Scientific Focus
ISBM develops and deploys next-generation biotechniques for molecular sensing and actuation of distributed cellular processes to reverse engineer cell-circuit function and guide future cell therapies.
The research of ISBM focuses on three synergistic areas:
Team
Image | Name | Job Title | Telephone | Building/Room | |
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Prof. Dr. Westmeyer, Gil Gregor |
Director | +49 (0) 89 3187 2123 | 35.32/202 | |
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Ammer, Anja |
Laboratory manager | +49(0)89 3187 2157 | 35.32/201 | |
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Armbrust, Niklas |
Ph.D. student | 3532 / 003 | ||
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MD Bodea, Silviu-Vasile |
Ph.D. student | +49 (0) 89 3187 49429 | 35.32/207 | |
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Berezin, Oleksandr |
Ph.D. student | +49 (0) 89 3187 49429 | 35.32/207 | |
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Dr. Efremova, Mariia |
Postdoctoral Fellow | +49 (0) 89 3187 43488 | 35.32/207 | |
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Geilenkeuser, Julian |
Master Student | 35.32/003 | ||
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Piovesan, Alberto |
Ph.D. student | +49 (0) 89 3187 43026 | 35.32/208 | |
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Santl, Tobias |
Trainee | 35.32/003 | ||
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Scherbauer, Thomas |
HiWi | 35.32/001 | ||
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Dr. Sigmund, Felix |
Group Leader | +49 (0)89 3187 2217 | 35.32/201 | |
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Dr. Truong, Dong-Jiunn Jeffery |
Group Leader | +49 (0) 89 3187 3560 | 3532/003 | |
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Winkler, Stefanie |
Technical Assistant | +49 89 3187 43023 | 35.32/208 |
Publications
Truong, D.-J.J., Phlairaharn, T., Eßwein, B., Gruber, C., Tümen, D., Baligács, E., Armbrust, N., Vaccaro, F.L., Lederer, E.-M., Beck, E.M., Geilenkeuser, J., Göppert, S., Krumwiede, L., Grätz, C., Raffl, G., Schwarz, D., Zirngibl, M., Živanić, M., Beyer, M., Körner, J.D., Santl, T., Evsyukov, V., Strauß, T., Schwarz, S.C., Höglinger, G.U., Heutink, P., Doll, S., Conrad, M., Giesert, F., Wurst, W., Westmeyer, G.G., 2021. Non-invasive and high-throughput interrogation of exon-specific isoform expression. Nat Cell Biol 1–12. doi:10.1038/s41556-021-00678-x
Bodea, S.-V., Westmeyer, G.G., 2021. Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and Its Applications in Neuroscience. Frontiers in Neuroscience 15, 655247. doi:10.3389/fnins.2021.655247
Farhadi, A., Sigmund, F., Westmeyer, G.G., Shapiro, M.G. Genetically encodable materials for non-invasive biological imaging. Nature Materials (2021). doi:10.1038/s41563-020-00883-3
Grosch, M., Rusha, E., Ori, C., Truong, D.J.J., O'Neill, A.C., Pertek, A., Westmeyer, G.G., Drukker, M. Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation. BMC Biol. 18:42 (2020). doi:10.1186/s12915-020-00770-y
Shams, S.F., Ghazanfari, M.R., Pettinger, S., Tavabi, A.H., Siemensmeyer, K., Smekhova, A., Dunin-Borkowski, R.E., Westmeyer, G.G., Schmitz-Antoniak, C. Structural perspective on revealing heat dissipation behavior of CoFe 2 O 4 –Pd nanohybrids: great promise for magnetic fluid hyperthermia. Phys Chem Chem Phys 22, 26728–26741. (2020)doi:10.1039/d0cp02076a
Gabashvili, A.N., Chmelyuk, N.S., Efremova, M.V., Malinovskaya, J.A., Semkina, A.S., Abakumov, M.A. Encapsulins-bacterial protein nanocompartments: Structure, properties, and application. Biomolecules 10:966 (2020). doi:10.3390/biom10060966
Stefanoiu, A., Page, J., Symvoulidis, P., Westmeyer, G.G., Lasser, T. Artifact-free deconvolution in light field microscopy. Optics Express 27, 31644–31666 (2019). doi:10.1364/OE.27.031644
Sigmund, F., Pettinger,S., Kube, M., Schneider, F., Schifferer, M., Schneider, S., Efremova, M., Pujol-Martí, J., Aichler, M., Walch, A., Misgeld, T., Dietz, H., Westmeyer, G.G. Iron-Sequestering Nanocompartments as Multiplexed Electron Microscopy Gene Reporters. ACS Nano 13, 8114–8123 (2019). doi:10.1021/acsnano.9b03140
Lauri, A., Soliman, D., Omar,M., Stelzl, A., Ntziachristos, V., Westmeyer, G.G. Whole-cell photoacoustic sensor based on pigmentrelocalization. ACS Sensors 4, 603-612 (2019). doi:10.1021/acssensors.8b01319
Dang, K.M., Rinklin, P., Afanasenkau, D., Westmeyer, G., Schürholz, T., Wiegand, S., Wolfrum, B. Chip‐Based Heat Stimulation for Modulating Signal Propagation in HL‐1 Cell Networks. Advanced Biosystems 39, 1800138 (2018). doi:10.1002/adbi.201800138Sigmund, F., Massner, C., Erdmann, P., Stelzl, A., Rolbieski, H., Desai, M., Bricault, S., Wörner, T.P., Snijder, J., Geerlof, A., Fuchs, H., Hrabĕ de Angelis, M., Heck, A.J.R., Jasanoff, A., Ntziachristos, V., Plitzko J., Westmeyer, G.G. Bacterial encapsulins as orthogonal compartments for mammalian cell engineering. Nature Communications 9 (2018), DOI: 10.1038/s41467-018-04227-3
Massner, C., Sigmund, F., Pettinger, S., Seeger, M., Hartmann, C., Ivleva, N.P., Niessner, R., Fuchs, H., Hrabě de Angelis, M., Stelzl, A., Koonakampully, N.L., Rolbieski, H., Wiedwald, U., Spasova, M., Wurst, W., Ntziachristos, V., Winklhofer, M., Westmeyer, G.G. Genetically Controlled Lysosomal Entrapment of Superparamagnetic Ferritin for Multimodal and Multiscale Imaging and Actuation with Low Tissue Attenuation. Advanced Functional Materials 13 March 2018 (2018) doi.org/10.1002/adfm.201706793
Myklatun, A., Lauri, A., Eder, S.H.K., Cappetta, M., Shcherbakov, D., Wurst, W., Winklhofer, M., Westmeyer, G.G. Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception. Nat Commun 9, 802. (2018) doi:10.1038/s41467-018-03090-6
Myklatun A., Cappetta M., Winklhofer M., Ntziachristos V., Westmeyer G.G. Microfluidic sorting of intrinsically magnetic cells under visual control Sci Rep. 2017; 7: 6942. (2017) doi: 10.1038/s41598-017-06946-x
Symvoulidis P., Lauri A., Stefanoiu A., Cappetta M., Schneider S., Jia H., Stelzl A., Koch M., Perez C.C., Myklatun A., Renninger S., Chmyrov A., Lasser T., Wurst W., Ntziachristos V., Westmeyer G.G. NeuBtracker—imaging neurobehavioral dynamics in freely behaving fish, Nat Methods. 2017 Oct 2. (2017) doi: https://doi.org/10.1038/nmeth.4459
Roberts S., Seeger M., Jiang Y., Mishra A., Sigmund F., Stelzl A., Lauri A., Symvoulidis P., Rolbieski H., Preller M., Deán Ben X.L., Razansky D., Orschmann T., Desbordes S., Vetschera P., Bach T., Ntziachristos V., Westmeyer G.G. Calcium Sensor for Photoacoustic Imaging J. Am. Chem. Soc., Just Accepted Manuscript (2017) doi: 10.1021/jacs.7b03064
Mishra, A, Pariani, G., Oerther T., Schwaiger, M., Westmeyer, G. G. Hyperpolarized Multi-Metal 13C-Sensors for Magnetic Resonance Imaging. Anal. Chem., Article ASAP, (2016), doi: 10.1021/acs.analchem.6b03546
Mishra A, Jiang Y., Roberts S., Ntziachristos V,. Westmeyer G. G. Near-infrared photoacoustic imaging probe responsive to calcium, Anal. Chem., Article ASAP, (2016), doi: 10.1021/acs.analchem.6b03039
Fiallos A., Bricault S., Cai L., Worku H., Colonnese M., Westmeyer G. G., Jasanoff A. Reward magnitude tracking by neural populations in ventral striatum, NeuroImage, (2016), doi: 10.1016/j.neuroimage.2016.10.036
Deán-Ben, X., Sela, G., Lauri, A., Kneipp, M., Ntziachristos, V., Westmeyer, G. G., Shoham S., Razansky, D. Functional optoacoustic neuro-tomography (FONT) for scalable whole-brain monitoring of calcium indicators. Light: Science & Applications, (2016), doi: 10.1038/lsa.2016.201
Jiang, Y., Sigmund, F., Reber, J., Deán-Ben, X. L., Glasl, S., Kneipp, M., Estrada, H., Razansky, D., Ntziachristos, V., and Westmeyer, G. G., Violacein as a genetically-controlled, enzymatically amplified and photobleaching-resistant chromophore for optoacoustic bacterial imaging, Sci Rep 5, (2015), doi: 10.1038/srep11048
Stiel, A. C., Deán-Ben, X. L., Jiang, Y., Ntziachristos, V., Razansky, D., and Westmeyer, G. G High-contrast imaging of reversibly switchable fluorescent proteins via temporally unmixed multispectral optoacoustic tomography Optics letters 40, 367–370 (2015), doi: 10.1364/OL.40.000367
Westmeyer, G. G., Emer, Y., Lintelmann, J., & Jasanoff, A. MRI-Based Detection of Alkaline Phosphatase Gene Reporter Activity Using a Porphyrin Solubility Switch. Chemistry & Biology. (2014), doi: 10.1016/j.chembiol.2014.01.012
Westmeyer, G. G., Durocher, Y., and Jasanoff, A. A secreted enzyme reporter system for MRI, Angew Chem Int Ed Engl, 49: 3909-3911 (2010), doi: 10.1002/anie.200906712
Shapiro*, M. G., Westmeyer*, G. G., Romero, P. A., Szablowski, J. O., Kuster, B., Shah, A., Otey, C. R., Langer, R., Arnold, F. H., and Jasanoff, A. Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine, Nat Biotechnol 28: 264-270; (2010), doi: 10.1038/nbt.1609
Westmeyer, G. G., and Jasanoff, A. Genetically controlled MRI contrast mechanisms and their prospects in systems neuroscience research, Magn Reson Imaging 25: 1004-1010 (2007), doi: 10.1016/j.mri.2006.11.027
Shapiro, M. G., Atanasijevic, T., Faas, H., Westmeyer, G. G., and Jasanoff, A. Dynamic imaging with MRI contrast agents: quantitative considerations, Magn Reson Imaging 24: 449-462 (2006), doi: 10.1016/j.mri.2005.12.033
Westmeyer, G. G., Willem, M., Lichtenthaler, S. F., Lurman, G., Multhaup, G., Assfalg-Machleidt, I., Reiss, K., Saftig, P., and Haass, C. Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme, J Biol Chem, 279: 53205-53212 (2006), doi: 10.1074/jbc.M410378200