Epigenetic alterations may reflect behavior that is associated with eating habits, physical activity, weight gain and weight loss. Epigenetic changes or marks may not only serve as markers for a certain behavior, they may also represent a mechanism that links obesity to related comorbid disorders.
Thus, we analyze targeted and genome wide DNA methylation, mRNA expression and miRNA changes in cells from blood and adipose tissue of individuals i) participating in randomized controlled behavior intervention trials, ii) undergoing metabolic surgery or iii) living in a predefined obesogenic or healthy environment based on diet, physical activity, smoking and alcohol.
The obtained stable and modifiable epigenetic pattern will then be used to develop markers and targets for personalized obesity therapy.
Scientists working in the project
Dr. Maria KellerPostDoc
Prof. Dr. Matthias BlüherHI-MAG Director and Head of Clinical Obesity Research Group View profile
Prof. Dr. Michael StumvollClinical Programme Director View profile
Changes in Circulating microRNAs-99/100and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL MRI Randomized Controlled Trial
Lifestyle Weight-Loss Intervention May Attenuate Methylation Aging: The CENTRAL MRI Randomized Controlled Trial