LISA
The LISA study is a long-term, population-based prospective birth cohort study comprising 3094 children from four regions of Germany (Munich, Leipzig, Wesel, Bad Honnef). The aims of the LISA study are to monitor the development and natural course of atopic diseases and to investigate the influence of life-style and environmental factors. Further topics such as mental well-being, lung function, nutrition, body composition and physical activity were added later and the LISA study is now further contributing data in a multitude of collaborative efforts to further understand childhood allergies, growth and genetics.
Our website for the participants of the LISA study: www.lisastudie.de (in German).
The LISA study is a long-term, population-based prospective birth cohort study comprising 3094 children from four regions of Germany (Munich, Leipzig, Wesel, Bad Honnef). The aims of the LISA study are to monitor the development and natural course of atopic diseases and to investigate the influence of life-style and environmental factors. Further topics such as mental well-being, lung function, nutrition, body composition and physical activity were added later and the LISA study is now further contributing data in a multitude of collaborative efforts to further understand childhood allergies, growth and genetics.
Our website for the participants of the LISA study: www.lisastudie.de (in German).
About our Cohort Study
The LISA study is a prospective, multi-center and population-based birth cohort, which recruited children born between November 1997 to January 1999 and focuses on the influence of Life-style factors on the Development of the Immune System and Allergies in East and West Germany (LISA).
3097 healthy and full-term newborns were enrolled in the four study regions, Munich (n = 1467), Leipzig (n = 976), Wesel (n = 348) and Bad Honnef (n = 306) and followed up at 0.5, 1, 1.5, 2, 4, 6, 10, 15, 20 and now 25 years of age, as well as during the COVID-19 pandemic.
General
- To determine the influence of life-style factors, environmental exposures, and health-related behaviour on the development of the immune system and the incidence of allergic diseases in children.
- To determine the influence of traffic emissions and genetics
The 25-year-follow up will start at the beginning of 2023.
Study region Munich
- Helmholtz Munich – Institute of Epidemiology: Marie Standl
Wesel
- Marien-Hospital Wesel, Department of Pediatrics: Andrea von Berg
Düsseldorf
- IUF – Leibniz Research Institute for Environmental Medicine: Tamara Schikowski
- Evangelisches Krankenhaus Düsseldorf, Children‘s Hospital: Monika Gappa.
Leipzig
- Helmholtz Centre for Environmental Research – UFZ, Department of Environmental Immunology: Gunda Herberth
Bad Honnef
- Medical Praxis for Children, Bad Honnef: B. Schaaf
- To determine the influence of life-style factors, environmental exposures, and health-related behaviour on the development of the immune system and the incidence of allergic diseases in children.
- To determine the influence of traffic emissions and genetics
The 25-year-follow up will start at the beginning of 2023.
Study region Munich
- Helmholtz Munich – Institute of Epidemiology: Marie Standl
Wesel
- Marien-Hospital Wesel, Department of Pediatrics: Andrea von Berg
Düsseldorf
- IUF – Leibniz Research Institute for Environmental Medicine: Tamara Schikowski
- Evangelisches Krankenhaus Düsseldorf, Children‘s Hospital: Monika Gappa.
Leipzig
- Helmholtz Centre for Environmental Research – UFZ, Department of Environmental Immunology: Gunda Herberth
Bad Honnef
- Medical Praxis for Children, Bad Honnef: B. Schaaf
People at LISA
Highlight Publications
2017 Allergol Select DOI: 10.5414/ALX01455E
2022 Allergy DOI: 10.1111/all.15511
2022 Allergy DOI: 10.1111/all.15315
2022 Clin Epigenet DOI: 10.1186/s13148-022-01332-5
DNA methylation and aeroallergen sensitization: The chicken or the egg?
2019 Sci Rep DOI: 10.1038/s41598-019-49160-7
Early life determinants induce sustainable changes in the gut microbiome of six-year-old children
