Newsroom.

Sporadic Parkinson's Disease (sPD) is a progressive neurodegenerative disorder influenced by both genetic and environmental factors. While mitochondrial dysfunction contributes to this condition, its role across disease progression remains unclear.…

Scientists from the Bonev Lab at the PioneerCampus at Helmholtz Munich present 3DRAM-seq, a revolutionary technique that maps spatial genome organization, chromatin accessibility, DNA methylation, and gene expression - all at once.

A groundbreaking study now published in Nature Genetics marks a turning point in depression genetics, offering new hope for personalized medicine through enhanced Polygenic Risk Scores (PRS).

Helmholtz Munich researchers have discovered, that air pollutants activate previously dormant herpes viruses leading to a immune response. These new findings are now published in ASC Nano.

Scientists from the PioneerCampus at Helmholtz Munich unraveled rather transcriptionally distinct subgroups of human hepatocytes with relevance to human disease and personalized treatment.

Understanding ferroptosis is essential for addressing degenerative diseases and certain cancers. Researchers, led by Dr. Kamyar Hadian from Helmholtz Munich, revealed that the Farnesoid X Receptor (FXR), activated by bile acids, serves as a master…

Chronic obstructive pulmonary disease (COPD) was in 2019 the primary cause of deaths from chronic respiratory diseases, accounting for 3.3 million deaths worldwide. In Germany, according to the “European Lung White Book”, the number of COPD patients…

Prediabetes is a precursor to type 2 diabetes with an increased risk of heart attacks, kidney and eye diseases, and various types of cancer. In Germany, there is no approved medication for prediabetes. Scientists from the German Center for Diabetes…

An in vitro roadmap guiding vascularization in tissue engineering

With the dilemma of the need for organ transplants by far surpassing available donor organs, the number of patients dying while waiting for a suitable transplant will inevitably…

A collaborative endeavor between computer scientists and diabetes researchers at Helmholtz Munich has yielded novel insights into the mechanisms underlying type 1 and type 2 diabetes. This collaboration has resulted in the creation of the first mouse…

A recent discovery led by Dr. Anika Seel and Dr. Kurt Schmoller at the Institute for Functional Epigenetics (IFE) at Helmholtz Munich has uncovered a fascinating link between cell size and mitochondrial DNA regulation, shedding light on a previously…

Researchers from Helmholtz Munich have reached a significant milestone in precision medicine with their new publication on the 'Oncology Biomarker Discovery (OncoBird)' framework. This innovative approach aims to systematically identify actionable…

DNA origami structures fitted with antibodies help immune system to target cancer cells

Immunotherapy is viewed as an exceptionally promising weapon in the fight against cancer. In essence, the aim is to activate the body’s immune system in such a…

The coexistence of multiple chronic diseases in a single individual, defined as multimorbidity, poses a significant challenge in healthcare as the global population ages. In a collaborative effort, researchers investigated the link between type 2…

Over the past decades, epidemiological studies have clearly demonstrated the effects of air pollution on health. There are now explicit recommendations from the World Health Organization regarding guidelines for particulate matter, especially PM2.5…

Diagnosis of type 1 diabetes (T1D) can come with serious complications for families: too often, the autoimmune disease is only detected after severe symptoms develop. In Germany, more than 20 percent of all children and adolescents diagnosed with T1D…

Human health is closely connected to the health of our environment. So far, the complex ways in which they influence each other are not fully understood. The concept of One Health recognizes this interconnectedness of human, animal, and environmental…

New algorithm six times more reliable at predicting defective RNA

So far, it has not been possible to explain the causes of around half of all rare hereditary diseases. A Munich research team has developed an algorithm that predicts the effects of…

Predicting the effects of drugs regarding dosage, timing, possible drug combinations and other types of intervention such as gene knockouts can be experimentally difficult and very time-consuming. Nonetheless, this is one of the most important tasks…

Inflammatory fatty liver disease (NASH, nonalcoholic steatohepatitis) and the resulting liver cancer are driven by autoaggressive T cells. Scientists from the German Cancer Research Center (DKFZ), Helmholtz Munich and the Technical University Munich…

It is commonly known that DNA assembles into heterochromatin, a densely composed structure, thereby preventing access to the information encoded by the DNA and gene expression. Until now it is not completely understood how this structure forms during…

Triose phosphates (TPs) are the primary products of photosynthetic CO₂ fixation in chloroplasts, which need to be exported into the cytosol across the chloroplast inner envelope (IE) and outer envelope (OE) membranes to sustain plant growth.

A team…

Lean, metabolically unhealthy, people have a risk of cardiovascular disease (CVD) that is higher than the risk observed in obese, metabolically healthy people. Recently, novel cluster analyses (computer-based grouping of people) also identified a…

Identification of a previously unknown function of adipose tissue in insulin secretion.

Scientists at Helmholtz Munich and the University of Augsburg have made an important breakthrough in better understanding early processes in the development of…

Type 2 diabetes disease progression and successful intervention depend on individual’s unique clinical, genetic, genomic, and environmental information partly represented by gene expression patterns. An international team of researchers around…

Non-alcoholic fatty liver disease (NAFLD) is an important risk factor for type 2 diabetes and cardiovascular diseases. In a Perspective in Cell Metabolism, Norbert Stefan from Helmholtz Munich, the German Center for Diabetes Research and the…

Modern cancer therapy aims to tailor treatment to each individual patient's needs by identifying specific molecular targets with essential functions in the tumor of these patients. Leukemia, or blood cancer, is a common tumor in children and occurs…

How can the clinical translation of research findings be accelerated to improve human health? What role does bioengineering play in driving the development of medicine and biology solutions? Matthias Tschöp, CEO at Helmholtz Munich and Alexander von…

The renal phosphate wasting disease X-linked hypophosphatemia (XLH) is a rare metabolic disorder of the bones associated with severe renal phosphate loss. The first symptoms of the genetic defect appear in childhood and adolescence and can…

Which factors drive non-communicable inflammatory skin diseases? A research team led by Stefanie Eyerich, Michael Menden, as well as Kilian Eyerich have investigated this question and applied a new spatial transcriptomics technology, that gives…

A research team from Helmholtz Munich and the Leipzig University’s Faculty of Medicine has discovered a new mechanism that is associated with severe obesity in children. This genetic rearrangement leads to an unusual expression of a gene that can…

Three approaches with a reputation for slowing aging processes have proven largely ineffective. For their study, researchers developed a new method to measure aging, which accounts for the complexity of aging in organisms.

It is well known that genes and environmental factors such as air pollutants, bacteria and also diet can influence the development of allergies or asthma. Researchers at Helmholtz Munich have now examined the role of food in more detail. Their…

How is a muscle protein related to energy production in brown adipose tissue (BAT)? And could this be a possible starting point in the fight against obesity? A team of researchers led by John Heiker from the Helmholtz Institute for Metabolic, Obesity…

The discovery of gut hormone dual and triple co-agonist drug classes by Matthias Tschöp and Richard DiMarchi has led to a series of new therapeutics in clinical development. The first co-agonist at the receptors for GLP-1 and GIP has recently been…

Through the course of the last several decades, the rate of obesity has progressively increased and is now one of the leading causes of death worldwide – according to the World Health Organization (WHO) 650 million adults are classified as obese. The…

Does exercise help against diabetes and obesity? Researchers around PD Dr Stephanie Kullmann from Helmholtz Munich and DZD have investigated this question in a clinical study. The results show that just eight weeks of exercise can help restore the…

More than three percent of the world’s population (around 300 million people) are living with a chronic hepatitis B virus (HBV) infection. Having chronic hepatitis B increases the risk for patients to develop liver failure, liver cancer or cirrhosis…

Helmholtz Munich researcher Kristian Unger, head of Translational Bioinformatics at the Department of Radiation Cytogenetics (ZYTO), together with scientists from the LMU Radiation Clinic and the LMU Medical Physics, has developed the AI method…

Surface molecules EGFR and Integrin beta 4 play a key role in this process

Frequently, cancer patients do not die because of their “initial tumor” in a specific organ. Only when individual cells of the primary tumor transform, migrate or colonize…

New Publication of Ali Doryab and Otmar Schmid (Schmid Lab, Institute of Lung Health and Immunity) in Advanced Materials

Parkinson's disease, formerly known as shaking palsy, is the second most common neurodegenerative disease in Germany after Alzheimer's disease. It affects about 400,000 people in Germany alone and can neither be cured nor can its progression be…

The use of artificial intelligence (AI) in the field of pathology, especially in the early detection of diseases, has increased rapidly in the past decade. However, despite an ever-growing number of publications in the field, only few methods are…