Adipokines and (B)AT Activity

This project focusses on the role of various previously unrecognized proteins, enzymes, serpins and proteases in brown adipose tissue activation and thermogenesis. These candidates were e.g. found highly induced or repressed in BAT of cold-exposed mice and are investigated in (B)AT-specific knock out mouse models. On the cellular level, we use the Seahorse analyzer to investigate consequences of manipulating candidate protein expression in white and brown, primary and immortalized adipocytes on mitochondrial respiration and metabolic substrate preference.

Immunhistochemische Analyse im braunen Fettgewebe

Temperature-dependence of MB expression in brown adipose tissue (BAT). Representative images of MB immunohistochemistry in brown adipose tissue (BAT) female C57BL/6N mice housed either at 30 °C, 23 °C or 8 °C for 1 week.

PD Dr. Dr. John Heiker

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J. Weiner, L. Roth, M. Kranz, P. Brust, A. Boelen, N. Klöting, J. T. Heiker, M. Blüher, A. Tönjes, P. Pfluger, M. Stumvoll, J. Mittag, K. Krause:

Leptin Counteracts Hypothermia in Hypothyroidism through its Pyrexic Effects and by Stabilizing Serum Thyroid Hormone

S. Epperlein, C. Gebhardt, K. Rohde, R. Chakaroun, M. Patt, I. Schamarek, S. Kralisch, J. T. Heiker, M. Scholz, M. Stumvoll, P. Kovacs, J. Breitfeld, A. Tönjes

The Role of FGF21 and its Genetic Variation in Eating Behavior

A. Kunath, J. T. Heiker, M. Kern, J. Kosacka, G. Flehmig, M. Stumvoll, P. Kovacs, M. Blüher, N. Klöting

Nicotinamide Nucleotide Transhydrogenase (Nnt) is Related to Obesity in Mice

T. Suchý, C. Zieschang, Y. Popkova, I. Kaczmarek, J. Weiner, A. D. Liebing, M. V. Çakir, K. Landgraf, M. Gericke, J. A. Pospisilik, A. Körner, J. T. Heiker, D. Dannenberger, J. Schiller, T. Schöneberg, I. Liebscher, D. Thor

The Repertoire of Adhesion G Protein-Coupled Receptors in Adipocytes and their Functional Relevance

S. Heinitz, C. Gebhardt, P. Piaggi, J. Krüger, H. Heyne, J. Weiner, J. H. Heiker, M. Stumvoll, M. Blüher, L. Baier, A. Rudich, P. Kovacs, A. Tönjes

Atg7-Knockdown Reduces Chemerin Secretion in Murine Adipocytes

Adipokines and (B)AT Activity

Adipokines and (B)AT Activity

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Scientists working in the project

PD Dr. Dr. John Heiker

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Cooperation Partners

Leipzig University

Universitätsklinikum Leipzig

CRC1052 "Obesity Mechanisms"

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PD Dr. Dr. John Heiker

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