Insulin Signalling in Beta Cells

Our discovery of inceptor, a novel and druggable insulin inhibitory receptor, is a significant milestone for diabetes research as the scientific community celebrates 100 years of insulin and 50 years of insulin receptor discovery. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission.

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Our discovery of inceptor, a novel and druggable insulin inhibitory receptor, is a significant milestone for diabetes research as the scientific community celebrates 100 years of insulin and 50 years of insulin receptor discovery. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission.

Follow us on X

Our discovery of inceptor, a novel and druggable insulin inhibitory receptor, is a significant milestone for diabetes research as the scientific community celebrates 100 years of insulin and 50 years of insulin receptor discovery. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission.

Model of insulin inhibitory receptor 'inceptor' (in black) desensetizing the insulin recptor (in color) on a pancreatic beta cell. Insulin in blue.

Dr. Ralph Böttcher

Team Leader Insulin Signalling in Beta Cells

Prof. Dr. Thomas Floss

Dr. Prisca Chapouton

Senior Scientist Insulin Signalling in Beta Cells

Dr. Alessandro Dema

Senior Postdoc Insulin Signalling in Beta Cells, IDR

Dr. Ana Gabriela Acosta Montalvo

Postdoc Insulin Signalling in Beta Cells

Verena Geiger

PhD Student

Sreya Bhattacharya

PhD Student Insulin Signalling in Beta Cells

Jin Feng

PhD Student Insulin Signalling in Beta Cells

Leopold Schomann

PhD Student Insulin Signalling in Beta Cells

Carola Eggert

TA Insulin Signalling in Beta Cells

Siehler J, Bilekova S, Chapouton P, Dema A, Albanese P, Tamara S, Jain C, Sterr M, Enos SJ, Chen C, Malhotra C, Villalba A, Schomann L, Bhattacharya S, Feng J, Akgün Canan M, Ribaudo F, Ansarullah, Burtscher I, Ahlbrecht C, Plettenburg O, Kurth T, Scharfmann R, Speier S, Scheltema RA, Lickert H

Inceptor binds to and directs insulin towards lysosomal degradation in β cells

Grandl G, Collden G, Feng J, Bhattacharya S, Klingelhuber F, Schomann L, Bilekova S, Ansarullah, Xu W, Fathi Far F, Tost M, Gruber T, Bastidas-Ponce A, Zhang Q, Novikoff A, Liskiewicz A, Liskiewicz D, Garcia-Caceres C, Feuchtinger A, Tschöp MH, Krahmer N, Lickert H#, Müller TD#

Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity

Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H

Inceptor counteracts insulin signalling in β-cells to control glycaemia

Wissmiller K, Bilekova S, Franko A, Lutz SZ, Katsburg M, Gulde S, Pellegata NS, Stenzl A, Heni M, Berti L, Häring HU, Lickert H

Inceptor correlates with markers of prostate cancer progression and modulates insulin/IGF1 signaling and cancer cell migration

Bilekova S, Garcia-Colomer B, Cebrian-Serrano A, Schirge S, Krey K, Sterr M, Kurth T, Hauck SM, Lickert H

Inceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility

Insulin Signalling in Beta Cells

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