Gas-particle partitioning of SVOCs and the impact on human health

The goal is to investigate the adverse effects of semi-volatile organic compounds (SVOCs) under consideration of their physical state (gas versus particle phase) in a suitable in vitro exposure system at the air-liquid interface (ALI). Thus, a self-designed exposure system together with an aerosol production line was set up to investigate the toxicity of gas versus particle phases of a model substance (dibutyl phthalate). The project requires a strong collaboration between the Aerosol Physics and Aerosol Toxicology groups.

Project funded by the German Social Accident Insurance (DGUV), Project FP 425.

Scientist involved: Stephanie Binder (PhD project)

Collaboration with the Aerosol Physics group: Dr. Narges Rastack and Dr. Martin Sklorz.

Binder S, Cao X, Bauer S, Rastak N, Kuhn E, Dragan GC, Monsé C, Ferron G, Breuer D, Oeder S, Karg E, Sklorz M, Di Bucchianico S, Zimmermann R.

In vitro genotoxicity of dibutyl phthalate on A549 lung cells at air-liquid interface in exposure concentrations relevant at workplaces