Fernandez Lab

bronchiolus_querschnitt_helmholtz_1920x640px

Our scientific focus is to understand the contribution of the immune system to organ fibrosis. Fibrosis is a common final outcome of most chronic inflammatory diseases, especially chronic lung diseases.

Graphic illustration of lung fibrosis | Angelika Cramer

To date, as many as 45% of all deaths in the developed world are related to pathological tissue remodeling. Chronic lung diseases (CLD) are the 3rd leading cause of death worldwide. Among CLD, Pulmonary Fibrosis (PF) is a debilitating and incurable disease. Scaring of the lung leads to respiratory failure and 50% of patients die 3-5 years after diagnosis. Our understanding of the pathophysiology of PF is unfortunately limited to established and advanced stages when the extensive lung scaring is irreversible.

Human lung tissue under microscope view.

Functional assessment of interactions between mononuclear myeloid cells and lung structural cells
Identification of key ligand/receptor interactions in immune-structural lung cell crosstalk
Molecular characterization of in immune-structural lung cell interaction
Target evaluation in in-vitro models

Dr. Loredana Asarian

Scientist

Benteng Deng

PhD Student

Daniela Dietel

Lab Manager

Subhasree Dutta

PhD Student

Wei Han

PhD Student

Shaoping Hu

PhD Student

Jianlong Jia

PhD Student

Shuzhen Li

PhD Student

Lara Paulini

PhD Student

Elisabeth Schindler

Technical Assistant

Dmytro Sirokha

PhD Student

Vesa Stana

Doctoral candidate

Jia, J. ; Trassl, L. ; Kong, F. ; Deng, B. ; Liu, R. ; Sun, Z. ; Lan, X. ; Yildirim, A.Ö. ; Stathopoulos, G.T. ; Fernandez, I.E. ; Schamberger, A.C.

Improved survival of patients with stage III small-cell lung cancer with primary resection: A SEER-based analysis.

Mayr, C. ; Sengupta, A. ; Asgharpour, S. ; Ansari, M. ; Pestoni, J. ; Ogar, P. ; Angelidis, I. ; Liontos, A. ; Rodriguez-Castillo, J.A. ; Lang, N.J. ; Strunz, M. ; Porras-Gonzalez, D.L. ; Gerckens, M. ; De Sadeleer, L.J. ; Oehrle, B. ; Viteri-Alvarez, V. ; Fernandez, I.E. ; Tallquist, M. ; Irmler, M. ; Beckers, J. ; Eickelberg, O. ; Stoleriu, M.G. ; Behr, J. ; Kneidinger, N. ; Wuyts, W.A. ; Wasnick, R. ; Yildirim, A.Ö. ; Ahlbrecht, K. ; Morty, R.E. ; Samakovlis, C. ; Theis, F.J. ; Burgstaller, G. ; Schiller, H.

Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts.

Wang, X. ; Zhang, H. ; Wang, Y. ; Bramasole, L. ; Guo, K. ; Mourtada, F. ; Meul, T. ; Hu, Q. ; Viteri-Alvarez, V. ; Kammerl, I.E. ; Königshoff, M. ; Lehmann, M. ; Magg, T. ; Hauck, F. ; Fernandez, I.E. ; Meiners, S.

DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T-cell immunity.

Alessandrini, F. ; de Jong, R.J. ; Wimmer, M. ; Maier, A.-M. ; Fernandez, I.E. ; Hils, M. ; Buters, J.T.M. ; Biedermann, T. ; Zissler, U.M. ; Hoffmann, C. ; Esser-von Bieren, J. ; Schmidt-Weber, C.B. ; Ohnmacht, C.

Lung epithelial CYP1 activity regulates aryl hydrocarbon receptor dependent allergic airway inflammation.

Preisendörfer, S. ; Ishikawa, Y. ; Hennen, E. ; Winklmeier, S. ; Schupp, J.C. ; Knüppel, L. ; Fernandez, I.E. ; Binzenhöfer, L. ; Flatley, A. ; Juan-Guardela, B.M. ; Ruppert, C. ; Guenther, A. ; Frankenberger, M. ; Hatz, R.A. ; Kneidinger, N. ; Behr, J. ; Feederle, R. ; Schepers, A. ; Hilgendorff, A. ; Kaminski, N. ; Meinl, E. ; Bächinger, H.P. ; Eickelberg, O. ; Staab-Weijnitz, C.A.

FK506-binding protein 11 is a novel plasma cell-specific antibody folding catalyst with increased expression in idiopathic pulmonary fibrosis.

Fernandez Lab

Our scientific focus is to understand the contribution of the immune system to organ fibrosis. Fibrosis is a common final outcome of most chronic inflammatory diseases, especially chronic lung diseases.

Our scientific focus is to understand the contribution of the immune system to organ fibrosis. Fibrosis is a common final outcome of most chronic inflammatory diseases, especially chronic lung diseases.

On This Page

Fibrosis - Incurable with limited therapies

Project details

Scientists at Fernandez Lab

Publications

Contact