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GINIplus

The GINIplus study is a long-term birth cohort study, which recruited 5991 children from two regions of Germany (Munich and Wesel each with surrounding area). The study is ongoing, with numerous participant follow-ups carried out from birth to young adulthood.

The aim of the GINIplus study is to investigate the role of environmental exposures, life-style factors and genetic predisposition in the development of common chronic diseases with a specific focus on the development of allergic diseases.

The GINIplus study is further contributing data in a multitude of collaborative efforts to further understand childhood allergies, growth and genetics.

Our website for the participants of the GINIplus study: www.ginistudie.de (in German).

The GINIplus study is a long-term birth cohort study, which recruited 5991 children from two regions of Germany (Munich and Wesel each with surrounding area). The study is ongoing, with numerous participant follow-ups carried out from birth to young adulthood.

The aim of the GINIplus study is to investigate the role of environmental exposures, life-style factors and genetic predisposition in the development of common chronic diseases with a specific focus on the development of allergic diseases.

The GINIplus study is further contributing data in a multitude of collaborative efforts to further understand childhood allergies, growth and genetics.

Our website for the participants of the GINIplus study: www.ginistudie.de (in German).

About our Cohort Study

The German Infant Study on the Influence of Nutrition Intervention plus Air pollution and Genetics on Allergy Development (GINIplus) is a multicentre, population-based prospective birth cohort study. The study consists of two arms: an interventional and an observational arm. Both arms together represent a population-based birth cohort. Newborns with family history of allergy were recruited for the interventional arm (GINI = German Infant Nutritional Intervention program): a randomized, double-blind controlled trial with 3 hydrolysed formulae versus cow’s milk formula feeding during first 4 months of life (n=1165 in Munich, n=1087 in Wesel). Newborns with a negative family history or positive family history but refusing participation in the trial were included in the observational study arm.

In total (both arms) the study enrolled 5991 healthy full-term newborns in two German regions, Munich (n = 2949) representing an urban area and Wesel (n = 3042) representing a rural area. Enrollment started in September 1995 and ended in June 1998. Participants were followed-up since birth at 1, 2, 3, 4, 6, 10, 15, 20 and now 25 years of age, as well as during the COVID-19 pandemic.

General

  • To describe the natural course of a broad spectrum of selected health parameters starting from infancy to young adulthood with a focus on the development of atopic diseases.
  • To determine the impact of feeding regimen in infancy, environmental exposures, life style factors and genetic predisposition.
  • To investigate the influence of mental health, nutrition, body weight and physical activity on child and adolescent health.

The 25-year-follow up started in 2022.

 

Study region Munich

  • Helmholtz Munich - Institute of Epidemiology: Marie Standl (PI GINIplus)
  • Department of Pediatrics, Dr. von Hauner Children’s Hospital, LMU Klinikum, University of Munich: Sibylle Koletzko (Previously PI GINIplus)
  • Department of Pediatrics, Technical University Munich: Carl P. Bauer (Previously PI GINIplus)

Wesel

  • Marien-Hospital Wesel, Department of Pediatrics, Research Institute: Dietrich Berdel (Previously PI GINIplus), Andrea von Berg

Düsseldorf

  • IUF – Leibniz Research Institute for Environmental Medicine: Tamara Schikowski (PI GINIplus)
  • Evangelisches Krankenhaus Düsseldorf, Children‘s Hospital. Clinical PI Monika Gappa

  • To describe the natural course of a broad spectrum of selected health parameters starting from infancy to young adulthood with a focus on the development of atopic diseases.
  • To determine the impact of feeding regimen in infancy, environmental exposures, life style factors and genetic predisposition.
  • To investigate the influence of mental health, nutrition, body weight and physical activity on child and adolescent health.

The 25-year-follow up started in 2022.

 

Study region Munich

  • Helmholtz Munich - Institute of Epidemiology: Marie Standl (PI GINIplus)
  • Department of Pediatrics, Dr. von Hauner Children’s Hospital, LMU Klinikum, University of Munich: Sibylle Koletzko (Previously PI GINIplus)
  • Department of Pediatrics, Technical University Munich: Carl P. Bauer (Previously PI GINIplus)

Wesel

  • Marien-Hospital Wesel, Department of Pediatrics, Research Institute: Dietrich Berdel (Previously PI GINIplus), Andrea von Berg

Düsseldorf

  • IUF – Leibniz Research Institute for Environmental Medicine: Tamara Schikowski (PI GINIplus)
  • Evangelisches Krankenhaus Düsseldorf, Children‘s Hospital. Clinical PI Monika Gappa

People at GINIplus

Dr. Marie Standl

Head of Research Group 'Allergic Disease Epidemiology', Head (ad interim) of Research Group 'Lung Epidemiology', Statistician View profile

Lika Palabiyik

Study Nurse

Ines Trentinaglia

Data Manager

Miriam Leskien

PhD Student

Sarah Wagner

PhD Student

Lisa Maier

PhD Student

Carla Harris

Research Fellow

Maike Ferland

B.Sc., Data Manager

Dr. Claudia Flexeder

Postdoc, Statistician

Birgit Schmuck

Study Doctor

Elke Luxenburger

Technician

Megi Vogli

Research Fellow

Mingming Wang

PhD Student

Dr. Elisabeth Thiering

Postdoc, Statistician

Dr. Stefan Karrasch

MD, Epidemiologist

Sonja Braun

Doctoral Student

Claudia Zeller

Technical Assistant

Contact for study participants

Claudia Zeller

Technical Assistant

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Responsible Investigator for GINIplus Munich

Dr. Marie Standl

Head of Research Group 'Allergic Disease Epidemiology', Head (ad interim) of Research Group 'Lung Epidemiology', Statistician

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