Publications from Dr. Christian Gieger
2022 Scientific Article in Genome Biology Genome Biol. 23:268 (2022)
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
2022 Scientific Article in Nature Nature 612, 720–724 (2022)
Genetic diversity fuels gene discovery for tobacco and alcohol use.
2022 Scientific Article in ACR Open Rheumatology ACR Open Rheumatol. 4, 528-533 (2022)
47XXY and 47XXX in scleroderma and myositis.
2022 Scientific Article in Environmental Science & Technology Environ. Sci. Technol. 56, 17815-17824 (2022)
Higher daily air temperature is associated with shorter leukocyte telomere length: KORA F3 and KORA F4.
2022 Nature Nature 612:E7 (2022)
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries.
2022 Scientific Article in Journal of Lipid Research J. Lipid Res. 63, 11:100306 (2022)
The kringle IV type 2 domain variant 4925G>A causes the elusive association signal of the LPA pentanucleotide repeat.
2022 Scientific Article in Genome Medicine Genome Med. 14:125 (2022)
Network reconstruction for trans acting genetic loci using multi-omics data and prior information.
2022 Scientific Article in Nature Cardiovascular Research Nat. Cardio. Res. 1, 727–731 (2022)
Triggering of myocardial infarction by heat exposure is modified by medication intake.
2022 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 109, 1366-1387 (2022)
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
2022 Scientific Article in Immunity Immunity 55, 2285-2299.e7 (2022)
Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease.
2022 Scientific Article in Nature Communications Nat. Commun. 13:6204 (2022)
Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.
2022 Scientific Article in Neurology Neurology 99, E1738-E1754 (2022)
Contribution of common genetic variants to risk of early onset ischemic stroke.
2022 Scientific Article in Nature Nature 611, 115-123 (2022)
Stroke genetics informs drug discovery and risk prediction across ancestries.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 1332–1344 (2022)
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.
2022 Scientific Article in Sleep Sleep 45:zsac098 (2022)
Reassessment of candidate gene studies for idiopathic restless legs syndrome in a large GWAS dataset of European ancestry.
2022 Scientific Article in Nature Communications Nat. Commun. 13:5198 (2022)
Identification of risk loci for primary aldosteronism in genome-wide association studies.
2022 Scientific Article in Aging Aging 14, 5620-5627 (2022)
Common electrocardiogram measures are not associated with telomere length.
2022 Scientific Article in Cancers Cancers 14:3363 (2022)
Uncovering the contribution of moderate-penetrance susceptibility genes to breast cancer by whole-exome sequencing and targeted enrichment sequencing of candidate genes in women of European ancestry.
2022 Scientific Article in Stroke Stroke 53, 2331-2339 (2022)
A family and a genome-wide polygenic risk score are independentlyassociated with stroke in a population-based study.
2022 Scientific Article in Pancreatology Pancreatol. 22, 449-456 (2022)
Colocalization analysis of pancreas eQTLs with risk loci from alcoholic and novel non-alcoholic chronic pancreatitis GWAS suggests potential disease causing mechanisms.
2022 Scientific Article in Atherosclerosis Atherosclerosis 349, 151-159 (2022)
The effect of LPA Thr3888Pro on lipoprotein(a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G>A.
2022 Scientific Article in Kidney International Kidney Int. 102, 624-639 (2022)
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 560-572 (2022)
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
2022 Scientific Article in JCI insight JCI insight 7:e157035 (2022)
Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases.
2022 Scientific Article in Communications Biology Comm. Biol. 5:580 (2022)
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
2022 Scientific Article in Aging Cell Aging Cell:e13608 (2022)
Integrative analysis of clinical and epigenetic biomarkers of mortality.
2022 Scientific Article in Atherosclerosis Atherosclerosis 352, 10-17 (2022)
Association between a polygenic and family risk score on the prevalence and incidence of myocardial infarction in the KORA-F3 study.
2022 Scientific Article in eLife eLife 11:e71802 (2022)
Epigenetic scores for the circulating proteome as tools for disease prediction.
2022 Scientific Article in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 15:e003489 (2022)
Genome-wide characterization of a highly penetrant form of hyperlipoproteinemia associated with genetically elevated cardiovascular Risk.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 437-449 (2022)
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals.
2022 Scientific Article in Diagnostics Diagnostics 12:965 (2022)
Validation of the 30-year Framingham Risk Score in a German population-based cohort.
2022 Scientific Article in New Biotechnology New Biotech. 68, 37-47 (2022)
Impact of the pre-examination phase on multicenter metabolomic studies.
2022 Scientific Article in Diabetologia Diabetologia 65, 763-776 (2022)
Epigenome-wide association study of incident type 2 diabetes: A meta-analysis of five prospective European cohorts.
2022 Nature Communications Nat. Commun. 13:1122 (2022)
Author Correction: Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis (Nature Communications, (2022), 13, 1, (143), 10.1038/s41467-021-27706-6).
2022 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 109, 81-96 (2022)
Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes.
2022 Scientific Article in Briefings in Bioinformatics Brief. Bioinform. 23:bbab535 (2022)
TIGER: Technical variation elimination for metabolomics data using ensemble learning architecture.
2022 Scientific Article in Nature Genetics Nat. Genet. 54, 18–29 (2022)
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
2022 Scientific Article in Nature Communications Nat. Commun. 13:143 (2022)
Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.
2022 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 31, 3367-3376 (2022)
First mitochondrial genome wide association study with metabolomics.
2022 Scientific Article in Cardiovascular Research Cardiovasc. Res. 118, 1088–1102 (2022)
Cis-epistasis at the LPA locus and risk of cardiovascular diseases.
2021 Scientific Article in Nature Communications Nat. Commun. 12:7174 (2021)
Meta-analyses identify DNA methylation associated with kidney function and damage.
2021 Scientific Article in Nature Communications Nat. Commun. 12:7173 (2021)
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.
2021 Scientific Article in Nature Nature 600, 675-679 (2021)
The power of genetic diversity in genome-wide association studies of lipids.
2021 Scientific Article in Nature Communications Nat. Commun. 12:6233 (2021)
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
2021 Scientific Article in Nature Communications Nat. Commun. 12:6618 (2021)
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
2021 Scientific Article in Brain: A Journal of Neurology Brain, DOI: 10.1093/brain/awab360 (2021)
Blood DNA methylation provides an accurate biomarker of KMT2B-related dystonia and predicts onset.
2021 Scientific Article in Nature human behaviour Nat. Hum. Behav. 5, 1717-1730 (2021)
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.
2021 Scientific Article in Scientific Reports Sci. Rep. 11:19365 (2021)
Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function.
2021 Scientific Article in Epilepsia Epilepsia 62, 1518-1527 (2021)
Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations.
2021 Scientific Article in Lancet, The Lancet 398, 957-980 (2021)
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: A pooled analysis of 1201 population-representative studies with 104 million participants.
2021 Scientific Article in Nature Nature 596, 393-397 (2021)
Genetic insights into biological mechanisms governing human ovarian ageing.
2021 Scientific Article in Journal of Hypertension J. Hypertens. 39, 2527-2533 (2021)
N-glycosylation of immunoglobulin G predicts incident hypertension.
2021 Scientific Article in Genome Biology Genome Biol. 22:194 (2021)
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
2021 Scientific Article in Clinical Chemistry Clin. Chem. 67, 1153-1155 (2021)
Metabolomic fingerprints in large population cohorts: Impact of preanalytical heterogeneity.
2021 Nature Communications Nat. Commun. 12:4256 (2021)
Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
2021 Scientific Article in Cardiovascular Research Cardiovasc. Res. 118:1742–1757 (2021)
Chronically elevated branched chain amino acid levels are pro-arrhythmic.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:121 (2021)
DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.
2021 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 45, 633-650 (2021)
Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study.
2021 Scientific Article in Nature Communications Nat. Commun. 12:3505 (2021)
Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes.
2021 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 32, 1747-1763 (2021)
Plasma proteomics of renal function: A trans-ethnic metaanalysis and Mendelian randomization study.
2021 Scientific Article in Nature Communications Nat. Commun. 12:3987 (2021)
A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
2021 Scientific Article in Molecular Psychiatry Mol. Psychiatry 26, 7372–7383 (2021)
A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression.
2021 Scientific Article in Cardiovascular Diabetology Cardiovasc. Diabetol. 20:111 (2021)
Metabolic syndrome and the plasma proteome: From association to causation.
2021 Scientific Article in Molecular Psychiatry Mol. Psychiatry 26, 6293-6304 (2021)
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
2021 Scientific Article in British Journal of Dermatology - BJD Br. J. Dermatol. 185, 573-584 (2021)
Host traits, lifestyle and environment are associated with the human skin bacteria.
2021 Scientific Article in Human Genetics and Genomics Advances HGG Advances 2:100013 (2021)
Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits.
2021 Nature Communications Nat. Commun. 12:995 (2021)
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:60 (2021)
Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases.
2021 Scientific Article in Journal of human genetics J. Hum. Genet. 66, 625–636 (2021)
Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease.
2021 Scientific Article in Nature Communications Nat. Commun. 12:24 (2021)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
2021 Scientific Article in Nature Communications Nat. Commun. 12:1279 (2021)
Revealing the role of the human blood plasma proteome in obesity using genetic drivers.
2021 Scientific Article in Metabolites Metabolites 11:89 (2021)
Validation of candidate phospholipid biomarkers of chronic kidney disease in hyperglycemic individuals and their organ-specific exploration in leptin receptor-deficient db/db mouse.
2021 Scientific Article in Clinical Epigenetics Clin. Epigenet. 13:7 (2021)
DNA methylation and lipid metabolism: An EWAS of 226 metabolic measures.
2021 Scientific Article in Kidney International Kidney Int. 99, 926-939 (2021)
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.
2021 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 108, 284-294 (2021)
Genome-wide association study identifies novel susceptibility loci for KIT D816V positive mastocytosis.
2021 Scientific Article in Movement Disorders Mov. Disord. 36, 449-459 (2021)
Shared genetics of multiple system atrophy and inflammatory bowel disease.
2021 Scientific Article in Nature human behaviour Nat. Hum. Behav. 5, 59–70 (2021)
Genome-wide association study identifies 48 common genetic variants associated with handedness.
2021 Scientific Article in Glycobiology Glycobiology 31, 82-88 (2021)
Replication of fifteen loci involved in human plasma protein N-glycosylation in 4,802 samples from four cohorts.
2021 Scientific Article in Molecular Psychiatry Mol. Psychiatry 26, 2111–2125 (2021)
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
2021 Scientific Article in Addiction Biology Addict. Biol. 26:e12855 (2021)
Alcohol consumption is associated with widespread changes in blood DNA methylation: Analysis of cross-sectional and longitudinal data.
2020 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 201:A5527 (2020)
Systemic biomarkers of lung function and FEV1 decline across multiple cohorts.
2020 Scientific Article in Circulation Genomic and precision medicine Circ. Genom. Precis. Med. 13, 640-648 (2020)
Genetic predisposition to coronary artery disease in type 2 diabetes mellitus.
2020 Scientific Article in Diabetes Diabetes 69, 2756-2765 (2020)
Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes.
2020 Scientific Article in Diabetes Diabetes 69, 2766-2778 (2020)
Deciphering the plasma proteome of type 2 diabetes.
2020 Scientific Article in Annals of Neurology Ann. Neurol. 88, 736-746 (2020)
Circulating metabolites differentiate acute ischemic stroke from stroke mimics.
2020 Scientific Article in Aging Aging 12, 15222-15259 (2020)
Global variability of the human IgG glycome.
2020 Scientific Article in Lancet Respiratory Medicine, The Lancet Resp. Med. 8, 696-708 (2020)
Chronic obstructive pulmonary disease and related phenotypes: Polygenic risk scores in population-based and case-control cohorts.
2020 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 106, 389-404 (2020)
Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length.
2020 Scientific Article in Diabetes Care Diabetes Care 43, 875-884 (2020)
Epigenetic link between statin therapy and type 2 diabetes.
2020 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 16:e1007616 (2020)
DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning.
2020 Scientific Article in PLoS ONE PLoS ONE 15:e0227648 (2020)
Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples.
2020 Scientific Article in Nature Communications Nat. Commun. 11:15 (2020)
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.
2020 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 145, 1208-1218 (2020)
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
2020 Scientific Article in Annals of Neurology Ann. Neurol. 87, 184-193 (2020)
Identification of restless legs syndrome genes by mutational load analysis.
2020 Scientific Article in European Journal of Nutrition Eur. J. Nutr. 59, 1357-1369 (2020)
Modifying effect of metabotype on diet-diabetes associations.
In: Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. 2019. 309-347
Omics: Potential role in early phase drug development.
2019 GigaScience GigaScience 8:giz162 (2019)
A network-based conditional genetic association analysis of the human metabolome (vol 7, gij137, 2018).
2019 Scientific Article in Nature Communications Nat. Commun. 10:5121 (2019)
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.
In: (Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2019, 23-27 June 2019, Munich, Germany). 2019.:8871546
Broadband IR-fingerprinting of human blood as a universal tool for diseases diagnostics.
2019 Scientific Article in Nature Communications Nat. Commun. 10:4957 (2019)
Associations of autozygosity with a broad range of human phenotypes.
2019 Meeting abstract in Multiple Sclerosis Journal Mult. Scler. J. 25, 906-907 (2019)
Identification of functionally relevant genetic variants associated with multiple sclerosis using deep learning.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 1459-1474 (2019)
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
2019 Scientific Article in Circulation Circulation 140, 645-657 (2019)
Blood leukocyte DNA methylation predicts risk of future myocardial infarction and coronary heart disease: A longitudinal study of 11,461 participants from population-based cohorts.
2019 Scientific Article in Scientific Reports Sci. Rep. 9:11623 (2019)
Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: The ENGAGE consortium.
2019 Scientific Article in JAMA cardiology JAMA Cardiol. 4, 575-579 (2019)
Estimation of the required lipoprotein(a)-lowering therapeutic effect size for reduction in coronary heart disease outcomes a mendelian randomization analysis.
2019 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 28, 2062-2077 (2019)
Defining the genetic control of human blood plasma N-glycome using genome-wide association study.
2019 Scientific Article in American Journal of Epidemiology Am. J. Epidemiol. 188, 991-1012 (2019)
The consortium of metabolomics studies (COMETS): Metabolomics in 47 prospective cohort studies.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 957-972 (2019)
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
2019 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 28, 2615-2633 (2019)
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.
2019 Scientific Article in Nature Nature 570, 71-76 (2019)
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
2019 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 166, 11370-11379 (2019)
Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk.
2019 Scientific Article in European Heart Journal Eur. Heart J. 40, 2883-2896 (2019)
Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease.
2019Poster: RECOMB 2019, 4-8 May 2019, Washington D.C.. (2019)
Reconstructing regulatory networks from multi-omics data using prior information.
2019 Scientific Article in American Journal of Epidemiology Am. J. Epidemiol. 188, 1033-1054 (2019)
Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 636-648 (2019)
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
2019 Scientific Article in Journal of the American College of Cardiology J. Am. Coll. Cardiol. 73, 58-66 (2019)
Association of the PHACTR1/EDN1 genetic locus with spontaneous coronary artery dissection.
2019 Scientific Article in Metabolites Metabolites 9:61 (2019)
Metabolomics identifies novel blood biomarkers of pulmonary function and COPD in the general population.
2019 Scientific Article in Human Genetics Hum. Genet. 138, 375–388 (2019)
The metabolic network coherence of human transcriptomes is associated with genetic variation at the cadherin 18 locus.
2019 Scientific Article in Metabolites Metabolites 9:44 (2019)
Ageing investigation using two-time-point metabolomics data from KORA and CARLA studies.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 481-493 (2019)
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 494-505 (2019)
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
2019 Scientific Article in Nature Communications Nat. Commun. 10:376 (2019)
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
2019 Scientific Article in Nature Genetics Nat. Genet. 51, 245-257 (2019)
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
2019 Scientific Article in American Journal of Clinical Nutrition Am. J. Clin. Nutr. 109, 276-287 (2019)
Disentangling the genetics of lean mass.
2018 Meeting abstract in European Heart Journal Eur. Heart J. 39, 998-998 (2018)
Using the plasma proteome to decipher metabolic syndrome pathophysiology and discover a diagnostic biomarker panel.
2018 Scientific Article in Clinical Epigenetics Clin. Epigenet. 10:161 (2018)
Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction.
2018 Scientific Article in Nature Communications Nat. Commun. 9:5269 (2018)
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.
2018 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 197 (2018)
Proteomic profiling identifies novel circulating markers associated with lung function.
2018 Scientific Article in Nature Communications Nat. Commun. 9:4919 (2018)
Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests.
2018 Scientific Article in GigaScience GigaScience 7, DOI: 10.1093/gigascience/giy137 (2018)
A network-based conditional genetic association analysis of the human metabolome.
2018 Scientific Article in EBioMedicine EBioMedicine 38, 206-216 (2018)
Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 1505-1513 (2018)
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 1514-1523 (2018)
Genetics of blood lipids among similar to 300,000 multi-ethnic participants of the Million Veteran Program.
2018 Meeting abstract in Genetic Epidemiology Genet. Epidemiol. 42, 719-720 (2018)
Pharmacogenetic effects in population-based metabolic profiles.
2018 Scientific Article in Nature Communications Nat. Commun. 9:4455 (2018)
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:15249 (2018)
Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 1412-1425 (2018)
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
2018 Nature Communications Nat. Commun. 9:3853 (2018)
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease (vol 9, 3268, 2018).
2018 Scientific Article in American Journal of Clinical Nutrition Am. J. Clin. Nutr. 108, 453-475 (2018)
Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies.
2018 Scientific Article in Metabolomics Metabolomics 14:128 (2018)
Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies.
2018 Scientific Article in Nature Communications Nat. Commun. 9:3268 (2018)
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.
2018 Nature Genetics Nat. Genet. 50:1343 (2018)
Author correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
2018 Scientific Article in Molecular Nutrition and Food Research Mol. Nutr. Food Res. 62:1800117 (2018)
Identification of comprehensive metabotypes associated with cardiometabolic diseases in the population-based KORA study.
2018 Scientific Article in Nature Genetics Nat. Genet. 52, 1112-1121 (2018)
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
2018 Scientific Article in Diabetes Diabetes 67, 1414-1427 (2018)
A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes.
2018 Scientific Article in Blood Blood 132, 1842-1850 (2018)
DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 1072–1080 (2018)
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
2018 Scientific Article in JAMA cardiology JAMA Cardiol. 3, 463-472 (2018)
Association of methylation signals with incident coronary heart disease in an epigenome-wide assessment of circulating tumor necrosis factor.
2018 Scientific Article in Nature Communications Nat. Commun. 9:2427 (2018)
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes.
2018 Scientific Article in Nature Genetics Nat. Genet. 50, 834-848 (2018)
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.
2018 Scientific Article in PLoS Genetics PLoS Genet. 14:e1007329 (2018)
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.
2018 Scientific Article in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 38, 1230-1241 (2018)
Genetic factors explain a major fraction of the 50% lower lipoprotein(a) concentrations in Finns.
2018 Scientific Article in Frontiers in Immunology Front. Immunol. 9:277 (2018)
Genome-wide association study on immunoglobulin G glycosylation patterns.
2018 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 102, 375-400 (2018)
A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure.
2018 Nature Communications Nat. Commun. 9:706 (2018)
Erratum: Publisher Correction: Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway (Nature communications (2017) 8 1 (1483)).
2018 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 27, 1106-1121 (2018)
Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation.
2018 Scientific Article in Nature Communications Nat. Commun. 9:260 (2018)
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
2018 Scientific Data Sci. Data 5:180002 (2018)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
2018 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 27, 546-558 (2018)
Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin.
2018 Scientific Article in Biochimica et Biophysica Acta - General Subjects Biochim. Biophys. Acta-Gen. Subj. 1862, 637-648 (2018)
IgG glycosylation and DNA methylation are interconnected with smoking.
2018 Scientific Article in Neuropsychopharmacology Neuropsychopharmacology 43, 342-353 (2018)
Anxiety associated increased CpG methylation in the promoter of Asb1: A translational approach evidenced by epidemiological and clinical studies and a murine model.
2017 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 25, 137-146 (2017)
Across-cohort QC analyses of GWAS summary statistics from complex traits.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1722–1730 (2017)
Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.
2017 Scientific Article in Scientific Data Sci. Data 4:170179 (2017)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1758-1766 (2017)
Exome-wide association study of plasma lipids in >300,000 individuals.
2017 Scientific Article in OncoTarget Oncotarget 8, 98623-98634 (2017)
Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.
2017 Scientific Article in Nature Communications Nat. Commun. 8:1483 (2017)
Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 1752-1757 (2017)
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
2017 Scientific Article in Molecular Psychiatry Mol. Psychiatry 22, 1680-1690 (2017)
An epigenome-wide association study meta-analysis of educational attainment.
2017 Nature Communications Nat. Commun. 8:1414 (2017)
Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0182472 (2017)
Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.
2017 Scientific Article in Neurology Neurology 89, 1829-1839 (2017)
COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls.
2017 Scientific Article in BMC Genomics BMC Genomics 18:805 (2017)
The dynamics of smoking-related disturbed methylation: A two time-point study of methylation change in smokers, non-smokers and former smokers.
2017 Scientific Article in Genetics Genetics 207, 1275-1283 (2017)
RL-SKAT: An exact and efficient score Test for heritability and set tests.
2017 Scientific Article in BMC Bioinformatics BMC Bioinformatics 18:429 (2017)
pulver: An R package for parallel ultra-rapid p-value computation for linear regression interaction terms.
2017 Scientific Article in Lancet Neurology, The Lancet Neurol. 16, 898–907 (2017)
Identification of novel risk loci for restless legs syndrome: A meta-analysis of genome-wide association studies in individuals of European ancestry: A meta-analysis.
2017 Scientific Article in Diabetologia Diabetologia 61, 117-129 (2017)
Metabolite ratios as potential biomarkers for type 2 diabetes: A DIRECT study.
2017 Meeting abstract in Allergy Allergy 72, 53-53 (2017)
Association of atopic dermatitis with cardiovascular risk factors and diseases.
2017 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 28, 2311-2321 (2017)
NFAT5 and SLC4A10 loci associate with plasma osmolality.
2017 Scientific Article in Journal of Lipid Research J. Lipid Res. 58, 1834-1844 (2017)
A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.
2017 Scientific Article in PLoS Medicine PLoS Med. 14:e1002383 (2017)
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0181038 (2017)
Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation.
2017 Scientific Article in Hypertension Hypertension 70, 713-750 (2017)
Transcriptome-wide analysis identifies novel associations with blood pressure.
2017 Scientific Article in Obesity Obesity 25, 1618-1624 (2017)
Metabolomic profiling of long-term weight change: Role of oxidative stress and urate levels in weight gain.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:8734 (2017)
Evaluating the causal relation of ApoA-IV with disease-related traits - A bidirectional two-sample mendelian randomization study.
2017 Scientific Article in Nature Communications Nat. Commun. 8:80 (2017)
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
2017 Scientific Article in Hypertension Hypertension 70, e4-e19 (2017)
Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney.
2017 Scientific Article in British Journal of Nutrition Br. J. Nutr. 117, 1631-1644 (2017)
Metabotyping and its application in targeted nutrition: An overview.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:6037 (2017)
Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes.
2017 Scientific Article in PLoS Genetics PLoS Genet. 13:e1006812 (2017)
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.
2017 Scientific Article in European Heart Journal Eur. Heart J. 38, 1823-1831 (2017)
A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction.
2017 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 137, 1945-1954 (2017)
miR-146b probably assists miRNA-146a in the suppression of keratinocyte proliferation and inflammatory responses in psoriasis.
2017 Scientific Article in Diabetes Diabetes 66, 2888-2902 (2017)
An expanded genome-wide association study of type 2 diabetes in Europeans.
2017 Scientific Article in PLoS Genetics PLoS Genet. 13:e1006755 (2017)
Identifying systematic heterogeneity patterns in genetic association meta-analysis studies.
2017 Scientific Article in Biological Psychiatry Biol. Psychiatry 81, 325-335 (2017)
Genome-wide association for major depression through age at onset stratification: Major depressive disorder working group of the Psychiatric Genomics Consortium.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 834-841 (2017)
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
2017 Scientific Article in Nature Communications Nat. Commun. 8:15466 (2017)
Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1.
2017 Scientific Article in Diabetes Diabetes 66, 2019-2032 (2017)
A low-frequency inactivating Akt2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk.
2017 Scientific Article in PLoS Genetics PLoS Genet. 13:e1006528 (2017)
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:45040 (2017)
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0176372 (2017)
Validation of standard operating procedures in a multicenter retrospective study to identify -omics biomarkers for chronic low back pain.
2017 Scientific Article in Arthritis & Rheumatology Arthritis Rheum. 69, 1090-1099 (2017)
Immune-array analysis in sporadic inclusion body myositis reveals HLA-DRB1 amino acid heterogeneity across the myositis spectrum.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:45652 (2017)
Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci.
2017 Scientific Article in Biochimica et Biophysica Acta - General Subjects Biochim. Biophys. Acta-Gen. Subj. 1861, 1152-1158 (2017)
Effects of statins on the immunoglobulin G glycome.
2017 Scientific Article in Nature Communications Nat. Commun. 8:14357 (2017)
Connecting genetic risk to disease end points through the human blood plasma proteome.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 416-425 (2017)
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
2017 Scientific Article in Nature Genetics Nat. Genet. 49, 403-415 (2017)
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
2017 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 137, 1074-1081 (2017)
Association of atopic dermatitis with cardiovascular risk factors and diseases.
2017 Scientific Article in Epigenetics & Chromatin Epigenetics Chromatin 10:1 (2017)
Genome-wide methylation data mirror ancestry information.
2017 Scientific Article in Nature Nature 541, 81-86 (2017)
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.
2017 Scientific Article in Molecular Psychiatry Mol. Psychiatry 22, 192-201 (2017)
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.
2016 Meeting abstract in Diabetologia Diabetologia 59, S176-S177 (2016)
Genome wide meta-analysis identifies novel regulators of circulating serum progranulin.
2016 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 113, 14372-14377 (2016)
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.
2016 Meeting abstract in Atherosclerosis Atherosclerosis 252, E263-E263 (2016)
Associations between lipoprotein subfractions and genome-wide DNA methylation in KORA F4.
2016 Meeting abstract in Allergy Allergy 71, 431-431 (2016)
Genome-wide association study unravels genetic determinants of the atopic march.
2016 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 9, 250-258 (2016)
Common and rare genetic variation in CCR2, CCR5, or CX3CR1 and risk of atherosclerotic coronary heart disease and glucometabolic traits.
2016 Scientific Article in Nature Communications Nat. Commun. 7:13357 (2016)
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.
2016 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 113, 13366-13371 (2016)
Genetic variants linked to education predict longevity.
2016 Scientific Article in Clinical Epigenetics Clin. Epigenet. 8:124 (2016)
Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0165548 (2016)
Are epigenetic factors implicated in chronic widespread pain?
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0166015 (2016)
Epigenetic signatures at AQP3 and SOCS3 engage in low-grade inflammation across different tissues.
2016 Scientific Article in BMJ Open BMJ Open 6:e012070 (2016)
'Omics' biomarkers associated with chronic low back pain: Protocol of a retrospective longitudinal study.
2016 Scientific Article in PLoS Genetics PLoS Genet. 12:e1006379 (2016)
Effect of insulin resistance on monounsaturated fatty acid levels: A multi-cohort non-targeted metabolomics and mendelian randomization study.
2016 Scientific Article in Nature Genetics Nat. Genet. 48, 1462-1472 (2016)
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
2016 Scientific Article in OncoTarget Oncotarget 7, 74510-74525 (2016)
Long-term exposure to air pollution is associated with biological aging.
2016 Scientific Article in Aging Aging 8, 1844-1865 (2016)
DNA methylation-based measures of biological age: Meta-analysis predicting time to death.
2016 Scientific Article in Journal of the American College of Cardiology J. Am. Coll. Cardiol. 68, 1435-1448 (2016)
52 Genetic loci influencing myocardial mass.
2016 Scientific Article in Diabetes Diabetes 65, 3776-3785 (2016)
Metformin effect on non-targeted metabolite profiles in patients with type 2 diabetes and multiple murine tissues.
2016 Scientific Article in Scientific Reports Sci. Rep. 6:25853 (2016)
Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium.
2016 Scientific Article in Diabetologia Diabetologia 59, 1214-1221 (2016)
Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
2016 Scientific Article in Cancer Epidemiology, Biomarkers & Prevention Cancer Epidemiol. Biomarkers Prev. 25, 1043-1049 (2016)
Genetic variation associated with longer telomere length increases risk of chronic lymphocytic leukemia.
2016 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 45, 1469-1481 (2016)
Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: A cross-sectional analysis in population-based data.
2016 Scientific Article in Parkinsonism & Related Disorders Parkinsonism Relat. Disord. 31, 119-123 (2016)
Systematic TOR1A non-c.907_909delGAG variant analysis in isolated dystonia and controls.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0158101 (2016)
Meta-analysis of genome-wide association studies and network analysis-based integration with gene expression data identify new suggestive loci and unravel a Wnt-centric network associated with Dupuytren's disease.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 4094-4106 (2016)
Analysis with the exome array identifies multiple new independent variants in lipid loci.
2016 Scientific Article in European Journal of Nutrition Eur. J. Nutr. 56, 2379-2391 (2016)
Metabolites of milk intake: A metabolomic approach in UK twins with findings replicated in two European cohorts.
2016 Scientific Article in Arthritis Research & Therapy Arthritis Res. Ther. 18:156 (2016)
Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 3635-3646 (2016)
A genome-wide association meta-analysis on apolipoprotein A-IV concentrations.
2016 Scientific Article in Nature Nature 536, 41-47 (2016)
The genetic architecture of type 2 diabetes.
2016 Scientific Article in Diabetologia Diabetologia 59, 2114-2124 (2016)
Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes.
2016 Scientific Article in Carcinogenesis Carcinogenesis 37, 576-582 (2016)
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.
2016 Scientific Article in Science Advances Sci. Adv. 2:e1501678 (2016)
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.
2016 Scientific Article in Nature Nature 533, 539-542 (2016)
Genome-wide association study identifies 74 loci associated with educational attainment.
2016 Scientific Article in PLoS Genetics PLoS Genet. 12:e1006034 (2016)
Discovery of genetic variation on chromosome 5q22 associated with mortality in heart failure.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0153163 (2016)
The pharmacogenetic footprint of ACE inhibition: A population-based metabolomics study.
2016 Meeting abstract in Experimental Dermatology Exp. Dermatol. 25, E16 (2016)
Epidemiologic and genetic association between atopic dermatitis, rheumatoid arthritis, inflammatory bowel disease, and type-1 diabetes.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11122 (2016)
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.
2016 Scientific Article in Nature Genetics Nat. Genet. 48, 624-633 (2016)
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0152314 (2016)
Association between DNA methylation in whole blood and measures of glucose metabolism: Kora F4 study.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11008 (2016)
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0147388 (2016)
Association of forced vital capacity with the developmental gene NCOR2.
2016 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 25, 2082-2092 (2016)
Testing the role of predicted gene knockouts in human anthropometric trait variation.
2016 Scientific Article in Lancet Neurology, The Lancet Neurol. 15, 174-184 (2016)
Loci associated with ischaemic stroke and its subtypes (SiGN): A genome-wide association study.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10494 (2016)
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10495 (2016)
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10023 (2016)
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
2016 Scientific Article in Aging Aging 8, 77-94 (2016)
Metabolomics profiling reveals novel markers for leukocyte telomere length.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0147129 (2016)
Alterations in lipid and inositol metabolisms in two dopaminergic disorders.
2016 Scientific Article in Stroke Stroke 47, 307-316 (2016)
Genome-wide association analysis of young onset stroke identifies a locus on chromosome 10q25 near HABP2.
2016 Scientific Article in Journal of Proteome Research J. Proteome Res. 15, 554-562 (2016)
Diagnostic and prognostic metabolites identified for joint symptoms in the KORA population.
2016 Scientific Article in Diabetes Diabetes 65, 803-817 (2016)
Genome-wide association studies identify genetic loci associated with albuminuria in diabetes.
2016 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 27, 1175-1188 (2016)
A metabolome-wide association study of kidney function and disease in the general population.
2016 Scientific Article in Annals of the Rheumatic Diseases : ARD online Ann. Rheum. Dis. 75, 1558-1566 (2016)
Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.
2016 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 137, 130–136 (2016)
Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes.
2015 Scientific Article in Diabetes Diabetes 64, 4312-4321 (2015)
Genetic predisposition to weight loss and regain with lifestyle intervention: Analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials.
2015 Scientific Article in OncoTarget Oncotarget 6, 42468-42477 (2015)
Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.
2015 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 39, 624-634 (2015)
A Bayesian approach to the overlap analysis of epidemiologically linked traits.
2015 Other: Opinion in Obstetrics & Gynecology Obstet. Gynecol. 70, 758-762 (2015)
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility, and BRCA1-mediated DNA repair.
2015 Scientific Article in Nature Communications Nat. Commun. 6:8658 (2015)
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1415-1425 (2015)
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
2015 Scientific Article in Genetic Epidemiology Genet. Epidemiol. 39, 499-508 (2015)
Evaluating the calibration and power of three gene-based association tests of rare variants for the X chromosome.
2015 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 97, 816-836 (2015)
Genome-wide association analysis of psoriatic arthritis and cutaneous psoriasis reveals differences in their genetic architecture.
In: Krentz, A.J.* ; Heinemann, L.* ; Hompesch, M.* [Eds.]: Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development. London: Springer, 2015. 189-222
Omics: Potential role in early-phase drug development.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1449-1456 (2015)
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
2015 Scientific Article in Nature Communications Nat. Commun. 6:8804 (2015)
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
2015 Scientific Article in BMC Medical Genomics BMC Med. Genomics 8:65 (2015)
Extensive alterations of the whole-blood transcriptome are associated with body mass index: Results of an mRNA profiling study involving two large population-based cohorts.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1294-1303 (2015)
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
2015 Scientific Article in Epigenetics & Chromatin Epigenetics Chromatin 8:43 (2015)
Characterization of whole-genome autosomal differences of DNA methylation between men and women.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005378 (2015)
The influence of age and sex on genetic associations with adult body size and shape: A large-scale genome-wide interaction study.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 6836-6848 (2015)
Integrative pathway genomics of lung function and airflow obstruction.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1121-1130 (2015)
A comprehensive 1000 genomes–based genome-wide association meta-analysis of coronary artery disease.
2015 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 618-627 (2015)
Effect of bile acid sequestrants on the risk of cardiovascular events: A mendelian randomization analysis.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 1282-1293 (2015)
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005487 (2015)
Genome-wide association study with targeted and non-targeted NMR metabolomics identifies 15 novel loci of urinary human metabolic individuality.
2015 Scientific Article in European Journal of Neurology Eur. J. Neurol. 22, 1488-1491 (2015)
Heritability of young- and old-onset ischaemic stroke.
2015 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 135, S63 (2015)
Epidemiologic and genetic association between atopic dermatitis, rheumatoid arthritis, inflammatory bowel disease, and type-1 diabetes.
2015 Meeting abstract in International Journal of Stroke Int. J. Stroke 10, 250 (2015)
Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease.
2015 Scientific Article in Parkinsonism & Related Disorders Parkinsonism Relat. Disord. 21, 1278-1281 (2015)
Large-scale TUBB4A mutational screening in isolated dystonia and controls.
2015 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 24, 521-528 (2015)
Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research.
2015 Scientific Article in Metabolomics Metabolomics 11, 1815-1833 (2015)
Gender-specific pathway differences in the human serum metabolome.
2015 Scientific Article in International Journal of Genomics Int. J. Genomics 2015:693193 (2015)
Genetic geostatistical framework for spatial analysis of fine-scale genetic heterogeneity in modern populations: Results from the KORA study.
2015 Scientific Article in Diabetes Care Diabetes Care 38, 1858-1867 (2015)
Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes.
2015 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 44, 662-672 (2015)
Mendelian randomization study of height and risk of colorectal cancer.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 172-179 (2015)
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, R93-R101 (2015)
Genetics of human metabolism: An update.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005230 (2015)
Discovery and fine-mapping of glycaemic and obesity-related trait loci using high-density imputation.
2015 Scientific Article in Nature Nature 523, 459-462 (2015)
Directional dominance on stature and cognition in diverse human populations.
2015 Scientific Article in Lancet Diabetes and Endocrinology Lancet Diabet. Endocrinol. 3, 526-534 (2015)
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control study.
2015 Scientific Article in Diabetic Medicine Diabetic Med. 32, 1479-1483 (2015)
Low serum omentin levels in the elderly population with type 2 diabetes and polyneuropathy.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005274 (2015)
The human blood metabolome-transcriptome interface.
2015 Scientific Article in Molecular Psychiatry Mol. Psychiatry 20, 735-743 (2015)
The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects.
2015 Scientific Article in Atherosclerosis Atherosclerosis 241, 419-426 (2015)
Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.
2015 Scientific Article in Nature Communications Nat. Commun. 6:7208 (2015)
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.
2015 Scientific Article in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 192, 727-736 (2015)
Identification of immune-relevant factors conferring sarcoidosis genetic risk.
2015 Scientific Article in Hypertension Hypertension 66, 422-429 (2015)
Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate.
2015 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 44, 578-586 (2015)
Adiposity as a cause of cardiovascular disease: A Mendelian randomization study.
2015 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 96, 695-708 (2015)
Genome-wide analysis of body proportion classifies height-associated variants by mechanism of action and implicates genes important for skeletal development.
2015 Scientific Article in International Journal of Hygiene and Environmental Health Int. J. Hyg. Environ. Health 218, 535-542 (2015)
Associations between short-term exposure to particulate matter and ultrafine particles and myocardial infarction in Augsburg, Germany.
2015 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 96, 883-893 (2015)
Recessive mutations in the α3 (VI) collagen gene COL6A3 cause early-onset isolated dystonia.
2015 Scientific Article in Genetics Genetics 200, 707-718 (2015)
Non-additive effects of genes in human metabolomics.
2015 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 334-342 (2015)
DNA methylation of lipid-related genes affects blood lipid levels.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 589-597 (2015)
The impact of low-frequency and rare variants on lipid levels.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005226 (2015)
Burden analysis of rare microdeletions suggests a strong impact of neurodevelopmental genes in genetic generalised epilepsies.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005165 (2015)
The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease.
2015 Meeting abstract in Experimental Dermatology Exp. Dermatol. 24, E15 (2015)
Psoriasis and cardiometabolic risk: independent association but distinct genetic architectures.
2015 Scientific Article in Pain Pain 156, 1845-1851 (2015)
An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker.
2015 Scientific Article in Human Genome Variation Hum. Genome Var. 2:14028 (2015)
Excess of rare coding variants in PLD3 in late- but not early-onset Alzheimer’s disease.
2015 Scientific Article in Nature Communications Nat. Commun. 6:6804 (2015)
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.
2015 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 136, 802-806 (2015)
A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.ϖ
2015 Scientific Article in European Journal of Epidemiology Eur. J. Epidemiol. 30, 305-315 (2015)
Prevalence of refractive error in Europe: The European Eye Epidemiology (E3) consortium.
2015 Nature Communications Nat. Commun. 6:6542 (2015)
Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
2015 Review in Human Molecular Genetics Hum. Mol. Genet. 24, 3582-3594 (2015)
Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: A systematic review and meta-analysis with evidence from up to 331 175 individuals.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0119752 (2015)
Modulation of genetic associations with serum urate levels by body-mass-index in humans.
2015 Scientific Article in Nature Communications Nat. Commun. 6:5890 (2015)
Biological interpretation of genome-wide association studies using predicted gene functions.
2015 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 24, 1185-1199 (2015)
Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci.
2015 Scientific Article in BMC Medicine BMC Med. 13:48 (2015)
Multi-omic signature of body weight change: Results from a population-based cohort study.
2015 Scientific Article in Diabetologia Diabetologia 58, 1118-1128 (2015)
Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: The KORA S4 survey.
2015 Scientific Article in Lancet, The Lancet 385, 351-361 (2015)
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: Evidence from genetic analysis and randomised trials.
2015 Scientific Article in Diabetes Diabetes 64, 1841-1852 (2015)
Age- and sex-specific causal effects of adiposity on cardiovascular risk factors.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1004876 (2015)
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
2015 Scientific Article in Nature Nature 518, 197-206 (2015)
Genetic studies of body mass index yield new insights for obesity biology.
2015 Scientific Article in Nature Nature 518, 187-196 (2015)
New genetic loci link adipose and insulin biology to body fat distribution.
2015 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 23, 1328-1333 (2015)
Rare variants in β-Amyloid Precursor Protein (APP) and Parkinson's disease.
2015 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 135, 1283-1293 (2015)
Psoriasis and cardiometabolic traits: Modest association but distinct genetic architectures.
2015 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 96, 104-120 (2015)
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
2015 Scientific Article in PLoS Genetics PLoS Genet. 10:e1004854 (2015)
Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in the regulation of circulating serum chemerin.
2015 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 8, 159-167 (2015)
Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 78-83 (2015)
Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection.
2015 Scientific Article in Human Genetics Hum. Genet. 134, 131-146 (2015)
Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: The CREAM consortium.
2015 Scientific Article in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 35, 229-236 (2015)
Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease.
2015 Scientific Article in Molecular Psychiatry Mol. Psychiatry 20, 647-656 (2015)
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
2014 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 23, 6944-6960 (2014)
Trans-ethnic meta-analysis of white blood cell phenotypes.
2014 Meeting abstract in Diabetologia Diabetologia 57, S50-S51 (2014)
Fine-mapping type 2 diabetes susceptibility loci with high-density imputation.
2014 Meeting abstract in Diabetologia Diabetologia 57, S66 (2014)
FOXA2 bound sites are enriched for type 2 diabetes risk variants.
2014 Meeting abstract in Diabetologia Diabetologia 57, S67-S68 (2014)
Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in regulation of circulating serum chemerin.
2014 Scientific Article in Clinical Endocrinology Clin. Endocrinol. 81, 702-710 (2014)
Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: A systematic meta-analysis.
2014 Scientific Article in Nature Communications Nat. Commun. 5:4926 (2014)
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
2014 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 22, 1217-1224 (2014)
Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R.
2014 Meeting abstract in Journal of Human Hypertension J. Hum. Hypertens. 28, 638 (2014)
Circulating levels of a dicarboxylic acid associate with blood pressure, predict mortality and response to antihypertensive drugs. A multi-omics study.
2014 Scientific Article in PLoS Genetics PLoS Genet. 10:e100451 (2014)
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.
2014 Scientific Article in Journal of Clinical Periodontology J. Clin. Periodontol. 41, 1115-1121 (2014)
Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men.
2014 Scientific Article in Lancet Neurology, The Lancet Neurol. 13, 893-903 (2014)
Genetic determinants of common epilepsies: A meta-analysis of genome-wide association studies.
2014 Scientific Article in Nature Genetics Nat. Genet. 46, 1173-1186 (2014)
Defining the role of common variation in the genomic and biological architecture of adult human height.
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A systematic evaluation of short tandem repeats in lipid candidate genes: Riding on the SNP-wave.
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2014 Scientific Article in American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics Am. J. Med. Genet. B 165, 283-293 (2014)
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2014 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 95, 85-95 (2014)
Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome.
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Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits.
2014 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 95, 24-38 (2014)
Gene-age interactions in blood pressure regulation: A large-scale investigation with the CHARGE, Global BPgen, and ICBP consortia.
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Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
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16p11.2 600 kb duplications confer risk for typical and atypical Rolandic epilepsy.
2014 Scientific Article in Nature Genetics Nat. Genet. 46, 669-677 (2014)
Genome-wide association analysis identifies six new loci associated with forced vital capacity.
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Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses.
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Simulation of finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland.
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An atlas of genetic influences on human blood metabolites.
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Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism.
2014 Meeting abstract in Experimental Dermatology Exp. Dermatol. 23, E21 (2014)
Genome-wide comparative analysis of atopic eczema and psoriasis gives insight into disease mechanisms.
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SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis.
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Mitochondrial DNA variants in obesity.
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JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants.
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Mapping the genetic architecture of gene regulation in whole blood.
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An integrated epigenetic and transcriptomic analysis reveals distinct tissue-specific patterns of DNA methylation associated with atopic dermatitis.
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An excess of risk-increasing low-frequency variants can be a signal of polygenic inheritance in complex diseases.
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Increased amino acids levels and the risk of developing hypertriglyceridemia in a 7-year follow-up.
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Interrogating causal pathways linking genetic variants, small molecule metabolites and circulating lipids.
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
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Diastrophic dysplasia sulfate transporter (SLC26A2) is expressed in the adrenal cortex and regulates aldosterone secretion.
2014 Scientific Article in PLoS Genetics PLoS Genet. 10:e1004123 (2014)
Identification of novel genetic loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
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Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.
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Leveraging cross-species transcription factor binding site patterns: From diabetes risk loci to disease mechanisms.
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Gene-centric meta-analyses for central adiposity traits in up to 57412 individuals of European descent confirm known loci and reveal several novel associations.
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DNA mismatch repair gene MSH6 implicated in determining age at natural menopause.
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Telomere length in circulating leukocytes is associated with lung function and disease.
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Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity.
2014 Scientific Article in Neurogenetics Neurogenetics 15, 49-57 (2014)
Rare variants in LRRK1 and Parkinson's disease.
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Rare sequence variants in ANO3 and GNAL in a primary torsion dystonia series and controls.
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Genome-wide association study identifies three novel loci for type 2 diabetes.
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Comparative analysis of plasma metabolomics response to metabolic challenge tests in healthy subjects and influence of the FTO obesity risk allele.
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Epigenetics meets metabolomics: An epigenome-wide association study with blood serum metabolic traits.
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Metabolite profiling reveals new insights into the regulation of serum urate in humans.
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Evaluating empirical bounds on complex disease genetic architecture.
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Assessing association between protein truncating variants and quantitative traits.
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Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants.
2013 Meeting abstract in Human Heredity Hum. Hered. 76, 94-95 (2013)
Genome-wide environmental sensitivity analysis of human metabolomics data.
2013 Meeting abstract in Human Heredity Hum. Hered. 76, 94 (2013)
Genome-wide scan of metabolomics data using non-additive intra-locus models.
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Niemann-pick C disease gene mutations and age-related neurodegenerative disorders.
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Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci.
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Mining the human phenome using allelic scores that index biological intermediates.
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Genetic variants from lipid-related pathways and risk for incident myocardial infarction.
2013 Scientific Article in BMC Genomics BMC Genomics 14:865 (2013)
Automated wokflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles.
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Rare variants in PLXNA4 and Parkinson's disease.
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Biomarkers for type 2 diabetes and impaired fasting glucose using a non-targeted metabolomics approach.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 1353-1360 (2013)
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
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A common biological basis of obesity and nicotine addiction.
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Genetic loci for retinal arteriolar microcirculation.
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Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
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Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.
2013 Scientific Article in International Journal of Epidemiology Int. J. Epidemiol. 42, 1111-1119 (2013)
Metabolomic markers reveal novel pathways of ageing and early development in human populations.
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Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations.
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Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.
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Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 1274-1283 (2013)
Discovery and refinement of loci associated with lipid levels.
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The SH2B1 obesity locus and abnormal glucose homeostasis: Lack of evidence for association from a meta-analysis in individuals of European ancestry.
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Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 1345-1352 (2013)
Common variants associated with plasma triglycerides and risk for coronary artery disease.
2013 Scientific Article in The journal of allergy and clinical immunology J. Allergy Clin. Immunol. 132, 1121-1129 (2013)
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.
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Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.
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Telomere length in circulating leukocytes is associated with lung function and disease.
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Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
2013 Scientific Article in American Journal of Epidemiology Am. J. Epidemiol. 178, 451-460 (2013)
Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.
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Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
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The role of adiposity in cardiometabolic traits: A mendelian randomization analysis.
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Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: Findings from 3,000 participants in the population-based KORA F4 study.
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Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
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A genomewide association study of smoking relapse in four European population-based samples.
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Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error.
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GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.
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Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
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Metabolites associate with kidney function decline and incident chronic kidney disease in the general population.
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Variants in RUNX3 contribute to susceptibility to psoriatic arthritis, exhibiting further common ground with ankylosing spondylitis.
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Tobacco smoking leads to extensive genome-wide changes in DNA methylation.
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
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Causal relationship between obesity and vitamin D status: Bi-directional Mendelian randomization analysis of multiple cohorts.
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The role of SCARB2 as susceptibility factor in Parkinson's disease.
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The molecular genetic architecture of self-employment.
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Loci influencing blood pressure identified using a cardiovascular gene-centric array.
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Seven new loci associated with age-related macular degeneration.
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Identification of seven loci affecting mean telomere length and their association with disease.
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ImmunoChip study implicates antigen presentation to T cells in narcolepsy.
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Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma.
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Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.
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Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
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Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.
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Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity.
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Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma.
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Gene-centric meta-analyses of 108912 individuals confirm known body mass index loci and reveal three novel signals.
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A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 76-82 (2013)
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
2013 Scientific Article in Nature Genetics Nat. Genet. 45, 145-154 (2013)
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
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Dilution of candidates: The case of iron-related genes in restless legs syndrome.
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Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood.
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Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.
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Common variants at CDKAL1 and KLF9 are associated with body mass index in East Asian populations.
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Meta-analysis identifies common variants associated with body mass index in east Asians.
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Evidence of widespread selection on standing variation in Europe at height-associated SNPs.
2012 Scientific Article in Nature Genetics Nat. Genet. 44, 297-301 (2012)
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.
2012 Meeting abstract in Journal of Psychosomatic Research J. Psychosomat. Res. 72, 491 (2012)
PTSD is associated with attrition of leukocyte telomere length. Findings from the KORA F4 Study.
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Evaluation of gene-obesity interaction effects on cholesterol levels: A genetic predisposition score on HDL-cholesterol is modified by obesity.
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Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.
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Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.
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Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
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Seventy-five genetic loci influencing the human red blood cell.
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Analyzing illumina gene expression microarray data from different tissues: Methodological aspects of data analysis in the MetaXpress consortium.
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Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.
2012 Scientific Article in Nature Nature 491, 119-124 (2012)
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
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Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
2012 Scientific Article in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 186, 877-885 (2012)
A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1.
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Genome-wide meta-analysis of common variant differences between men and women.
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Sex-specific differences in effect size estimates at established complex trait loci.
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Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
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A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.
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Genetic variation in metabolic phenotypes: Study designs and applications.
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Mining the unknown: A systems approach to metabolite identification combining genetic and metabolic information.
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On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies.
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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
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Novel biomarkers for pre-diabetes identified by metabolomics.
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Human serum metabolic profiles are age dependent.
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Serum metabolite concentrations and decreased GFR in the general population.
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Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson's disease.
2012 Scientific Article in Journal of Hepatology J. Hepatol. 57, 366-375 (2012)
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.
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Impact of common variation in bone-related genes on type 2 diabetes and related traits.
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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
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Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function.
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Body fat free mass is associated with the serum metabolite profile in a population-based study.
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Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits.
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Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL.
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Replication study of Multiple Sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients.
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Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder.
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PSEA: Phenotype Set Enrichment Analysis - a new method for analysis of multiple phenotypes.
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Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
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Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.
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Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.
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Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals.
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A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
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Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk.
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A genome-wide association search for type 2 diabetes genes in African Americans.
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Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
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Genome-wide association study to identify common variants associated with brachial circumference: A meta-analysis of 14 cohorts.
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Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
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Genetic associations with lipoprotein subfractions provide information on their biological nature.
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Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
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SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents.
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Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
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Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: Meta-analysis of genome-wide association studies from five community-based studies.
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Mutational screening of THAP1 in a German population with primary dystonia.
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Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
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Blood pressure loci identified with a gene-centric array.
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New gene functions in megakaryopoiesis and platelet formation.
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Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
2011 Scientific Article in Diabetologia Diabetologia 54, 1052-1056 (2011)
Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.
2011 Scientific Article in Diabetes Diabetes 60, 2407-2416 (2011)
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: A 14-cohort meta-analysis.
2011 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 89, 619-627 (2011)
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.
2011 Scientific Article in British Journal of Nutrition Br. J. Nutr. 106, 1263-1272 (2011)
Gene-PUFA interactions and obesity risk.
2011 Scientific Article in Diabetologia Diabetologia 54, 2038-2046 (2011)
Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
2011 Scientific Article in Diabetes Diabetes 60, 345-354 (2011)
Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 1131-1138 (2011)
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
2011 Scientific Article in PLoS ONE PLoS ONE 6:e15813 (2011)
Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans.
2011 Scientific Article in PLoS Genetics PLoS Genet. 7:e1002333 (2011)
A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 561-564 (2011)
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.
2011 Scientific Article in Diabetes Diabetes 60, 2624-2634 (2011)
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
2011 Scientific Article in PLoS Genetics PLoS Genet. 7:e1002260 (2011)
Large-scale gene-centric analysis identifies novel variants for coronary artery disease.
2011 Scientific Article in Cell Cell 147, 81-94 (2011)
The Lin28/let-7 axis regulates glucose metabolism.
2011 Scientific Article in BMC Neurology BMC Neurology 11:134 (2011)
Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features.
2011 Scientific Article in Nature Nature 478, 97-102 (2011)
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.
2011 Scientific Article in Nature Nature 478, 103-109 (2011)
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 1005-1011 (2011)
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 1082-1090 (2011)
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
2011 Scientific Article in BMC Genetics BMC Genet. 12:67 (2011)
Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays.
2011 Scientific Article in Neurology Neurology 76, 1106-1108 (2011)
Variant screening of the coding regions of MEIS1 in patients with restless legs syndrome.
2011 Scientific Article in PLoS ONE PLoS ONE 6:e22070 (2011)
The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits.
2011 Scientific Article in Nature Nature 477, 54-60 (2011)
Human metabolic individuality in biomedical and pharmaceutical research.
2011 Scientific Article in PLoS Genetics PLoS Genet. 7:e1002171 (2011)
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
2011 Scientific Article in PLoS Genetics PLoS Genet. 7:e1001324 (2011)
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
2011 Scientific Article in PLoS Genetics PLoS Genet. 7:e1002215 (2011)
Discovery of sexual dimorphisms in metabolic and genetic biomarkers.
2011 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 88, 664-673 (2011)
Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 753-760 (2011)
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
2011 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 19, 813-819 (2011)
Genetic architecture of circulating lipid levels.
2011 Scientific Article in Diabetes Diabetes 60, 1340-1348 (2011)
Updated genetic score based on 34 confirmed type 2 diabetes loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program.
2011 Scientific Article in International Journal of Molecular Epidemiology and Genetics Int. J. Mol. Epidemiol. Genet. 2, 163-177 (2011)
Effect of genome-wide simultaneous hypotheses tests on the discovery rate.
2011 Scientific Article in PLoS Genetics PLoS Genet. 7:e1002113 (2011)
Multiple loci are associated with white blood cell phenotypes.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 565-571 (2011)
A genome-wide association study of metabolic traits in human urine.
2011 Scientific Article in Journal of Medical Genetics J. Med. Genet. 48, 462-466 (2011)
MEIS1 and BTBD9: Genetic association with restless leg syndrome in end stage renal disease.
2011 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 20, 1241-1251 (2011)
A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
2011 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 88, 6-18 (2011)
Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 333-340 (2011)
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
2011 Scientific Article in Diabetologia Diabetologia 54, 111-119 (2011)
A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.
2011 Scientific Article in Circulation Circulation 123, 1864-1872 (2011)
Genetic predictors of fibrin D-dimer levels in healthy adults.
2011 Scientific Article in Circulation Circulation 123, 731-738 (2011)
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
2011 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 20, 1042-1047 (2011)
Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.
2011 Scientific Article in Diabetes Care Diabetes Care 34, 121-125 (2011)
Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
2011 Scientific Article in European Heart Journal Eur. Heart J. 32, 1121-1133 (2011)
Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 17-19 (2011)
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
2011 Scientific Article in Nature Genetics Nat. Genet. 43, 66-71 (2011)
Common variants in P2RY11 are associated with narcolepsy.
2011 Scientific Article in European Heart Journal Eur. Heart J. 32, 158-168 (2011)
Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23.
2010 Scientific Article in PLoS Genetics PLoS Genet. 6:e1001184 (2010)
Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 1077-1085 (2010)
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 996-999 (2010)
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.
2010 Scientific Article in PLoS Genetics PLoS Genet. 6:e1001058 (2010)
Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.
2010 Scientific Article in American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics Am. J. Med. Genet. B 158B, 1448-1458 (2010)
Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance.
2010 Scientific Article in Diabetes Diabetes 59, 3229-3239 (2010)
Common variants at 10 genomic loci influence hemoglobin A₁C levels via glycemic and nonglycemic pathways.
2010 Scientific Article in PLoS Genetics PLoS Genet. 6:e1001213 (2010)
Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 937-948 (2010)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
2010 Scientific Article in Nature Nature 467, 832-838 (2010)
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
2010 Scientific Article in PLoS ONE PLoS ONE 5:e13953 (2010)
Metabolic footprint of diabetes: A multiplatform metabolomics study in an epidemiological setting.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 991-995 (2010)
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
2010 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 19, 3885-3894 (2010)
Genome-wide association analysis identifies multiple loci related to resting heart rate.
2010 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 3, 331-339 (2010)
Genetic regulation of serum phytosterol levels and risk of coronary artery disease.
2010 Scientific Article in Neurobiology of Aging Neurobiol. Aging 31, 167-168 (2010)
Polymorphisms in the receptor for GDNF (RET) are not associated with Parkinson's disease in Southern Germany.
2010 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 21, 1223-1232 (2010)
Common genetic variants associate with serum phosphorus concentration.
2010 Scientific Article in PLoS Genetics PLoS Genet. 6:e1001045 (2010)
Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six loci influencing serum magnesium levels.
2010 Scientific Article in Nature Nature 466, 707-713 (2010)
Biological, clinical and population relevance of 95 loci for blood lipids.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 579-589 (2010)
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
2010 Scientific Article in Statistics in Medicine Stat. Med. 29, 2347-2358 (2010)
How to link call rate and p-values for Hardy-Weinberg equilibrium as measures of genome-wide SNP data quality.
2010 Scientific Article in Genes and Immunity Genes Immun. 11, 397-405 (2010)
IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci.
2010 Scientific Article in Blood Blood 115, 5289-5299 (2010)
Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators.
2010 Scientific Article in BMC Bioinformatics BMC Bioinformatics 11:318 (2010)
CONAN: Copy number variation analysis software for genome-wide association studies.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 448-453 (2010)
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
2010 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 19, 1129-1136 (2010)
European lactase persistence genotype shows evidence of association with increase in body mass index.
2010 Scientific Article in American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics Am. J. Med. Genet. B 153B, 684-690 (2010)
Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 292-294 (2010)
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 153-159 (2010)
Genome-wide association study of PR interval.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 105-116 (2010)
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 137-141 (2010)
A genome-wide perspective of genetic variation in human metabolism.
2010 Scientific Article in Atherosclerosis Atherosclerosis 208, 183-189 (2010)
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
2009 Scientific Article in Nature Nature 462, 868-874 (2009)
Parental origin of sequence variants associated with complex diseases.
2009 Scientific Article in BioSpektrum BioSpektrum 15, 263-265 (2009)
Eine genomweite Assoziationsstudie mit Stoffwechselprodukten.
2009 Scientific Article in European Journal of Human Genetics Eur. J. Hum. Genet. 17, 967-975 (2009)
An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population.
2009 Scientific Article in Nature Genetics Nat. Genet. 41, 1308-1314 (2009)
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
2009 Scientific Article in Molecular Nutrition and Food Research Mol. Nutr. Food Res. 53, 681-685 (2009)
Association between functional FABP2 promoter haplotypes and body mass index: Analyses of 8072 participants of the KORA cohort study.
2009 Scientific Article in Nature Genetics Nat. Genet. 41, 1191-1198 (2009)
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
2009 Scientific Article in Nature Genetics Nat. Genet. 41, 876-878 (2009)
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
2009 Scientific Article in Nature Genetics Nat. Genet. 41, 1182-1190 (2009)
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
2009 Scientific Article in Nature Genetics Nat. Genet. 41, 666-676 (2009)
Genome-wide association study identifies eight loci associated with blood pressure.
2009 Scientific Article in PLoS ONE PLoS ONE 4:e6034 (2009)
Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array.
2009 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 2, 125-133 (2009)
Association of novel genetic Loci with circulating fibrinogen levels: A genome-wide association study in 6 population-based cohorts.
2009 Scientific Article in BMC Bioinformatics BMC Bioinformatics 10, Suppl.1:S56 (2009)
Human gene expression sensitivity according to large scale meta-analysis.
2009 Scientific Article in PLoS Genetics PLoS Genet. 5:e1000504 (2009)
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
2009 Scientific Article in PLoS Genetics PLoS Genet. 5:e1000508 (2009)
Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution.
2009 Scientific Article in Journal of Medical Genetics J. Med. Genet. 46, 315-318 (2009)
Replication of restless legs syndrome loci in three European populations.
2009 Scientific Article in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 29, 774-780 (2009)
Large scale association analysis of novel genetic loci for coronary artery disease.
2009 Scientific Article in Nature Genetics Nat. Genet. 41, 407-414 (2009)
Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
2009 Scientific Article in Annals of Medicine Ann. Med. 41, 128-138 (2009)
Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.
2009 Scientific Article in Nature Genetics Nat. Genet. 41, 708-711 (2009)
Narcolepsy is strongly associated with the T-cell receptor alpha locus.
2009 Scientific Article in Genetic Testing and Molecular Biomarkers Genet. Test. Mol. Biomark. 13, 223-226 (2009)
Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort.
2009 Scientific Article in Nature Genetics Nat. Genet. 41, 25-34 (2009)
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
2009 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 18, 2288-2296 (2009)
Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations.
2009 Scientific Article in Blood Blood 113, 3831-3837 (2009)
A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function.
2009 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 18, 1524-1532 (2009)
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.
2009 Scientific Article in Nature Genetics Nat. Genet. 41, 47-55 (2009)
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
2009 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 84, 66-71 (2009)
A genome-wide association study identifies three loci associated with mean platelet volume.
2008 Scientific Article in Hormone and Metabolic Research Horm. Metab. Res. 40, 722-26 (2008)
Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies.
2008 Scientific Article in Molecular Genetics and Metabolism Mol. Genet. Metab. 95, 229-232 (2008)
MTTP variants and body mass index, waist circumference and serum cholesterol level: Association analyses in 7582 participants of the KORA study cohort.
2008 Scientific Article in PLoS ONE PLoS ONE 3:e3863 (2008)
Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study.
2008 Scientific Article in Annals of Neurology Ann. Neurol. 64, 402-409 (2008)
Risk Variants for Atrial Fibrillation on Chromosome 4q24 Associate with Ischemic Stroke.
2008 Scientific Article in Circulation: Cardiovascular Genetics Circ. Cardiovasc. Genet. 1, 10-20 (2008)
Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions.
2008 Scientific Article in PLoS Genetics PLoS Genet. 4:e1000282 (2008)
Genetics meets metabolomics: A genome-wide association study of metabolite profiles in human serum.
2008 Scientific Article in Nature Genetics Nat. Genet. 40, 946-948 (2008)
PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.
2008 Scientific Article in Current Biology Curr. Biol. 18, 1241-1248 (2008)
Correlation between genetic and geographic structure in Europe.
2008 Scientific Article in PLoS ONE PLoS ONE 3:e2986 (2008)
Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study.
2008 Scientific Article in PLoS Genetics PLoS Genet. 4:e1000166 (2008)
Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.
2008 Scientific Article in Nature Genetics Nat. Genet. 40, 584-591 (2008)
Identification of ten loci associated with height highlights new biological pathways in human growth.
2008 Scientific Article in Nature Genetics Nat. Genet. 40, 768-775 (2008)
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
2008 Scientific Article in Journal of Neurology J. Neurol. 255, 441-442 (2008)
Polymorphisms in the proteasomal subunit alpha4 are not associated with Parkinson's disease.
2008 Scientific Article in Nature Genetics Nat. Genet. 40, 430-436 (2008)
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects.
2008 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 105, 2592-2597 (2008)
A multimetric approach to analysis of genome-wide association by single markers and composite likelihood.
2008 Scientific Article in American Journal of Human Genetics, The Am. J. Hum. Genet. 82, 453-463 (2008)
On the use of general control samples for genome-wide association studies: Genetic matching highlights causal variants.
2007 Scientific Article in Molecular Nutrition and Food Research Mol. Nutr. Food Res. 51, 178-184 (2007)
Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations.
2007 Scientific Article in it - Information Technology Information Technol. 49, 381-387 (2007)
Biobanken in der genetisch-epidemiologiscen Forschung - Beispiel KORA-gen.
2007 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 92, 3183-3188 (2007)
Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations.
2007 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 16, 1821-1827 (2007)
Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans.
2007 Scientific Article in New England Journal of Medicine, The / NEJM N. Engl. J. Med. 357, 443-453 (2007)
Genomewide association analysis of coronary artery disease.
2007 Scientific Article in European Heart Journal Eur. Heart J. 28, 305-309 (2007)
The common non-synonymous variant G38S of the KCNE1-(minK)-gene is not associated to QT interval in Central European Caucasians: Results from the KORA study.
2007 Scientific Article in European Journal of Endocrinology Eur. J. Endocrinol. 157, R1-R5 (2007)
Genetic variants in the leukemia-associated Rho guanine nucleotide exchange factor (ARHGEF12) gene are not associated with T2DM and related parameters in Caucasians (KORA study).
2007 Scientific Article in Nature Genetics Nat. Genet. 39, 1000-1006 (2007)
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
2007 Scientific Article in Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Bundesgesundheitsbl.-Gesund. 50, 192-199 (2007)
Biobanken.
2006 Scientific Article in Diabetes Diabetes 55, 2915-2921 (2006)
IL6 gene promoter polymorphisms and type 2 diabetes: Joint analysis of individual participants' data from 21 studies.
2006 Scientific Article in Nature Genetics Nat. Genet. 38, 644-651 (2006)
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.
2005 Scientific Article in Applied Bioinformatics Appl. Bioinformatics 4, 75-84 (2005)
Automatic Scoring and Quality Assessment Using Accuracy Bounds for FP-TDI SNP Genotyping Data.
2005 Scientific Article in Gesundheitswesen, Das Gesundheitswesen 67, (Sonderheft 1), 26-30 (2005)
KORA-gen - Resource for population genetics, controls and a broad spectrum of disease phenotypes.
2005 Scientific Article in GenomXPress GenomXPress 3/05, 19-21 (2005)