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Priyanka Singh

YIG Diet-Induced Metabolic Alterations / Jais-Lab

The consumption of palatable, energy-dense food facilitates over-eating via central nervous system (CNS)-dependent mechanism. Circulating nutrients, metabolites and hormones, released by organs such as adipose tissue, liver, pancreas and the gastrointestinal tract act as feedback signals to the CNS, which implements appropriate behavioral and metabolic responses in order to maintain energy and metabolic homeostasis.

Our lab's research is focused on providing detailed insights into neurocircuitries activated by palatable, energy-dense food. We are using neuroscience approaches to define the anatomical distribution, molecular signature and neurocircuitry architecture of these neurons. Furthermore, we investigate the long-term effects governed by these neurons to determine their physiological relevance and their role in the deregulation of whole-body energy and metabolic homeostasis during obesity development.

The ultimate goal of this research is to develop novel noninvasive therapeutic interventions for obesity and other prevalent metabolic disorders.

The consumption of palatable, energy-dense food facilitates over-eating via central nervous system (CNS)-dependent mechanism. Circulating nutrients, metabolites and hormones, released by organs such as adipose tissue, liver, pancreas and the gastrointestinal tract act as feedback signals to the CNS, which implements appropriate behavioral and metabolic responses in order to maintain energy and metabolic homeostasis.

Our lab's research is focused on providing detailed insights into neurocircuitries activated by palatable, energy-dense food. We are using neuroscience approaches to define the anatomical distribution, molecular signature and neurocircuitry architecture of these neurons. Furthermore, we investigate the long-term effects governed by these neurons to determine their physiological relevance and their role in the deregulation of whole-body energy and metabolic homeostasis during obesity development.

The ultimate goal of this research is to develop novel noninvasive therapeutic interventions for obesity and other prevalent metabolic disorders.

Lab Members

Dr. Alexander Jais

Group Leader "Diet-Induced Metabolic Alterations"" View profile

Stephanie Puente Ruiz

PhD Candidate

Anja Moll

Technician

Dr. Adel Ben Kraiem

PostDoc

Dr. Julia Schuller

PostDoc

Publications

A. Jais, E. Einwallner, O. Sharif, K. Gossens, T. T. Lu, S. M. Soyal, D. Medgyesi, D. Neureiter, J. Paier-Pourani, K. Dalgaard, J. C. Duvigneau, J. Lindroos-Christensen, T. C. Zapf, S. Amann, S. Saluzzo, F. Jantscher, P. Stiedl, J. Todoric, R. Martins, H. Oberkofler, S. Muller, C. Hauser-Kronberger, L. Kenner, E. Casanova, H. Sutterluty-Fall, M. Bilban, K. Miller, A. V. Kozlov, F. Krempler, S. Knapp, C. N. Lumeng, W. Patsch, O. Wagner, J. A. Pospisilik and H. Esterbauer

Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man

Contact Jais-Lab

Dr. Alexander Jais

Group Leader "Diet-Induced Metabolic Alterations""

Leipzig