ISBM develops and deploys next-generation biotechniques for molecular sensing and actuation of distributed cellular processes to reverse engineer cell-circuit function and guide future cell therapies.

The research of ISBM focuses on three synergistic areas: 

Truong, D.-J.J., Phlairaharn, T., Eßwein, B., Gruber, C., Tümen, D., Baligács, E., Armbrust, N., Vaccaro, F.L., Lederer, E.-M., Beck, E.M., Geilenkeuser, J., Göppert, S., Krumwiede, L., Grätz, C., Raffl, G., Schwarz, D., Zirngibl, M., Živanić, M., Beyer, M., Körner, J.D., Santl, T., Evsyukov, V., Strauß, T., Schwarz, S.C., Höglinger, G.U., Heutink, P., Doll, S., Conrad, M., Giesert, F., Wurst, W., Westmeyer, G.G., 2021. Non-invasive and high-throughput interrogation of exon-specific isoform expression. Nat Cell Biol 1–12. doi:10.1038/s41556-021-00678-x

Bodea, S.-V., Westmeyer, G.G., 2021. Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and Its Applications in Neuroscience. Frontiers in Neuroscience 15, 655247. doi:10.3389/fnins.2021.655247

Farhadi, A., Sigmund, F., Westmeyer, G.G., Shapiro, M.G. Genetically encodable materials for non-invasive biological imaging. Nature Materials (2021).  doi:10.1038/s41563-020-00883-3

Grosch, M., Rusha, E., Ori, C., Truong, D.J.J., O'Neill, A.C., Pertek, A., Westmeyer, G.G., Drukker, M. Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation. BMC Biol. 18:42 (2020). doi:10.1186/s12915-020-00770-y

Shams, S.F., Ghazanfari, M.R., Pettinger, S., Tavabi, A.H., Siemensmeyer, K., Smekhova, A., Dunin-Borkowski, R.E., Westmeyer, G.G., Schmitz-Antoniak, C. Structural perspective on revealing heat dissipation behavior of CoFe 2 O 4 –Pd nanohybrids: great promise for magnetic fluid hyperthermia. Phys Chem Chem Phys 22, 26728–26741. (2020)doi:10.1039/d0cp02076a

Gabashvili, A.N., Chmelyuk, N.S., Efremova, M.V., Malinovskaya, J.A., Semkina, A.S., Abakumov, M.A. Encapsulins-bacterial protein nanocompartments: Structure, properties, and application. Biomolecules 10:966 (2020). doi:10.3390/biom10060966

Stefanoiu, A., Page, J., Symvoulidis, P., Westmeyer, G.G., Lasser, T. Artifact-free deconvolution in light field microscopy. Optics Express 27, 31644–31666 (2019). doi:10.1364/OE.27.031644

Sigmund, F., Pettinger,S., Kube, M., Schneider, F., Schifferer, M., Schneider, S., Efremova, M., Pujol-Martí, J., Aichler, M., Walch, A., Misgeld, T., Dietz, H., Westmeyer, G.G. Iron-Sequestering Nanocompartments as Multiplexed Electron Microscopy Gene Reporters. ACS Nano 13, 8114–8123 (2019). doi:10.1021/acsnano.9b03140

Lauri, A., Soliman, D., Omar,M., Stelzl, A., Ntziachristos, V., Westmeyer, G.G. Whole-cell photoacoustic sensor based on pigmentrelocalization. ACS Sensors 4, 603-612 (2019). doi:10.1021/acssensors.8b01319

Dang, K.M., Rinklin, P., Afanasenkau, D., Westmeyer, G., Schürholz, T., Wiegand, S., Wolfrum, B. Chip‐Based Heat Stimulation for Modulating Signal Propagation in HL‐1 Cell Networks. Advanced Biosystems 39, 1800138 (2018). doi:10.1002/adbi.201800138

Sigmund, F., Massner, C., Erdmann, P., Stelzl, A., Rolbieski, H., Desai, M., Bricault, S., Wörner, T.P., Snijder, J., Geerlof, A., Fuchs, H., Hrabĕ de Angelis, M., Heck, A.J.R., Jasanoff, A., Ntziachristos, V., Plitzko J., Westmeyer, G.G. Bacterial encapsulins as orthogonal compartments for mammalian cell engineering. Nature Communications 9 (2018), DOI: 10.1038/s41467-018-04227-3

Massner, C., Sigmund, F., Pettinger, S., Seeger, M., Hartmann, C., Ivleva, N.P., Niessner, R., Fuchs, H., Hrabě de Angelis, M., Stelzl, A., Koonakampully, N.L., Rolbieski, H., Wiedwald, U., Spasova, M., Wurst, W., Ntziachristos, V., Winklhofer, M., Westmeyer, G.G. Genetically Controlled Lysosomal Entrapment of Superparamagnetic Ferritin for Multimodal and Multiscale Imaging and Actuation with Low Tissue Attenuation. Advanced Functional Materials 13 March 2018 (2018) doi.org/10.1002/adfm.201706793

Myklatun, A., Lauri, A., Eder, S.H.K., Cappetta, M., Shcherbakov, D., Wurst, W., Winklhofer, M., Westmeyer, G.G. Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception. Nat Commun 9, 802. (2018) doi:10.1038/s41467-018-03090-6

Myklatun A., Cappetta M., Winklhofer M., Ntziachristos V., Westmeyer G.G. Microfluidic sorting of intrinsically magnetic cells under visual control Sci Rep. 2017; 7: 6942. (2017) doi:  10.1038/s41598-017-06946-x

Symvoulidis P., Lauri A., Stefanoiu A., Cappetta M., Schneider S., Jia H., Stelzl A., Koch M., Perez C.C., Myklatun A., Renninger S., Chmyrov A., Lasser T., Wurst W., Ntziachristos V., Westmeyer G.G. NeuBtracker—imaging neurobehavioral dynamics in freely behaving fish, Nat Methods. 2017 Oct 2. (2017) doi: https://doi.org/10.1038/nmeth.4459

Roberts S., Seeger M., Jiang Y., Mishra A., Sigmund F., Stelzl A., Lauri A., Symvoulidis P., Rolbieski H., Preller M., Deán Ben X.L., Razansky D., Orschmann T., Desbordes S., Vetschera P., Bach T., Ntziachristos V., Westmeyer G.G. Calcium Sensor for Photoacoustic Imaging J. Am. Chem. Soc., Just Accepted Manuscript (2017) doi: 10.1021/jacs.7b03064

Mishra, A, Pariani, G., Oerther T., Schwaiger, M., Westmeyer, G. G. Hyperpolarized Multi-Metal 13C-Sensors for Magnetic Resonance Imaging. Anal. Chem., Article ASAP, (2016), doi: 10.1021/acs.analchem.6b03546

Mishra A, Jiang Y., Roberts S., Ntziachristos V,. Westmeyer G. G. Near-infrared photoacoustic imaging probe responsive to calcium, Anal. Chem., Article ASAP, (2016), doi: 10.1021/acs.analchem.6b03039

Fiallos A., Bricault S., Cai L., Worku H., Colonnese M., Westmeyer G. G., Jasanoff A. Reward magnitude tracking by neural populations in ventral striatum, NeuroImage, (2016), doi: 10.1016/j.neuroimage.2016.10.036

Deán-Ben, X., Sela, G., Lauri, A., Kneipp, M., Ntziachristos, V., Westmeyer, G. G., Shoham S., Razansky, D. Functional optoacoustic neuro-tomography (FONT) for scalable whole-brain monitoring of calcium indicators. Light: Science & Applications,  (2016), doi: 10.1038/lsa.2016.201

Jiang, Y., Sigmund, F., Reber, J., Deán-Ben, X. L., Glasl, S., Kneipp, M., Estrada, H., Razansky, D., Ntziachristos, V., and Westmeyer, G. G., Violacein as a genetically-controlled, enzymatically amplified and photobleaching-resistant chromophore for optoacoustic bacterial imaging, Sci Rep 5, (2015), doi: 10.1038/srep11048

Stiel, A. C., Deán-Ben, X. L., Jiang, Y., Ntziachristos, V., Razansky, D., and Westmeyer, G. G High-contrast imaging of reversibly switchable fluorescent proteins via temporally unmixed multispectral optoacoustic tomography Optics letters 40, 367–370 (2015), doi: 10.1364/OL.40.000367

Westmeyer, G. G., Emer, Y., Lintelmann, J., & Jasanoff, A. MRI-Based Detection of Alkaline Phosphatase Gene Reporter Activity Using a Porphyrin Solubility Switch. Chemistry & Biology. (2014), doi: 10.1016/j.chembiol.2014.01.012

Westmeyer, G. G., Durocher, Y., and Jasanoff, A. A secreted enzyme reporter system for MRI, Angew Chem Int Ed Engl, 49: 3909-3911 (2010), doi: 10.1002/anie.200906712

Shapiro*, M. G., Westmeyer*, G. G., Romero, P. A., Szablowski, J. O., Kuster, B., Shah, A., Otey, C. R., Langer, R., Arnold, F. H., and Jasanoff, A. Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine, Nat Biotechnol 28: 264-270; (2010), doi: 10.1038/nbt.1609

Westmeyer, G. G., and Jasanoff, A. Genetically controlled MRI contrast mechanisms and their prospects in systems neuroscience research, Magn Reson Imaging 25: 1004-1010 (2007), doi: 10.1016/j.mri.2006.11.027

Shapiro, M. G., Atanasijevic, T., Faas, H., Westmeyer, G. G., and Jasanoff, A. Dynamic imaging with MRI contrast agents: quantitative considerations, Magn Reson Imaging 24: 449-462 (2006), doi: 10.1016/j.mri.2005.12.033

Westmeyer, G. G., Willem, M., Lichtenthaler, S. F., Lurman, G., Multhaup, G., Assfalg-Machleidt, I., Reiss, K., Saftig, P., and Haass, C. Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme, J Biol Chem, 279: 53205-53212 (2006), doi: 10.1074/jbc.M410378200