Publications
2024 Review in Nature Methods Nat. Methods 21, 1597-1602 (2024)
Small data methods in omics: The power of one.
2024 Wissenschaftlicher Artikel in Frontiers in bioengineering and biotechnology Front. Bioeng. Biotechnol. 12:1422235 (2024)
A multiparametric analysis including single-cell and subcellular feature assessment reveals differential behavior of spheroid cultures on distinct ultra-low attachment plate types.
Methods in Molecular Biology In: Chromatin Immunoprecipitation. 2024. 1-16 (Methods Mol. Biol. ; 2846)
Native ChIP: Studying the genome-wide distribution of histone modifications in cells and tissue.
Methods in Molecular Biology In: Chromatin Immunoprecipitation. 2024. 63-89 (Methods Mol. Biol. ; 2846)
Differential analysis of protein-DNA binding using ChIP-seq data.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:6611 (2024)
scTab: Scaling cross-tissue single-cell annotation models.
2024 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol., DOI: 10.1038/s41556-024-01512-w (2024)
Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:7611 (2024)
Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development.
2024 Review in Nature Methods Nat. Methods 21, 1430-1443 (2024)
Transformers in single-cell omics: A review and new perspectives.
2024 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J., DOI: 10.1038/s44318-024-00183-5 (2024)
Real-time assessment of mitochondrial DNA heteroplasmy dynamics at the single-cell level.
2024 Review in EMBO Reports EMBO Rep. 25, 3202-3220 (2024)
Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins.
2024 Wissenschaftlicher Artikel in Lancet, The Lancet 403, 1027-1050 (2024)
Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.
2024 Wissenschaftlicher Artikel in Kidney international reports Kidney Int. Rep. 9, 1849-1859 (2024)
Prioritization of kidney cell types highlights myofibroblast cells in regulating human blood pressure.
2024 Editorial in Developmental Cell Dev. Cell 59, 1623-1627 (2024)
Understanding how cells and organisms keep time during development.
2024 Wissenschaftlicher Artikel in Eye Eye, DOI: 10.1038/s41433-024-03264-1 (2024)
Evaluation of OCT biomarker changes in treatment-naive neovascular AMD using a deep semantic segmentation algorithm.
2024 Wissenschaftlicher Artikel in Nature Computational Science Nat. Comput. Sci. 4, 367–378 (2024)
MISATO: Machine learning dataset of protein-ligand complexes for structure-based drug discovery.
2024 Wissenschaftlicher Artikel in Cell Cell 187, 4637-4655.e26 (2024)
Innate immune memory after brain injury drives inflammatory cardiac dysfunction.
2024 Nature Communications Nat. Commun. 15:6190 (2024)
Author Correction: IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling.
2024 Wissenschaftlicher Artikel in Genes Genes 15:806 (2024)
Leveraging integrated RNA sequencing to decipher adrenomedullin's protective mechanisms in experimental bronchopulmonary dysplasia.
2024 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 40, i548-i557 (2024)
GraphCompass: Spatial metrics for differential analyses of cell organization across conditions.
2024 Nature Genetics Nat. Genet., DOI: 10.1038/s41588-024-01857-w (2024)
Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
2024 Wissenschaftlicher Artikel in Nature Nature 631, 645-653 (2024)
Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis.
2024 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 25:181 (2024)
Panpipes: A pipeline for multiomic single-cell and spatial transcriptomic data analysis.
2024 Wissenschaftlicher Artikel in Nature Neuroscience Nat. Neurosci. 27, 1260–1273 (2024)
Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1.
2024 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 56, 1397–1411 (2024)
Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:5577 (2024)
Multi-modal generative modeling for joint analysis of single-cell T cell receptor and gene expression data.
2024 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 25:109 (2024)
hadge: A comprehensive pipeline for donor deconvolution in single-cell studies.
2024 Wissenschaftlicher Artikel in Diabetes/Metabolism Research and Reviews Diabetes Metab. Res. Rev. 40:e3834 (2024)
Association of transketolase polymorphisms with diabetic polyneuropathy in the general population: The KORA F4 study.
2024 Wissenschaftlicher Artikel in Metabolites Metabolites 14:258 (2024)
Prediction of myocardial infarction using a combined generative adversarial network model and feature-enhanced loss function.
2024 Wissenschaftlicher Artikel in Biomolecules Biomolecules 14:662 (2024)
Smoking-induced DNA hydroxymethylation signature is less pronounced than true DNA methylation: The population-based KORA Fit cohort
In: (Proceedings of Machine Learning Research). 2024. 3664-3672 ( ; 238)
Mixed models with multiple instance learning.
2024 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-024-01341-3 (2024)
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase.
2024 Review in Redox Biology Redox Biol. 75:103211 (2024)
Ferroptosis in health and disease.
2024 Wissenschaftlicher Artikel in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 17:e004374 (2024)
Single-cell dissection of the immune response after acute myocardial infarction.
2024 Review in Physiological Reviews Physiol. Rev. 104, 1679-1717 (2024)
Eukaryotic cell size regulation and its implications for cellular function and dysfunction.
2024 Wissenschaftlicher Artikel in Developmental Cell Dev. Cell, DOI: 10.1016/j.devcel.2024.05.014 (2024)
An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration.
2024 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 26, 962-974 (2024)
Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators.
2024 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 56, 1090-1099 (2024)
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.
2024 Wissenschaftlicher Artikel in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:199 (2024)
Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i.
2024 Review in Genome Medicine Genome Med. 16:80 (2024)
Machine learning integrative approaches to advance computational immunology.
2024 Wissenschaftlicher Artikel in Nature Methods Nat. Methods, DOI: 10.1038/s41592-024-02303-9 (2024)
CellRank 2: Unified fate mapping in multiview single-cell data.
2024 Wissenschaftlicher Artikel in Genome Medicine Genome Med. 16:70 (2024)
Analysis of 3760 hematologic malignancies reveals rare transcriptomic aberrations of driver genes.
2024 Wissenschaftlicher Artikel in Nature medicine Nat. Med. 30, 1696-1710 (2024)
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes.
2024 Wissenschaftlicher Artikel in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:181 (2024)
Plasma proteome association with coronary heart disease and carotid intima media thickness: Results from the KORA F4 study.
2024 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 52, 6129-6144 (2024)
asteRIa enables robust interaction modeling between chromatin modifications and epigenetic readers.
2024 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 56, 778-791 (2024)
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.
2024 Review in Cell Cell 187, 2343-2358 (2024)
The future of rapid and automated single-cell data analysis using reference mapping.
2024 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 40:btae267 (2024)
Topological benchmarking of algorithms to infer Gene Regulatory Networks from Single-Cell RNA-seq Data.
2024 Wissenschaftlicher Artikel in Journal of Cell Biology, The J. Cell Biol. 223:e202309027 (2024)
Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells.
2024 Nature Genetics Nat. Genet. 56, 1032-1033 (2024)
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
2024 Nature Nature 628:E6 (2024)
Publisher Correction: Decoding chromatin states by proteomic profiling of nucleosome readers.
2024 Editorial in Cellular Reprogramming Cell. Reprogramm. 26, 37-42 (2024)
Reprogramming Stars #15: Colliding Cellular Reprogramming Paths- An Interview with Dr. Stefan Stricker.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:2960 (2024)
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells.
2024 Wissenschaftlicher Artikel in Journal of Hepatology J. Hepatol. 81, 289-302 (2024)
Polyploidisation pleiotropically buffers ageing in hepatocytes.
2024 Review in EMBO Reports EMBO Rep. 25, 1721-1733 (2024)
Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo.
2024 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 10:eadn9998 (2024)
Multiple parallel cell lineages in the developing mammalian cerebral cortex.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:2866 (2024)
Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex.
2024 Wissenschaftlicher Artikel in Nature Methods Nat. Methods, DOI: 10.1038/s41592-024-02212-x (2024)
SpatialData: An open and universal data framework for spatial omics.
2024 Review in Genes and Development Genes Dev. 38, 98-114 (2024)
Pan-cellular organelles and suborganelles-from common functions to cellular diversity?
2024 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 40:btae137 (2024)
Longmixr: A tool for robust clustering of high-dimensional cross-sectional and longitudinal variables of mixed data types.
2024 Wissenschaftlicher Artikel in Nature Nature 627, 671-679 (2024)
Decoding chromatin states by proteomic profiling of nucleosome readers.
2024 Review in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 85:102173 (2024)
The influencers' era: How the environment shapes chromatin in 3D.
2024 Wissenschaftlicher Artikel in Neuron Neuron 112, 1117-1132.e9 (2024)
Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle.
2024 Wissenschaftlicher Artikel in EBioMedicine EBioMedicine 101:105007 (2024)
Phenotypic and genome-wide studies on dicarbonyls: Major associations to glomerular filtration rate and gamma-glutamyltransferase activity.
2024 Wissenschaftlicher Artikel in Nature Nature 628, 130-138 (2024)
Genome-wide characterization of circulating metabolic biomarkers.
2024 Wissenschaftlicher Artikel in Biology of Sex Differences Biol. Sex Differ. 15:26 (2024)
Sex and statin-related genetic associations at the PCSK9 gene locus: Results of genome-wide association meta-analysis.
2024 Wissenschaftlicher Artikel in Clinical Epigenetics Clin. Epigenet. 16:29 (2024)
Epigenome-wide association study of dietary fatty acid intake.
2024 Wissenschaftlicher Artikel in Liver International Liver Int. 44, 838-847 (2024)
Penetrance, cancer incidence and survival in HFE haemochromatosis-A population-based cohort study.
2024 Wissenschaftlicher Artikel in Thorax Thorax 79, 524-537 (2024)
COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.
2024 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 15:888 (2024)
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.
2024 Wissenschaftlicher Artikel in Journal of Neuroinflammation J. Neuroinflamm. 21:33 (2024)
The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice.
2024 Editorial in Molecular Cell Mol. Cell 84, 186-188 (2024)
A quick restart: RNA polymerase jumping onto post-replicative chromatin.
2024 Wissenschaftlicher Artikel in Respiratory Research Respir. Res. 25:49 (2024)
Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air-liquid interface.
2024 Wissenschaftlicher Artikel in European Respiratory Journal Eur. Respir. J. 63:2301326 (2024)
Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts.
2024 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 300:105648 (2024)
Ribosome inactivation regulates translation elongation in neurons.
2024 Wissenschaftlicher Artikel in Cell Cell 187, 149-165.e23 (2024)
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma.
2024 Wissenschaftlicher Artikel in Physiological reports Physiol. Rep. 12:e15901 (2024)
LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.
2024 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 21, 28–31 (2024)
Modeling fragment counts improves single-cell ATAC-seq analysis.
2024 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 21, 50-59 (2024)
Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells.
2023 Letter to the Editor in Chest Chest 164, 85-89 (2023)
Longitudinal effects of 1-year smoking cessation on human bronchial epithelial transcriptome.
2023 Editorial in Cell Systems Cell Syst. 14, 423-427 (2023)
What do you most hope spatial molecular profiling will help us understand? Part 1.
2023Poster: NeurIPS 2023 AI for Science Workshop (2023)
SpatialSSL: Whole-Brain Spatial Transcriptomics in the Mouse Brain with Self-Supervised Learning.
2023 Meeting abstract in Neuroscience Applied Neurosci. App. 2:101038 (2023)
Effects of glucocorticoid exposure on gene expression and cell fate specification in cerebral organoids.
2023 Wissenschaftlicher Artikel in Neuroscience Applied Neurosci. App. 2:101126 (2023)
GPR101 loss promotes insulin resistance and diet-induced obesity risk.
2023 Wissenschaftlicher Artikel in Atherosclerosis Atherosclerosis 386:117384 (2023)
Meta-GWAS on PCSK9 concentrations reveals associations of novel loci outside the PCSK9 locus in White populations.
2023 Wissenschaftlicher Artikel in Gastroenterology Gastroenterology 165, 946-962.e13 (2023)
HLA-DP on epithelial cells enables tissue damage by NKp44+ natural killer cells in ulcerative colitis.
2023 Wissenschaftlicher Artikel in Stroke Stroke 54, 810-818 (2023)
Genetic risk Score for intracranial aneurysms: Prediction of subarachnoid hemorrhage and role in clinical heterogeneity.
2023 Wissenschaftlicher Artikel in The Lancet Public Health Lancet Public Health 8, e453-e462 (2023)
Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: A population-based cohort study using electronic health records.
2023 Wissenschaftlicher Artikel in Thorax Thorax 78, 496-503 (2023)
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease.
2023 Wissenschaftlicher Artikel in Gut (eGut) Gut 72, 2068-2080 (2023)
Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
2023 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-023-01179-1 (2023)
Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
2023 Letter to the Editor in Nature medicine Nat. Med. 29, 3018-3019 (2023)
Injury-specific signals elicit plasticity in glial cells from patients with brain injury.
2023 Meeting abstract in European Respiratory Journal Eur. Respir. J. 62:OA2624 (2023)
Spatiotemporal analysis of inflammaging and senescence programs in lung fibrosis using time-resolved single-cell transcriptomics and multiplexed immunofluorescence.
2023 Meeting abstract in European Respiratory Journal Eur. Respir. J. 62:2 (2023)
Evolution of epithelial-mesenchymal cell circuits in the progression of pulmonary fibrosis.
2023 Meeting abstract in European Respiratory Journal Eur. Respir. J. 62:3 (2023)
A spatially resolved extracellular matrix proteome atlas of the distal human lung.
2023 Wissenschaftlicher Artikel in Nature Nature 625, 401–409 (2023)
Emergence of replication timing during early mammalian development.
2023 Wissenschaftlicher Artikel in Nature human behaviour Nat. Hum. Behav. 7, 790-801 (2023)
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.
2023 Meeting abstract in Leukemia Research Leuk. Res. 128:2 (2023)
Multiomic analysis of chip bone marrow hematopoietic stem/progenitor cells reveals potential early stage of malignancy.
2023 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 64:4 (2023)
Single cell atlas of the human retina.
2023 Meeting abstract in Multiple Sclerosis Journal Mult. Scler. J. 29, 1097-1098 (2023)
A genetic association study identifying cis protein quantitative trait loci in patients with MS.
2023 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 64:332 (2023)
Predicting OCT-morphological anti-VEGF treatment response in patients with neovascular age-related degeneration using artificial intelligence.
2023 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 64:330 (2023)
New OCT based definition of treatment response to anti-VEGF in treatment naive neovascular AMD patients using an Deep Learning Algorithm.
2023 Wissenschaftlicher Artikel in Aging Aging 15, 14509-14552 (2023)
Mapping of the gene network that regulates glycan clock of ageing.
2023 Wissenschaftlicher Artikel in Science Translational Medicine Sci. Transl. Med. 15, 19:eadh0908 (2023)
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis.
2023 Wissenschaftlicher Artikel in Klinische Monatsblätter für Augenheilkunde Klin. Monatsbl. Augenheilkd., DOI: 10.1055/a-2227-3742 (2023)
Deep Learning based retinal layer segmentation in optical coherence tomography scans of patients with inherited retinal diseases.
2023 Wissenschaftlicher Artikel in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 109, 1318-1327 (2023)
Skeletal muscle gene expression signatures of obese high- and low- responders to endurance exercise training.
2023 Wissenschaftlicher Artikel in Nature Nature 615, 874-883 (2023)
Diminishing benefits of urban living for children and adolescents’ growth and development.
2023 Wissenschaftlicher Artikel in Nature medicine Nat. Med. 29, 3149–3161 (2023)
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain.
2023 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 9:eadj3793 (2023)
Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus.
2023 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 14:7888 (2023)
Explainable machine learning for profiling the immunological synapse and functional characterization of therapeutic antibodies.
2023 Editorial in Nature machine intelligence Nat. Mach. Intell. 5, 1176-1178 (2023)
Reporting electricity consumption is essential for sustainable AI.
2023 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 12, 1873-1883 (2023)
Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids.
2023 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 14:7674 (2023)
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease.
2023 Wissenschaftlicher Artikel in BioSpektrum BioSpektrum 29, 378-380 (2023)
Zugängliche KI-Algorithmen für bessere Zellmikroskopie.
2023 Sonstiges: Meinungsartikel in Molecular Cell Mol. Cell 83, 3946-3947 (2023)
Too big not to fail: Different paths lead to senescence of enlarged cells.
2023 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 51, 12303-12324 (2023)
Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency.
2023 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 37, 901-912 (2023)
Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity.
2023 Wissenschaftlicher Artikel in Journal of Visualized Experiments J. Vis. Exp. 2023:16 (2023)
Single-copy gene locus chromatin purification in Saccharomyces cerevisiae.
2023 Wissenschaftlicher Artikel in American Journal of Physiology - Cell Physiology Am. J. Physiol.-Cell Physiol. 325, C1131-C1143 (2023)
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes.
2023 Wissenschaftlicher Artikel in ACS Nano ACS Nano 17, 21056-21072 (2023)
Nanoparticle-exposure-triggered virus reactivation induces lung emphysema in mice.
2023 Wissenschaftlicher Artikel in Diabetes Diabetes 72, 1870-1880 (2023)
A faecal metabolite signature of impaired fasting glucose: Results from twoindependent population-based cohorts.
2023 Wissenschaftlicher Artikel in Cardiovascular Research Cardiovasc. Res. 119, 2743-2754 (2023)
Predictive metabolites for incident myocardial infarction: A two-step meta-analysis of individual patient data from six cohorts comprising 7,897 individuals from the the COnsortium of METabolomic Studies.
2023 Wissenschaftlicher Artikel in Clinical Epigenetics Clin. Epigenet. 15:166 (2023)
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome.
2023 Wissenschaftlicher Artikel in Frontiers in Genetics Front. Genet. 14:1235337 (2023)
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.
2023 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 24:234 (2023)
Single-cell metabolic profiling reveals subgroups of primary human hepatocytes with heterogeneous responses to drug challenge.
2023 Wissenschaftlicher Artikel in Hemasphere Hemasphere 7:e958 (2023)
CSF3R T618I collaborates With RUNX1-RUNX1T1 to expand hematopoietic progenitors and sensitizes to GLI inhibition.
2023 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 14:7206 (2023)
Speos: An ensemble graph representation learning framework to predict core gene candidates for complex diseases.
2023 Review in Genes and Development Genes Dev. 37, 779-780 (2023)
Folding makes an imprint.
2023 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 20, 1683-1692 (2023)
Population-level integration of single-cell datasets enables multi-scale analysis across samples.
2023 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 14:6840 (2023)
Reconstructing disease dynamics for mechanistic insights and clinical benefit.
2023 Wissenschaftlicher Artikel in iScience iScience 26:108205 (2023)
Human pluripotent stem cell fate trajectories toward lung and hepatocyte progenitors.
Lecture Notes in Computer Science In: (26th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), Vancouver, CANADA, 8-12 October 2023). Gewerbestrasse 11, Cham, Ch-6330, Switzerland: Springer International Publishing Ag, 2023. 514-524 (Lect. Notes Comput. Sc. ; 14227 LNCS)
B-Cos Aligned Transformers Learn Human-Interpretable Features.
2023 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 30, 1628-1639 (2023)
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
2023 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 30, 1549-1560 (2023)
Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth.
2023 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 20, 1037-1047 (2023)
Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.
Methods in Cell Biology In:. 525 B Street, Suite 1900, San Diego, Ca 92101-4495 Usa: Elsevier Academic Press Inc, 2023. 199-219 (Methods Cell Biol. ; 182)
An automated image analysis pipeline to quantify the coordination and overlap of transcription and replication activity in mammalian genomes.
2023 Review in AoB Plants AoB Plants 15:plad032 (2023)
Plant environmental memory: Implications, mechanisms and opportunities for plant scientists and beyond.
2023 Wissenschaftlicher Artikel in Human Molecular Genetics Hum. Mol. Genet. 32, 2717-2734 (2023)
Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria.
2023 Wissenschaftlicher Artikel in Annals of the American Thoracic Society Ann. Am. Thorac. Soc. 20, 1124-1135 (2023)
Systemic markers of lung function and forced expiratory volume in 1 second decline across diverse cohorts.
2023 Nature Immunology Nat. Immunol. 24:1960 (2023)
Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets (Nature Immunology, (2023), 24, 9, (1540-1551), 10.1038/s41590-023-01588-w).
2023 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 55, 1448-1461 (2023)
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
2023 Nature Genetics Nat. Genet. 55, 1778-1779 (2023)
Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk (Nature Genetics, (2023), 55, 3, (410-422), 10.1038/s41588-023-01314-0).
2023 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 14:5846 (2023)
epiAneufinder identifies copy number alterations from single-cell ATAC-seq data.
2023 Microbiome Microbiome 11:206 (2023)
Correction: Darier’s disease exhibits a unique cutaneous microbial dysbiosis associated with inflammation and body malodour (Microbiome, (2023), 11, 1, (162), 10.1186/s40168-023-01587-x).
2023 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 14:5391 (2023)
The Oncology Biomarker Discovery framework reveals cetuximab and bevacizumab response patterns in metastatic colorectal cancer.
2023 Wissenschaftlicher Artikel in Frontiers in Plant Science Front. Plant Sci. 14:1124899 (2023)
Arabidopsis histone deacetylase HD2A and HD2B regulate seed dormancy by repressing DELAY OF GERMINATION 1.
2023 Wissenschaftlicher Artikel in Genes Genes 14:27 (2023)
Histone deacetylases HD2A and HD2B undergo feedback regulation by ABA and modulate drought tolerance via mediating ABA-induced transcriptional repression.
2023 Wissenschaftlicher Artikel in Nature metabolism Nat. Metab. 5, 1615-1637 (2023)
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas.
2023 Wissenschaftlicher Artikel in Briefings in Bioinformatics Brief. Bioinform. 24:13 (2023)
Multi-omics regulatory network inference in the presence of missing data.
2023 Wissenschaftlicher Artikel in Stem Cell Reports Stem Cell Rep. 18, 1972-1986 (2023)
Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment.
2023 Editorial in Molecular Systems Biology Mol. Syst. Biol. 19:e11799 (2023)
Single-cell biology: What does the future hold?
2023 Wissenschaftlicher Artikel in Life Science Alliance Life Sci. All. 6:19 (2023)
A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler.
2023 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 37, 336-350 (2023)
A change in biophysical properties accompanies heterochromatin formation in mouse embryos.
2023 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 74:101748 (2023)
Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis.
2023 Editorial in Nucleic Acids Research Nucleic Acids Res. 51, 7709-7713 (2023)
Editorial: Colyn Crane-Robinson (1935-2023).
2023 Wissenschaftlicher Artikel in Development / Company of Biologists Development 150:12 (2023)
CIARA: A cluster-independent algorithm for identifying markers of rare cell types from single-cell sequencing data.
2023 Wissenschaftlicher Artikel in Physical Review E Phys. Rev. E 107:044403 (2023)
Emergent statistical laws in single-cell transcriptomic data.
2023 Editorial in Nature Reviews - Molecular Cell Biology Nat. Rev. Mol. Cell Biol. 24, 691-694 (2023)
Heterochromatin definition and function.
2023 Sonstiges: Meinungsartikel in Genes and Development Genes Dev. 37, 56-57 (2023)
Totipotency, development, and chromatin.
2023 Review in Developmental Cell Dev. Cell 58, 435-449 (2023)
Dynamics of nuclear architecture during early embryonic development and lessons from liveimaging.
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In: (Advances in Neural Information Processing Systems). 2022. ( ; 35)
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In: (Proceedings of Machine Learning Research). 2022. 162-176 ( ; 176)
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Informatik aktuell In: (Bildverarbeitung für die Medizin). 2022. 159 (Inf. aktuell ; 923)
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2022 Editorial in Frontiers in Plant Science Front. Plant Sci. 13:877438 (2022)
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EMPReSS: Standardized phenotype screens for functional annotation of the mouse genome (vol 37, pg 1155, 2005).
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Author Correction: Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis (Nature Communications, (2022), 13, 1, (143), 10.1038/s41467-021-27706-6).
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Spatial components of molecular tissue biology.
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TIGER: Technical variation elimination for metabolomics data using ensemble learning architecture.
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Tissue-specific multi-omics analysis of atrial fibrillation.
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CellRank for directed single-cell fate mapping.
2022 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 13:457 (2022)
Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development.
2022 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 13:143 (2022)
Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.
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Enhancer RNA expression in response to glucocorticoid treatment in murine macrophages.
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First mitochondrial genome wide association study with metabolomics.
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Determinants of expression of SARS-CoV-2 entry-related genes in upper and lower airways.
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Parameter inference with analytical propagators for stochastic models of autoregulated gene expression.
2021Vortrag: XV European Meeting on Glial Cells in Health and Disease, 07-10 July 2021, online. (2021)
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Graph representation learning for single cell biology.
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The power of genetic diversity in genome-wide association studies of lipids.
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Retrotransposing a promoter for development.
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2021 Wissenschaftlicher Artikel in Nature Nature 600, 285-289 (2021)
Single-cell transcriptomic characterization of a gastrulating human embryo.
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2021 Letter to the Editor in Trends in Neurosciences Trends Neurosci. 45, 3-5 (2021)
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A field guide to cultivating computational biology.
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Sickle cell disease severity prediction from percoll gradient images using graph convolutional networks.
Lecture Notes in Computer Science In: (24th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2021, 27 September-01 October 2021, Virtual, Online). 2021. 257-266 (Lect. Notes Comput. Sc. ; 12908 LNCS)
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Risk prediction of cardiovascular events by exploration of molecular data with explainable artificial intelligence.
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RNA velocity-current challenges and future perspectives.
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2021 Sonstiges: Meinungsartikel in Nature Cell Biology Nat. Cell Biol. 23, 814-816 (2021)
Deconfining heterochromatin for expression.
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N-glycosylation of immunoglobulin G predicts incident hypertension.
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Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.
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Single-molecule techniques to study chromatin.
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2021 Nature Cell Biology Nat. Cell Biol., DOI: 10.1038/s41556-021-00735-5 (2021)
Publisher Correction: Epithelial cell plasticity drives endoderm formation during gastrulation.
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Transcription coordinates histone amounts and genome content.
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Consequences and resolution of transcription-replication conflicts.
2021 Nature Communications Nat. Commun. 12:4256 (2021)
Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
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Machine learning for perturbational single-cell omics.
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Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study.
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Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes.
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2021 Review in EMBO Reports EMBO Rep. 22:e52774 (2021)
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Swarm Learning for decentralized and confidential clinical machine learning.
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Region-level epimutation rates in Arabidopsis thaliana.
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2021 Review in BioSpektrum BioSpektrum 27, 246-249 (2021)
Dem Anfang auf der Spur — die Suche nach DNA-Replikationsursprüngen.
2021Vortrag: Cell Bio Virtual 2020, 2-16 December 2020, Virtual. (2021)
Coordination of mitochondrial homeostasis with cell size.
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2021 Nature Cell Biology Nat. Cell Biol. 23, 566-576 (2021)
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Tens of images can suffice to train neural networks for malignant leukocyte detection.
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2021 Nature Nature 592:E1 (2021)
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CD81 marks immature and dedifferentiated pancreatic β-cells.
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Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers.
2021 Nature Nature 589, E6 (2021)
Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung (Nature, (2020), 588, 7836, (151-156), 10.1038/s41586-020-2882-8).
2021 Nature Nature 592:E8 (2021)
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (Nature, (2020), 587, 7834, (377-386), 10.1038/s41586-020-2715-9).
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2021 Nature Communications Nat. Commun. 12:995 (2021)
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Correction: Reoccuring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatio-temporal patterns.
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2021 Review in Journal of Experimental Botany J. Exp. Bot. 72, 777-780 (2021)
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2021 Wissenschaftlicher Artikel in Nature Nature 590, 326–331 (2021)
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2021 Review in Nature Neuroscience Nat. Neurosci. 24, 312-325 (2021)
Reactive astrocyte nomenclature, definitions, and future directions.
Methods in Molecular Biology In: Epigenetic Reprogramming During Mouse Embryogenesis. 2021. 265-282 (Methods Mol. Biol. ; 2214)
DamID to map genome-protein interactions in preimplantation mouse embryos.
In: (2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI), 13-16 April 2021, Nice, France). 2021. 966-970
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Deep learning the collisional cross sections of the peptide universe from a million experimental values.
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Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
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2020 Review in EMBO Journal, The EMBO J. 39:e105725 (2020)
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2020 Review in Current Topics in Developmental Biology Curr. Top. Dev. Biol. 142, 1-66 (2020)
The regulation of cortical neurogenesis.
2020 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 201:A5527 (2020)
Systemic biomarkers of lung function and FEV1 decline across multiple cohorts.
2020 BMC Public Health BMC Public Health 20:1335 (2020)
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Microfluidics for single-cell lineage tracking over time to characterize transmission of phenotypes in Saccharomyces cerevisiae.
2020 Wissenschaftlicher Artikel in Cell Systems Cell Syst. 11, 653-662.e8 (2020)
H4K20 methylation is differently regulated by dilution and demethylation in proliferating and cell-cycle-arrested xenopus embryos.
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Predicting single-cell gene expression profiles of imaging flow cytometry data with machine learning.
2020 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 36, 2, i610-i617 (2020)
Conditional out-of-distribution generation for unpaired data using transfer VAE.
2020 Wissenschaftlicher Artikel in Frontiers in Immunology Front. Immunol. 11:606338 (2020)
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2020 Review in Annual Review of Genetics Annu. Rev. Genet. 54, 167-187 (2020)
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2020 Wissenschaftlicher Artikel in Nature Nature 588, 466-472 (2020)
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2020 Review in Tumor Diagnostik und Therapie Tumordiagnos. Ther. 41, 666-668 (2020)
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Reoccurring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatiotemporal patterns.
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2020 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 12396 LNCS, 105-114 (2020)
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2020 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 48, 11394-11407 (2020)
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2020 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 21:259 (2020)
A genome assembly and the somatic genetic and epigenetic mutation rate in a wild long-lived perennial Populus trichocarpa.
2020 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 21:33023650 (2020)
AlphaBeta: Computational inference of epimutation rates and spectra from high-throughput DNA methylation data in plants.
2020 Wissenschaftlicher Artikel in iScience iScience 23:101601 (2020)
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2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:5653 (2020)
Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin.
2020 Wissenschaftlicher Artikel in Nature machine intelligence Nat. Mach. Intell. 2, 719-726 (2020)
Self-supervised retinal thickness prediction enables deep learning from unlabelled data to boost classification of diabetic retinopathy.
2020 Wissenschaftlicher Artikel in Nature Nature 588, 151–156 (2020)
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
2020 Wissenschaftlicher Artikel in Nature Genetics Nat. Genet. 52, 1151-1157 (2020)
Regulation of single-cell genome organization into TADs and chromatin nanodomains.
2020 Wissenschaftlicher Artikel in Advanced materials Adv. Mater. 32:e2003913 (2020)
Prediction of chronic inflammation for inhaled particles: The impact of material cycling and quarantining in the lung epithelium.
2020 Wissenschaftlicher Artikel in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 8:587778 (2020)
Dose-dependent and subset-specific regulation of midbrain dopaminergic neuron differentiation by LEF1-mediated WNT1/b-catenin signaling.
2020 Wissenschaftlicher Artikel in Communications Biology Comm. Biol. 3:628 (2020)
PAX6 mutation alters circadian rhythm and beta cell function in mice without affecting glucose tolerance.
2020 Wissenschaftlicher Artikel in Frontiers in Plant Science Front. Plant Sci. 11:549913 (2020)
Improving air quality by nitric oxide consumption of climate-resilient trees suitable for urban greening.
2020 Review in Nature Nature 587, 377–386 (2020)
LifeTime and improving European healthcare through cell-based interceptive medicine.
2020 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 6:eaaz4551 (2020)
METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth.
2020 Wissenschaftlicher Artikel in International Journal of Cancer Int. J. Cancer 147, 3523-3538 (2020)
miR-34a is upregulated in AIP-mutated somatotropinomas and promotes octreotide resistance.
2020 Review in Development / Company of Biologists Development 147:dev189688 (2020)
The molecular and cellular features of 2-cell-like cells: a reference guide.
2020 Wissenschaftlicher Artikel in Glia Glia 69, 346-361 (2020)
Heterogeneity of astrocytes: Electrophysiological properties of juxtavascular astrocytes before and after brain injury.
2020 Wissenschaftlicher Artikel in Molecular Systems Biology Mol. Syst. Biol. 16:e9416 (2020)
Predicting antigen specificity of single T cells based on TCR CDR3 regions.
2020 Wissenschaftlicher Artikel in Diabetes Diabetes 69, 2756-2765 (2020)
Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes.
2020 Wissenschaftlicher Artikel in Royal Society Open Science R. Soc. Open Sci. 7:200701 (2020)
Ectopic fat accumulation in human astrocytes impairs insulin action.
2020 Wissenschaftlicher Artikel in Diabetes Diabetes 69, 2766-2778 (2020)
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2020 Review in Current Genetics Curr. Genet. 66, 1029–1035 (2020)
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2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:3559 (2020)
Alveolar regeneration through a Krt8+transitional stem cell state that persists in human lung fibrosis.
2020 Wissenschaftlicher Artikel in Annals of Neurology Ann. Neurol. 88, 736-746 (2020)
Circulating metabolites differentiate acute ischemic stroke from stroke mimics.
2020 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol. 38, 1408–1414 (2020)
Generalizing RNA velocity to transient cell states through dynamical modeling.
2020 Review in Trends in Molecular Medicine Trends Mol. Med. 26, 890-892 (2020)
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2020 Wissenschaftlicher Artikel in Aging Aging 12, 15222-15259 (2020)
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2020 Wissenschaftlicher Artikel in Lancet Respiratory Medicine, The Lancet Resp. Med. 8, 696-708 (2020)
Chronic obstructive pulmonary disease and related phenotypes: Polygenic risk scores in population-based and case-control cohorts.
2020 Wissenschaftlicher Artikel in Journal of Clinical Investigation J. Clin. Invest. 130, 6093-6108 (2020)
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
2020 Wissenschaftlicher Artikel in Nature Cell Biology Nat. Cell Biol. 22, 767-778 (2020)
Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3.
2020 Editorial in Mammalian Genome Mamm. Genome, DOI: 10.1007/s00335-020-09843-3 (2020)
Introduction to mammalian genome special issue: Epigenetics.
2020 Review in Current Opinion in Genetics & Development Curr. Opin. Genet. Dev. 64, 26-30 (2020)
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2020 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J.:e103373 (2020)
Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells.
2020 Wissenschaftlicher Artikel in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 147, 587-599 (2020)
Inflammatory macrophage memory in nonsteroidal anti-inflammatory drug–exacerbated respiratory disease.
2020 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 48, 8393-8407 (2020)
Anti-inflammatory functions of the glucocorticoid receptor require DNA binding.
2020 Wissenschaftlicher Artikel in BMC Public Health BMC Public Health 20:1036 (2020)
Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19).
2020 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 40:101038 (2020)
Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting.
2020 Review in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 18, 1330-1341 (2020)
Seq-ing answers: Current data integration approaches to uncover mechanisms of transcriptional regulation.
2020 Wissenschaftlicher Artikel in Nature Nature 582, 592–596 (2020)
The proteome landscape of the kingdoms of life.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:3068 (2020)
Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces.
2020 Wissenschaftlicher Artikel in Particle and Fibre Toxicology Part. Fibre Toxicol. 17:27 (2020)
Influence of wood species on toxicity of log-wood stove combustion aerosols: A parallel animal and air-liquid interface cell exposure study on spruce and pine smoke.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:2952 (2020)
Cell size sets the diameter of the budding yeast contractile ring.
2020 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 78, 915-925 (2020)
Single-cell tracing dissects regulation of maintenance and inheritance of transcriptional reinduction memory.
2020 Review in New Phytologist New Phytol. 227, 1319-1325 (2020)
Regulating the regulator: Nitric oxide control of post-translational modifications.
2020 Review in Frontiers in Genetics Front. Genet. 11:450 (2020)
Proximity labeling techniques to study chromatin.
Informatik aktuell In: Bildverarbeitung für die Medizin 2020. 2020. 53-54 (Inf. aktuell)
Abstract: Recognition of AML blast cells in a curated single-cell dataset of leukocyte morphologies using deep convolutional neural networks.
2020 Wissenschaftlicher Artikel in Cell Cell 181, 1016-1035 (2020)
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues.
2020 Review in Current opinion in pharmacology Curr. Opin. Pharmacol. 53, 35-44 (2020)
Anti-inflammatory glucocorticoid action: Genomic insights and emerging concepts.
2020 Review in Molecular Metabolism Mol. Metab. 38:100951 (2020)
Interactions between metabolism and chromatin in plant models.
2020 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 36, 4296-4300 (2020)
COMUNET: A tool to explore and visualize intercellular communication.
2020 Review in Cell Cell 181, 1189-1193 (2020)
Biomedical research goes viral: Dangers and opportunities.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:2306 (2020)
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.
2020 Wissenschaftlicher Artikel in Acta Physiologica Acta Physiol. 230:e13496 (2020)
Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling.
2020 Wissenschaftlicher Artikel in Cell Systems Cell Syst. 10, 363-378.e12 (2020)
Gene networks with transcriptional bursting recapitulate rare transient coordinated high expression states in cancer.
2020 Wissenschaftlicher Artikel in EMBO Molecular Medicine EMBO Mol. Med. 12:e11419 (2020)
Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy.
2020 Wissenschaftlicher Artikel in Nature medicine Nat. Med. 26, 681–687 (2020)
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
2020 Review in Molecular Metabolism Mol. Metab. 38:100987 (2020)
You are what you eat-How nutrition and metabolism shape the genome through epigenetics.
2020 Nature metabolism Nat. Metab. 2, 380 (2020)
Author Correction: Targeted pharmacological therapy restores β-cell function for diabetes remission (Nature Metabolism, (2020), 2, 2, (192-209), 10.1038/s42255-020-0171-3).
2020 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol. 38, 1061–1072 (2020)
Generation of pancreatic β cells from CD177+ anterior definitive endoderm.
2020 Meeting abstract in Wound repair and regeneration Wound Repair Regen. 28, A16-A16 (2020)
Scar formation is driven by N-cadherin dependent collective fibroblast migration.
2020 Review in Mammalian Genome Mamm. Genome 31, 119–133 (2020)
Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations.
2020 Wissenschaftlicher Artikel in Current Biology Curr. Biol. 30, 1142-1151 (2020)
Epithelial planar bipolarity emerges from Notch-mediated asymmetric inhibition of Emx2.
2020 Review in Genome Biology Genome Biol. 21:31 (2020)
Eleven grand challenges in single-cell data science.
2020 Meeting abstract in Wound repair and regeneration Wound Repair Regen. 28, A7-A7 (2020)
Fate trajectory modeling reveals convergence of airway derived progenitors and AT2 cells on transient KRT8+alveolar cell state during lung regeneration.
2020 Review in Philosophical Transactions of the Royal Society of London. Series B Philos. Trans. R. Soc. B - Biol. Sci. 375:20190339 (2020)
On transposons and totipotency.
2020 Wissenschaftlicher Artikel in eLife eLife 9:e52155 (2020)
The single-cell eQTLGen consortium.
2020 Wissenschaftlicher Artikel in Mammalian Genome Mamm. Genome 31, 30-48 (2020)
A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.
2020 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 36, 4291-4295 (2020)
Automatic identification of relevant genes from low-dimensional embeddings of single-cell RNA-seq data.
2020 Wissenschaftlicher Artikel in Genes and Development Genes Dev. 34, 715-729 (2020)
The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.
2020 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 106, 389-404 (2020)
Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length.
2020 Wissenschaftlicher Artikel in Cell Reports Cell Rep. 30, 1223-1234 (2020)
Domain model explains propagation dynamics and stability of histone H3K27 and H3K36 methylation landscapes.
2020 Review in Nature Nature 578, 522-524 (2020)
Turning connective tissue into neurons for 10 years.
2020 Review in Frontiers in Cellular Neuroscience Front. Cell. Neurosci. 14:32 (2020)
Filling the gaps - A call for comprehensive analysis of extracellular matrix of the glial scar in region- and injury-specific contexts.
2020 Wissenschaftlicher Artikel in Life Science Alliance Life Sci. All. 3:e201900499 (2020)
Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition.
2020 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 16:e1007147 (2020)
Model-based analysis of response and resistance factors of cetuximab treatment in gastric cancer cell lines.
2020 Wissenschaftlicher Artikel in Diabetes Care Diabetes Care 43, 875-884 (2020)
Epigenetic link between statin therapy and type 2 diabetes.
2020 Nature Plants Nat. Plants 6:328 (2020)
Author Correction: Widespread long-range cis-regulatory elements in the maize genome.
2020 Wissenschaftlicher Artikel in PLoS Computational Biology PLoS Comput. Biol. 16:e1007616 (2020)
DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning.
In: Beyond Our Genes. 2020. 175-208
The (not so) controversial role of DNA methylation in epigenetic inheritance across generations.
2020 Wissenschaftlicher Artikel in Nature metabolism Nat. Metab. 2, 192-209 (2020)
Targeted pharmacological therapy restores β-cell function for diabetes remission.
2020 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 15:e0227648 (2020)
Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:15 (2020)
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.
2020 Wissenschaftlicher Artikel in Cell Stem Cell Cell Stem Cell 26, 277-293.e8 (2020)
Defining the adult neural stem cell niche proteome identifies key regulators of adult neurogenesis.
2020 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 77, 294-309.e9 (2020)
MeCP2 represses the rate of transcriptional initiation of highly methylated long genes.
2020 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep. 21:e48354 (2020)
A distinct metabolic state arises during the emergence of 2-cell-like cells.
2020 Wissenschaftlicher Artikel in Bioinformatics Bioinformatics 36, 1260-1261 (2020)
breakpointR: An R/Bioconductor package to localize strand state changes in Strand-seq data.
2020 Wissenschaftlicher Artikel in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 145, 1208-1218 (2020)
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
2020 Wissenschaftlicher Artikel in Annals of Neurology Ann. Neurol. 87, 184-193 (2020)
Identification of restless legs syndrome genes by mutational load analysis.
2020 Wissenschaftlicher Artikel in Journal of the European Academy of Dermatology and Venereology J. Eur. Acad. Dermatol. Venereol. 34, 800-809 (2020)
IL-17C amplifies epithelial inflammation in human psoriasis and atopic eczema.
2020 Review in Biochimica et Biophysica Acta - Gene Regulatory Mechanisms Biochim. Biophys. Acta-Gene Regul. Mech. 1863:194444 (2020)
Gene networks in cancer are biased by aneuploidies and sample impurities.
2020 Review in New Phytologist New Phytol. 225, 1828-1834 (2020)
Recommendations on terminology and experimental best practice associated with plant nitric oxide research.
2020 Wissenschaftlicher Artikel in European Journal of Nutrition Eur. J. Nutr. 59, 1357-1369 (2020)
Modifying effect of metabotype on diet-diabetes associations.
2020 Wissenschaftlicher Artikel in Thorax Thorax 75, 184-187 (2020)
Altered relaxation times in MRI indicate bronchopulmonary dysplasia.
2020 Wissenschaftlicher Artikel in Briefings in Bioinformatics Brief. Bioinform. 21, 272-281 (2020)
Copy number aberrations from Affymetrix SNP 6.0 genotyping data-how accurate are commonly used prediction approaches?
In: Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. 2019. 309-347
Omics: Potential role in early phase drug development.
2019Poster: Intestinal organoids - from stem cells to metabolism and microbiome interactions, 29 September 2019, Kopenhagen. (2019)
Gradual pioneer factor expression resolves enteroendocrine lineage recruitment from intestinal stem cells.
2019 Meeting abstract in European Neuropsychopharmacology : ENP Eur. Neuropsychopharmacol. 29, S7-S8 (2019)
Brain organoids as models of the developing human brain: deciphering the molecular signature of prenatal stress.
2019 GigaScience GigaScience 8:giz162 (2019)
A network-based conditional genetic association analysis of the human metabolome (vol 7, gij137, 2018).
2019 Meeting abstract in Glia Glia 67, E689-E690 (2019)
Tlr2 and Cxcr3 pathways modulate scar formation after traumatic brain injury.
2019 Meeting abstract in Glia Glia 67, E693-E693 (2019)
Injury-induced plasticity of parenchymal astrocytes in the human cerebral cortex.
2019 Meeting abstract in Glia Glia 67, E758-E758 (2019)
Lrp1 loss in radial glia and their progeny - astrocytic dysfunctions contribute to spontaneous epileptogenesis.
2019 Journal of the European Academy of Dermatology and Venereology J. Eur. Acad. Dermatol. Venereol. 33, 2380-2380 (2019)
Is the humoral immunity dispensable for the pathogenesis of psoriasis? (vol 33, pg 115, 2019).
2019 Sonstiges: Meinungsartikel in Informatik-Spektrum Inf.-Spektrum, DOI: 10.1007/s00287-019-01220-y (2019)
Munich School for Data Science (MUDS) – Eine Graduiertenschule für Data Science in München.
2019 Wissenschaftlicher Artikel in Nature Plants Nat. Plants 5, 1237-1249 (2019)
Widespread long-range cis-regulatory elements in the maize genome.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:5121 (2019)
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.
2019 Wissenschaftlicher Artikel in Nature machine intelligence Nat. Mach. Intell. 1, 538-544 (2019)
Human-level recognition of blast cells in acute myeloid leukemia with convolutional neural networks.
2019 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11764 LNCS, 676-684 (2019)
Multi-task learning of a deep K-nearest neighbour network for histopathological image classification and retrieval.
2019 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11764 LNCS, 685-693 (2019)
Multiclass deep active learning for detecting red blood cell subtypes in brightfield microscopy.
2019 Nature Structural & Molecular Biology Nat. Struct. Mol. Biol., DOI: 10.1038/s41594-019-0341-8 (2019)
Author Correction: G-tract RNA removes Polycomb repressive complex 2 from genes (Nature Structural & Molecular Biology, (2019), 26, 10, (899-909), 10.1038/s41594-019-0293-z).
In: (Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2019, 23-27 June 2019, Munich, Germany). 2019.:8871546
Broadband IR-fingerprinting of human blood as a universal tool for diseases diagnostics.
2019 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep. 20:e47952 (2019)
Expression and phase separation potential of heterochromatin proteins during early mouse development.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:4957 (2019)
Associations of autozygosity with a broad range of human phenotypes.
2019 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 76, 531-545.e5 (2019)
Cistromic reprogramming of the diurnal glucocorticoid hormone response by high-fat diet.
2019 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 60 (2019)
Predicting retinal thickness from fundus images across modalities using deep learning.
2019 Wissenschaftlicher Artikel in Genome Biology Genome Biol. 20:225 (2019)
Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues.
2019 Meeting abstract in Multiple Sclerosis Journal Mult. Scler. J. 25, 906-907 (2019)
Identification of functionally relevant genetic variants associated with multiple sclerosis using deep learning.
2019 Meeting abstract in Xenotransplantation Xenotransplantation 26 (2019)
Studying in vivo beta cell maturation in pigs by scRNAseq.
2019 Editorial in Development / Company of Biologists Development 146:dev185025 (2019)
Chromatin and epigenetics in development: A Special Issue.
2019 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 26, 899-909 (2019)
G-tract RNA removes Polycomb repressive complex 2 from genes.
Lecture Notes in Computer Science In:. 2019. 184-186 (Lect. Notes Comput. Sc. ; 11729 LNCS)
In-silico staining from bright-field and fluorescent images using deep learning.
2019 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11731 LNCS, 289-298 (2019)
Quantifying structural heterogeneity of healthy and cancerous mitochondria using a combined segmentation and classification USK-net.
2019 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11728 LNCS, 673-686 (2019)
Evaluation of domain adaptation approaches for robust classification of heterogeneous biological data sets.
2019 Editorial in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11731 LNCS, v-vii (2019)
Preface.
2019 Meeting abstract in European Journal of Immunology Eur. J. Immunol. 49, 48-48 (2019)
Identification of a DC precursor population with pDC and cDC potential responding to endosomal TLR stimulation with increased pDC output.
2019 Meeting abstract in European Journal of Immunology Eur. J. Immunol. 49, 88-88 (2019)
Analysis of EV-decorated CD8+T cells during viral infection.
2019 Wissenschaftlicher Artikel in Molecular Metabolism Mol. Metab. 30, 16-29 (2019)
Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro.
2019 Editorial in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11729 LNCS, v-vii (2019)