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Adipokines and (B)AT Activity
Adipokines and (B)AT Activity
This project focusses on the role of various previously unrecognized proteins, enzymes, serpins and proteases in brown adipose tissue activation and thermogenesis. These candidates were e.g. found highly induced or repressed in BAT of cold-exposed mice and are investigated in (B)AT-specific knock out mouse models. On the cellular level, we use the Seahorse analyzer to investigate consequences of manipulating candidate protein expression in white and brown, primary and immortalized adipocytes on mitochondrial respiration and metabolic substrate preference.