Matthias Meier

Principal Investigator Helmholtz Pioneer Campus

+49 89 3187 49564 Email meBuilding/Room: 36.20

Research Area

Matthias Meier is a German biophysicist who received his PhD from the University of Basel in Switzerland in 2006. In 2008 he was awarded with the Feodor-Lynen postdoctoral fellowship from the Alexander von Humboldt Foundation and worked 4 years with Steven Quake at Stanford University. With help of an Emmy-Noether-Fellowship from the German Research Foundation he returned to Europe and established an independent research group at the Microsystem Engineering department of the University of Freiburg. In 2017 Dr. Meier received the ERC Consolidator grant for performing research in medical engineering field of Organ-on-Chips. In 2018 Matthias Meier joined the Helmholtz Pioneer Campus.

Initiative and Networking Fund of the Helmholtz association

µLUMEN-Chip, a validation project builds upon the pioneering work of Matthias Meier’s lab.

Professional Background

Since 2022

Full Professorship at the Institut of Biochemistry of the University of Leipzig

Since 2018

Principal Investigator at Helmholtz Pioneer Campus, Helmholtz Zentrum München

2012 - 2018

Independent Research Group Leader (DFG Emmy-Noether Fellow) at IMTEK, University of Freiburg, Germany

2009 - 2011

Postdoc at Stanford University, Laboratory of Professor Stephen Quake, USA

2008 - 2009

Postdoc at University of Chicago, Laboratory of Professor Rustem Ismagilov, USA

Honors and Awards

Award Number One
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2013
Award Number Two
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2019

Publications

2024 Scientific Article in STAR Protocols

Remmert, C. ; Otgonbayar, M. ; Perschel, J.A. ; Marder, M. ; Meier, M.

Protocol to generate a microfluidic vessels-on-chip platform using human pluripotent stem cell-derived endothelial cells.

2024 Scientific Article in Cell Reports

Marder, M. ; Remmert, C. ; Perschel, J.A. ; Otgonbayar, M. ; von Toerne, C. ; Hauck, S.M. ; Bushe, J. ; Feuchtinger, A. ; Sheikh, B. ; Moussus, M. ; Meier, M.

Stem cell-derived vessels-on-chip for cardiovascular disease modeling.

2024 Scientific Article in Biosensors and Bioelectronics

Schmidt, S. ; Li, W. ; Schubert, M. ; Binnewerg, B. ; Prönnecke, C. ; Zitzmann, F.D. ; Bulst, M. ; Wegner, S. ; Meier, M. ; Guan, K. ; Jahnke, H.G.

Novel high-dense microelectrode array based multimodal bioelectronic monitoring system for cardiac arrhythmia re-entry analysis.

2024 Scientific Article in Biosensors and Bioelectronics

Zitzmann, F.D. ; Schmidt, S. ; Frank, R. ; Weigel, W. ; Meier, M. ; Jahnke, H.G.

Microcavity well-plate for automated parallel bioelectronic analysis of 3D cell cultures.

2023 Scientific Article in Advanced Materials Technologies

Hörner, M. ; Becker, J. ; Bohnert, R. ; Baños, M. ; Jerez-Longres, C. ; Mühlhäuser, V. ; Härrer, D. ; Wong, T.W. ; Meier, M. ; Weber, W.

A photoreceptor-based hydrogel with red light-responsive reversible sol-gel transition as transient cellular matrix.

2023 Scientific Article in Stem Cell Reports

Rosowski, S. ; Remmert, C. ; Marder, M. ; Akishiba, M. ; Bushe, J. ; Feuchtinger, A. ; Platen, A. ; Ussar, S. ; Theis, F.J. ; Wiedenmann, S. ; Meier, M.

Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment.

2023 Scientific Article in Nature Communications

Wirth, J. ; Huber, N. ; Yin, K. ; Brood, S. ; Chang, S.C.-E. ; Martinez Jimenez, C.P. ; Meier, M.

Spatial transcriptomics using multiplexed deterministic barcoding in tissue.

2023 Scientific Article in Cell Reports Methods

Atwell, S. ; Waibel, D.J.E. ; Shetab Boushehri, S. ; Wiedenmann, S. ; Marr, C. ; Meier, M.

Label-free imaging of 3D pluripotent stem cell differentiation dynamics on chip.

2022 Scientific Article in Lecture Notes in Computer Science

Waibel, D.J.E. ; Atwell, S. ; Meier, M. ; Marr, C. ; Rieck, B.

Capturing shape information with multi-scale topological loss terms for 3D reconstruction.

2022 Scientific Article in LAB on a chip

Compera, N. ; Atwell, S. ; Wirth, J. ; von Toerne, C. ; Hauck, S.M. ; Meier, M.

Adipose microtissue-on-chip: A 3D cell culture platform for differentiation, stimulation, and proteomic analysis of human adipocytes.

2022 Scientific Article in iScience

Waibel, D.J.E. ; Kiermeyer, N. ; Atwell, S. ; Sadafi, A. ; Meier, M. ; Marr, C.

SHAPR predicts 3D cell shapes from 2D microscopic images.

2021 Scientific Article in STAR Protocols

Breunig, M. ; Merkle, J. ; Melzer, M.K. ; Heller, S. ; Seufferlein, T. ; Meier, M. ; Hohwieler, M. ; Kleger, A.

Differentiation of human pluripotent stem cells into pancreatic duct-like organoids.

2021 Scientific Article in LAB on a chip

Ardila Riveros, J.C. ; Blöchinger, A. ; Atwell, S. ; Moussus, M. ; Compera, N. ; Rajabnia, O. ; Georgiev, T. ; Lickert, H. ; Meier, M. ; Lickert, H.

Automated optimization of endoderm differentiation on chip.

2021 Scientific Article in Cancers

Merkle, J. ; Breunig, M. ; Schmid, M. ; Allgöwer, C. ; Krüger, J. ; Melzer, M.K. ; Bens, S. ; Siebert, R. ; Perkhofer, L. ; Azoitei, N. ; Seufferlein, T. ; Heller, S. ; Meier, M. ; Müller, M. ; Kleger, A. ; Hohwieler, M.

Cdkn2a-mutated pancreatic ductal organoids from induced pluripotent stem cells to model a cancer predisposition syndrome.

2021 Review in Nature Reviews - Drug Discovery

Siehler, J. ; Blöchinger, A. ; Meier, M. ; Lickert, H.

Engineering islets from stem cells for advanced therapies of diabetes.

2021 Scientific Article in LAB on a chip

Compera, N. ; Atwell, S. ; Wirth, J. ; Wolfrum, B. ; Meier, M.

Upscaling of pneumatic membrane valves for the integration of 3D cell cultures on chip.

2021 Scientific Article in Nature biomedical engineering

Wiedenmann, S. ; Breunig, M. ; Merkle, J. ; von Toerne, C. ; Georgiev, T. ; Moussus, M. ; Schulte, L.N. ; Seufferlein, T. ; Sterr, M. ; Lickert, H. ; Weissinger, S.E. ; Möller, P. ; Hauck, S.M. ; Hohwieler, M. ; Kleger, A. ; Meier, M.

Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip.

2021 Scientific Article in LAB on a chip

Moussus, M. ; Meier, M.

A 3D-printed Arabidopsis thaliana root imaging platform.

2021 Scientific Article in Cell Stem Cell

Breunig, M. ; Merkle, J. ; Wagner, M. ; Melzer, M.K. ; Barth, T.F.E. ; Engleitner, T. ; Krumm, J. ; Wiedenmann, S. ; Cohrs, C.M. ; Perkhofer, L. ; Jain, G. ; Krüger, J. ; Hermann, P.C. ; Schmid, M. ; Madácsy, T. ; Varga, A. ; Griger, J. ; Azoitei, N. ; Müller, M. ; Wessely, O. ; Robey, P.G. ; Heller, S. ; Dantes, Z. ; Reichert, M. ; Günes, C. ; Bolenz, C. ; Kuhn, F. ; Maléth, J. ; Speier, S. ; Liebau, S. ; Sipos, B. ; Kuster, B. ; Seufferlein, T. ; Rad, R. ; Meier, M. ; Hohwieler, M. ; Kleger, A.

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.

2021 Nature

Ansarullah ; Jain, C. ; Far, F.F. ; Homberg, S. ; Wißmiller, K. ; von Hahn, F. ; Raducanu, A. ; Schirge, S. ; Sterr, M. ; Bilekova, S. ; Siehler, J. ; Wiener, J. ; Oppenländer, L. ; Morshedi, A. ; Bastidas-Ponce, A. ; Collden, G. ; Irmler, M. ; Beckers, J. ; Feuchtinger, A. ; Grzybek, M. ; Ahlbrecht, C. ; Feederle, R. ; Plettenburg, O. ; Müller, T.D. ; Meier, M. ; Tschöp, M.H. ; Coskun, Ü. ; Lickert, H.

Author Correction: Inceptor counteracts insulin signalling in β-cells to control glycaemia.

2021 Scientific Article in Molecular Metabolism

Ruiz Ojeda, F.J. ; Wang, J. ; Bäcker, T. ; Krueger, M. ; Zamani, S. ; Rosowski, S. ; Gruber, T. ; Onogi, Y. ; Feuchtinger, A. ; Schulz, T.J. ; Fässler, R. ; Müller, T.D. ; García-Cáceres, C. ; Meier, M. ; Blüher, M. ; Ussar, S.

Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis.

2021 Scientific Article in Nature

Ansarullah ; Jain, C. ; Far, F.F. ; Homberg, S. ; Wissmiller, K. ; Gräfin von Hahn, F. ; Raducanu, A. ; Schirge, S. ; Sterr, M. ; Bilekova, S. ; Siehler, J. ; Wiener, J. ; Oppenländer, L. ; Morshedi, A. ; Bastidas-Ponce, A. ; Collden, G. ; Irmler, M. ; Beckers, J. ; Feuchtinger, A. ; Grzybek, M. ; Ahlbrecht, C. ; Feederle, R. ; Plettenburg, O. ; Müller, T.D. ; Meier, M. ; Tschöp, M.H. ; Coskun, Ü. ; Lickert, H.

Inceptor counteracts insulin signalling in β-cells to control glycaemia.

2020 Scientific Article in Scientific Reports

Wiener, J. ; Kokotek, D. ; Rosowski, S. ; Lickert, H. ; Meier, M.

Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics.

2019 Scientific Article in Nature

Karakus, U. ; Thamamongood, T. ; Ciminski, K. ; Ran, W. ; Günther, S.C. ; Pohl, M.O. ; Eletto, D. ; Jeney, C. ; Hoffmann, D. ; Reiche, S. ; Schinköthe, J. ; Ulrich, R. ; Wiener, J. ; Hayes, M.G.B. ; Chang, M.W. ; Hunziker, A. ; Yángüez, E. ; Aydillo, T. ; Krammer, F. ; Oderbolz, J. ; Meier, M. ; Oxenius, A. ; Halenius, A. ; Zimmer, G. ; Benner, C. ; Hale, B.G. ; García-Sastre, A. ; Beer, M. ; Schwemmle, M. ; Stertz, S.

Prof. Dr. Matthias Meier

News

Initiative and Networking Fund of the Helmholtz association

Full Professorship at the Institut of Biochemistry of the University of Leipzig

Principal Investigator at Helmholtz Pioneer Campus, Helmholtz Zentrum München

Independent Research Group Leader (DFG Emmy-Noether Fellow) at IMTEK, University of Freiburg, Germany

Postdoc at Stanford University, Laboratory of Professor Stephen Quake, USA

Postdoc at University of Chicago, Laboratory of Professor Rustem Ismagilov, USA

Honors and Awards

Publications