laser reflect on optic table un quantum laboratory

Tower ALI System - with laser detection

Exposing in vitro cells at the air liquid interface (ALI) is a powerful tool to investigate the cellular response to different aerosols, such as ultrafine particles or allergen extracts, but is usually limited to very specific sizes or solutions. Therefore, a new ALI System is developed which allows in vitro cell exposure to a wide range of particles, including nanoparticle, fibers, pollen as well as mixtures of different sizes. The particles/fibers are directly used, without changing the chemical and physical properties by e.g. dispersing them in a solution. Additionally, particles and fibers > 0.5 µm can be directly quantified by using a newly developed laser detection approach.

Scientist involved: Elias Zimmermann

Collaboration with Dr Robert Irsig, Photonion GmbH

Publications

Binder S, Cao X, Bauer S, Rastak N, Kuhn E, Dragan GC, Monsé C, Ferron G, Breuer D, Oeder S, Karg E, Sklorz M, Di Bucchianico S, Zimmermann R.

In vitro genotoxicity of dibutyl phthalate on A549 lung cells at air-liquid interface in exposure concentrations relevant at workplaces