Experimental AllergologyLab Alessandrini
Our aim is to understand the interaction between individual predisposition, environment and the development of allergy with the ultimate goal of increasing our knowledge of the basic mechanisms of allergies and providing insights for allergy prevention or treatment.
Our group focuses on molecular allergology as well as on understanding the immunological mechanisms of allergen-specific immunotherapy and immune tolerance to allergens. This includes the development of novel immunomodulatory strategies to enhance immunotherapeutic approaches.
Our lab interests cover the influence of both environmental pollution, especially anthropogenic particles, and irritant gases on lung and skin allergic inflammation and the effects of climate change on pollen-induced lung allergic reactions. Moreover, its activities focus on studying the impact of combining the above listed risk factors with individual susceptibility factors like obesity or with nutrition factors on allergy development.
- Our first field of interest covers the effects of climate change on pollen-induced allergic reactions, in particular ragweed-induced lung allergic diseases.
- A second field of activities lies in studying the influence of both environmental pollution, especially anthropogenic particles and irritant gases, and industrial engineered nanoparticles in allergic lung and skin inflammation.
- Third, our activities focus on investigating the combination of the above listed risk factors with individual susceptibility factors like obesity on allergy development.
To identify the effects of said metabolic and/or environmental risk factors, several mouse models for the evaluation of allergic lung and skin diseases have been and are currently developed.