Helmholtz Munich | Maria Keller
CRISPR dCAS9 Based Epigenetic Editing in vitro
CRISPR dCAS9 Based Epigenetic Editing in vitro
Based on previous findings for obesity specific methylation pattern in human subcutaneous- and omental visceral adipose tissue (e.g. Keller et al, 2016, Mol Met), this project aims to identify possible epigenetic alterations that define a "point of no return" in obesity and comorbidities development. Thus, we are testing the reversibility of methylation remodeling in (human) adipocytes by means of epigenetic editing.
