Publications
Liu, N. ; O'Connor, P. ; Gujrati, V. ; Gorpas, D. ; Glasl, S. ; Blutke, A. ; Walch, A.K. ; Kleigrewe, K. ; Sattler, M. ; Plettenburg, O. ; Ntziachristos, V.
Facile synthesis of a croconaine-based nanoformulation for optoacoustic imaging and photothermal therapy.Albanese, M. ; Chen, Y.-F. A. ; Hüls, C. ; Gärtner, K. ; Tagawa, T. ; Mejias-Perez, E. ; Keppler, O.T. ; Göbel,C. ; Zeidler, R. ; Shein, M. ; Schütz, A.K. ; Hammerschmidt, W.
MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells.Lopez, A. ; Dahiya, V. ; Delhommel, F. ; Freiburger, L. ; Stehle, R. ; Asami, S. ; Rutz, D. ; Blair, L. ; Buchner, J. ; Sattler, M.
Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network.Li, M. ; Gaussmann, S. ; Tippler, B. ; Ott, J.J. ; Popowicz, G.M. ; Schliebs, W. ; Sattler, M. ; Erdmann, R. ; Kalel, V.C.
Novel trypanocidal inhibitors that block glycosome biogenesis by targeting PEX3–PEX19 interaction.Olguín-Contreras, L.F. ; Mendler, A.N. ; Popowicz, G.M. ; Hu, B. ; Nößner, E.
Double strike approach for tumor attack: Engineering T cells using a CD40L:CD28 chimeric co-stimulatory switch protein for enhanced tumor targeting in adoptive cell therapy.Behrens, G. ; Edelmann, S.L. ; Raj, T. ; Kronbeck, N. ; Monecke, T. ; Davydova, E.-O. ; Wong, E.H. ; Kifinger, L. ; Giesert, F. ; Kirmaier, M.E. ; Hohn, C. ; de Jonge, L.S. ; Pisfil, M.G. ; Fu, M. ; Theurich, S. ; Feske, S. ; Kawakami, N. ; Wurst, W. ; Niessing, D. ; Heissmeyer, V.
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.Ghosh, D. ; Koch, U. ; Hadian, K. ; Sattler, M. ; Tetko, I.V.
Highly accurate filters to flag frequent hitters in alphascreen assays by suggesting their mechanism.Mühlhofer, M. ; Peters, C. ; Kriehuber, T. ; Kreuzeder, M. ; Kazman, P. ; Rodina, N. ; Reif, B. ; Haslbeck, M. ; Weinkauf, S. ; Buchner, J.
Phosphorylation activates the yeast small heat shock protein Hsp26 by weakening domain contacts in the oligomer ensemble.Mishra, K. ; Fuenzalida Werner, J.P. ; Pennacchietti, F. ; Janowski, R. ; Chmyrov, A. ; Huang, Y. ; Zakian Dominguez, C.M. ; Klemm, U. ; Testa, I. ; Niessing, D. ; Ntziachristos, V. ; Stiel, A.-C.
Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging.Fottner, M. ; Weyh, M. ; Gaussmann, S. ; Schwarz, D. ; Sattler, M. ; Lang, K.
A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase enzymes.Makarov, D.M. ; Fadeeva, Y.A. ; Shmukler, L.E. ; Tetko, I.V.
Beware of proper validation of models for ionic Liquids!Fino, R. ; Lenhart, D. ; Kalel, V.C. ; Softley, C. ; Napolitano, V. ; Byrne, R. ; Schliebs, W. ; Dawidowski, M. ; Erdmann, R. ; Sattler, M. ; Schneider, G. ; Plettenburg, O. ; Popowicz, G.M.
Computer-aided design and synthesis of a new class of PEX14 inhibitors: substituted 2,3,4,5-tetrahydrobenzo[F][1,4]oxazepines as potential new trypanocidal agents.Zhang, X. ; Schuhmachers, P. ; Mourao, A. ; Giansanti, P. ; Murer, A. ; Thumann, S. ; Kuklik-Roos, C. ; Beer, S. ; Hauck, S.M. ; Hammerschmidt, W. ; Kuppers, R. ; Kuster, B. ; Raab, M. ; Strebhardt, K. ; Sattler, M. ; Münz, C. ; Kempkes, B.
PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice.Kleinstreuer, N.C. ; Tetko, I.V. ; Tong, W.
Introduction to special issue: Computational toxicology.Günsel, U. ; Hagn, F.
Lipid nanodiscs for high-resolution NMR studies of membrane proteins.Tošner, Z. ; Brandl, M.J. ; Blahut, J. ; Glaser, S.J. ; Reif, B.
Maximizing efficiency of dipolar recoupling in solid-state NMR using optimal control sequences.Sperl, L.E. ; Rührnößl, F. ; Schiller, A. ; Haslbeck, M. ; Hagn, F.
High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane.Mehar, R. ; Swarnakar, S. ; Lakkakula, S. ; Verma, A.K. ; Bhaskar, L.V.K.S.
Interleukin-6 gene -174G>C promoter polymorphism reduces the risk of periodontitis in Brazilian populations: A meta-analysis.Höfig, K.P. ; Reim, A. ; Gallus, C. ; Wong, E.H. ; Behrens, G. ; Conrad, C. ; Xu, M. ; Kifinger, L. ; Ito-Kureha, T. ; Defourny, K.A.Y. ; Geerlof, A. ; Mautner, J.M. ; Hauck, S.M. ; Baumjohann, D. ; Feederle, R. ; Mann, M. ; Wierer, M. ; Glasmacher, E. ; Heissmeyer, V.
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation.Walla, B. ; Bischoff, D. ; Janowski, R. ; Von Den Eichen, N. ; Niessing, D. ; Weuster-Botz, D.
Transfer of a rational crystal contact engineering strategy between diverse alcohol dehydrogenases.Tan, H. ; Su, W. ; Zhang, W. ; Zhang, J. ; Sattler, M. ; Zou, P.
Generation of novel long-acting GLP-1R agonists using DARPins as a scaffold.Fukumura, K. ; Yoshimoto, R. ; Sperotto, L. ; Kang, H.-S. ; Hirose, T. ; Inoue, K. ; Sattler, M. ; Mayeda, A.
SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns.Reyes Romero, A. ; Lunev, S. ; Popowicz, G.M. ; Calderone, V. ; Gentili, M. ; Sattler, M. ; Plewka, J. ; Taube, M. ; Kozak, M. ; Holak, T.A. ; Dömling, A.S.S. ; Groves, M.R.
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.Zak, K.M. ; Bostock, M.J. ; Waligorska, I. ; Thøgersen, I.B. ; Enghild, J.J. ; Popowicz, G.M. ; Grudnik, P. ; Potempa, J.S. ; Ksiazek, M.
Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia.Sperl, L.E. ; Hagn, F.
NMR structural and biophysical analysis of the disease-linked inner mitochondrial membrane protein MPV17.Lian, X. ; Xia, Z. ; Li, X. ; Karpov, P. ; Jin, H. ; Tetko, I.V. ; Xia, J. ; Wu, S.
Anti-MRSA drug discovery by ligand-based virtual screening and biological evaluation.Hermann, J. ; Bischoff, D. ; Grob, P. ; Janowski, R. ; Hekmat, D. ; Niessing, D. ; Zacharias, M. ; Weuster-Botz, D.
Controlling protein crystallization by free energy guided design of interactions at crystal contacts.Munshaw, S. ; Bruche, S. ; Redpath, A.N. ; Jones, A. ; Patel, J. ; Dube, K.N. ; Lee, R. ; Hester, S.S. ; Davies, R. ; Neal, G. ; Handa, A. ; Sattler, M. ; Fischer, R. ; Channon, K.M. ; Smart, N.
Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.Mansouri, K. ; Karmaus, A.L. ; Fitzpatrick, J. ; Patlewicz, G. ; Pradeep, P. ; Alberga, D. ; Alepee, N. ; Allen, T.E.H. ; Allen, D. ; Alves, V.M. ; Andrade, C.H. ; Auernhammer, T.R. ; Ballabio, D. ; Bell, S. ; Benfenati, E. ; Bhattacharya, S. ; Bastos, J.V. ; Boyd, S. ; Brown, J.B. ; Capuzzi, S.J. ; Chushak, Y. ; Ciallella, H. ; Clark, A.M. ; Consonni, V. ; Daga, P.R. ; Ekins, S. ; Farag, S. ; Fedorov, M. ; Fourches, D. ; Gadaleta, D. ; Gao, F. ; Gearhart, J.M. ; Goh, G. ; Goodman, J.M. ; Grisoni, F. ; Grulke, C.M. ; Hartung, T. ; Hirn, M. ; Karpov, P. ; Korotcov, A. ; Lavado, G.J. ; Lawless, M. ; Li, X. ; Luechtefeld, T. ; Lunghini, F. ; Mangiatordi, G.F. ; Marcou, G. ; Marsh, D. ; Martin, T. ; Mauri, A. ; Muratov, E.N. ; Myatt, G.J. ; Nguyen, D.T. ; Nicolotti, O. ; Note, R. ; Pande, P. ; Parks, A.K. ; Peryea, T. ; Polash, A.H. ; Rallo, R. ; Roncaglioni, A. ; Rowlands, C.J. ; Ruiz, P. ; Russo, D.P. ; Sayed, A. ; Sayre, R. ; Sheils, T. ; Siegel, C. ; Silva, A.C. ; Simeonov, A. ; Sosnin, S. ; Southall, N. ; Strickland, J. ; Tang, Y. ; Teppen, B. ; Tetko, I.V. ; Thomas, D. ; Tkachenko, V. ; Todeschini, R. ; Toma, C. ; Tripodi, I. ; Trisciuzzi, D. ; Tropsha, A. ; Varnek, A. ; Vukovic, K. ; Wang, Z. ; Wang, L. ; Waters, K.M. ; Wedlake, A.J. ; Wijeyesakere, S.J. ; Wilson, D. ; Xiao, Z. ; Yang, H. ; Zahoranszky-Kohalmi, G. ; Zakharov, A.V. ; Zhang, F.F. ; Zhang, Z. ; Zhao, T. ; Zhu, H. ; Zorn, K.M. ; Casey, W. ; Kleinstreuer, N.C.
CATMoS: Collaborative acute toxicity modeling suite.Stadler, D. ; Kächele, M. ; Jones, A. ; Hess J. ; Urban, C. ; Schneider, J. ; Xia, Y. ; Oswald, A. ; Nebioglu, F. ; Bester, R. ; Lasitschka, F. ; Ringelhan, M. ; Ko, C. ; Chou, W.M. ; Geerlof, A. ; van de Klundert, M. ; Wettengel, J.M. ; Schirmacher, P. ; Heikenwälder, M. ; Schreiner, S. ; Bartenschlager, R. ; Pichlmair, A. ; Sattler, M. ; Unger, K. ; Protzer, U.
Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20.Georgiadi, A. ; Lopez Salazar, V. ; El-Merahbi, R. ; Karikari, R.A. ; Ma, X. ; Mourao, A. ; Klepac, K. ; Bühler, L. ; Alfaro, A.J. ; Kaczmarek, I. ; Linford, A. ; Bosma, M. ; Shilkova, O. ; Ritvos, O. ; Nakamura, N. ; Hirose, S. ; Lassi, M. ; Teperino, R. ; Machado, J. ; Scheideler, M. ; Dietrich, A. ; Geerlof, A. ; Feuchtinger, A. ; Blutke, A. ; Fischer, K. ; Müller, T.D. ; Kessler, K. ; Schöneberg, T. ; Thor, D. ; Hornemann, S. ; Kruse, M. ; Nawroth, P.P. ; Pivovarova-Ramich, O. ; Pfeiffer, A.F.H. ; Sattler, M. ; Blüher, M. ; Herzig, S.
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.Liu, N. ; Gujrati, V. ; Malekzadeh-Najafabadi, J. ; Werner, J.P,F. ; Klemm, U. ; Tang, L. ; Chen, Z. ; Prakash, J. ; Huang, Y. ; Stiel, A.-C. ; Mettenleiter, G. ; Aichler, M. ; Blutke, A. ; Walch, A.K. ; Kleigrewe, K. ; Razansky, D. ; Sattler, M. ; Ntziachristos, V.
Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors.Bauer, S. ; Mekonnen, D.W. ; Hartmann, M. ; Yildiz, I. ; Janowski, R. ; Lange, B. ; Geist, B. ; Zeier, J. ; Schäffner, A.
UGT76B1, a promiscuous hub of small molecule-based immune signaling, glucosylates N-hydroxypipecolic acid, and balances plant immunity.Gaussmann, S. ; Gopalswamy, M. ; Eberhardt, M. ; Reuter, M. ; Zou, P. ; Schliebs, W. ; Erdmann, R. ; Sattler, M.
Membrane interactions of the peroxisomal proteins PEX5 and PEX14.Pallesen, J.S. ; Narayanan, D. ; Tran, K.T. ; Solbak, S.M. ; Marseglia, G. ; Sørensen, L.M.E. ; Høj, L.J. ; Munafò, F. ; Carmona, R.M.C. ; Garcia, A.D. ; Desu, H.L. ; Brambilla, R. ; Johansen, T.N. ; Popowicz, G.M. ; Sattler, M. ; Gajhede, M. ; Bach, A.
Deconstructing noncovalent kelch-like ECH-associated protein 1 (Keap1) inhibitors into fragments to reconstruct new potent compounds.Molitor, L. ; Bacher, S. ; Burczyk, S. ; Niessing, D.
The molecular function of PURA andi Its implications in neurological diseases.Liu, N. ; O'Connor, P. ; Gujrati, V. ; Gorpas, D. ; Glasl, S. ; Blutke, A. ; Walch, A.K. ; Kleigrewe, K. ; Sattler, M. ; Plettenburg, O. ; Ntziachristos, V.
Facile synthesis of a croconaine-based nanoformulation for optoacoustic imaging and photothermal therapy.Schuch, L.A. ; Forstner, M. ; Rapp, C.K. ; Li, Y. ; Smith, D.E.C. ; Mendes, M.I. ; Delhommel, F. ; Sattler, M. ; Emiralioğlu, N. ; Taskiran, E.Z. ; Orhan, D. ; Kiper, N. ; Rohlfs, M. ; Jeske, T. ; Hastreiter, M. ; Gerstlauer, M. ; Torrent-Vernetta, A. ; Moreno-Galdó, A. ; Kammer, B. ; Brasch, F. ; Reu-Hofer, S. ; Griese, M.
FARS1-related disorders caused by bi-allelic mutations in cytosolic phenylalanyl-tRNA synthetase genes: Look beyond the lungs!Zhang, M. ; Gui, M. ; Wang, Z.F. ; Gorgulla, C. ; Yu, J.J. ; Wu, H. ; Sun, Z.J. ; Klenk, C. ; Merklinger, L. ; Morstein, L. ; Hagn, F. ; Plückthun, A. ; Brown, A. ; Nasr, M.L. ; Wagner, G.
Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.Naarmann-de Vries, I.S. ; Senatore, R. ; Moritz, B. ; Marx, G. ; Urlaub, H. ; Niessing, D. ; Ostareck, D.H. ; Ostareck-Lederer, A.
Methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis.Biebl, M.M. ; Lopez, A. ; Rehn, A. ; Freiburger, L. ; Lawatscheck, J. ; Blank, B. ; Sattler, M. ; Buchner, J.
Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle.Wu, L. ; Huang, R. ; Tetko, I.V. ; Xia, Z. ; Xu, J. ; Tong, W.
Trade off predictivity and explainability for machine-learning powered predictive toxicology: An in-depth investigation with Tox21 data sets.Reuter, M. ; Kooshapur, H. ; Suda, J.G. ; Gaussmann, S. ; Neuhaus, A. ; Brühl, L. ; Bharti, P. ; Jung, M. ; Schliebs, W. ; Sattler, M. ; Erdmann, R.
Competitive microtubule binding of PEX14 coordinates peroxisomal protein import and motility.Semenyuta, I.V. ; Trush, M.M. ; Kovalishyn, V.V. ; Rogalsky, S.P. ; Hodyna, D.M. ; Karpov, P. ; Xia, Z. ; Tetko, I.V. ; Metelytsia, L.O.
Structure-activity relationship modeling and experimental validation of the imidazolium and pyridinium based ionic liquids as potential antibacterials of mdr Acinetobacter baumannii and Staphylococcus aureus.Savitskiy, S. ; Wachtel, R. ; Pourjafar-Dehkordi, D. ; Kang, H.-S. ; Trauschke, V. ; Lamb, D.C. ; Sattler, M. ; Zacharias, M. ; Itzen, A.
Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation.Schütz, A.K.
Solid-state NMR approaches to investigate large enzymes in complex with substrates and inhibitors.Zorro Shahidian, L. ; Haas, M. ; Le Gras, S. ; Nitsch, S. ; Mourao, A. ; Geerlof, A. ; Margueron, R. ; Michaelis, J. ; Daujat, S. ; Schneider, R.
Succinylation of H3K122 destabilizes nucleosomes and enhances transcription.Siehler, J. ; Blöchinger, A. ; Akgün, M. ; Wang, X. ; Shahryari, A. ; Geerlof, A. ; Lickert, H. ; Burtscher, I.
Generation of a heterozygous C-peptide-mCherry reporter human iPSC line (HMGUi001-A-8).Lopez, A. ; Elimelech, A.R. ; Klimm, K. ; Sattler, M.
The charged linker modulates the conformations and molecular interactions of Hsp90.Liwocha, J. ; Krist, D.T. ; van der Heden van Noort, G.J. ; Hansen, F.M. ; Truong, V.H. ; Karayel, O. ; Purser, N. ; Houston, D. ; Burton, N. ; Bostock, M.J. ; Sattler, M. ; Mann, M. ; Harrison, J.S. ; Kleiger, G. ; Ovaa, H. ; Schulman, B.A.
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.Goba, I. ; Goricanec, D. ; Schum, D. ; Hillenbrand, M. ; Plückthun, A. ; Hagn, F.
Probing the conformation states of neurotensin receptor 1 variants by NMR site-directed methyl labeling.Tan, H. ; Su, W. ; Zhang, W. ; Zhang, J. ; Sattler, M. ; Zou, P.
Albumin-binding domain extends half-life of glucagon-like peptide-1.Pradhan, T. ; Annamalai, K. ; Sarkar, R. ; Hegenbart, U. ; Schönland, S. ; Fändrich, M. ; Reif, B.
Solid state NMR assignments of a human λ-III immunoglobulin light chain amyloid fibril.