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Prof. Dr. med. Irmela Jeremias

Head of the “Research Unit Apoptosis in Hematopoietic Stem Cells” at Helmholtz Munich
+49 89-3187-1424Email meBuilding/Room: 90

“I am a Pediatrician interested in improving treatment of children with acute leukemias. Focusing on leukemia stem cells, we use preclinical models and genetic engineering to identify novel therapeutic targets and treatment options.”

“I am a Pediatrician interested in improving treatment of children with acute leukemias. Focusing on leukemia stem cells, we use preclinical models and genetic engineering to identify novel therapeutic targets and treatment options.”

Academic Career

I am working as a Medical Doctor at Dr. von Haunersches Kinderspital of LMU Munich since 1993, starting as a Resident, later Attending Physician in Intensive Care and board certified Pediatrician, currently with a focus on Molecular Tumor Board. After my PostDoc at the German Cancer Research Center I started my own lab in Munich in 1998. In 2005 I started with a Junior Research group at Helmholtz Munich where I still work today, as tenured group leader and later as head of Department. I was and I am part of the German Cancer Research Center, several Collaborative Research Centers and Leukemia Study Groups.

My research aim is improving treatment of children and adults suffering acute leukemia, both the lymphoblastic (ALL) as well as the myeloid (AML) subtype. By generating genetically engineered patient-derived xenograft (PDX) leukemia models, I am collaborating with partners worldwide to identify and validate novel treatment options for these patients. My focus is on eliminating leukemia stem cells to prevent disease relapse and improve outcome.

Fields of Work and Expertise

Patient-derived xenograft (PDX) mouse modelsGenetic engineering of patients´ leukemia cells Preclinical in vivo treatment trials

Professional Background

since 2017

Head of the “Research Unit Apoptosis in Hematopoietic Stem Cells” at Helmholtz Munich

since 2017

Mildred Scheel Professorship of the German Cancer Aid at the Ludwig-Maximilian-Universität (LMU), Munich

since 2005

Head of the Research Group „Apoptosis“ at Helmholtz Munich, tenured since 2012

since 1996-1998

Postdoctoral Position at German Cancer Center (DKFZ), Heidelberg, under guidance of Prof. K.-M. Debatin working on mechanisms of apoptosis in pediatric tumors

since 1993

Resident, Pediatrician, Attending Physician at Dr. von Haunersches Kinderspital, LMU, Munich

Honors and Awards

  • Mildred Scheel Professorship of German Cancer Aid
    2017-2022

  • Consolidator Grant of European Research Council (ERC CoG)
    2016-2021

  • Award for „Excellent Women“
    within the Impuls- and Integration Fond (IVF) by the Helmholtz Association (HGF)
    2013-2018

  • Postdoctoral Fellowship of the German Research Foundation (DFG)
    1996-1998

Highlight Publications

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2016 Cancer Cell

Sarah Ebinger, Erbey Ziya Özdemir, Christoph Ziegenhain, Sebastian Tiedt, Catarina Castro Alves, Michaela Grunert, Michael Dworzak, Christoph Lutz, Virginia A. Turati, Tariq Enver, Hans-Peter Horny, Karl Sotlar, Swati Parekh, Karsten Spiekermann, Wolfgang Hiddemann, Aloys Schepers, Bernhard Polzer, Stefan Kirsch, Martin Hoffmann, Bettina Knapp, Jan Hasenauer, Heike Pfeifer, Renate Panzer-Grümayer, Wolfgang Enard, Olivier Gires, Irmela Jeremias

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

Networks and Affiliations

Bettina-Bräu-Stiftung

LMU Haunersches Kinderspital