Dr. Andreas Ruepp
Group Leader, Institute of Experimental Genetics, Research Group ‘Biocuration for Digital Health’A large body of information that was generated in decades of experimental research is waiting in the scientific literature to be presented in a comprehensive way.
A large body of information that was generated in decades of experimental research is hidden in the scientific literature.
Academic Career and Research Areas
Andreas is a microbiologist by training and obtained a PhD at the Max-Planck Institute of Biochemistry/Ludwig-Maximilians University Munich. After completing his PhD, Andreas joined the department of Prof. Wolfgang Baumeister at the Max-Planck Institute of Biochemistry. There, he sequenced the complete genome of the archaeon Thermoplasma acidophium. In the following two years, he worked a senior scientist at the biotech company Epidaurus GmbH. In 2001, Andreas joined Helmholtz Munich as group leader at the institute of Bioinformatics and Systems Biology. He initiated the generation of databases such as CORUM which is the gold standard for protein complex analysis. A second focus of his work are disease-related interaction networks that are used for the interpretation of experimental data. In 2019, his group moved to the Institute of Experimental Genetics. Recently, he and his group were involved in the analysis of 705 new genes from the IMPC which were found to be associated with cardiac dysfunction.
Fields of Work and Expertise
BiocurationManual AnnotationDatabasesNetwork MedicineProtein ComplexesGenome Annotation
Highlight Publications
See all Publications of Andreas RueppNucleic Acids Res., DOI: 10.1093/nar/gkac1015 (2022)
CORUM: the comprehensive resource of mammalian protein complexes–2022
Nature 407, pages 508–513 (2000)
The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum
Genome Biol. 11:R6 (2010)
PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes
Genome Biol. 11:R6 (2010)
CIDeR: multifactorial interaction networks in human diseases
Orphanet J. Rare Dis. 13:22 (2018)
PhenoDis: a comprehensive database for phenotypic characterization of rare cardiac diseases