Sarah Kim-Hellmuth

Group Leader Immunogenomics

+49 89 3187 48956 sarah.kim-hellmuth@helmholtz-muenchen.de Website

Gebäude / Raum: 3533/218

Sarah Kim-Hellmuth received her MD from the LMU and TU Munich. She was trained as a postdoctorate fellow in immunology and underwent her specialist training as a Clinical Geneticist at the University of Bonn. Combining her research interests both in immunology and human genetics, Sarah pioneered the study of genetic effects on gene expression that influence the human immune response to pathogens. In 2015, she joined Tuuli Lappalainen at the New York Genome Center and Columbia University as a computational postdoctorate fellow. During her postdoc, Sarah was a lead analyst in the Genotype-Tissue Expression (GTEx) Consortium focussing on the context-specificity (tissue-, cell type-, sex-specificity) of QTLs and how they elucidate the molecular mechanisms of genetic associations to complex diseases and traits.

Sarah is presently leading an Emmy Noether Research Group at the Institute of Translational Genomics at Helmholtz Munich and the Dr. von Hauner Children’s Hospital of the LMU, where she and her team study the genetic basis of human immune response variation and its effects on cellular functions linked to immune-related diseases.

Since 2022

at the Institute of Translational Genomics, Helmholtz Munich and the Dr. von Hauner Children’s Hospital, University Hospital LMU Munich

Since 2021

at the Institute of Translational Genomics, Helmholtz Munich

Since 2020

at the Dr. von Hauner Children’s Hospital, University Hospital LMU Munich, and Munich Child Health Alliance

2021

(This competitive award funded the first year of my group and was replaced by the more generous Emmy Noether programme)

2015 - 2019

at the New York Genome Center and Columbia University, Lead analyst of Genotype-Tissue Expression (GTEx) consortium, and subgroup leader of the cell type composition analysis team

2011 - 2015

at the Institute of Human Genetics and Institute for Clinical Chemistry and Clinical Pharmacology, University of Bonn

Guest researcher at Statistical Genetics, Max-Planck-Institute of Psychiatry, Munich

2009 - 2011

at the Institute for Clinical Chemistry and Clinical Pharmacology, University of Bonn

2023 - Ingrid zu Solms Award for Medicine
2022 - ERC Starting Grant
2022 - Member of the Junge Akademie
2022 - Friedmund Neumann Prize, Schering Stiftung
2022 - Science Award for Basic Medical Research, GlaxoSmithKline Foundation
2022 - Emmy Noether Programme, German Research Foundation
2021 - Helmholtz Young Investigator Group
2021 - Adalbert Czerny Award, German Society of Pediatrics and Adolescent Medicine
2020 - Reinhard-Frank/Care-for-Rare Fellowship
2017 - Marie Skłodowska-Curie Individual Global Fellowship, European Commission
2017 - ASHG/Charles J. Epstein Trainee Award for Excellence in Human Genetics Research – Semifinalist
2016 - Postdoctoral fellowship, German Research Foundation
2016 - Dissertation Award, Münchener Universitätsgesellschaft

Variante: Gold Star Awards Luxury Background — Gold Star Awards Luxury Background

GTEx Consortium (Lead Analyst)

The GTEx Consortium atlas of genetic regulatory effects across human tissues

Kim-Hellmuth, S.*, Aguet, F.*, Oliva, M., Muñoz-Aguirre, M., Kasela, S., Wucher, V., Castel, S. E., Hamel, A. R., Viñuela, A., Roberts, A. L., Mangul, S., Wen, X., Wang, G., Barbeira, A. N., Garrido-Martin, D., Nadel, B., Zou, Y., Bonazzola, R., Quan, J., Brown, A., Martinez-Perez, A., Soria, J. M., GTEx Consortium, Getz, G., Dermitzakis, E., Small, K. S., Stephens, M., Xi, H. S., Im, H. K., Guigó, R., Segre, A. V., Stranger, B. E., Ardlie, K. G. & Lappalainen, T. *contributed equally

Cell type-specific genetic regulation of gene expression across human tissues

Oliva, M.*, Muñoz-Aguirre, M.*, Kim-Hellmuth, S.*, Wucher, V., Gewirtz, A., Cotter, D., Parsana, P., Kasela, S., Balliu, B., Viñuela, A., Castel, S. E., Mohammadi, P., Aguet, F., Zou, Y., Khramtsova, E., Skol, A., Garrido-Martin, D., Reverter, F., Brown, A., Evans, P., Gamazon, E., Payne, A., Bonazzola, R., Barbeira, A. N., Hamel, A. R., Martinez-Perez, A., Soria, J. M., GTEx Consortium, Pierce, B., Stephens, M., Eskin, E., Dermitzakis, E., Segre, A. V., Im, H. K., Engelhardt, B., Ardlie, K. G., Montegomery, S., Battle, A., Lappalainen, T., Guigó, R. & Stranger, B. E. *contributed equally

The impact of sex on gene expression across human tissues

Kim-Hellmuth, S., Bechheim, M., Pütz, B., Mohammadi, P., Nédélec, Y., Giangreco, N., Becker, J., Kaiser, V., Fricker, N., Beier, E., Boor, P., Castel, S. E., Nöthen, M. M., Barreiro, L. B., Pickrell, J. K., Müller-Myhsok, B., Lappalainen, T., Schumacher, J. & Hornung, V.

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations

Kim, S., Becker, J., Bechheim, M., Kaiser, V., Noursadeghi, M., Fricker, N., Beier, E., Klaschik, S., Boor, P., Hess, T., Hofmann, A., Holdenrieder, S., Wendland, J. R., Fröhlich, H., Hartmann, G., Nöthen, M. M., Müller-Myhsok, B., Pütz, B., Hornung, V. & Schumacher, J.

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

Dr., med. Sarah Kim-Hellmuth

Academic Career and Research Areas

Professional Background

Emmy Noether Research Group Leader

Group Leader Immunogenomics

Principal Investigator of Ped-COVID-19 study

Helmholtz Young Investigator Group Leader

Postdoctoral Scientist

Research Fellow

MD Thesis Research Fellow

Honors and Awards

Publications

Affiliations

LMU Klinikum