Ebert Lab
Our lab is interested in the study of cell signaling pathways related to cell death and inflammation manipulated during host-pathogen interactions for novel therapeutic development.
About our research
Our research is focused on the characterization of host-pathogen interactions and the role of cell signaling and cell death during intracellular infections to identify novel host and virulence factors that manipulate the host to facilitate infection. Analysis and understanding of involved signaling pathways and factors allow us to identify novel potent therapeutic targets and strategies to fight infections. We aim to identify and design small molecule compounds that inhibit or eliminate these factors to support the control of infection, including chronic hepatitis B, SARS-CoV-2 and bunyavirus infection. Our work intersects with the fields of molecular virology, cell signaling, immunology and biochemistry and includes in vitro based cell culture assays and tools as well as in vivo infection models in BSL2 and BSL3 laboratories.
Gruppenleiter
PhD Student
Technician
Technician
Publications
Rong, Z. ; Mai, H. ; Ebert, G. ; Kapoor, S. ; Puelles, V.G. ; Czogalla, J. ; Hu, S. ; Su, J. ; Prtvar, D. ; Singh, I. ; Schädler, J. ; Delbridge, C. ; Steinke, H. ; Frenzel, H. ; Schmidt, K. ; Braun, C. ; Bruch, G. ; Ruf, V. ; Ali, M. ; Sühs, K.W. ; Nemati, M. ; Hopfner, F. ; Ulukaya, S. ; Jeridi, D. ; Mistretta, D. ; Caliskan, Ö.S. ; Wettengel, J.M. ; Cherif, F. ; Kolabas, Z.I. ; Molbay, M. ; Horvath, I. ; Zhao, S. ; Krahmer, N. ; Yildirim, A.Ö. ; Ussar, S. ; Herms, J. ; Huber, T.B. ; Tahirovic, S. ; Schwarzmaier, S.M. ; Plesnila, N. ; Höglinger, G. ; Ondruschka, B. ; Bechmann, I. ; Protzer, U. ; Elsner, M. ; Bhatia, H.S. ; Hellal, F. ; Ertürk, A.
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19.Huang, Y. ; Bergant, V. ; Grass, V. ; Emslander, Q. ; Hamad, M.S. ; Hubel, P. ; Mergner, J. ; Piras, A. ; Krey, K. ; Henrici, A. ; Öllinger, R. ; Tesfamariam, Y.M. ; Dalla Rosa, I. ; Bunse, T. ; Sutter, G. ; Ebert, G. ; Schmidt, F.I. ; Way, M. ; Rad, R. ; Bowie, A.G. ; Protzer, U. ; Pichlmair, A.
Multi-omics characterization of the monkeypox virus infection.Kohantorabi, M. ; Ugolotti, A. ; Sochor, B. ; Rössler, J. ; Wagstaffe, M. ; Meinhardt, A. ; Beck, E.E. ; Dolling, D.S. ; Garcia, M.B. ; Creutzburg, M. ; Keller, T.F. ; Schwartzkopf, M. ; Vayalil, S.K. ; Thuenauer, R. ; Guédez, G. ; Löw, C. ; Ebert, G. ; Protzer, U. ; Hammerschmidt, W. ; Zeidler, R. ; Roth, S.V. ; Di Valentin, C. ; Stierle, A. ; Noei, H.
Light-induced transformation of virus-like particles on TiO2.Falke, S. ; Lieske, J. ; Herrmann, A. ; Loboda, J. ; Karničar, K. ; Günther, S. ; Reinke, P.Y.A. ; Ewert, W. ; Usenik, A. ; Lindič, N. ; Sekirnik, A. ; Dretnik, K. ; Tsuge, H. ; Turk, V. ; Chapman, H.N. ; Hinrichs, W. ; Ebert, G. ; Turk, D. ; Meents, A.
Structural elucidation and antiviral activity of covalent cathepsin L inhibitors.Gruber, C. ; Krautner, L. ; Bergant, V. ; Grass, V. ; Ma, Z. ; Rheinemann, L. ; Krus, A. ; Reinhardt, F. ; Mazneykova, L. ; Rocha-Hasler, M. ; Truong, D.J.J. ; Westmeyer, G.G. ; Pichlmair, A. ; Ebert, G. ; Giesert, F. ; Wurst, W.
Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting.Tu, T. ; Wettengel, J.M. ; Xia, Y. ; Testoni, B. ; Littlejohn, M. ; Le Bert, N. ; Ebert, G. ; Verrier, E.R. ; Tavis, J.E. ; Cohen, C.
Major open questions in the hepatitis B and D field – Proceedings of the inaugural International emerging hepatitis B and hepatitis D researchers workshop.Deerain, J.M. ; Aktepe, T.E. ; Trenerry, A.M. ; Ebert, G. ; Hyde, J.L. ; Charry, K. ; Edgington-Mitchell, L. ; Xu, B. ; Ambrose, R.L. ; Sarvestani, S.T. ; Lawlor, K.E. ; Pearson, J.S. ; White, P.A. ; Mackenzie, J.M.
Murine norovirus infection of macrophages induces intrinsic apoptosis as the major form of programmed cell death.Reinke, P.Y.A. ; de Souza, E.E. ; Gunther, S. ; Falke, S. ; Lieske, J. ; Ewert, W. ; Loboda, J. ; Herrmann, A. ; Rahmani Mashhour, A. ; Karničar, K. ; Usenik, A. ; Lindič, N. ; Sekirnik, A. ; Botosso, V.F. ; Santelli, G.M.M. ; Kapronezai, J. ; de Araújo, M.V. ; Silva-Pereira, T.T. ; Filho, A.F.S. ; Tavares, M.S. ; Flórez-Álvarez, L. ; de Oliveira, D.B.L. ; Durigon, E.L. ; Giaretta, P.R. ; Heinemann, M.B. ; Hauser, M. ; Seychell, B. ; Böhler, H. ; Rut, W. ; Drag, M. ; Beck, T. ; Cox, R. ; Chapman, H.N. ; Betzel, C. ; Brehm, W. ; Hinrichs, W. ; Ebert, G. ; Latham, S.L. ; Guimarães, A.M.S. ; Turk, D. ; Wrenger, C. ; Meents, A.
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.Garnish, S.E. ; Martin, K.R. ; Kauppi, M. ; Jackson, V.E. ; Ambrose, R. ; Eng, V.V. ; Chiou, S. ; Meng, Y. ; Frank, D. ; Tovey Crutchfield, E.C. ; Patel, K.M. ; Jacobsen, A.V. ; Atkin-Smith, G.K. ; Di Rago, L. ; Doerflinger, M. ; Horne, C.R. ; Hall, C. ; Young, S.N. ; Cook, M. ; Athanasopoulos, V. ; Vinuesa, C.G. ; Lawlor, K.E. ; Wicks, I.P. ; Ebert, G. ; Ng, A.P. ; Slade, C.A. ; Pearson, J.S. ; Samson, A.L. ; Silke, J. ; Murphy, J.M. ; Hildebrand, J.M.
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.Kohantorabi, M. ; Wagstaffe, M. ; Creutzburg, M. ; Ugolotti, A. ; Kulkarni, S. ; Jeromin, A. ; Krekeler, T. ; Feuerherd, M. ; Herrmann, A. ; Ebert, G. ; Protzer, U. ; Guédez, G. ; Löw, C. ; Thuenauer, R. ; Schlueter, C. ; Gloskovskii, A. ; Keller, T.F. ; Di Valentin, C. ; Stierle, A. ; Noei, H.
Adsorption and inactivation of SARS-CoV-2 on the surface of anatase TiO2(101).Frank, D. ; Garnish, S.E. ; Sandow, J.J. ; Weir, A. ; Liu, L. ; Clayer, E. ; Meza, L. ; Rashidi, M. ; Cobbold, S.A. ; Scutts, S.R. ; Doerflinger, M. ; Anderton, H. ; Lawlor, K.E. ; Lalaoui, N. ; Kueh, A.J. ; Eng, V.V. ; Ambrose, R.L. ; Herold, M.J. ; Samson, A.L. ; Feltham, R. ; Murphy, J.M. ; Ebert, G. ; Pearson, J.S. ; Vince, J.E.
Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death.Grohmann, C. ; Marapana, D.S. ; Ebert, G.
Targeted protein degradation at the host-pathogen interface.Contact