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 41, 708-711 (2009)
Narcolepsy is strongly associated with the T-cell receptor alpha locus.
2009 Wissenschaftlicher Artikel in Engineering Applications of Artificial Intelligence Eng. Appl. Artif. Intel. 22, 497-504 (2009)
ICA, kernel methods and nonnegativity: New paradigms for dynamical component analysis of fMRI data.
2008 Wissenschaftlicher Artikel in Physical Review A Phys. Rev. A 78:033612 (2008)
Two-component repulsive Fermi gases with population imbalance in elongated harmonic traps.
2008 Wissenschaftlicher Artikel in Hormone and Metabolic Research Horm. Metab. Res. 40, 722-26 (2008)
Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies.
2008 Wissenschaftlicher Artikel in Molecular Genetics and Metabolism Mol. Genet. Metab. 95, 229-232 (2008)
MTTP variants and body mass index, waist circumference and serum cholesterol level: Association analyses in 7582 participants of the KORA study cohort.
2008 Wissenschaftlicher Artikel in Physiologia Plantarum Physiol. Plant. 133, 211-228 (2008)
Regulation of plant cytosolic glyceraldehyde 3-phosphate dehydrogenase isoforms by thiol modifications.
Methods in Molecular Biology In: Hanock, J.T.* [Eds.]: Redox-Mediated Signal Transduction. Totowa, NJ: Humana Press, 2008. 210-222 (Methods Mol. Biol. ; 476)
Generation and detection of S-nitrosothiols.
2008 Wissenschaftlicher Artikel in Biological Chemistry Biol. Chem. 389, 333-343 (2008)
The histone H1 family: Specific members, specific functions?
2008 Wissenschaftlicher Artikel in Development / Company of Biologists Development 135, 1935-1946 (2008)
The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity.
2008 Wissenschaftlicher Artikel in Molecular and Cellular Biology Mol. Cell. Biol. 28, 4688-4696 (2008)
Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.
2008 Wissenschaftlicher Artikel in Nature Nature 452, 877-881 (2008)
Chromatin dynamics during epigenetic reprogramming in the mouse germ line.
2008 Wissenschaftlicher Artikel in Development, Growth and Differentiation Dev. Growth Differ. 50, 615-621 (2008)
Bone morphogenetic protein 4 signaling regulates development of the anterior visceral endoderm in the mouse embryo.
2008 Wissenschaftlicher Artikel in Human Reproduction Hum. Reprod. 23, 1246-1252 (2008)
Cell identity in the preimplantation mammalian embryo: An epigenetic perspective from the mouse.
2008 Wissenschaftlicher Artikel in Molecular and Cellular Biology Mol. Cell. Biol. 28, 1739-1754 (2008)
Histone H3 tails containing dimethylated lysine and adjacent phosphorylated serine modifications adopt a specific conformation during mitosis and meiosis.
2008 Wissenschaftlicher Artikel in BMC Developmental Biology BMC Dev. Biol. 8:118 (2008)
Pleiotropic effects in Eya3 knockout mice.
2008 Wissenschaftlicher Artikel in Annals of Neurology Ann. Neurol. 64, 402-409 (2008)
Risk Variants for Atrial Fibrillation on Chromosome 4q24 Associate with Ischemic Stroke.
2008 Wissenschaftlicher Artikel in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 1, 10-20 (2008)
Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions.
2008 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 3:e3863 (2008)
Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study.
2008 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 105, 15570-15575 (2008)
Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior.
In: Adult neurogenesis.. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2008. 227-265 ( ; 52)
Similarities and differences in stem cell fate, proliferation, migration, and differentiation in distinct forebrain regions.
In: Gage, F.H.* ; Kempermann, G.* ; Song, H.* [Eds.]: Adult Neurogenesis. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2008. (Cold Spring Harbor Monograph Series ; 52)
Adult neurogenesis: Similarities and differences in stem cell fate, proliferation, migration, and differentiation in distinct forebrain regions.
2008 Wissenschaftlicher Artikel in Plant Signaling & Behavior Plant Signal. Behav. 3, 827-828 (2008)
In silico search for nitric oxide sensitive promoter elements in Arabidopsis thaliana.
2008 Wissenschaftlicher Artikel in IEEE Pervasive Computing IEEE Pervasive Comput. 7, 28-35 (2008)
Money Circulation, Trackable Items, and the Emergence of Universal Human Mobility Patterns.
2008 Wissenschaftlicher Artikel in BMC Bioinformatics BMC Bioinformatics 9:100 (2008)
Analyzing M-CSF dependent monocyte/macrophage differentiation: expression modes and meta-modes derived from an independent component analysis.
2008 Wissenschaftlicher Artikel in BMC Biology BMC Biol. 6:37 (2008)
Erythropoietin enhances hippocampal long-term potentiation and memory.
2008 Wissenschaftlicher Artikel in Molecular Medicine Mol. Med. 14, 546-552 (2008)
Episode-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling supports novel treatment approaches.
2008 Wissenschaftlicher Artikel in Neurocomputing Neurocomp. 71, 2209-2216 (2008)
A robust model for spatiotemporal dependencies.
2008 Wissenschaftlicher Artikel in BMC Genomics BMC Genomics 9:629 (2008)
An evolutionary and structural characterization of mammalian protein complex organization.
2008 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 4:e1000282 (2008)
Genetics meets metabolomics: A genome-wide association study of metabolite profiles in human serum.
2008 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 40, 946-948 (2008)
PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.
2008 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 3:e2986 (2008)
Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study.
2008 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 4:e1000166 (2008)
Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.
2008 Wissenschaftlicher Artikel in Current Biology Curr. Biol. 18, 1241-1248 (2008)
Correlation between genetic and geographic structure in Europe.
2008 Wissenschaftlicher Artikel in BMC Systems Biology BMC Syst. Biol. 2:18 (2008)
Dissecting the logical types of network control in gene expression profiles.
2008 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 24, 1688-1697 (2008)
Knowledge-based gene expression classification via matrix factorization.
2008 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 40, 584-591 (2008)
Identification of ten loci associated with height highlights new biological pathways in human growth.
2008 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 40, 768-775 (2008)
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
2008 Wissenschaftlicher Artikel in Neurobiology of Aging Neurobiol. Aging 29, 1404-1411 (2008)
Creatine improves health and survival of mice.
2008 Wissenschaftlicher Artikel in Molecular and Cellular Neuroscience Mol. Cell. Neurosci. 38, 15-42 (2008)
Prospective isolation of functionally distinct radial glial subtypes--lineage and transcriptome analysis.
2008 Wissenschaftlicher Artikel in Journal of Neuroscience J. Neurosci. 28, 434-445 (2008)
Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells.
2008 Wissenschaftlicher Artikel in Journal of Neuroscience J. Neurosci. 28, 6439-6452 (2008)
A Dlx2- and Pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb.
2008 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 105, 3581-3586 (2008)
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain.
2008 Wissenschaftlicher Artikel in Glia Glia 56, 809-820 (2008)
Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors.
2008 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 2, 472-483 (2008)
Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion.
2008 Wissenschaftlicher Artikel in Methods in Enzymology Methods Enzymol. 440, 283-293 (2008)
Identification of S-nitrosylated proteins in plants.
2008 Wissenschaftlicher Artikel in Journal of Experimental Botany J. Exp. Bot. 59, 177-186 (2008)
Nitric oxide-responsive genes and promoters in Arabidopsis thaliana: A bioinformatics approach.
2008 Wissenschaftlicher Artikel in Frontiers in Bioscience Front. Biosci. 13, 5810-5823 (2008)
'Sighted C3H' mice - a tool for analysing the influence of vision on mouse behaviour?
2008 Wissenschaftlicher Artikel in Journal of Neurology J. Neurol. 255, 441-442 (2008)
Polymorphisms in the proteasomal subunit alpha4 are not associated with Parkinson's disease.
2008 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 40, 430-436 (2008)
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects.
2008 Wissenschaftlicher Artikel in Development / Company of Biologists Development 135, 11-28 (2008)
Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex.
2008 Wissenschaftlicher Artikel in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 49, 1533-1541 (2008)
Novel allele of crybb2 in the mouse and its expression in the brain.
2008 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 105, 2592-2597 (2008)
A multimetric approach to analysis of genome-wide association by single markers and composite likelihood.
2008 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 82, 453-463 (2008)
On the use of general control samples for genome-wide association studies: Genetic matching highlights causal variants.
2008 Wissenschaftlicher Artikel in Proteomics Proteomics 8, 1248-1256 (2008)
Systematic gene expression profiling of mouse model series reveals coexpressed genes.
2008 Wissenschaftlicher Artikel in Proteomics Proteomics 8, 1257-1265 (2008)
Transcriptome and proteome analysis of early embryonic mouse brain development.
2008 Wissenschaftlicher Artikel in Proteomics Proteomics 8, 1162-1164 (2008)
BrainProfileDB - a platform for integration of functional genomics data.
2008 Wissenschaftlicher Artikel in Proteomics Proteomics 8, 1170-1178 (2008)
Interlocking transcriptomics, proteomics and toponomics technologies for brain tissue analysis in murine hippocampus.
2008 Wissenschaftlicher Artikel in Proteomics Proteomics 8, 1165-1169 (2008)
An approach to handling and interpretation of ambiguous data in transcriptome and proteome comparisons.
2008 Wissenschaftlicher Artikel in Inhalation Toxicology Inhal. Toxicol. 20, 319-337 (2008)
Health effects of ambient particulate matter - biological mechanisms and inflammatory responses to in vitro and in vivo particle exposures.
2007 Letter to the Editor in EMBO Reports EMBO Rep. 8, 1016-1018 (2007)
TBP homologues in embryo transcription: Who does what?
2007 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 9, 347-353 (2007)
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.
2007 Review in Genes and Development Genes Dev. 21, 3027-3043 (2007)
Dynamics and interplay of nuclear architecture, genome organization, and gene expression.
2007 Wissenschaftlicher Artikel in Reproduction Reproduction 134, 51-62 (2007)
Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development.
2007 Wissenschaftlicher Artikel in Developmental Biology Dev. Biol. 309, 97-112 (2007)
The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation.
2007 Wissenschaftlicher Artikel in Nature Nature 445, 214-218 (2007)
Histone arginine methylation regulates pluripotency in the early mouse embryo.
2007 Wissenschaftlicher Artikel in Developmental Biology Dev. Biol. 302, 40-49 (2007)
Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling.
2007Vortrag: HUPO Brain Proteome Project, 8th March 2007, Hinxton, England. (2007)
Deciphering genotype-phenotype correlation : The German Mouse Clinic and more.
2007Vortrag: NGFN-Projektleiter-Treffen, 10-11 November 2007, Heidelberg, Germany. (2007)
Systemic analysis of mouse mutants at the German Mouse Clinic.
2007Vortrag: 19th Mouse Molecular Genetics Meeting, 5-9 September 2007, Hinxton/Cambridge, UK. (2007)
A genetic screen for modifiers of the delta1-dependent notch signalling function in the mouse.
2007Vortrag: 6th NGFN Meeting 2007, 10-11 November 2007, Heidelberg, Germany. (2007)
German Mouse Clinic: Systematic gene expression profiling of mouse models reveals co-expressed genes.
2007 Wissenschaftlicher Artikel in it - Information Technology Information Technol. 49, 381-387 (2007)
Biobanken in der genetisch-epidemiologiscen Forschung - Beispiel KORA-gen.
2007 Wissenschaftlicher Artikel in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 92, 3183-3188 (2007)
Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations.
2007 Wissenschaftlicher Artikel in Molecular Nutrition and Food Research Mol. Nutr. Food Res. 51, 178-184 (2007)
Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations.
2007 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 1, 529-540 (2007)
Neurotrophin receptor-mediated death of misspecified neurons generated from embryonic stem cells lacking Pax6.
In: Lamattina, L.* ; Lorenzo, J.C.* [Eds.]: Nitric Oxide in Plant Growth, Development and Stress Physiology. Berlin: Springer, 2007. 53-71 (Plant Cell Monographs ; 5)
S-nitrosylation in plants - spectrum and selectivity.
2007 Wissenschaftlicher Artikel in Physical Review E Phys. Rev. E 75:041917 (2007)
Regularizing capacity of metabolic networks.
2007 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 4666, 49-56 (2007)
Independent subspace analysis is unique, given irreducibility.
2007 Wissenschaftlicher Artikel in Signal Processing Signal Process. 87, 1890-1903 (2007)
Joint low-rank approximation for extracting non-Gaussian subspaces.
2007 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 4666, 121-128 (2007)
Colored subspace analysis.
2007 Wissenschaftlicher Artikel in EURASIP Journal on Advances in Signal Processing EURASIP J. Adv. Signal Process. 2007:052105 (2007)
Robust sparse component analysis based on a generalized Hough transform.
2007 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 16, 1821-1827 (2007)
Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans.
2007 Wissenschaftlicher Artikel in New England Journal of Medicine, The / NEJM N. Engl. J. Med. 357, 443-453 (2007)
Genomewide association analysis of coronary artery disease.
2007 Wissenschaftlicher Artikel in Development / Company of Biologists Development 134, 2727-2738 (2007)
Chondroitin sulfate glycosaminoglycans control proliferation, radial glia cell differentiation and neurogenesis in neural stem/progenitor cells.
2007 Wissenschaftlicher Artikel in European Heart Journal Eur. Heart J. 28, 305-309 (2007)
The common non-synonymous variant G38S of the KCNE1-(minK)-gene is not associated to QT interval in Central European Caucasians: Results from the KORA study.
2007 Wissenschaftlicher Artikel in Journal of Neuroscience J. Neurosci. 27, 11376-11388 (2007)
The marginal zone/layer i as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex.
2007 Wissenschaftlicher Artikel in European Journal of Endocrinology Eur. J. Endocrinol. 157, R1-R5 (2007)
Genetic variants in the leukemia-associated Rho guanine nucleotide exchange factor (ARHGEF12) gene are not associated with T2DM and related parameters in Caucasians (KORA study).
2007 Wissenschaftlicher Artikel in Progress in Neurobiology Prog. Neurobiol. 83, 2-23 (2007)
Radial glial cell heterogeneity--the source of diverse progeny in the CNS.
2007 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 39, 1000-1006 (2007)
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
2007 Wissenschaftlicher Artikel in BioSpektrum BioSpektrum 13, 504-506 (2007)
Von der funktionellen Genomforschung zur systemischen Krankheitsanalyse.
2007 Wissenschaftlicher Artikel in Proteomics Proteomics 7, 2490-2496 (2007)
High Performance Proteomics: 7th HUPO Brain Proteome Project Workshop.
2007 Wissenschaftlicher Artikel in Journal of Theoretical Biology J. Theor. Biol. 248, 120-129 (2007)
Cell-based simulation of dynamic expression patterns in the presomitic mesoderm.
2007 Wissenschaftlicher Artikel in BMC Developmental Biology BMC Dev. Biol. 7:68 (2007)
Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints.
2007 Wissenschaftlicher Artikel in Journal of Neuroscience J. Neurosci. 27, 8654-8664 (2007)
Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia.
2007 Wissenschaftlicher Artikel in Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Bundesgesundheitsbl.-Gesund. 50, 192-199 (2007)
Biobanken.
2007 Wissenschaftlicher Artikel in Neural Development Neural Dev. 2:11 (2007)
Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina.
In: Fox, J.* [Eds.]: The Mouse in Biomedical Research. Amsterdam: Elsevier, 2007. 225-260
Chemical mutagenesis in mice.
2007 Wissenschaftlicher Artikel in European Journal of Neuroscience Eur. J. Neurosci. 25, 2581-2590 (2007)
Directing neurotransmitter identity of neurones derived from expanded adult neural stem cells.
2007 Wissenschaftlicher Artikel in Physiological Genomics Physiol. Genomics 28, 301-310 (2007)
Profiling at mRNA, protein, and metabolite levels reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2–/– mice.
2007 Wissenschaftlicher Artikel in Current Opinion in Neurobiology Curr. Opin. Neurobiol. 17, 338-344 (2007)
Signaling in adult neurogenesis: From stem cell niche to neuronal networks.
2007 Wissenschaftlicher Artikel in Genetics Genetics 175, 1451-1463 (2007)
A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse.
2007 Wissenschaftlicher Artikel in Molecular and Cellular Neuroscience Mol. Cell. Neurosci. 34, 99-119 (2007)
Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon.
2006 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 8, 623-630 (2006)
Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells.
2006 Wissenschaftlicher Artikel in Journal of Cell Biology, The J. Cell Biol. 174, 329-338 (2006)
Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote.
2006 Wissenschaftlicher Artikel in International Journal of Developmental Biology Int. J. Dev. Biol. 50, 455-461 (2006)
Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos.
2006 Wissenschaftlicher Artikel in Mechanisms of Development Mech. Dev. 123, 288-296 (2006)
Regionalised signalling within the extraembryonic ectoderm regulates anterior visceral endoderm positioning in the mouse embryo.
2006 Wissenschaftlicher Artikel in Methods in Molecular Biology Methods Mol. Biol. 329, 397-407 (2006)
Use of chemical mutagenesis in mouse embryonic stem cells.
In: Fox, J.G.* ; Barthold, S.W.* ; Davisson, M.T.* ; Newcomer, C.E.* ; Quimby, F.W.* ; Smith, A.L.* [Eds.]: The Mouse in Biomedical Research, 2nd Edition. Amsterdam: Elsevier Press, 2006. 225-260 ( ; 1)
Chemical mutagenesis in mice.
In: Hrabě de Angelis, M.* ; Chambon, P.* ; Brown, S.* [Eds.]: Standards of Mouse Model Phenotyping. Weinheim: Wiley-VCH, 2006. 15-34
Molecular phenotyping: Gene expression profiling.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2006, 107 S.
Gene expression profiling and gene regulation for functional genomics in mouse models.
2006Vortrag: Entwicklungsbiologischer Sino-German Workshop über Mesodermbildung und -differenzierung, 0.-03 September 2006, Beijing, China. (2006)
The Notch gene regulatory network during somitogenesis.
2006Vortrag: ICMSB, 2nd August 2006, München, Germany. (2006)
The Notch gene regulatory network during somitogenesis.
2006Vortrag: Mouse Molecular Genetics Meeting, 28th. August - 3rd September 2006, Cold Spring Harbor, USA. (2006)
A new standard: Phenotyping in the German Mouse Clinic.
2006Vortrag: International Mouse Genome Congress (IMGC), 12-16 November 2006, Charleston, USA. (2006)
Open access mouse phenotyping platform: The German Mouse Clinic.
In: Thiel, G.* [Eds.]: Transcription Factors in the Nervous System: Development, Brain Function, and Diseases. Weinheim: Wiley-VCH, 2006. 23-51
The Role of Pax6 in the nervous system during development and in adulthood: Master control regulator or modular function?
Handbook of Experimental Pharmacology In: Stem Cells. Berlin: Springer, 2006. 319-360 (Handb. Exp. Pharmacol. ; 174)
Neural stem cells: On where they hide, in which disguise, and how we may lure them out.
2006 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 9, 470-472 (2006)
Go with the flow: Signaling from the ventricle directs neuroblasts migration.
In: Handb. Exp.Pharmacol.. Berlin; Heidelberg: Springer, 2006. 319-360 ( ; 174)
Neural stem cells : On where they hide, in which disguise, and how we may lure them out.
In: Thiel, G.* [Eds.]: Transcription Factors in the Nervous System: Development, Brain Function and Diseases. Weinheim: Wiley, 2006. 23-51
The role of Pax6 in the nervous system during development and in adulthood : Master control regulator or modular function?
2006 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 9, 1099-1107 (2006)
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface.
2006 Wissenschaftlicher Artikel in Physics Letters A Phys. Lett. A 349, 302-305 (2006)
Similar impact of topological and dynamic noise on complex patterns.
2006 Wissenschaftlicher Artikel in Developmental Biology Dev. Biol. 296, 239-252 (2006)
The transcription factors Emx1 and Emx2 suppress choroid plexus development and promote neuroepithelial cell fate.
2006 Wissenschaftlicher Artikel in Cerebral Cortex Cereb. Cortex, 1, 121-131 (2006)
P-GAP-43 is enriched in horizontal cell divisions throughout rat cortical development.
2006 Wissenschaftlicher Artikel in Development / Company of Biologists Development 133, 3245-3254 (2006)
Basement membrane attachment is dispensable for radial glial cell fate and for proliferation, but affects positioning of neuronal subtypes.
2006 Wissenschaftlicher Artikel in Diabetes Diabetes 55, 2915-2921 (2006)
IL6 gene promoter polymorphisms and type 2 diabetes: Joint analysis of individual participants' data from 21 studies.
2006 Wissenschaftlicher Artikel in Developmental Biology Dev. Biol. 295, 278-293 (2006)
Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon.
2006 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 38, 644-651 (2006)
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.
2006 Wissenschaftlicher Artikel in Glia Glia 54, 21-34 (2006)
Inducible gene deletion in astroglia and radial glia-A valuable tool for functional and lineage analysis.
2006 Wissenschaftlicher Artikel in Journal of Experimental Botany J. Exp. Bot. 57, 507-516 (2006)
Nitric oxide and gene regulation in plants.
2006 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 281, 4285-4291 (2006)
Differential inhibition of Arabidopsis methionine adenosyltransferases by protein S-nitrosylation.
2005 Wissenschaftlicher Artikel in Gene Expression Patterns Gene Expr. Patterns 6, 94-101 (2005)
Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling.
2005 Wissenschaftlicher Artikel in Nature Nature 437, 436-439 (2005)
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.
2005 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 280, 38090-38095 (2005)
HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding.
2005 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 280, 17732-17736 (2005)
Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes.
2005 Wissenschaftlicher Artikel in BMC Developmental Biology BMC Dev. Biol. 5:28 (2005)
Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi.
2005 Wissenschaftlicher Artikel in GenomXPress GenomXPress 2, 7-10 (2005)
Mäuse als Modelle für menschliche Erkrankungen.
2005 Wissenschaftlicher Artikel in Applied Bioinformatics Appl. Bioinformatics 4, 75-84 (2005)
Automatic Scoring and Quality Assessment Using Accuracy Bounds for FP-TDI SNP Genotyping Data.
2005 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 102, 18183-18188 (2005)
Expression pattern of the transcription factor Olig2 in response to brain injuries: Implications for neuronal repair.
2005 Wissenschaftlicher Artikel in Physica A Physica A 354, 641-662 (2005)
Topology regulates pattern formation capacity of binary cellular automata on graphs.
2005 Wissenschaftlicher Artikel in Laser Physics Laser Phys. 15, 162-169 (2005)
Speeding up gate operations through dissipation.
2005 Wissenschaftlicher Artikel in Gesundheitswesen, Das Gesundheitswesen 67, (Sonderheft 1), 26-30 (2005)
KORA-gen - Resource for population genetics, controls and a broad spectrum of disease phenotypes.
2005 Wissenschaftlicher Artikel in Neuron Neuron 46, 369-372 (2005)
Radial glial cells defined and major intermediates between embryonic stem cells and CNS neurons.
2005 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 8, 865-872 (2005)
Neuronal fate determinants of adult olfactory bulb neurogenesis.
2005 Wissenschaftlicher Artikel in Nature Reviews - Molecular Cell Biology Nat. Rev. Mol. Cell Biol. 6, 777-788 (2005)
The Cell Biology of Neurogenesis.
2005 Wissenschaftlicher Artikel in Current Topics in Developmental Biology Curr. Top. Dev. Biol. 69, 67-99 (2005)
The Novel Roles of Glial Cells Revisited: The Contribution of Radial Glia and Astrocytes to Neurogenesis.
2005 Wissenschaftlicher Artikel in Development / Company of Biologists Development 132, 3327-3332 (2005)
Cortical Development: The art of generating cell diversity.
2005 Wissenschaftlicher Artikel in GenomXPress GenomXPress 3/05, 19-21 (2005)
KORA-gen : Ressource für Populationsgenetik, Kontrollen und ein weites Spektrum an Krankheitsphänotypen.
2005 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 37, 1155 (2005)
EMPReSS: Standardized phenotype screens for functional annotation of the mouse genome.
2005 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 2, 403-404 (2005)
Introducing the German Mouse Clinic: Open access platform for standardized phenotyping.
2005 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 349, 487-500 (2005)
Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells.
2005 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 102, 8621-8626 (2005)
Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues.
2005 Wissenschaftlicher Artikel in Plant Physiology Plant Physiol. 137, 921-930 (2005)