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Adipokines and (B)AT Activity

Adipokines and (B)AT Activity

This project focusses on the role of various previously unrecognized proteins, enzymes, serpins and proteases in brown adipose tissue activation and thermogenesis. These candidates were e.g. found highly induced or repressed in BAT of cold-exposed mice and are investigated in (B)AT-specific knock out mouse models. On the cellular level, we use the Seahorse analyzer to investigate consequences of manipulating candidate protein expression in white and brown, primary and immortalized adipocytes on mitochondrial respiration and metabolic substrate preference.

Scientists working in the project

Publications

Contact Project Leader

PD Dr. Dr. John Heiker

YIG Leader

Leipzig