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Development of new drug
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Detailed chemical characterization of complex pharmaceuticals

 

The detailed chemical description of drugs is a crucial aspect in determining their pharmaceutical activity. It is also necessary for distinguishing between competitors, generics and imitation products, and is advantageous for the development of follow-on products. However, there are drugs that are too chemically complex to be described comprehensively by the standard analytical methods described in pharmacopoeias. Some of these complex drugs have been used for centuries, and while their pharmaceutical effects are well documented, the chemical composition is often only partially known.

The project address this missing knowledge and target the chemical description of chemically very complex APIs (active pharmaceutical ingredients). The JMSC with their research topic Ultrahigh Resolution Mass Spectrometry and Comprehensive Chromatographic Separation at the University Rostock respectively the Helmholtz Zentrum München are engaged with two doctoral students. In Rostock, the APIs are analyzed via (ultra)high mass resolution techniques. In Munich, different comprehensive gas chromatography coupled to high-resolution mass spectrometry (GC×GC HR-ToF-MS) methods are developed. The combination of both techniques allows to cross-verify the results and to overcome the difficulties of limited background information, standard materials and established methods for these kind pharmaceuticals.

The project is a cooperation between the Helmholtz Zentrum München, the University of Rostock and the Ichthyol-Gesellschaft as industrial partner and funder of the project.

 

Detailed chemical characterization of complex pharmaceuticals

 

The detailed chemical description of drugs is a crucial aspect in determining their pharmaceutical activity. It is also necessary for distinguishing between competitors, generics and imitation products, and is advantageous for the development of follow-on products. However, there are drugs that are too chemically complex to be described comprehensively by the standard analytical methods described in pharmacopoeias. Some of these complex drugs have been used for centuries, and while their pharmaceutical effects are well documented, the chemical composition is often only partially known.

The project address this missing knowledge and target the chemical description of chemically very complex APIs (active pharmaceutical ingredients). The JMSC with their research topic Ultrahigh Resolution Mass Spectrometry and Comprehensive Chromatographic Separation at the University Rostock respectively the Helmholtz Zentrum München are engaged with two doctoral students. In Rostock, the APIs are analyzed via (ultra)high mass resolution techniques. In Munich, different comprehensive gas chromatography coupled to high-resolution mass spectrometry (GC×GC HR-ToF-MS) methods are developed. The combination of both techniques allows to cross-verify the results and to overcome the difficulties of limited background information, standard materials and established methods for these kind pharmaceuticals.

The project is a cooperation between the Helmholtz Zentrum München, the University of Rostock and the Ichthyol-Gesellschaft as industrial partner and funder of the project.