Aberrant cell death is the hallmark of organ failure, neurodegenerative disease and cancer. The recognition of distinct regulated cell death pathways thus presents tantalizing possibilities for gaining control over life and death decisions made by cells to both prevent (age-dependent) degenerative diseases and to fight cancer. As such, understanding the metabolic and genetic determinants underlying these cell death modalities enables us to develop novel tools and drugs to specifically modulate cell death in order to prevent these often yet incurable diseases. read more ...