Publications
2022 Wissenschaftlicher Artikel in eLife eLife 11:e77443 (2022)
DNA damage independent inhibition of NF-kB transcription by anthracyclines.
2022 Wissenschaftlicher Artikel in European Journal of Medicinal Chemistry Eur. J. Med. Chem. 243:114778 (2022)
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
2022 Wissenschaftlicher Artikel in Biological Chemistry Biol. Chem., DOI: 10.1515/hsz-2022-0177 (2022)
Distinct conformational and energetic features define the specific recognition of (di)aromatic peptide motifs by PEX14.
2022 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J. 41:e112440 (2022)
Biochemically validated structural model of the 15-subunit intraflagellar transport complex IFT-B.
2022 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 434:167861 (2022)
The advanced properties of circularized MSP nanodiscs facilitate high-resolution NMR studies of membrane proteins: Advanced NMR properties of circular MSP nanodiscs.
2022 Wissenschaftlicher Artikel in Journal of Medicinal Chemistry J. Med. Chem. 65, 14481-14526 (2022)
Development of noncovalent small-molecule Keap1-Nrf2 inhibitors by fragment-based drug discovery.
2022 Wissenschaftlicher Artikel in Journal of Molecular Liquids J. Mol. Liq. 366:120247 (2022)
Machine learning models for phase transition and decomposition temperature of ionic liquids.
2022 Wissenschaftlicher Artikel in Journal of the American Chemical Society J. Am. Chem. Soc. 144, 17336-17340 (2022)
Sensitivity-enhanced multidimensional solid-state NMR spectroscopy by optimal-control-based transverse mixing sequences.
2022 Editorial in Chemical Research in Toxicology Chem. Res. Toxicol. 35, 1289-1290 (2022)
Artificial intelligence meets toxicology.
2022 Wissenschaftlicher Artikel in Journal of Chemical Information and Modeling J. Chem. Inf. Model. 62, 3685-3694 (2022)
ULYSSES: An efficient and easy to use semiempirical library for C+.
2022 Wissenschaftlicher Artikel in Frontiers in Immunology Front. Immunol. 13:958952 (2022)
A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria.
2022 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 12:14705 (2022)
Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma.
2022 Wissenschaftlicher Artikel in Journal of Structural Biology J. Struct. Biol. 6:100069 (2022)
SAA fibrils involved in AA amyloidosis are similar in bulk and by single particle reconstitution: A MAS solid-state NMR study.
2022 Wissenschaftlicher Artikel in ChemPhysChem ChemPhysChem 23:e202200395 (2022)
Acid rain and flue gas: Quantum chemical hydrolysis of NO2.
2022 Wissenschaftlicher Artikel in Nanophotonics Nanophotonics 11, 4637–4647 (2022)
Multifunctional croconaine nanoparticles for efficient optoacoustic imaging of deep tumors and photothermal therapy.
2022 Wissenschaftlicher Artikel in ACS Chemical Biology ACS Chem. Biol. 17, 2655-2663 (2022)
Exploring the surface of the ectodomain of the PD-L1 immune checkpoint with small-molecule fragments.
2022 Wissenschaftlicher Artikel in Journal of Computational Chemistry J. Comput. Chem. 43, 1633-1640 (2022)
Explicit solvent repulsive scaling replica exchange molecular dynamics (RS-REMD) in molecular modeling of protein-glycosaminoglycan complexes.
2022 Wissenschaftlicher Artikel in ACS Chemical Biology ACS Chem. Biol. 17, 1745-1755 (2022)
19F-NMR unveils the ligand-induced conformation of a catalytically inactive twisted homodimer of tRNA-guanine transglycosylase.
2022 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 434:167705 (2022)
Conformational effects of a cancer-linked mutation in pri-miR-30c RNA.
2022 Wissenschaftlicher Artikel in Molecules Molecules 27:3838 (2022)
How to catch the ball: Fullerene binding to the corannulene pincer.
2022 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 12:9593 (2022)
Characterization of SARS-CoV-2 replication complex elongation and proofreading activity.
2022 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 298:102101 (2022)
Extended conformational states dominate the Hsp90 chaperone dynamics.
2022 Wissenschaftlicher Artikel in Structure Structure 30, 1050-1054.e2 (2022)
Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.
2022 Wissenschaftlicher Artikel in Nature Nature 608, 778-783 (2022)
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
2022 Wissenschaftlicher Artikel in Antibiotics Antibiotics 11:491 (2022)
Theoretical and experimental studies of phosphonium ionic liquids as potential antibacterials of MDR Acinetobacter baumannii.
2022 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 8:eabp9153 (2022)
Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1.
2022 Review in Progress in Nuclear Magnetic Resonance Spectroscopy Prog. Nucl. Magn. Reson. Spectrosc. 130-131, 45-59 (2022)
Field and magic angle spinning frequency dependence of proton resonances in rotating solids.
2022 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 17:e0265805 (2022)
Galectin-1 and -3 in high amounts inhibit angiogenic properties of human retinal microvascular endothelial cells in vitro.
2022 Wissenschaftlicher Artikel in Virulence Virulence 13, 483-501 (2022)
Presence and function of Hbl B', the fourth protein component encoded by the hbl operon in Bacillus cereus.
2022 Wissenschaftlicher Artikel in Plant Biotechnology Journal Plant Biotechnol. J. 20, 1928-1939 (2022)
The transient expression of recombinant proteins in plant cell packs facilitates stable isotope labeling for NMR spectroscopy.
2022 Wissenschaftlicher Artikel in Journal of Experimental Botany J. Exp. Bot. 73, 3531–3551 (2022)
Two wrongs make a right: Heat stress reversion of a male-sterile Brassica napus line.
2022 Wissenschaftlicher Artikel in Molecules Molecules 27:3247 (2022)
Anion binding by fluorescent ureido-hexahomotrioxacalix[3]arene receptors: An NMR, absorption and emission spectroscopic study.
2022 Wissenschaftlicher Artikel in Informatics Informatics 9:8 (2022)
What features of ligands are relevant to the opening of cryptic pockets in drug targets?
2022 Wissenschaftlicher Artikel in Journal of the American Chemical Society J. Am. Chem. Soc. 144, 8536-8550 (2022)
Transient RNA interactions leave a covalent imprint on a viral capsid protein.
2022 Wissenschaftlicher Artikel in Journal of Applied Polymer Science J. Appl. Polym. Sci. 139:52189 (2022)
Acidic wood extractives accelerate the curing process of emulsion polymer isocyanate adhesives.
2022 Wissenschaftlicher Artikel in International Journal of Molecular Sciences Int. J. Mol. Sci. 23:1201 (2022)
More is not always better: Local models provide accurate predictions of spectral properties of porphyrins.
2022 Wissenschaftlicher Artikel in Cell Chemical Biology Cell Chem. Bio. 29, 774-784.e8 (2022)
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.
2022 Wissenschaftlicher Artikel in Life Science Alliance Life Sci. All. 5:e202101252 (2022)
Structural basis of Nrd1-Nab3 heterodimerization.
2022 Editorial in Signal transduction and targeted therapy Signal Transduct. Target. Ther. 7:140 (2022)
Vaccination versus SARS-CoV-2 Omicron: Three vaccine doses win the battle.
2022 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 50, 2350-2362 (2022)
Structural effects of m6A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1.
2022 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 82, 555-569.e7 (2022)
NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems.
2022 Wissenschaftlicher Artikel in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 20, 443-458 (2022)
Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death.
2022 Wissenschaftlicher Artikel in Journal of Neuroscience J. Neurosci. 42, 1557-1573 (2022)
Collagen VI regulates motor circuit plasticity and motor performance by cannabinoid modulation.
2022 Wissenschaftlicher Artikel in Spectrochimica acta, Part A Spectrochim. Acta A 267:120577 (2022)
Deep neural network model for highly accurate prediction of BODIPYs absorption.
2022 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 434:167347 (2022)
Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases.
2022 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 50, 490-511 (2022)
Structural basis of DNA methylation-dependent site selectivity of the Epstein-Barr virus lytic switch protein ZEBRA/Zta/BZLF1.
2022 Wissenschaftlicher Artikel in Circulation Research Circ. Res. 130, 67-79 (2022)
Locus-conserved circular RNA cZNF292 controls endothelial cell flow responses.
2022 Review in Chemical Reviews Chem. Rev. 122, 10019-10035 (2022)
Deuteration for high-resolution detection of protons in protein magic angle spinning (MAS) solid-state NMR.
2022 Wissenschaftlicher Artikel in Life Science Alliance Life Sci. All. 5:e202101164 (2022)
Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage.
In: (European Conference on Biomedical Optics, 20–24 June 2021, Munich Germany). 2021. DOI: 10.1117/12.2615998 ( ; 11923)
Facile synthesis of a croconaine-based nanoformulation for optoacoustic imaging and photothermal therapy.
2021 Wissenschaftlicher Artikel in PLoS Genetics PLoS Genet. 17:e1009951 (2021)
MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells.
2021 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 7:eabl7295 (2021)
Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network.
2021 Wissenschaftlicher Artikel in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:737159 (2021)
Novel trypanocidal inhibitors that block glycosome biogenesis by targeting PEX3–PEX19 interaction.
2021 Wissenschaftlicher Artikel in Frontiers in Immunology Front. Immunol. 12:750478 (2021)
Double strike approach for tumor attack: Engineering T cells using a CD40L:CD28 chimeric co-stimulatory switch protein for enhanced tumor targeting in adoptive cell therapy.
2021 Wissenschaftlicher Artikel in Nature Immunology Nat. Immunol. 22, 1563-1576 (2021)
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.
2021 Wissenschaftlicher Artikel in Molecular Informatics Mol. Inform., DOI: 10.1002/minf.202100151:e2100151 (2021)
Highly accurate filters to flag frequent hitters in alphascreen assays by suggesting their mechanism.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:6697 (2021)
Phosphorylation activates the yeast small heat shock protein Hsp26 by weakening domain contacts in the oligomer ensemble.
2021 Wissenschaftlicher Artikel in Nature Biotechnology Nat. Biotechnol., DOI: 10.1038/s41587-021-01100-5 (2021)
Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:6515 (2021)
A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase enzymes.
2021 Wissenschaftlicher Artikel in Journal of Molecular Liquids J. Mol. Liq. 344:117722 (2021)
Beware of proper validation of models for ionic Liquids!
2021 Wissenschaftlicher Artikel in Journal of Chemical Information and Modeling J. Chem. Inf. Model. 61, 5256-5268 (2021)
Computer-aided design and synthesis of a new class of PEX14 inhibitors: substituted 2,3,4,5-tetrahydrobenzo[F][1,4]oxazepines as potential new trypanocidal agents.
2021 Wissenschaftlicher Artikel in Bio-Protocol Bio Protoc. 11:e4161 (2021)
Protocol for RNA-seq expression analysis in yeast.
2021 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep.:e53007 (2021)
PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice.
2021 Review in Chemical Research in Toxicology Chem. Res. Toxicol. 34, 171-175 (2021)
Introduction to special issue: Computational toxicology.
2021 Review in Chemical Reviews Chem. Rev. 122, 9395-9421 (2021)
Lipid nanodiscs for high-resolution NMR studies of membrane proteins.
2021 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 7:eabj5913 (2021)
Maximizing efficiency of dipolar recoupling in solid-state NMR using optimal control sequences.
2021 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J.:e107159 (2021)
High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane.
2021 Wissenschaftlicher Artikel in Journal of Oral Biosciences J. Oral Biosci., DOI: 10.1016/j.job.2021.08.003 (2021)
Interleukin-6 gene -174G>C promoter polymorphism reduces the risk of periodontitis in Brazilian populations: A meta-analysis.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:5208 (2021)
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation.
2021 Wissenschaftlicher Artikel in Crystals Crystals 11:975 (2021)
Transfer of a rational crystal contact engineering strategy between diverse alcohol dehydrogenases.
2021 Wissenschaftlicher Artikel in International Journal of Pharmaceutics Int. J. Pharm. 607:121043 (2021)
Generation of novel long-acting GLP-1R agonists using DARPins as a scaffold.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:4910 (2021)
SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns.
2021 Wissenschaftlicher Artikel in Communications Biology Comm. Biol. 4:949 (2021)
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.
2021 Wissenschaftlicher Artikel in Journal of Enzyme Inhibition and Medicinal Chemistry J. Enzyme Inhib. Med. Chem. 36, 1267-1281 (2021)
Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia.
2021 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 433:167098 (2021)
NMR structural and biophysical analysis of the disease-linked inner mitochondrial membrane protein MPV17.
2021 Wissenschaftlicher Artikel in Bioorganic chemistry Bioorg. Chem. 114:105042 (2021)
Anti-MRSA drug discovery by ligand-based virtual screening and biological evaluation.
2021 Wissenschaftlicher Artikel in Crystals Crystals 11:588 (2021)
Controlling protein crystallization by free energy guided design of interactions at crystal contacts.
2021 Wissenschaftlicher Artikel in Journal of Clinical Investigation J. Clin. Invest. 131:e127884 (2021)
Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.
2021 Wissenschaftlicher Artikel in Environmental Health Perspectives Environ. Health Perspect. 129:47013 (2021)
CATMoS: Collaborative acute toxicity modeling suite.
2021 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep. 22:e49568 (2021)
Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:2999 (2021)
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
2021 Wissenschaftlicher Artikel in Photoacoustics Photoacoustics 22:100263 (2021)
Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors.
2021 Wissenschaftlicher Artikel in The Plant cell Plant Cell 33, 714-734 (2021)
UGT76B1, a promiscuous hub of small molecule-based immune signaling, glucosylates N-hydroxypipecolic acid, and balances plant immunity.
2021 Wissenschaftlicher Artikel in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:651449 (2021)
Membrane interactions of the peroxisomal proteins PEX5 and PEX14.
2021 Wissenschaftlicher Artikel in Journal of Medicinal Chemistry J. Med. Chem. 64, 4623-4661 (2021)
Deconstructing noncovalent kelch-like ECH-associated protein 1 (Keap1) inhibitors into fragments to reconstruct new potent compounds.
2021 Review in Frontiers in Genetics Front. Genet. 12:638217 (2021)
The molecular function of PURA andi Its implications in neurological diseases.
2021 Wissenschaftlicher Artikel in Advanced healthcare materials Adv. Healthc. Mater. 10:e2002115 (2021)
Facile synthesis of a croconaine-based nanoformulation for optoacoustic imaging and photothermal therapy.
2021 Wissenschaftlicher Artikel in Clinical Genetics Clin. Genet. 99, 789-801 (2021)
FARS1-related disorders caused by bi-allelic mutations in cytosolic phenylalanyl-tRNA synthetase genes: Look beyond the lungs!
2021 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 28, 258-267 (2021)
Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
2021 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 49, 3507-3523 (2021)
Methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis.
2021 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 12:828 (2021)
Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle.
2021 Wissenschaftlicher Artikel in Chemical Research in Toxicology Chem. Res. Toxicol. 34, 541-549 (2021)
Trade off predictivity and explainability for machine-learning powered predictive toxicology: An in-depth investigation with Tox21 data sets.
2021 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 433:166765 (2021)
Competitive microtubule binding of PEX14 coordinates peroxisomal protein import and motility.
2021 Wissenschaftlicher Artikel in International Journal of Molecular Sciences Int. J. Mol. Sci. 22:563 (2021)
Structure-activity relationship modeling and experimental validation of the imidazolium and pyridinium based ionic liquids as potential antibacterials of mdr Acinetobacter baumannii and Staphylococcus aureus.
2021 Wissenschaftlicher Artikel in iScience iScience 24:101940 (2021)
Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation.
2021 Wissenschaftlicher Artikel in Biochemical Society Transactions Biochem. Soc. Trans. 49, 131-144 (2021)
Solid-state NMR approaches to investigate large enzymes in complex with substrates and inhibitors.
2021 Wissenschaftlicher Artikel in EMBO Reports EMBO Rep. 22:e51009 (2021)
Succinylation of H3K122 destabilizes nucleosomes and enhances transcription.
2021 Wissenschaftlicher Artikel in Stem Cell Research Stem Cell Res. 50:102126 (2021)
Generation of a heterozygous C-peptide-mCherry reporter human iPSC line (HMGUi001-A-8).
2021 Wissenschaftlicher Artikel in ChemBioChem ChemBioChem, DOI: 10.1002/cbic.202000699 (2021)
The charged linker modulates the conformations and molecular interactions of Hsp90.
2021 Wissenschaftlicher Artikel in Nature Chemical Biology Nat. Chem. Biol. 17, 272–279 (2021)
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
2021 Wissenschaftlicher Artikel in ChemBioChem ChemBioChem 22, 139-146 (2021)
Probing the conformation states of neurotensin receptor 1 variants by NMR site-directed methyl labeling.
2021 Wissenschaftlicher Artikel in European Journal of Pharmacology Eur. J. Pharmacol. 890:173650 (2021)
Albumin-binding domain extends half-life of glucagon-like peptide-1.
2021 Wissenschaftlicher Artikel in Biomolecular NMR Assignments Biomol. NMR Assign. 15, 9-16 (2021)
Solid state NMR assignments of a human λ-III immunoglobulin light chain amyloid fibril.
2020 Wissenschaftlicher Artikel in Advanced materials Adv. Mater. 59, 5820-5830 (2020)
Structural insight into IAPP-derived amyloid inhibitors and their mechanism of action.
2020 Review in Journal of Cheminformatics J. Cheminformatics 12:74 (2020)
From Big Data to Artificial Intelligence: Chemoinformatics meets new challenges.
In: New Developments in NMR. 2020. 266-279 ( ; 2020-January)
Chapter 14: Singlet-assisted exchange NMR spectroscopy.
2020 Wissenschaftlicher Artikel in NAR: Genomics and Bioinformatics NAR Gen. Bioinfo. 2:lqaa090 (2020)
Machine learning a model for RNA structure prediction.
2020 Wissenschaftlicher Artikel in Chemical Communications Chem. Commun. 56, 15454-15457 (2020)
Deep learning model predicts water interaction sites on the surface of proteins using limited-resolution data.
2020 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 295, 18474-18484 (2020)
Seeded fibrils of the germline variant of human λ-III immunoglobulin light chain FOR005 have a similar core as patient fibrils with reduced stability.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:5575 (2020)
State-of-the-art augmented NLP transformer models for direct and single-step retrosynthesis.
2020 Wissenschaftlicher Artikel in The journal of physical chemistry C J. Phys. Chem. C. 124, 22631-22637 (2020)
Impact of magnetic field strength on resolution and sensitivity of proton resonances in biological solids.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:5167 (2020)
Active coacervate droplets as a model for membraneless organelles and protocells.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:5621 (2020)
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.
2020 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 6:eabc3786 (2020)
The dynamics of linear polyubiquitin.
2020 Wissenschaftlicher Artikel in Cell Communication and Signaling Cell Commun. Signal. 18:180 (2020)
The intrinsically disordered region of GCE protein adopts a more fixed structure by interacting with the LBD of the nuclear receptor FTZ-F1.
2020 Wissenschaftlicher Artikel in Journal of Hepatology J. Hepatol. 73, 1347-1359 (2020)
Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.
2020 Wissenschaftlicher Artikel in Autophagy Autophagy 16, 2294-2296 (2020)
Autophagy unleashes noncanonical microRNA functions.
2020 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 80, 102-113.e6 (2020)
DNA structure-specific cleavage of DNA-protein crosslinks by the SPRTN protease.
2020 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J. 39:e104247 (2020)
γ-Secretase cleavage of the Alzheimer risk factorTREM2 is determined by its intrinsic structural dynamics.
2020 Wissenschaftlicher Artikel in Journal of the American Chemical Society J. Am. Chem. Soc. 142, 14472-14480 (2020)
Observation of a transient reaction intermediate illuminates the mechanochemical cycle of the AAA-ATPase p97.
2020 Wissenschaftlicher Artikel in Analytical Chemistry Anal. Chem. 92, 10717-10724 (2020)
Challenging a preconception: Optoacoustic spectrum differs from the absorption spectrum of proteins and dyes for molecular imaging.
2020 Editorial in Structure Structure 28, 730-732 (2020)
When less is more: Combining site-specific isotope labeling and NMR unravels structural details of huntingtin repeats.
2020 Wissenschaftlicher Artikel in Biophysical Journal Biophys. J. 119, 99-114 (2020)
Determining the stoichiometry of small protein oligomers using steady-state fluorescence anisotropy.
2020 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J.:e103373 (2020)
Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells.
2020 Review in Annual review of virology Annu. Rev. Virol. 7, 263-288 (2020)
The hepatitis B virus envelope proteins: Molecular gymnastics throughout the viral life cycle.
2020 Antimicrobial Agents and Chemotherapy Antimicrob. Agents Chemother. 64:e01077-20 (2020)
Structure and molecular recognition mechanism of IMP-13 metallo-β-lactamase. (vol 64, e00123-20, 2020).
2020 Chemical Society reviews Chem. Soc. Rev. 49, 3716 (2020)
QSAR without borders (vol 10, pg 531, 2020).
2020 Wissenschaftlicher Artikel in Journal of Cheminformatics J. Cheminformatics 12:39 (2020)
QSAR-derived affinity fingerprints (part 1): Fingerprint construction and modeling performance for similarity searching, bioactivity classification and scaffold hopping.
2020 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 432, 4127-4138 (2020)
Conformational dynamics from ambiguous zinc coordination in the RanBP2-type zinc finger of RBM5.
2020 Review in Journal of Biomolecular NMR J. Biomol. NMR 74, 287–309 (2020)
Paramagnetic NMR in drug discovery.
2020 Wissenschaftlicher Artikel in Science Translational Medicine Sci. Transl. Med. 12:eaaz2294 (2020)
Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis.
2020 Wissenschaftlicher Artikel in ChemBioChem ChemBioChem 21, 2495-2502 (2020)
Mapping of the binding interface of PET tracer molecules and Alzheimer Disease Aβ fibrils using MAS solid-state NMR spectroscopy.
2020 Wissenschaftlicher Artikel in Biochemical Journal / Reviews Biochem. J. 477, 1651-1668 (2020)
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.
2020 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 48, 7385-7403 (2020)
Structural basis for the recognition of transiently structured AU-rich elements by Roquin.
2020 Wissenschaftlicher Artikel in RNA Biology RNA Biol. 17, 1228-1238 (2020)
The large family of PC4-like domains - similar folds and functions throughout all kingdoms of life.
2020 Wissenschaftlicher Artikel in FEBS Letters FEBS Lett. 594, 2406-2420 (2020)
A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells.
2020 Wissenschaftlicher Artikel in ChemPhysChem ChemPhysChem 21, 863-869 (2020)
The photocatalyzed thiol-ene reaction: A new tag to yield fast, selective and reversible paramagnetic tagging of proteins.
2020 Review in Journal of Molecular Biology J. Mol. Biol. 432, 2890-2912 (2020)
Current approaches for integrating solution NMR spectroscopy and small-angle scattering to study the structure and dynamics of biomolecular complexes.
2020 Wissenschaftlicher Artikel in Science Translational Medicine Sci. Transl. Med. 12:eaay0605 (2020)
An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products.
2020 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 11:1410 (2020)
Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90.
2020 Wissenschaftlicher Artikel in Bioorganic chemistry Bioorg. Chem. 98:103717 (2020)
Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl) acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide.
2020 Wissenschaftlicher Artikel in Chemical Communications Chem. Commun. 56, 4360-4363 (2020)
Water envelope has a critical impact on the design of protein-protein interaction inhibitors.
2020 Review in Chemical Society reviews Chem. Soc. Rev. 49, 3525-3564 (2020)
QSAR without borders.
2020 Wissenschaftlicher Artikel in Journal of Cheminformatics J. Cheminformatics 12:22 (2020)
GEN: Highly efficient SMILES explorer using autodidactic generative examination networks.
2020 Wissenschaftlicher Artikel in Neurochemistry International Neurochem. Int. 136:104713 (2020)
Detection and quantification of the anti-obesity drug celastrol in murine liver and brain.
2020 Wissenschaftlicher Artikel in Biotechnology Journal Biotechnol. J. 15:2000010 (2020)
Crystal contact engineering enables efficient capture and purification of an oxidoreductase by technical crystallization.
2020 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 117, 5772-5781 (2020)
Conformational control of small GTPases by AMPylation.
2020 Wissenschaftlicher Artikel in Chemical biology & drug design Chem. Biol. Drug Des. 95, 624-630 (2020)
In silico and in vitro studies of a number PILs as new antibacterials against MDR clinical isolate Acinetobacter baumannii.
2020 Wissenschaftlicher Artikel in Journal of Cheminformatics J. Cheminformatics 12:17 (2020)
Transformer-CNN: Swiss knife for QSAR modeling and interpretation.
2020 Wissenschaftlicher Artikel in Molecular Pharmaceutics Mol. Pharm. 17, 1663-1673 (2020)
Ferritin-displayed GLP-1 with improved pharmacological activities and pharmacokinetics.
2020 Wissenschaftlicher Artikel in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 18, 603-611 (2020)
Introducing the CSP analyzer: A novel machine learning-based application for automated analysis of two-dimensional NMR spectra in NMR fragment-based screening.
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New frontiers in drug discovery: Academia meets industry at the International Helmholtz Drug Discovery Conference (HDDC).
2020 Wissenschaftlicher Artikel in Antimicrobial Agents and Chemotherapy Antimicrob. Agents Chemother. 64:e00123-20 (2020)
Structure and molecular recognition mechanism of IMP-13 metallo-β-lactamase.
2020 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 117, 7140-7149 (2020)
An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2.
2020 Editorial in Chemical Research in Toxicology Chem. Res. Toxicol. 33, 687-688 (2020)
Computational toxicology.
2020 Editorial in Journal of Chemical Information and Modeling J. Chem. Inf. Model. 60, 1069-1071 (2020)
Joint virtual special issue on computational toxicology.
2020 Wissenschaftlicher Artikel in Environmental Health Perspectives Environ. Health Perspect. 128:27002 (2020)
CoMPARA: Collaborative modeling project for androgen receptor activity.
2020 Wissenschaftlicher Artikel in Biochimica et Biophysica Acta - Biomembranes Biochim. Biophys. Acta-Biomembr. 1862:183190 (2020)
Quantifying the insertion of membrane proteins into lipid bilayer nanodiscs using a fusion protein strategy.
2020 Wissenschaftlicher Artikel in Angewandte Chemie - Internationale Edition Angew. Chem.-Int. Edit. 59, 2-13 (2020)
Structural insight into IAPP-derived amyloid inhibitors and their mechanism of action.
2020 Wissenschaftlicher Artikel in Journal of Medicinal Chemistry J. Med. Chem. 63, 847-879 (2020)
Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 Protein-Protein Interaction (PPI) with trypanocidal activity.
2020 Wissenschaftlicher Artikel in Journal of Medicinal Chemistry J. Med. Chem. 63, 1156-1177 (2020)
Developing inhibitors of the p47phox-p22phox protein-protein interaction by fragment-based drug discovery.
2020 Review in Journal of Hazardous Materials J. Hazard. Mater. 384:121429 (2020)
A review of recent advances towards the development of QSAR models for toxicity assessment of ionic liquids.
2020 Wissenschaftlicher Artikel in Journal of Computer-Aided Molecular Design J. Comput.-Aided Mol. Des. 34, 769–782 (2020)
Focused library generator: Case of Mdmx inhibitors.
2020 Wissenschaftlicher Artikel in Redox Biology Redox Biol. 28:101316 (2020)
Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16(INK4A).
2019 Wissenschaftlicher Artikel in Neurology Genetics Neurol. Genet. 5:e373 (2019)
Defining and expanding the phenotype of QARS-associated developmental epileptic encephalopathy.
2019 Meeting abstract in European Heart Journal Eur. Heart J. 40, 3127-3127 (2019)
Endothelial autophagy triggers nuclear enrichment of miR-126-5p via a Mex3a-dependent pathway to confers endothelial protection and prevent atherosclerosis.
2019 Wissenschaftlicher Artikel in Biochimica et Biophysica Acta - Molecular Cell Research Biochim. Biophys. Acta-Mol. Cell Res. 1866:118520 (2019)
Evolutionary divergent PEX3 is essential for glycosome biogenesis and survival of trypanosomatid parasites.
2019 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 26, 1141-1150 (2019)
The structure and oxidation of the eye lens chaperone αA-crystallin.
2019 Wissenschaftlicher Artikel in Nature Nature 575, 693-698 (2019)
FSP1 is a glutathione-independent ferroptosis suppressor.
2019 Wissenschaftlicher Artikel in JACC CardioOncology JACC CardioOnco. 1, 84-102 (2019)
Prokineticin receptor-1 signaling inhibits dose- and time-dependent anthracycline-induced cardiovascular toxicity via myocardial and vascular protection.
2019 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 9:15903 (2019)
Accessing methyl groups in proteins via 1H-detected MAS solid-state NMR spectroscopy employing random protonation.
2019 Meeting abstract in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 60 (2019)
Human recombinant Galectin-1 mitigates the cellular mechanisms of proliferative vitreoretinopathy in primary human tractive membranes in-vitro.
2019 Meeting abstract in FEBS Open Bio FEBS Open Bio 9, 426-427 (2019)
Glycosomal protein import: A new target against trypanosomiasis.
2019 Meeting abstract in FEBS Open Bio FEBS Open Bio 9, 276-276 (2019)
Crystal structure of a unique glucokinase from Kluyveromyces lactis.
2019 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11731 LNCS, 764-770 (2019)
Analysis and modelling of false positives in GPCR assays.
2019 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11731 LNCS, 831-835 (2019)
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2019 Editorial in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11731 LNCS, v-vii (2019)
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2019 Wissenschaftlicher Artikel in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11731 LNCS, 817-830 (2019)
A transformer model for retrosynthesis.
2019 Meeting abstract in European Journal of Immunology Eur. J. Immunol. 49, 221-222 (2019)
Roquin and Regnase-1 cooperatively determine cell fate decisions in T cells.
2019 Editorial in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11727 LNCS, v-vii (2019)
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2019 Editorial in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11728 LNCS, v-vii (2019)
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2019 Editorial in Lecture Notes in Computer Science Lect. Notes Comput. Sc. 11729 LNCS, v-vii (2019)
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2019 Wissenschaftlicher Artikel in International Journal of Molecular Sciences Int. J. Mol. Sci. 20:4821 (2019)
Crystal structure of kluyveromyces lactis glucokinase (KlGlk1).
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:4121 (2019)
The molecular basis of chaperone-mediated interleukin 23 assembly control.
2019 Review in Progress in Nuclear Magnetic Resonance Spectroscopy Prog. Nucl. Magn. Reson. Spectrosc. 114-115, 271-283 (2019)
Beyond detergent micelles: The advantages and applications of non-micellar and lipid-based membrane mimetics for solution-state NMR.
2019 Wissenschaftlicher Artikel in Journal of Biomolecular NMR J. Biomol. NMR 73, 625-631 (2019)
MAS dependent sensitivity of different isotopomers in selectively methyl protonated protein samples in solid state NMR.
2019 Meeting abstract in Abstracts of Papers of the American Chemical Society Abstr. Pap. Am. Chem. Soc. 257 (2019)
Enhancement of acute toxicity prediction by multi-task learning.
2019 Angewandte Chemie - Internationale Edition Angew. Chem.-Int. Edit., DOI: 10.1002/anie.201908888 (2019)
Selective inhibitors of FKBP51 employ conformational selection of dynamic invisible states (vol 58, pg 9429, 2019).
2019 Wissenschaftlicher Artikel in Angewandte Chemie - Internationale Edition Angew. Chem.-Int. Edit. 58, 9429-9433 (2019)
Selective inhibitors of FKBP51 employ conformational selection of dynamic invisible states.
2019 Wissenschaftlicher Artikel in Journal of Biomolecular NMR J. Biomol. NMR 73, 471-475 (2019)
Determination of methyl order parameters using solid state NMR under off magic angle spinning.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:3626 (2019)
The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range.
2019 Wissenschaftlicher Artikel in mBio mBio 10:e00277-19 (2019)
Cross-talk of cellulose and mannan perception pathways leads to inhibition of cellulase production in several filamentous fungi.
2019 Wissenschaftlicher Artikel in Nature Nature 10:3393 (2019)
The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
2019 Review in Journal of Molecular Cell Biology J. Mol. Cell Biol. 11, 845-859 (2019)
Challenges and perspectives for structural biology of lncRNAs-the example of the Xist lncRNA A-repeats.
2019 Wissenschaftlicher Artikel in Journal of Cellular and Molecular Medicine J. Cell. Mol. Med. 23, 5225-5234 (2019)
Potentiation of ABCA3 lipid transport function by ivacaftor and genistein.
2019 Wissenschaftlicher Artikel in Structure Structure 27, 1137-1147.e5 (2019)
Structure, function, and dynamics of the G alpha binding domain of Ric-8A.
2019 Wissenschaftlicher Artikel in Journal of Experimental Medicine J. Exp. Med. 216, 1700-1723 (2019)
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:2266 (2019)
Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3.
2019 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 431, 2581-2598 (2019)
Increased aggregation tendency of alpha-synuclein in a fully disordered protein complex.
2019 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 294, 7098-7112 (2019)
NMR- and MD simulation-based structural characterization of the membrane-associating FATC domain of ataxia telangiectasia mutated.
2019 Wissenschaftlicher Artikel in Journal of Biomolecular NMR J. Biomol. NMR 73, 183-189 (2019)
Selective isotope labeling for NMR structure determination of proteins in complex with unlabeled ligands.
2019 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 431, 2213-2221 (2019)
Structural insights into BET client recognition of endometrial and prostate cancer-associated SPOP mutants.
2019 Wissenschaftlicher Artikel in Stem Cell Reports Stem Cell Rep. 12, 861-868 (2019)
Pathological ASXL1 mutations and protein variants impair neural crest development.
2019 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 10:1659 (2019)
Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.
2019 Wissenschaftlicher Artikel in Molecular Cell Mol. Cell 74, 73-87.e8 (2019)
The co-chaperone Cnsl and the recruiter protein Hgh1 Link Hsp90 to translation elongation via chaperoning elongation factor 2.
2019 Wissenschaftlicher Artikel in FEBS Journal, The FEBS J. 286, 2366-2380 (2019)
Structure and characterization of Aspergillus fumigatus lipase B with a unique, oversized regulatory subdomain.
2019 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 47, 4859-4871 (2019)
Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors.
2019 Wissenschaftlicher Artikel in RSC Advances RSC Adv. 9, 5151-5157 (2019)
Chemical space exploration guided by deep neural networks.
2019 Wissenschaftlicher Artikel in Nature Nature 567, 113-117 (2019)
The centrosome protein AKNA regulates neurogenesis via microtubule organization.
2019 Wissenschaftlicher Artikel in Angewandte Chemie - Internationale Edition Angew. Chem.-Int. Edit. 58, 4286-4290 (2019)
Accurate determination of H-1-N-15 dipolar couplings using inaccurate settings of the magic angle in solid-state NMR spectroscopy.
2019 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 47, 1011-1029 (2019)
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs.
2019 Wissenschaftlicher Artikel in Journal of Chemical Information and Modeling J. Chem. Inf. Model. 59, 1062-1072 (2019)
Comparative study of multitask toxicity modeling on a broad chemical space.
2019 Wissenschaftlicher Artikel in Journal of Proteomics J. Proteomics 193, 1-9 (2019)
Dissecting the molecular effects of cigarette smoke on proteasome function.
2019 Wissenschaftlicher Artikel in Biomolecular NMR Assignments Biomol. NMR Assign. 13, 131-137 (2019)
NMR backbone and methyl resonance assignments of an inhibitory G-alpha subunit in complex with GDP.
2019 Wissenschaftlicher Artikel in EMBO Journal, The EMBO J. 37:e99876 (2019)
Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.
2019 Wissenschaftlicher Artikel in Structure Structure 27, 327-334.e3 (2019)
The structure of the SPOP-Pdx1 interface reveals insights into the phosphorylation-dependent binding regulation.
2019 Wissenschaftlicher Artikel in Molecular Informatics Mol. Inform. 38:1800104 (2019)
Bimolecular nucleophilic substitution reactions: Predictive models for rate constants and Molecular Reaction Pairs analysis.
2019 Wissenschaftlicher Artikel in Bioorganic chemistry Bioorg. Chem. 82, 284-289 (2019)
NMR fragment-based screening for development of the CD44-binding small molecules.
2019 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 431, 223-243 (2019)
The N-Terminal segment of the voltage-dependent anion channel: A possible membrane-bound intermediate in pore unbinding.
2019 Wissenschaftlicher Artikel in International Journal of Obesity Int. J. Obes. 43, 1305-1318 (2019)
Fluorescent blood-brain barrier tracing shows intact leptin transport in obese mice.
2018 Review in Emerging topics in life sciences / Royal Society of Biology ; Biochemical Society Emerg. Top. Life Sci. 2, 107-119 (2018)
Capturing dynamic conformational shifts in protein-ligand recognition using integrative structural biology in solution.
2018 Review in Current Pharmaceutical Design Curr. Pharm. Des. 24, 4932-4946 (2018)
Recent advances in half-life extension strategies for therapeutic peptides and proteins.
2018 Wissenschaftlicher Artikel in The journal of physical chemistry C J. Phys. Chem. C. 122, 16437-16442 (2018)
Magic-angle spinning frequencies beyond 300 kHz are necessary to yield maximum sensitivity in selectively methyl protonated protein samples in solid-state NMR.
2018 Wissenschaftlicher Artikel in Journal of Medicinal Chemistry J. Med. Chem. 61, 11144-11157 (2018)
Celastrol promotes weight loss in diet-induced obesity by inhibiting the protein tyrosine phosphatases PTP1B and TCPTP in the hypothalamus.
2018 Review in Current opinion in microbiology Curr. Opin. Microbiol. 46, 116-122 (2018)
Come, sweet death: Targeting glycosomal protein import for antitrypanosomal drug development.
2018 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 197 (2018)
Dissecting the molecular effects of cigarette smoke on proteasome function.
2018 Review in Molecular Informatics Mol. Inform. 37:1800108 (2018)
A survey of multi-task learning methods in chemoinformatics.
In: Applied Chemoinformatics: Achievements and Future Opportunities. 2018. 53-81
Prediction of physicochemical properties of compounds.
2018 Wissenschaftlicher Artikel in Angewandte Chemie - Internationale Edition Angew. Chem.-Int. Edit. 57, 14498-14502 (2018)
Ultrashort broadband cooperative pulses for multidimensional bio-molecular NMR experiments.
2018 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 430, 4925-4940 (2018)
The antibody light-chain linker regulates domain orientation and amyloidogenicity.
2018 Wissenschaftlicher Artikel in Angewandte Chemie - Internationale Edition Angew. Chem.-Int. Edit. 130, 14722-14726 (2018)
Overcoming volume selectivity of dipolar recoupling in biological solid-state NMR spectroscopy
In: Modern Magnetic Resonance. 2018. 879-910
Proton-detection in biological MAS solid-state NMR spectroscopy.
2018 Wissenschaftlicher Artikel in Journal of Structural Biology J. Struct. Biol. 204, 519-522 (2018)
Crystal structure of a biliverdin-bound phycobiliprotein: Interdependence of oligomerization and chromophorylation.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:3810 (2018)
Roquin targets mRNAs in a 3 '-UTR-specific manner by different modes of regulation.
2018 Wissenschaftlicher Artikel in Diabetes Diabetes 67, 2456-2465 (2018)
Celastrol-induced weight loss is driven by hypophagia and independent from UCP1.
2018 Wissenschaftlicher Artikel in ChemBioChem ChemBioChem 19, 1927-1933 (2018)
A split-intein-based method for the efficient production of circularized nanodiscs for structural studies of membrane proteins.
2018 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 4:eaaq1702 (2018)
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-beta aggregation.
2018 Wissenschaftlicher Artikel in Methods in Molecular Biology Methods Mol. Biol. 1764, 87-100 (2018)
Reconstitution of isotopically labeled ribosomal protein L29 in the 50S large ribosomal subunit for solution-state and solid-state NMR.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:2479 (2018)
Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:1472 (2018)
A switch point in the molecular chaperone Hsp90 responding to client interaction.
2018 Wissenschaftlicher Artikel in Genome Research Genome Res. 28, 699-713 (2018)
In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors.
2018 Wissenschaftlicher Artikel in Chemical biology & drug design Chem. Biol. Drug Des. 92, 1272-1278 (2018)
Rational design of isonicotinic acid hydrazide derivatives with antitubercular activity: Machine learning, molecular docking, synthesis and biological testing.
2018 Wissenschaftlicher Artikel in OncoTarget Oncotarget 9, 29365-29378 (2018)
Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs.
2018 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 293, 13191-13203 (2018)
Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity.
2018 Wissenschaftlicher Artikel in American Journal of Human Genetics, The Am. J. Hum. Genet. 102, 1018-1030 (2018)
Mutations in PPCS, encoding phosphopantothenoylcysteine synthetase, cause autosomal-recessive dilated cardiomyopathy.
2018 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 293, 8994-9005 (2018)
A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor.
2018 Wissenschaftlicher Artikel in Cell Cell 173, 706-719.e13 (2018)
Phase separation of FUS is suppressed by its nuclear import receptor and arginine methylation.
2018 Wissenschaftlicher Artikel in Journal of Chemical Information and Modeling J. Chem. Inf. Model. 58, 933-942 (2018)
Luciferase advisor: High-accuracy model to flag false positive hits in luciferase HTS assays.
2018 Wissenschaftlicher Artikel in ChemistrySelect ChemistrySelect 3, 5207-5211 (2018)
Three regioselectively acylated flavonoid aglycone derivatives in equimolar yield at one blow.
2018 Wissenschaftlicher Artikel in Chemistry - A European Journal Chem. Eur. J. 24, 5493-5499 (2018)
Production and structural analysis of membrane-anchored proteins in phospholipid nanodiscs.
2018 Wissenschaftlicher Artikel in eLife eLife 7:e33067 (2018)
Crystal structure of intraflagellar transport protein 80 reveals a homodimer required for ciliogenesis.
2018 Wissenschaftlicher Artikel in European Journal of Medicinal Chemistry Eur. J. Med. Chem. 150, 261-267 (2018)
Identification of small-molecule inhibitors of USP2a.
2018 Wissenschaftlicher Artikel in Science Translational Medicine Sci. Transl. Med. 10:eaao1313 (2018)
Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.
2018 Wissenschaftlicher Artikel in Chemical Communications Chem. Commun. 54, 5426-5429 (2018)
hIAPP forms toxic oligomers in plasma.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:1990 (2018)
Bacterial encapsulins as orthogonal compartments for mammalian cell engineering.
2018 Wissenschaftlicher Artikel in Journal of Structural Biology J. Struct. Biol. 203, 71-80 (2018)
Baculovirus-driven protein expression in insect cells: A benchmarking study.
2018 Wissenschaftlicher Artikel in Biomolecular NMR Assignments Biomol. NMR Assign. 12, 149-154 (2018)
H-1, N-15, and C-13 chemical shift assignments of the micelle immersed FAT C-terminal (FATC) domains of the human protein kinases ataxia-telangiectasia mutated (ATM) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) fused to the B1 domain of streptococcal protein G (GB1).
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:699 (2018)
Physical basis of amyloid fibril polymorphism.
2018 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 8:1116 (2018)
Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice.
2018 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 9:299 (2018)
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
2018 Wissenschaftlicher Artikel in Journal of Cell Biology, The J. Cell Biol. 217, 745-762 (2018)
A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.
2018 Wissenschaftlicher Artikel in Protein Science Protein Sci. 27, 546-560 (2018)
Target of rapamycin FATC domain as a general membrane anchor: The FKBP-12 like domain of FKBP38 as a case study.
2018 Wissenschaftlicher Artikel in Angewandte Chemie - Internationale Edition Angew. Chem.-Int. Edit. 57, 486-490 (2018)
Conformational selection of dimethylarginine recognition by the survival motor neuron tudor domain.
2018 Wissenschaftlicher Artikel in Nature Protocols Nat. Protoc. 13, 79-98 (2018)
Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR.
In: Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. 2017. 393-428
Empirical and physics-based calculations of physical–chemical properties.
2017Vortrag: Interdisciplinary School and Conference ITaS 2017, 14-17 September 2017, Ufa, Russia. (2017)
Conformal classification in problems of predicting the physicochemical properties of molecules.
2017 Letter to the Editor in Amyloid Amyloid 24, 10-10 (2017)
Solid- and solution-state nuclear magnetic resonance spectroscopic studies on antibody light chain amyloid formation and interactions with epigallocatechin gallate.
2017 Wissenschaftlicher Artikel in FEBS Letters FEBS Lett. 592, 130-146 (2017)
NMR analysis of the backbone dynamics of the small GTPase Rheb and its interaction with the regulatory protein FKBP38.
2017 Wissenschaftlicher Artikel in Journal of Visualized Experiments J. Vis. Exp.:e54886 (2017)
Combining wet and dry lab techniques to guide the crystallization of large coiled-coil containing proteins.
2017 Wissenschaftlicher Artikel in eLife eLife 6:e31226 (2017)
Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate.
2017 Wissenschaftlicher Artikel in Journal of Medical Genetics J. Med. Genet. 55, 104-113 (2017)
PURA syndrome: clinical delineation and genotype-phenotype study in 32 individuals with review of published literature.
2017 Meeting abstract in FEBS Journal, The FEBS J. 284, 263-263 (2017)
Innovative therapeutic modalities for solid EpCAM-positive tumours.
2017 Meeting abstract in FEBS Journal, The FEBS J. 284, 184-184 (2017)
The neuronal S100B cytokine targeting amyloid-beta aggregation in Alzheimer's disease.
2017 Wissenschaftlicher Artikel in Nucleic Acids Research Nucleic Acids Res. 45, 12536-12550 (2017)
Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference.
2017 Review in Microbial cell Microb. Cell 4, 229-232 (2017)
Inhibitors of glycosomal protein import provide new leads against trypanosomiasis.
2017 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 292, 17073-17083 (2017)
A chemical compound inhibiting the Aha1–Hsp90 chaperone complex.
2017 Wissenschaftlicher Artikel in Wiley Interdisciplinary Reviews: RNA Wiley Interdiscip. Rev. RNA 9, DOI: 10.1002/wrna.1453 (2017)
mRNA transport in fungal top models.
2017 Wissenschaftlicher Artikel in Journal of Physical Chemistry B J. Phys. Chem. B 121, 8719-8730 (2017)
Comparative study of REDOR and CPPI derived order parameters by 1H-detected MAS NMR and MD simulations.
2017 Wissenschaftlicher Artikel in Chemistry - A European Journal Chem. Eur. J. 23, 14267-14277 (2017)
Effects of fluorophore attachment on protein conformation and dynamics studied by spFRET and NMR spectroscopy.
2017 Wissenschaftlicher Artikel in Journal of Magnetic Resonance J. Magn. Reson. 284, 20-32 (2017)
Radiofrequency fields in MAS solid state NMR probes.
2017 Wissenschaftlicher Artikel in Toxins Toxins 9:288 (2017)
Evidence for complex formation of the Bacillus cereus haemolysin BL components in solution.
2017 Review in BioSpektrum BioSpektrum 23, 510-512 (2017)
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2017 Wissenschaftlicher Artikel in Journal of the American Chemical Society J. Am. Chem. Soc. 139, 12165-12174 (2017)
Characterization of protein-protein interfaces in large complexes by solid-state NMR solvent paramagnetic relaxation enhancements.
2017 Wissenschaftlicher Artikel in RNA RNA 23, 1780-1787 (2017)
Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the pre-ribosomal protein Nop53.
2017 Wissenschaftlicher Artikel in Food and Chemical Toxicology Food Chem. Toxicol. 112, 507-517 (2017)
Modelling the toxicity of a large set of metal and metal oxide nanoparticles using the OCHEM platform.
2017 Wissenschaftlicher Artikel in Protein Expression and Purification Protein Expr. Purif. 140, 74-80 (2017)
Expression and purification of a difficult sarcomeric protein: Telethonin.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:7444 (2017)
Limits of resolution and sensitivity of proton detected MAS solid-state NMR experiments at 111 kHz in deuterated and protonated proteins.
2017 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 12:e0181799 (2017)
MAK33 antibody light chain amyloid fibrils are similar to oligomeric precursors.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:5393 (2017)
RNA structure refinement using NMR solvent accessibility data.
2017 Wissenschaftlicher Artikel in Angewandte Chemie - Internationale Edition Angew. Chem.-Int. Edit. 56, 9322-9325 (2017)
Segmental, domain-selective perdeuteration and small-angle neutron scattering for structural analysis of multi-domain proteins.
2017 Wissenschaftlicher Artikel in ChemMedChem ChemMedChem 13, 599-606 (2017)
Matched molecular pair analysis on large melting point datasets: A big data perspective.
2017 Wissenschaftlicher Artikel in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 140, 1187-1191 (2017)
Flexible IgE epitope containing domains of Phl p 5 cause high allergenic activity.
2017 Wissenschaftlicher Artikel in Applied Microbiology and Biotechnology Appl. Microbiol. Biotechnol. 101, 5689-5697 (2017)
Enhancing H2O2 resistance of an esterase from Pyrobaculum calidifontis by structure-guided engineering of the substrate binding site.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:1051 (2017)
Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator.
2017 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 292, 7462-7473 (2017)
Structural basis of outer dynein arm intraflagellar transport by the transport adaptor protein ODA16 and the intraflagellar transport protein IFT46.
2017 Wissenschaftlicher Artikel in Molecular and Cellular Proteomics Mol. Cell. Proteomics 16, 1528-1546 (2017)
Proteome-wide identification of glycosylation-dependent interactors of Galectin-1 and Galectin-3 on mesenchymal retinal pigment epithelial cells.
2017 Wissenschaftlicher Artikel in Science Advances Sci. Adv. 3:e1602498 (2017)
Long-range allosteric signaling in red light-regulated diguanylyl cyclases.
2017 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 8:14635 (2017)
Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.
2017 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 12:e0174337 (2017)
Transient helicity in intrinsically disordered Axin-1 studied by NMR spectroscopy and molecular dynamics simulations.
München, Technische Universität, Fakultät für Chemie, Diss., 2017, 185 S.
Structural and functional characterization of the ASH1-mRNP transport-complex from budding yeast.
2017 Wissenschaftlicher Artikel in Science Science 355, 1416-1420 (2017)
Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
2017 Wissenschaftlicher Artikel in Biological Chemistry Biol. Chem. 398, 341-357 (2017)
Comparison of enzymatic properties and small molecule inhibition of γ-glutamyltranspeptidases from pathogenic and commensal bacteria.
2017 Wissenschaftlicher Artikel in Methods Methods 118, 119-136 (2017)
Integrated structural biology to unravel molecular mechanisms of protein-RNA recognition.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:41515 (2017)
Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains.
2017 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 7:44041 (2017)
The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
2017 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 24, 152-161 (2017)
Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex.
2017 Wissenschaftlicher Artikel in Molecular Informatics Mol. Inform. 36:1600082 (2017)
Public (Q)SAR services, integrated modeling environments, and model repositories on the web: State of the art and perspectives for future development.
2017 Wissenschaftlicher Artikel in Nature Methods Nat. Methods 14, 49-52 (2017)
Covalently circularized nanodiscs for studying membrane proteins and viral entry.
2016 Wissenschaftlicher Artikel in ChemistrySelect ChemistrySelect 1, 836-839 (2016)
Lipase-driven epoxidation is a two-stage synergistic process.
2016 Wissenschaftlicher Artikel in Journal of Medicinal Chemistry J. Med. Chem. 59, 10190-10197 (2016)
Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing.
2016 Wissenschaftlicher Artikel in eLife eLife 5:e14707 (2016)
Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation.
2016 Wissenschaftlicher Artikel in Journal of Biological Chemistry, The J. Biol. Chem. 291, 27062-27072 (2016)
Oxidative unfolding of the rubredoxin domain and the natively disordered N-terminal region regulate the catalytic activity of Mycobacterium tuberculosis protein kinase G.
2016 Wissenschaftlicher Artikel in Frontiers in Plant Science Front. Plant Sci. 7:1669 (2016)
ROS-mediated inhibition of S-nitrosoglutathione reductase contributes to the activation of anti-oxidative mechanisms.
2016 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 113, E7169-E7175 (2016)
Recognition of the 3′ splice site RNA by the U2AF heterodimer involves a dynamic population shift.
2016 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 23, 1020-1028 (2016)
Importance of cycle timing for the function of the molecular chaperone Hsp90.
2016 Wissenschaftlicher Artikel in Frontiers in Environmental Science Front. Env. Sci. 4:2 (2016)
Consensus modeling for HTS assays using in silico descriptors calculates the best balanced accuracy in Tox21 challenge.
2016 Wissenschaftlicher Artikel in Angewandte Chemie - Internationale Edition Angew. Chem.-Int. Edit. 55, 14847-14851 (2016)
Increasing the chemical-shift dispersion of unstructured proteins with a covalent lanthanide shift reagent.
2016 Review in Future medicinal chemistry Future Med. Chem. 8, 1801-1806 (2016)
Does 'Big Data' exist in medicinal chemistry, and if so, how can it be harnessed?
2016 Wissenschaftlicher Artikel in Acta crystallographica / International Union of Crystallography Act. Cryst. F 72, 743-749 (2016)
Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4.
2016 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 6, 34525 (2016)
DNA annealing by Redβ is insufficient for homologous recombination and the additional requirements involve intra- and inter-molecular interactions.
2016 Review in Frontiers in Molecular Biosciences Front. Mol. Biosci. 3, 54 (2016)
Investigating the role of large-scale domain dynamics in protein-protein interactions.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:12897 (2016)
PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells.
2016 Wissenschaftlicher Artikel in Biomolecular NMR Assignments Biomol. NMR Assign. 10, 401-406 (2016)
Chemical shift assignment of the intrinsically disordered N-terminus and the rubredoxin domain in the folded metal bound and unfolded oxidized state of mycobacterial protein kinase G.
2016 Wissenschaftlicher Artikel in Chemistry - A European Journal Chem. Eur. J. 22, 15350-15359 (2016)
Site-specific isotope-labeling of inosine phosphoramidites and NMR analysis of an inosine-containing RNA duplex.
2016 Wissenschaftlicher Artikel in Angewandte Chemie - Internationale Edition Angew. Chem.-Int. Edit. 55, 11970-11974 (2016)
Prediction of protein structure using surface accessibility data.
2016 Wissenschaftlicher Artikel in Molecular Informatics Mol. Inform. 35, 615-621 (2016)
BIGCHEM: Challenges and opportunities for big data analysis in chemistry.
2016 Review in Expert Opinion on Drug Discovery Expert Opin. Drug Discov. 11, 785-795 (2016)
A renaissance of neural networks in drug discovery.
2016 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 113, E4357-E4366 (2016)
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:11874 (2016)
Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length.
2016 Wissenschaftlicher Artikel in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 113, E3629-E3638 (2016)
Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding.
2016 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 6:26707 (2016)
Solution structure and binding specificity of the p63 DNA binding domain.
2016 Wissenschaftlicher Artikel in Chemical Research in Toxicology Chem. Res. Toxicol. 29, 768-775 (2016)
ToxCast EPA in vitro to in vivo challenge: Insight into the rank-I model.
2016 Wissenschaftlicher Artikel in Diabetologia Diabetologia 59, 1743-1752 (2016)
Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice.
2016 Wissenschaftlicher Artikel in FEBS Open Bio FEBS Open Bio 6, 477-483 (2016)
Lid mobility in lipase SMG1 validated using a thiol/disulfide redox potential probe.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:11032 (2016)
Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.
2016 Wissenschaftlicher Artikel in Solid State Nuclear Magnetic Resonance Solid State Nucl. Magn. Reson. 76-77, 7-14 (2016)
Immobilization of soluble protein complexes in MAS solid-state NMR: Sedimentation versus viscosity.
2016 Wissenschaftlicher Artikel in Journal of Biomolecular Screening J. Biomol. Screen. 21, 596-607 (2016)
Identification of small-molecule frequent hitters of glutathione S-transferase-glutathione interaction.
2016 Wissenschaftlicher Artikel in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 23, 324-332 (2016)
Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.
2016 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 6:22540 (2016)
Novel small molecules targeting ciliary transport of smoothened and oncogenic Hedgehog pathway activation.
2016 Wissenschaftlicher Artikel in Biochemistry Biochemistry 55, 1839-1849 (2016)
Sulindac sulfide induces the formation of large oligomeric aggregates of the Alzheimer's disease amyloid-β peptide which exhibit reduced neurotoxicity.
2016 Review in Wiley Interdisciplinary Reviews: RNA Wiley Interdiscip. Rev. RNA 7, 455-469 (2016)
RNA recognition by Roquin in posttranscriptional gene regulation.
2016 Wissenschaftlicher Artikel in Journal of the American Chemical Society J. Am. Chem. Soc. 138, 1601-1610 (2016)
Improved accuracy from joint X-ray and NMR refinement of a protein-RNA complex structure.
2016 Wissenschaftlicher Artikel in Environmental Health Perspectives Environ. Health Perspect. 124, 1023-1033 (2016)
CERAPP: Collaborative estrogen receptor activity prediction project.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0149477 (2016)
Pitchfork and Gprasp2 target smoothened to the primary cilium for Hedgehog pathway activation.
2016 Wissenschaftlicher Artikel in Acta Neuropathologica Acta Neuropathol. 131, 587-604 (2016)
Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.
2016 Wissenschaftlicher Artikel in Molecules Molecules 21, DOI: 10.3390/molecules21010001 (2016)
Extended Functional Groups (EFG): An efficient set for chemical characterization and structure-activity relationship studies of chemical compounds.
2016 Wissenschaftlicher Artikel in eLife eLife 5:e11297 (2016)
Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.
2016 Wissenschaftlicher Artikel in Journal of Chemical Theory and Computation J. Chem. Theory Comput. 12, 383-394 (2016)
A rigorous and efficient method to reweight very large conformational ensembles using average experimental data and to determine their relative information content.
2016 Wissenschaftlicher Artikel in Nature Communications Nat. Commun. 7:10355 (2016)
Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
2016 Wissenschaftlicher Artikel in Journal of Molecular Biology J. Mol. Biol. 428, 1315-1332 (2016)
A stable mutant predisposes antibody domains to amyloid formation through specific non-native interactions.
2016 Wissenschaftlicher Artikel in Journal of Cheminformatics J. Cheminformatics 8:2 (2016)
The development of models to predict melting and pyrolysis point data associated with several hundred thousand compounds mined from PATENTS.
2016 Wissenschaftlicher Artikel in PLoS ONE PLoS ONE 11:e0146887 (2016)
Epithelial-to-mesenchymal transition of RPE cells in vitro confers increased β1,6-N-glycosylation and increased susceptibility to galectin-3 binding.
2016 Wissenschaftlicher Artikel in Scientific Reports Sci. Rep. 6:18934 (2016)
Inhibition of canonical NF-κB signaling by a small molecule targeting NEMO-ubiquitin interaction.
2016 Wissenschaftlicher Artikel in Biochimica et Biophysica Acta - Molecular Cell Research Biochim. Biophys. Acta-Mol. Cell Res. 1863, 863-869 (2016)
Towards the molecular mechanism of the integration of peroxisomal membrane proteins.
2016 Wissenschaftlicher Artikel in Journal of Inorganic Biochemistry J. Inorg. Biochem. 156, 1-13 (2016)
Prediction of logP for Pt(II) and Pt(IV) complexes: Comparison of statistical and quantum-chemistry based approaches.
2016 Wissenschaftlicher Artikel in ACS Chemical Biology ACS Chem. Biol. 11, 1001-1011 (2016)
Spiroepoxytriazoles are fumagillin-like irreversible inhibitors of MetAP2 with potent cellular activityγ.
2016 Wissenschaftlicher Artikel in Biochimica et Biophysica Acta - Molecular Cell Research Biochim. Biophys. Acta-Mol. Cell Res. 1863, 804-813 (2016)