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Manuscript accepted in Analytical and Bioanalytical Chemistry
Lukas Schwalb and his colleagues have succeeded in chemically describing the complex medical substance sodium bituminosulfonate (SBS) as well as its process intermediates. For this study they have involved the online derivatization with tetramethylammonium hydroxide using comprehensive two-dimensional gas chromatography coupled to an electron ionization high-resolution time-of-fight mass spectrometer (GC×GC-HR-ToF–MS).
Schwalb et al.: Analysis of complex drugs by comprehensive two-dimensional gas chromatography and high-resolution mass spectrometry: detailed chemical description of the active pharmaceutical ingredient sodium bituminosulfonate and its process intermediates. Analytical and Bioanalytical Chemistry (2022)