All IDC Publications
2025 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 26:117 (2025)
Hypoxia regulates brown adipocyte differentiation and stimulates miR-210 by HIF-1α.
2024 Review in Endocrine Oncology Endocr. Oncol. 4:e240055 (2024)
NET Models Meeting 2024 white paper: The current state of neuroendocrine tumour research models and our future aspirations.
2024 Scientific Article in Neuroendocrinology Neuroendocrinology, DOI: 10.1159/000543136 (2024)
The novel SSTR3 full agonist ITF2984 shows antitumor properties against pancreatic neuroendocrine tumors (Pan-NETs).
Proceedings of SPIE In: (15th SPIE Conference on Developments in X-Ray Tomography, 19-22 August 2024, San Diego). 2024.:1315205 (Proc. SPIE ; 13152)
Development of a H&E multi-agent-staining method for laboratory-microCT applied to endocrine glands of MENX rats.
2024 Scientific Article in iScience iScience 27:110908 (2024)
Quiescence and aging of melanocyte stem cells and a novel association with programmed death-ligand 1.
2024 Scientific Article in Nature biomedical engineering Nat. Bio. Eng., DOI: 10.1038/s41551-024-01273-9 (2024)
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma.
2024 Review in Nature metabolism Nat. Metab., DOI: 10.1038/s42255-024-01167-9 (2024)
Cancer cachexia: Multilevel metabolic dysfunction.
2024 Scientific Article in Cellular and Molecular Life Sciences - CMLS Cell. Mol. Life Sci. 81:458 (2024)
NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency.
2024 Scientific Article in Diabetes Diabetes 74, 65-74 (2024)
Exploring structural and molecular features of sciatic nerve lesions in diabetic neuropathy: Unveiling pathogenic pathways and targets.
2024 Scientific Article in EMBO Journal, The EMBO J., DOI: 10.1038/s44318-024-00231-0 (2024)
TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia.
2024 Scientific Article in Cell Death and Differentiation Cell Death Differ., DOI: 10.1038/s41418-024-01398-z (2024)
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis.
2024 Scientific Article in ESC heart failure ESC Heart Fail., DOI: 10.1002/ehf2.15133 (2024)
Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy.
2024 Scientific Article in Obesity Obesity 32, 1885-1896 (2024)
Functional redundancy between glucocorticoid and mineralocorticoid receptors in mature corticotropin-releasing hormone neurons protects from obesity.
2024 Scientific Article in EMBO Journal, The EMBO J., DOI: 10.1038/s44318-024-00215-0 (2024)
IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat.
2024 Scientific Article in EMBO Journal, The EMBO J., DOI: 10.1038/s44318-024-00219-w (2024)
Systematic mapping of mitochondrial calcium uniporter channel (MCUC)-mediated calcium signaling networks.
2024 Letter to the Editor in Nature Reviews - Genetics Nat. Rev. Genet. 25:678 (2024)
The complex non-genetic inheritance of complex traits.
Methods in Molecular Biology In: Chromatin Immunoprecipitation. 2024. 35-45 (Methods Mol. Biol. ; 2846)
Chromatin immunoprecipitation in adipose tissue and adipocytes: How to proceed and optimize the protocol for transcription factor DNA binding.
2024 Scientific Article in Journal of Cellular and Molecular Medicine J. Cell. Mol. Med. 28:e18272 (2024)
Development, synthesis and validation of improved c-Myc/Max inhibitors.
2024 Scientific Article in Journal of Hepatology J. Hepatol., DOI: 10.1016/j.jhep.2024.06.040 (2024)
Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease.
2024 Review in Redox Biology Redox Biol. 75:103211 (2024)
Ferroptosis in health and disease.
2024 Scientific Article in Diabetes Care Diabetes Care 47, 1584-1592 (2024)
Glucose load following prolonged fasting increases oxidative stress-linked response in individuals with diabetic complications.
2024 Scientific Article in Molecular Metabolism Mol. Metab. 85:101956 (2024)
Sulfonylureas exert antidiabetic action on adipocytes by inhibition of PPARγ serine 273 phosphorylation.
2024 Scientific Article in Metabolites Metabolites 14:209 (2024)
Accumulation of non-pathological liver fat is associated with the loss of glyoxalase I activity in humans.
2024 Scientific Article in Journal of Peptide Science J. Pept. Sci.:e3611 (2024)
Targeted modulation of gene expression through receptor-specific delivery of small interfering RNA peptide conjugates.
2024 Scientific Article in Cardiovascular Research Cardiovasc. Res. 120, 1411-1426 (2024)
Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner.
2024 Review in Nature Reviews - Endocrinology Nat. Rev. Endocrinol., DOI: 10.1038/s41574-024-00992-y (2024)
AMPK as a mediator of tissue preservation: Time for a shift in dogma?
2024 Scientific Article in Nature Methods Nat. Methods, DOI: 10.1038/s41592-024-02245-2 (2024)
Virtual reality-empowered deep-learning analysis of brain cells.
2024 Editorial in Frontiers in Endocrinology Front. Endocrin. 15:1371113 (2024)
Editorial: Novel and emerging therapies for the treatment of obesity and related disorders.
2024 Letter to the Editor in JACC: Heart Failure JACC: Heart Fail., DOI: 10.1016/j.jchf.2024.03.012 (2024)
Myocardial mitochondrial function is impaired in cardiac light-chain amyloidosis compared to transthyretin amyloidosis.
2024 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab., DOI: 10.1210/clinem/dgae241 (2024)
Opposing effects of cannabidiol in patient-derived neuroendocrine tumor, pheochromocytoma/paraganglioma primary cultures.
2024 Scientific Article in Journal of Physiology - London J. Physiol.-London, DOI: 10.1113/JP286232 (2024)
Functions require junctions: Endurance exercise protects from age-induced alterations of the neuromuscular system.
2024 Scientific Article in Nature metabolism Nat. Metab., DOI: 10.1038/s42255-024-01033-8 (2024)
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.
2024 Scientific Article in EClinicalMedicine EClinicalMedicine 72:102633 (2024)
Effect of timed dosing of usual antihypertensives according to patient chronotype on cardiovascular outcomes: The Chronotype sub-study cohort of the Treatment in Morning versus Evening (TIME) study.
2024 Scientific Article in European Radiology Experimental Eur. Radiol. Exp. 8:37 (2024)
Diffusion tensor imaging in anisotropic tissues: Application of reduced gradient vector schemes in peripheral nerves.
2024 Letter to the Editor in Cardiovascular Diabetology Cardiovasc. Diabetol. 23:104 (2024)
CVOT Summit Report 2023: New cardiovascular, kidney, and metabolic outcomes.
2024 Review in Molecular Oncology Mol. Oncol., DOI: 10.1002/1878-0261.13590 (2024)
Cancer cachexia: Biomarkers and the influence of age.
2024 Editorial in Frontiers in Endocrinology Front. Endocrin. 15:1379994 (2024)
Editorial: Organ crosstalk in the pathophysiology and treatment of type-2 diabetes.
2024 Scientific Article in Nature Communications Nat. Commun. 15:1391 (2024)
Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape.
2024 Letter to the Editor in FEBS Letters FEBS Lett., DOI: 10.1002/1873-3468.14818 (2024)
Lipid sensing nuclear receptors involved in the pathogenesis of fatty liver disease.
2024 Scientific Article in Herz Herz 49, 118-123 (2024)
Cardiac proteostasis in obesity and cardiovascular disease.
2024 Scientific Article in Diabetes & vascular disease research Diab. Vasc. Dis. Res. 21:14791641231223701 (2024)
Utility of bioelectrical phase angle for cardiovascular risk assessment among individuals with and without diabetes mellitus.
2024 Scientific Article in European Radiology Experimental Eur. Radiol. Exp. 8:6 (2024)
Magnetization transfer ratio of the sciatic nerve differs between patients in type 1 and type 2 diabetes.
2024 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab., DOI: 10.1210/clinem/dgad737 (2024)
Phase angle of bioelectrical impedance analysis as an indicator for diabetic polyneuropathy in type 2 diabetes mellitus.
2024 Scientific Article in Cardiovascular Research Cardiovasc. Res. 120, 385-402 (2024)
Cyclophilin A is a ligand for RAGE in thrombo-inflammation.
2024 Review in Hormone and Metabolic Research Horm. Metab. Res. 56, 51-64 (2024)
Animal and cell culture models of PPGLs - Achievements and limitations.
2024 Scientific Article in Biochemical Journal / Reviews Biochem. J. 481, 33-44 (2024)
Non-cross-linking advanced glycation end products affect prohormone processing.
2024 Scientific Article in Diabetologia Diabetologia 67, 275-289 (2024)
A diminished sciatic nerve structural integrity is associated with distinct peripheral sensory phenotypes in individuals with type 2 diabetes.
2023 Scientific Article in Genes Genes 15:26 (2023)
Tribbles genes in gastric cancer: A tumor-suppressive role for TRIB2.
2023 Scientific Article in Journal of Endocrinology J. Endocrinol. 259:e230166 (2023)
Quercetin improves white adipose tissue redox homeostasis in ovariectomized rats.
2023 Letter to the Editor in Clinical and Translational Discovery Clin. Transl. Discovery 3:e230 (2023)
Live lean and CRISPR – Engineering metabolism with FGF21 and FNDC5.
2023 Scientific Article in Diabetes Diabetes 73, 135-146 (2023)
Sensory phenotypes provide insight into the natural course of diabetic polyneuropathy.
2023 Editorial in Frontiers in Oncology Front. Oncol. 13:1305140 (2023)
Editorial: Translational research for better diagnosis and treatment of endometrial cancer.
2023 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 30:12 (2023)
Regulation of epinephrine biosynthesis in HRAS-mutant paragangliomas.
2023 Scientific Article in European Journal of Endocrinology Eur. J. Endocrinol. 189, 546-565 (2023)
Responses to systemic therapy in metastatic pheochromocytoma/paraganglioma: A retrospective multicenter cohort study.
2023 Scientific Article in Nature Cancer Nat. Cancer 4, 1544-1560 (2023)
Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia.
2023 Scientific Article in EMBO Reports EMBO Rep. 24:e57600 (2023)
The obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes.
2023 Editorial in Frontiers in Physiology Front. Physiol. 14:1275319 (2023)
Editorial: Metabolism in nonalcoholic fatty liver disease.
2023 Scientific Article in Molecular Therapy Mol. Ther. 31, 2408-2421 (2023)
Development of a peptide drug restoring AMPK and adipose tissue functionality in cancer cachexia.
2023 Editorial in Nature metabolism Nat. Metab. 5, 1080-1081 (2023)
Brown fat has a sweet tooth.
2023 Letter to the Editor in BioEssays Bioessays 45:e2300093 (2023)
Endocrine communication of endoplasmic reticulum stress.
2023 Scientific Article in Methods in Enzymology Methods Enzymol. 689, 201-234 (2023)
17β-Hydroxysteroid dehydrogenases types 1 and 2: Enzymatic assays based on radiometric and mass-spectrometric detection.
2023 Scientific Article in Hepatology Hepatology 78, 1092-1105 (2023)
Semaphorin 3C exacerbates liver fibrosis.
2023 Scientific Article in Frontiers in Endocrinology Front. Endocrin. 14:1046690 (2023)
Sciatic nerve fractional anisotropy and neurofilament light chain protein are related to sensorimotor deficit of the upper and lower limbs in patients with type 2 diabetes.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 73:101729 (2023)
Diabetes increases mortality in patients with pancreatic and colorectal cancer by promoting cachexia and its associated inflammatory status.
2023 Review in Frontiers in Oncology Front. Oncol. 13:1120178 (2023)
Endometrial cancer diagnostic and prognostic algorithms based on proteomics, metabolomics, and clinical data: A systematic review.
2023 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 15:e17209 (2023)
Hypoxia-inducible factor 1A inhibition overcomes castration resistance of prostate tumors.
2023 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 108, 2676-2685 (2023)
Metastatic pheochromocytoma and paraganglioma: Somatostatin receptor 2 expression, genetics, and therapeutic responses.
2023 Scientific Article in EBioMedicine EBioMedicine 90:104516 (2023)
Elevated markers of DNA damage and senescence are associated with the progression of albuminuria and restrictive lung disease in patients with type 2 diabetes.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 71:101706 (2023)
Inceptor correlates with markers of prostate cancer progression and modulates insulin/IGF1 signaling and cancer cell migration.
2023 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 108, e979-e988 (2023)
Dysmetabolism-related early sensory deficits and their relationship with peripheral neuropathy development.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 74:101748 (2023)
Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis.
2023 Scientific Article in Frontiers in Endocrinology Front. Endocrin. 14:1143799 (2023)
Six-month periodic fasting does not affect somatosensory nerve function in type 2 diabetes patients.
2023 Review in Nature Reviews - Molecular Cell Biology Nat. Rev. Mol. Cell Biol. 24, 607-632 (2023)
Exercise metabolism and adaptation in skeletal muscle.
2023 Scientific Article in Frontiers in Endocrinology Front. Endocrin. 14:1176733 (2023)
The role of proteasome activators PA28αβ and PA200 in brown adipocyte differentiation and function.
2023 Editorial in Frontiers in Endocrinology Front. Endocrin. 14:1266148 (2023)
Editorial: New insights into multiple endocrine neoplasia type 1.
2023 Scientific Article in Nature Communications Nat. Commun. 14:5060 (2023)
Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD.
2023 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 109, e137-e144 (2023)
Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes.
2023 Scientific Article in Cell Cell 186, 3706-3725.e29 (2023)
Distinct molecular profiles of skull bone marrow in health and neurological disorders.
2023 Scientific Article in EMBO Reports EMBO Rep. 24:e55981 (2023)
Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism.
2023 Scientific Article in Clinical Neuroradiology Clin. Neuroradiol., 12 (2023)
Association of Small Fiber Function with Microvascular Perfusion of Peripheral Nerves in Patients with Type 2 Diabetes : Study using Quantitative Sensory Testing and Magnetic Resonance Neurography.
2023 Scientific Article in Science Science 381, 285-290 (2023)
Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.
2023 Scientific Article in Cancers Cancers 15:19 (2023)
Identification of a Novel SSTR3 full agonist for the treatment of nonfunctioning pituitary adenomas.
2023 Scientific Article in Journal of Personalized Medicine J. Pers. Med. 13:12 (2023)
Effect of surgical release of entrapped peripheral nerves in sensorimotor diabetic neuropathy on pain and sensory dysfunction-study protocol of a prospective, controlled clinical trial.
2023 Review in Nature Protocols Nat. Protoc. 18, 1197-1242 (2023)
Whole-mouse clearing and imaging at the cellular level with vDISCO.
2023 Review in Acta Physiologica Acta Physiol. 237:e13936 (2023)
When should I eat: A circadian view on food intake and metabolic regulation.
2023 Scientific Article in Pharmacological Research Pharmacol. Res. 187:106634 (2023)
Mirabegron-induced brown fat activation does not exacerbate atherosclerosis in mice with a functional hepatic ApoE-LDLR pathway.
2023 Editorial in Journal of Physiology - London J. Physiol.-London 601, 711-713 (2023)
From honeymoon to dysfunction: Brown fat remodeling in obesity.
2023 Scientific Article in Diabetes Diabetes 72, 362-366 (2023)
Lower hepatic fat is associated with improved insulin secretion in a high-risk prediabetes subphenotype during lifestyle intervention.
2023 Scientific Article in Molecular and Cellular Biochemistry Mol. Cell. Biochem. 478, 581-595 (2023)
Circadian disruption alters gut barrier integrity via a ß-catenin-MMP-related pathway.
2023 Review in Nature Reviews - Endocrinology Nat. Rev. Endocrinol. 19, 28–45 (2023)
Endosomal trafficking in metabolic homeostasis and diseases.
2022 Letter to the Editor in Clinical and Translational Discovery Clin. Transl. Discovery 2:e153 (2022)
Breathe and burn: Novel roles for myoglobin in thermogenesis.
In: Molecular Exercise Physiology. 2022. 25 S. ( ; 11)
Altitude, temperature, circadian rhythms and exercise.
2022 Scientific Article in Diabetologia Diabetologia 66, 579-589 (2022)
Serum neurofilament light chain: A novel biomarker for early diabetic sensorimotor polyneuropathy.
2022 Scientific Article in Cancers Cancers 14:5481 (2022)
Combined targeting of pathogenetic mechanisms in pancreatic neuroendocrine tumors elicits synergistic antitumor effects.
2022 Letter to the Editor in Signal transduction and targeted therapy Signal Transduct. Target. Ther. 7:375 (2022)
Fire up the pyre: Inosine thermogenic signaling for obesity therapy.
2022 Scientific Article in Arteriosclerosis, Thrombosis, and Vascular Biology Arterioscler. Thromb. Vasc. Biol. 43, e29-e45 (2022)
Cargo-specific role for retriever subunit VPS26C in hepatocyte lipoprotein receptor recycling to control postprandial triglyceride-rich lipoproteins.
2022 Scientific Article in Frontiers in Endocrinology Front. Endocrin. 13:891442 (2022)
Advanced glycation end-products are associated with diabetic neuropathy in young adults with type 1 diabetes.
2022 Scientific Article in Nature Communications Nat. Commun. 13:6754 (2022)
Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.
2022 Scientific Article in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 20, 5622-5638 (2022)
Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes.
2022 Review in Cancer and Metastasis Reviews Cancer Metastasis Rev. 41, 517–547 (2022)
Obesity and cancer-extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases.
2022 Editorial in Frontiers in Pharmacology Front. Pharmacol. 13:975812 (2022)
Editorial: Ion channels and transporters in diabetes and metabolic diseases.
2022 Nature Reviews - Endocrinology Nat. Rev. Endocrinol. 19:62 (2022)
Author Correction: Endosomal trafficking in metabolic homeostasis and diseases (Nature Reviews Endocrinology, (2022), 10.1038/s41574-022-00737-9).
2022 Review in Antioxidants Antioxidants 11:1541 (2022)
The prognostic value of derivatives-reactive oxygen metabolites (d-ROMs) for cardiovascular disease events and mortality: A review.
2022 Scientific Article in Toxicology Letters Toxicol. Lett. 368, 33-46 (2022)
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay.
2022 Scientific Article in Molecular Metabolism Mol. Metab. 64:101556 (2022)
Tryptophan metabolism is a physiological integrator regulating circadian rhythms.
2022 Scientific Article in Antioxidants Antioxidants 11:1689 (2022)
Exercise improves redox homeostasis and mitochondrial function in white adipose tissue.
2022 Editorial in Diabetologie und Stoffwechsel Diabetol. Stoffwechs. 17, 357-358 (2022)
Hunger metabolism - from molecular basis to therapeutic use Werner Creutzfeldt prize 2022-a brief overview of the award winner Stephan Herzig.
2022 Editorial in Molecular Metabolism Mol. Metab. 63:101547 (2022)
10 years of molecular metabolism.
2022 Scientific Article in Annals of Surgery Ann. Surg. 276, 814-821 (2022)
Gastric bypass resolves metabolic dysfunction-associated fatty liver disease (MAFLD) in low-BMI patients: A prospective cohort study.
2022 Scientific Article in Nature metabolism Nat. Metab. 4, 1071-1083 (2022)
GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.
2022 Scientific Article in Science Advances Sci. Adv. 8:eabo5555 (2022)
TSC22D4 interacts with Akt1 to regulate glucose metabolism.
2022 Scientific Article in Cell Metabolism Cell Metab. 34, 1824-1842.e9 (2022)
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.
2022 Scientific Article in Advanced science Adv. Sci. 9:e2104291 (2022)
Trip13 depletion in liver cancer induces a lipogenic response contributing to plin2-dependent mitotic cell death.
2022 Scientific Article in Circulation Circulation 146, 1189-1191 (2022)
Impaired myocardial mitochondrial respiration in humans with prediabetes: A footprint of prediabetic cardiomyopathy.
2022 Review in Advances in Experimental Medicine and Biology Adv. Exp. Med. Biol. 1390, 61-82 (2022)
Nuclear receptors in energy metabolism.
2022 Scientific Article in Molecular Metabolism Mol. Metab. 62:101518 (2022)
Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3.
2022 Scientific Article in European Journal of Neurology Eur. J. Neurol. 29, 3081-3091 (2022)
Diabetic neuropathy is a generalized phenomenon with impact on hand functional performance and quality of life.
Methods in Molecular Biology In: Circadian Regulation. 2022. 311-327 (Methods Mol. Biol. ; 2482)
Untargeted and targeted circadian metabolomics using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and flow injection-electrospray ionization-tandem mass spectrometry (FIA-ESI-MS/MS).
2022 Scientific Article in Life Sciences Life Sci. 303:120601 (2022)
Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain.
2022 Scientific Article in Nature Nature 608, 778-783 (2022)
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
2022 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 29, 285-306 (2022)
Personalized drug testing in human pheochromocytoma/paraganglioma primary cultures.
2022 Scientific Article in Molecular Metabolism Mol. Metab. 60:101497 (2022)
Angiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.
2022 Scientific Article in Molecular Metabolism Mol. Metab. 60:101487 (2022)
Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function.
2022 Scientific Article in Non-coding RNA Non-coding RNA 8:32 (2022)
Comprehensive transcriptional profiling and mouse phenotyping reveals dispensable role for adipose tissue selective long noncoding RNA Gm15551.
2022 Scientific Article in FEBS Letters FEBS Lett. 596, 1434-1444 (2022)
Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction.
2022 Scientific Article in Cell Reports Cell Rep. 39:110910 (2022)
ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity.
2022 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 107, 2167-2181 (2022)
Six-month periodic fasting in patients with type 2 diabetes and diabetic nephropathy: A proof-of-concept study.
2022 Scientific Article in Frontiers in Neuroscience Front. Neurosci. 15:811085 (2022)
Magnetic resonance neurography reveals smoking-associated decrease in sciatic nerve structural integrity in Type 2 diabetes.
2022 Letter to the Editor in Journal of Cell Science J. Cell Sci. 135:jcs259793 (2022)
First person - Syed Qaaifah Gillani.
2022 Review in FEBS Letters FEBS Lett. 596, 2596-2616 (2022)
How to tame your genes: Mechanisms of inflammatory gene repression by glucocorticoids.
2022 Scientific Article in Biochemical and Biophysical Research Communications Biochem. Biophys. Res. Commun. 618, 46-53 (2022)
TSC22D4 promotes TGFβ1-induced activation of hepatic stellate cells.
2022 Scientific Article in Metabolites Metabolites 12:99 (2022)
Analogues of natural chalcones as efficient inhibitors of AKR1C3.
2022 Scientific Article in Cells Cells 11:560 (2022)
Treatment of pheochromocytoma cells with recurrent cycles of hypoxia: A new pseudohypoxic in vitro model.
2022 Scientific Article in Metabolites Metabolites 12:445 (2022)
Effects of acute and chronic resistance exercise on the skeletal muscle metabolome.
2022 Scientific Article in Frontiers in Neuroscience Front. Neurosci. 15:741494 (2022)
Fractional anisotropy and troponin T parallel structural nerve damage at the upper extremities in a group of patients with prediabetes and type 2 diabetes - a study using 3T magnetic resonance neurography.
2022 Scientific Article in Molecular Metabolism Mol. Metab. 57:101436 (2022)
NFE2L1-mediated proteasome function protects from ferroptosis.
2022 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e14364 (2022)
Angpt2/Tie2 autostimulatory loop controls tumorigenesis.
2022 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 119:e2200083119 (2022)
Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease.
2022 Scientific Article in Cell Metabolism Cell Metab. 34, 473-486.e9 (2022)
A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis.
2022 Scientific Article in Cardiovascular Research Cardiovasc. Res., DOI: 10.1093/cvr/cvac022 (2022)
Properties and fate of human mesenchymal stem cells upon miRNA let-7f-promoted recruitment to atherosclerotic plaques.
2022 Review in Lancet Diabetes and Endocrinology Lancet Diabet. Endocrinol. 10, 221-230 (2022)
Sexual dimorphism in COVID-19: Potential clinical and public health implications.
2022 Letter to the Editor in Pflügers Archiv Pflugers Arch. 474, 185-186 (2022)
MALDI MSI for a fresh view on atherosclerotic plaque lipids.
2022 Scientific Article in Cell Metabolism Cell Metab. 34, 329-345.e8 (2022)
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis.
2022 Review in Advanced Drug Delivery Reviews Adv. Drug Deliv. Rev. 181:114110 (2022)
Delivery of miRNAs to the adipose organ for metabolic health.
2022 Scientific Article in Molecular Metabolism Mol. Metab. 56:101412 (2022)
Adipocyte-specific tribbles pseudokinase 1 regulates plasma adiponectin and plasma lipids in mice.
2022 Scientific Article in Cancers Cancers 14:90 (2022)
Aging aggravates cachexia in tumor-bearing mice.
2022 Scientific Article in Cells Cells 11:28 (2022)
Enhancer RNA expression in response to glucocorticoid treatment in murine macrophages.
2022 Scientific Article in Clinical Cancer Research Clin. Cancer Res. 28, 1038-1052 (2022)
Therapy-related transcriptional subtypes in matched primary and recurrent head and neck cancer.
2022 Diabetologia Diabetologia 65:257 (2022)
Correction to: Neuron-specific biomarkers predict hypo- and hyperalgesia in individuals with diabetic peripheral neuropathy.
In: Endocrine Surgery Comprehensive Board Exam Guide. 2021. 935–950
Multiple endocrine neoplasia type 4 (MEN 4).
In: Gigantism and Acromegaly. 2021. 157-172
CDKN1B (p27) defects leading to pituitary tumors.
Endocrinology In: Polyendocrine Disorders and Endocrine Neoplastic Syndromes. 2021. 245-274 (Endocrinology)
Multiple endocrine neoplasia-type 4 (MEN4) and other MEN1-like syndromes.
2021 Review in Frontiers in Endocrinology Front. Endocrin. 12:765201 (2021)
Diabetic pneumopathy-a new diabetes-associated complication: Mechanisms, consequences and treatment considerations.
2021 Review in EJNMMI Research EJNMMI Res. 11:121 (2021)
Imaging pheochromocytoma in small animals: Preclinical models to improve diagnosis and treatment.
2021 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 22:12695 (2021)
Cardioprotective effects of palmitoleic acid (C16:1n7) in a mouse model of catecholamine-induced cardiac damage are mediated by PPAR activation.
2021 Scientific Article in Cell Reports Medicine Cell Rep. Med. 2:100434 (2021)
Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice.
2021 Scientific Article in Nature Communications Nat. Commun. 12:6883 (2021)
Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α.
2021 Scientific Article in Cell Reports Cell Rep. 37:110003 (2021)
ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue.
2021 Scientific Article in Peptides Peptides 146:170677 (2021)
Calcitonin gene-related peptide exerts inhibitory effects on autophagy in the heart of mice.
2021 Scientific Article in Frontiers in Endocrinology Front. Endocrin. 12:739021 (2021)
Role of ubiquilins for brown adipocyte proteostasis and thermogenesis.
2021 Review in Cell and Tissue Research Cell Tissue Res., DOI: 10.1007/s00441-021-03539-z (2021)
P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke.
2021 Review in EJNMMI Research EJNMMI Res. 11:94 (2021)
Imaging modalities for diagnosis and monitoring of cancer cachexia.
2021 Review in Journal of Physiology - London J. Physiol.-London, DOI: 10.1113/JP281979 (2021)
Adipocyte function and the development of cardiometabolic disease.
2021 Review in Nature Reviews - Endocrinology Nat. Rev. Endocrinol., DOI: 10.1038/s41574-021-00577-z (2021)
Is the association between diabetes mellitus and pulmonary fibrosis real?
2021 Scientific Article in Radiology Radiology 302, 153-161 (2021)
Diffusion MRI in peripheral nerves: Optimized b values and the role of non-Gaussian diffusion.
2021 Scientific Article in STAR Protocols STAR Protoc. 2:100805 (2021)
Purification of GFP-tagged nuclei from frozen livers of INTACT mice for RNA- and ATAC-sequencing.
2021 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 22:9979 (2021)
A novel uplc-ms/ms method identifies organ-specific dipeptide profiles.
2021 Scientific Article in ESC heart failure ESC Heart Fail., DOI: 10.1002/ehf2.13607 (2021)
Human myocardial mitochondrial oxidative capacity is impaired in mild acute heart transplant rejection.
2021 Scientific Article in Cancers Cancers 13:4433 (2021)
Mri‐determined psoas muscle fat infiltration correlates with severity of weight loss during cancer cachexia.
2021 Scientific Article in Diabetologia Diabetologia, DOI: 10.1007/s00125-021-05557-6 (2021)
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2021 Scientific Article in Life Science Alliance Life Sci. All. 4:e202101037 (2021)
RNA sequencing reveals niche gene expression effects of beta-hydroxybutyrate in primary myotubes.
2021 Scientific Article in STAR Protocols STAR Protoc. 2:100700 (2021)
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2021 Scientific Article in Journal of Cachexia, Sarcopenia and Muscle J. Cachexia Sarcopenia Muscle, DOI: 10.1002/jcsm.12758 (2021)
Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy.
2021 Scientific Article in Nature Communications Nat. Commun. 12:5068 (2021)
O-GlcNAcylated p53 in the liver modulates hepatic glucose production.
2021 Scientific Article in Diabetes Diabetes 70, 2785-2795:2785-2795 (2021)
Different effects of lifestyle intervention in high- and low-risk prediabetes.
2021 Nature Communications Nat. Commun. 12:4796 (2021)
Author Correction: Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing.
2021 Editorial in Frontiers in Endocrinology Front. Endocrin. 12:739065 (2021)
Editorial: Brown adipose tissue: From heat production in rodents to metabolic health in humans.
2021 Editorial in EMBO Molecular Medicine EMBO Mol. Med.:e14618 (2021)
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2021 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 22:7958 (2021)
Common muscle metabolic signatures highlight arginine and lysine metabolism as potential therapeutic targets to combat unhealthy aging.
2021 Review in Advanced science Adv. Sci., e2100275 (2021)
Emerging targets in type 2 diabetes and diabetic complications.
2021 Scientific Article in Cell Metabolism Cell Metab. 33, 1685-1700.e9 (2021)
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication.
2021 Journal of Nutritional Biochemistry, The J. Nutr. Biochem. 97:108807 (2021)
Corrigendum to "Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance" [The Journal of Nutritional Biochemistry 57 (2018) 189-196].
2021 Scientific Article in Advanced science Adv. Sci. 8:e2101281 (2021)
Reduced acrolein detoxification in akr1a1a zebrafish mutants causes impaired insulin receptor signaling and microvascular alterations.
2021 Editorial in Frontiers in Endocrinology Front. Endocrin. 12:722790 (2021)
Editorial: Stem cells in endocrine tumors.
2021 Scientific Article in Cancers Cancers 13:3097 (2021)
Gender-specific efficacy revealed by head-to-head comparison of pasireotide and octreotide in a representative in vivo model of nonfunctioning pituitary tumors.
2021 Editorial in Molecular Metabolism Mol. Metab. 50:101274 (2021)
NAFLD - A rising metabolic disease.
2021 Scientific Article in Cancers Cancers 13:2843 (2021)
Elevated expression of the rage variant-v in sclc mitigates the effect of chemotherapeutic drugs.
2021 Scientific Article in Cell Death & Disease Cell Death Dis. 12:516 (2021)
Let-7f miRNA regulates SDF-1α- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release.
2021 Scientific Article in STAR Protocols STAR Protoc. 2:100609 (2021)
Protocol for using heterologous spike-ins to normalize for technical variation in chromatin immunoprecipitation.
2021 Scientific Article in Diabetes Aktuell Diabetes akt. 19, 82-85 (2021)
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2021 Scientific Article in Nature Communications Nat. Commun. 12:2999 (2021)
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
2021 Scientific Article in Diabetologia Diabetologia 64, 1850-1865 (2021)
HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling.
2021 Scientific Article in Cell Metabolism Cell Metab. 33, 1155-1170.e10 (2021)
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.
2021 Scientific Article in Molecular Metabolism Mol. Metab. 51:101235 (2021)
Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload.
2021 Scientific Article in Comprehensive Physiology Compr. Physiol. 11, 1759-1783 (2021)
Glucagon's metabolic action in health and disease.
2021 Scientific Article in Thrombosis and Haemostasis Thromb. Haemost. 121, 1464-1475 (2021)
Methylglyoxal drives a distinct, nonclassical macrophage activation status.
2021 Scientific Article in Frontiers in Neuroscience Front. Neurosci. 15:642589 (2021)
Diffusion tensor imaging of the sciatic nerve as a surrogate marker for nerve functionality of the upper and lower limb in patients with diabetes and prediabetes.
2021 Scientific Article in Nature Communications Nat. Commun. 12:1588 (2021)
Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population.
2021 Review in Nature Reviews - Endocrinology Nat. Rev. Endocrinol. 17, 276-295 (2021)
Lipid and glucose metabolism in white adipocytes: Pathways, dysfunction and therapeutics.
2021 Nature Communications Nat. Commun. 12:989 (2021)
Publisher Correction: Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.
2021 Scientific Article in Cell Reports Cell Rep. 34:108742 (2021)
The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers.
2021 Scientific Article in Molecular Metabolism Mol. Metab. 49:101181 (2021)
Spatiotemporal GLP-1 and GIPR receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists.
2021 Review in Molecular Metabolism Mol. Metab. 47:101169 (2021)
A guide to understanding endoplasmic reticulum stress in metabolic disorders.
2021 Scientific Article in Cell Reports Cell Rep. 34:108624 (2021)
Endogenous fatty acid synthesis drives brown adipose tissue involution.
2021 Scientific Article in Cancers Cancers 13:126 (2021)
Mutation of the cell cycle regulator p27kip1 drives pseudohypoxic pheochromocytoma development.
2021 Scientific Article in Nature metabolism Nat. Metab. 3, 394–409 (2021)
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
2021 Scientific Article in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:641410 (2021)
TBL1XR1 ensures balanced neural development through NCOR complex-mediated regulation of the MAPK pathway.
2021 Scientific Article in Life Science Alliance Life Sci. All. 4:e202000898 (2021)
Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control.
2021 Scientific Article in Cell Metabolism Cell Metab. 33, 833-844.e5 (2021)
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.
2021 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e12461 (2021)
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.
2021 Scientific Article in Nature Communications Nat. Commun. 12:426 (2021)
Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.
2021 Scientific Article in Journal of Steroid Biochemistry and Molecular Biology, The J. Steroid Biochem. Mol. Biol. 206:105790 (2021)
Homology modeling meets site-directed mutagenesis: An ideal combination to elucidate the topology of 17β-HSD2.
2021 Scientific Article in Diabetes Diabetes 70, 616-626 (2021)
CaM kinase II-δ is required for diabetic hyperglycemia and retinopathy but not nephropathy.
2021 Scientific Article in Progress in Biophysics and Molecular Biology Prog. Biophys. Mol. Biol. 159, 86-104 (2021)
Transcriptional signatures regulated by TRPC1/C4-mediated Background Ca2+ entry after pressure-overload induced cardiac remodelling.
2020Vortrag: ASCB/EMBO Cell Bio Vitrual, 07.-12.12.2020, online. (2020)
Endosomal sorting complex protein Vps37a regulates hepatic glucose production via regulating glucagon receptor trafficking.
2020 Meeting abstract in Diabetologia Diabetologia 63, 1, S384-S385 (2020)
Urinary cathepsin levels are predictive of the improvement of albuminuria and are associated with elevated excretion of free glucosepane.
2020 Scientific Article in Laryngoscope, The Laryngoscope, DOI: 10.1002/lary.29300 (2020)
Fibrin gel suspended autologous chondrocytes as cell-based material for long-term injection laryngoplasty.
2020 Scientific Article in Frontiers in Immunology Front. Immunol. 11:574046 (2020)
Tribbles-1 expression and its function to control inflammatory cytokines, including interleukin-8 levels are regulated by miRNAs in macrophages and prostate cancer cells.
2020 Molecular Metabolism Mol. Metab. 41:101068 (2020)
Molecular regulation of urea cycle function by the liver glucocorticoid receptor (vol 4, pg 732, 2015).
2020 Scientific Article in Redox Biology Redox Biol. 37:101723 (2020)
Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans.
2020 Scientific Article in iScience iScience 23:101763 (2020)
Regulation of guconeogenesis by aldo-keto-reductase 1a1b in zebrafish.
2020 Scientific Article in Frontiers in Neuroscience Front. Neurosci. 14:570744 (2020)
Diabetic polyneuropathy is associated with pathomorphological changes in human dorsal root ganglia: A study using 3T MR neurography.
2020 Review in Antioxidants Antioxidants 9:939 (2020)
The glyoxalase system—new insights into an ancient metabolism.
2020 Scientific Article in Journal of Cachexia, Sarcopenia and Muscle J. Cachexia Sarcopenia Muscle 11, 1459-1475 (2020)
High levels of modified ceramides are a defining feature of murine and human cancer cachexia.
2020 Review in Current opinion in pharmacology Curr. Opin. Pharmacol. 53, 101-116 (2020)
Exploiting common aspects of obesity and cancer cachexia for future therapeutic strategies.
2020 Scientific Article in International Journal of Cancer Int. J. Cancer 147, 3523-3538 (2020)
miR-34a is upregulated in AIP-mutated somatotropinomas and promotes octreotide resistance.
2020 Scientific Article in FASEB Journal FASEB J. 34, 12946-12962 (2020)
cAMP-dependent protein kinase inhibits FoxO activity and regulates skeletal muscle plasticity in mice.
2020 Other: Opinion in Cell Metabolism Cell Metab. 32, 512-513 (2020)
Mitochondrial ejection for cardiac protection: The Macrophage Connection.
2020 Scientific Article in Nutrients Nutrients 12:2124 (2020)
Compound 18 improves glucose tolerance in a hepatocyte TGR5-dependent manner in mice.
2020 Scientific Article in Liver International Liver Int. 40, 2982-2997 (2020)
High-protein diet more effectively reduces hepatic fat than low-protein diet despite lower autophagy and FGF21 levels.
2020 Other: Opinion in Cell Metabolism Cell Metab. 32, 331-333 (2020)
An antibody attack against body wasting in cancer.
2020 Other: Opinion in Nature metabolism Nat. Metab., DOI: 10.1038/s42255-020-0263-0 (2020)
Career pathways, part 2.
2020 Scientific Article in Molecular Metabolism Mol. Metab. 40:101026 (2020)
STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue.
2020 Review in Molecular Metabolism Mol. Metab. 39:101044 (2020)
Diabetes, infection risk and COVID-19.
2020 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 48, 8393-8407 (2020)
Anti-inflammatory functions of the glucocorticoid receptor require DNA binding.
2020 Review in Computational and Structural Biotechnology Journal Comp. Struc. Biotech. J. 18, 1330-1341 (2020)
Seq-ing answers: Current data integration approaches to uncover mechanisms of transcriptional regulation.
2020 Scientific Article in Journal of Diabetes and its Complications J. Diab. Complic. 34:107648 (2020)
Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study.
2020 Review in Seminars in cell & developmental biology Semin. Cell Dev. Biol. 108, 72-81 (2020)
Hepatic lipid droplet homeostasis and fatty liver disease.
2020 Scientific Article in Scientific Reports Sci. Rep. 10:7593 (2020)
Characterization of experimental diabetic neuropathy using multicontrast magnetic resonance neurography at ultra high field strength.
2020 Scientific Article in Molecular Metabolism Mol. Metab. 36:100953 (2020)
De novo discovery of metabolic heterogeneity with immunophenotype-guided imaging mass spectrometry.
2020 Review in Current opinion in pharmacology Curr. Opin. Pharmacol. 53, 35-44 (2020)
Anti-inflammatory glucocorticoid action: Genomic insights and emerging concepts.
2020 Scientific Article in Acta Physiologica Acta Physiol. 230:e13496 (2020)
Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling.
2020 Review in Cell Cell 181, 1189-1193 (2020)
Biomedical research goes viral: Dangers and opportunities.
2020 Scientific Article in EMBO Journal, The EMBO J. 39:e103477 (2020)
Compromised DNA repair is responsible for diabetes-associated fibrosis.
2020 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 12:e09271 (2020)
Endothelial Notch signaling controls insulin transport in muscle.
2020 Review in Biological Chemistry Biol. Chem. 401, 1019-1030 (2020)
Proteostasis in thermogenesis and obesity.
2020 Scientific Article in Diabetes Diabetes 69, 713-723 (2020)
Troponin T parallels structural nerve damage in type 2 diabetes: A cross-sectional study using magnetic resonance neurography.
2020 Scientific Article in FASEB Journal FASEB J. 34, 3336-3346 (2020)
Robo4-mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes.
2020 Scientific Article in Radiology Radiology 294, 405-414 (2020)
Structural nerve remodeling at 3-t mr neurography differs between painful and painless diabetic polyneuropathy in type 1 or 2 diabetes.
2020 Scientific Article in EMBO Reports EMBO Rep. 21:e48354 (2020)
A distinct metabolic state arises during the emergence of 2-cell-like cells.
2020 Scientific Article in Nature Biotechnology Nat. Biotechnol. 38, 293-296 (2020)
Label-free metabolic imaging by mid-infrared optoacoustic microscopy in living cells.
2020 Review in Chemistry and Physics of Lipids Chem. Phys. Lipids 226:104837 (2020)
Lipid nanocarriers for microRNA delivery.
2019 Meeting abstract in Journal of Cachexia, Sarcopenia and Muscle J. Cachexia Sarcopenia Muscle, 1387 (2019)
Exploring the contribution of the liver to cancer cachexia development.
2019 Scientific Article in Diabetes Diabetes 69, 436-447 (2019)
Understanding diabetic neuropathy: From subclinical nerve lesions to severe nerve fiber deficits. A cross-sectional study in patients with type 2 diabetes and healthy controls.
2019 Scientific Article in Nature Communications Nat. Commun. 10:5686 (2019)
Glucose homeostasis is regulated by pancreatic beta-cell cilia via endosomal EphA-processing.
2019 Scientific Article in Molecular Cell Mol. Cell 76, 531-545.e5 (2019)
Cistromic reprogramming of the diurnal glucocorticoid hormone response by high-fat diet.
2019 Scientific Article in Nature metabolism Nat. Metab. 1, 1009-1026 (2019)
Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity.
2019 Editorial in European Heart Journal Eur. Heart J. 40, 3544-3546 (2019)
The new age of radiomic risk profiling: perivascular fat at the heart of the matter.
2019 Scientific Article in EMBO Reports EMBO Rep. 20:e48552 (2019)
The glucocorticoid receptor in brown adipocytes is dispensable for control of energy homeostasis.
2019 Scientific Article in JCI insight JCI insight 4:e126154 (2019)
The combination of loss of glyoxalase1 and obesity results in hyperglycemia.
2019 Scientific Article in PLoS ONE PLoS ONE 14:e0222771 (2019)
Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes.
2019 Review in Frontiers in Immunology Front. Immunol. 10:1859 (2019)
Fighting the fire: Mechanisms of inflammatory gene regulation by the glucocorticoid receptor.
2019 Scientific Article in Molecular Metabolism Mol. Metab. 28, 91-106 (2019)
alpha-Calcitonin gene-related peptide inhibits autophagy and calpain systems and maintains the stability of neuromuscular junction in denervated muscles.
2019 Review in Molecular Aspects of Medicine Mol. Aspects Med. 68, 90-100 (2019)
The role of brown and beige adipose tissue in glycaemic control.
2019 Scientific Article in Archives of Toxicology Arch. Toxicol. 93, 1609-1637 (2019)
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.
2019 Scientific Article in Scientific Reports Sci. Rep. 9:9299 (2019)
Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR.
2019 Scientific Article in Nature Communications Nat. Commun. 10:2474 (2019)
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic beta-cells.
2019 Review in Traffic Traffic 20, 552-570 (2019)
Metabolic regulation through the endosomal system.
2019 Scientific Article in JAMA network open JAMA net. open 2:e194798 (2019)
Association of serum cholesterol levels with peripheral nerve damage in patients with type 2 diabetes.
2019 Scientific Article in Cellular and Molecular Life Sciences - CMLS Cell. Mol. Life Sci. 76, 4551-4568 (2019)
CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications.
2019 Scientific Article in VASA Vasa 48, 186-192 (2019)
Effect of metformin treatment in patients with type 2 diabetes with respect to glyoxalase 1 activity in atherosclerotic lesions.
2019 Scientific Article in Journal of Biophotonics J. Biophotonics 12:e201800439 (2019)
Capsule optoacoustic endoscopy for esophageal imaging.
Handbook of Experimental Pharmacology In: Brown Adipose Tissue. 2019. (Handb. Exp. Pharmacol. ; 251)
Preface.
2019 Review in Handbook of Experimental Pharmacology Handb. Exp. Pharmacol. 251, 215-237 (2019)
Regulatory small and long noncoding RNAs in brite/brown adipose tissue.
2019 Review in Thrombosis and Haemostasis Thromb. Haemost. 119, 567-575 (2019)
Endocannabinoid signalling in atherosclerosis and related metabolic complications.
2019 Review in Acta pharmaceutica Sinica Acta Pharm. Sin. B 9, 443-454 (2019)
Highlights of the 2nd International Symposium on Tribbles and Diseases: Tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer.
2019 Scientific Article in Endocrine Connections Endocr. Connect. 8, 367–377 (2019)
Aip-mutated acromegaly resistant to first-generation somatostatin analogs: Long-term control with pasireotide lar in two patients.
2019 Review in EMBO Reports EMBO Rep. 20:e47258 (2019)
Energy metabolism in cachexia.
2019 Scientific Article in Neurobiology of Disease Neurobiol. Dis. 127, 76-86 (2019)
Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes.
2019 Scientific Article in Cellular Signalling Cell. Signal. 57, 45-57 (2019)
Chemical genetic screen identifies Gapex-5/GAPVDI and STBD1 as novel AMPK substrates.
2019 Scientific Article in Plant Signaling & Behavior Plant Signal. Behav. 14:e1581561 (2019)
Proportional subcellular localization of Arabidopsis thaliana RabA1a.
2019 Scientific Article in FASEB Journal FASEB J. 33, 5924-5941 (2019)
A miR-29a-driven negative feedback loop regulates peripheral glucocorticoid receptor signaling.
2019 Scientific Article in Nature Communications Nat. Commun. 10:306 (2019)
E47 modulates hepatic glucocorticoid action.
2019 Meeting abstract in Naunyn-Schmiedeberg's Archives of Pharmacology Naunyn-Schmiedebergs Arch. Pharmakol. 392, S39-S39 (2019)
Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes.
2019 Scientific Article in Diabetes Therapy Diabetes Ther. 10, 229-243 (2019)
Clinical trials on diabetic nephropathy: A cross-sectional analysis.
2019 Scientific Article in Molecular Metabolism Mol. Metab. 19, 97-106 (2019)
Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis.
2019 Scientific Article in Gastroenterology Gastroenterology 156, 203-217.e20 (2019)
Levels of the autophagy-related 5 protein affect progression and metastasis of pancreatic tumors in mice.
2019 Scientific Article in Clinical Cancer Research Clin. Cancer Res. 25, 1505-1516 (2019)
A five-microRNA signature predicts survival and disease control of patients with head and neck cancer negative for HPV-infection.
2019 Review in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 127, 203-214 (2019)
Effects of the reactive metabolite methylglyoxal on cellular signalling, insulin action and metabolism – What we know in mammals and what we can learn from yeast.
2018 Scientific Article in npj Aging and Mechanisms of Disease npj Aging Mech. Dis. 4:4 (2018)
Blocking negative effects of senescence in human skin fibroblasts with a plant extract.
2018 Scientific Article in BMC Genomics BMC Genomics 19:794 (2018)
Norepinephrine triggers an immediate-early regulatory network response in primary human white adipocytes.
2018 Editorial in Diabetologie und Stoffwechsel Diabetol. Stoffwechs. 13, 394-395 (2018)
Dicarbonyl compounds affect cardiovascular mortality in type 2 diabetes comment.
2018 Scientific Article in Molecules Molecules 23:2823 (2018)
Comparative gene expression analysis in WM164 melanoma cells revealed that beta-beta-Dimethylacrylshikonin leads to ROS generation, loss of mitochondrial membrane potential, and autophagy induction.
2018 Review in Trends in cancer Trends Cancer 4, 849-860 (2018)
Cancer cachexia: More than skeletal muscle wasting.
2018 Scientific Article in Developmental Cell Dev. Cell 47, 205-221.e7 (2018)
Organellar proteomics and phospho-proteomics reveal subcellular teorganization in diet-induced hepatic steatosis.
2018 Scientific Article in Molecular Metabolism Mol. Metab. 18, 143-152 (2018)
Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes.
2018 Editorial in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 126, 590-591 (2018)
Diabetic pulmopathy: A new clinical challenge for diabetology.
2018 Scientific Article in World Journal of Gastroenterology World J. Gastroenterol. 24, 4028-4035 (2018)
Adiponectin affects the mechanical responses in strips from the mouse gastric fundus.
2018 Scientific Article in Molecular and Cellular Proteomics Mol. Cell. Proteomics 17, 2358-2370 (2018)
Comparative secretome analyses of primary murine white and brown adipocytes reveal novel adipokines.
2018 Scientific Article in Nature Communications Nat. Commun. 9:3129 (2018)
Dietary stearic acid regulates mitochondria in vivo in humans.
2018 Scientific Article in Respiration Respiration 96, 29-40 (2018)
Breathlessness and restrictive lung disease: AniImportant diabetes-related feature in patients with type 2 diabetes.
2018 Scientific Article in Cellular Physiology and Biochemistry Cell. Physiol. Biochem. 46, 713-726 (2018)
Carnosine catalyzes the formation of the oligo/polymeric products of methylglyoxal.
2018 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 10:e8613 (2018)
Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.
2018 Scientific Article in Transplant international Transpl. Int. 31, 751-760 (2018)
Cell cycle arrest and cell death correlate with the extent of ischaemia and reperfusion injury in patients following kidney transplantation – results of an observational pilot study.
2018 Scientific Article in Science Signaling Sci. Signal. 11:eaai7838 (2018)
Jak-TGF beta cross-talk links transient adipose tissue inflammation to beige adipogenesis.
2018 Scientific Article in Journal of Nutritional Biochemistry, The J. Nutr. Biochem. 57, 189-196 (2018)
Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance.
2018 Scientific Article in Aging Aging 10, 1103-1132 (2018)
Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype.
2018 Scientific Article in Journal of Lipid Research J. Lipid Res. 59, 452-461 (2018)
Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function.
2018 Scientific Article in Diabetes Care Diabetes Care 41, 1068-1075 (2018)
Risk factors for incident diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes followed for 13 years: Addition-Denmark.
2018 Scientific Article in Annals of Neurology Ann. Neurol. 83, 588-598 (2018)
Diabetic neuropathy differs between type 1 and type 2 diabetes: Insights from magnetic resonance neurography.
2018 Scientific Article in Acta Diabetologica Acta Diabetol. 55, 585-592 (2018)
Urine levels of 5-aminoimidazole-4-carboxamide riboside (AICAR) in patients with type 2 diabetes.
2018 Scientific Article in Cell Metabolism Cell Metab. 27, 926-934.e8 (2018)
Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type 2 diabetes.
2018 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 293, 4845-4859 (2018)
High-glucose toxicity is mediated by AICAR-transformylase/ IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans.
2018 Scientific Article in Circulation Circulation 137, 2592-2608 (2018)
Inhibition of endothelial notch signaling impairs fatty acid transport and leads to metabolic and vascular remodeling of the adult heart.
2018 Scientific Article in Molecular Metabolism Mol. Metab. 9, 156-167 (2018)
TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.
2018 Scientific Article in Redox Biology Redox Biol. 15, 12-21 (2018)
The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.
2018 Scientific Article in Nature medicine Nat. Med. 24, 62-72 (2018)
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.
2018 Scientific Article in Journal of Diabetes and its Complications J. Diab. Complic. 32, 130-138 (2018)
Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice.
2018 Scientific Article in Cell Cell 172, 409–422.e21 (2018)
Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis.
2018 Scientific Article in Gerontology Gerontology 64, 229–236 (2018)
Age-induced changes in white, brite, and brown adipose depots: A mini-review.
2018 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 25, 145-162 (2018)
Characterization of neuroendocrine tumors in heterozygous mutant MENX rats: A novel model of invasive medullary thyroid carcinoma.
2018 Scientific Article in Journal of Proteome Research J. Proteome Res. 17, 203-211 (2018)
Long-Term Stability of Human Plasma Metabolites during Storage at-80 degrees C.
2017 Meeting abstract in Acta clinica Belgica Acta Clin. Belg. 72, 16-17 (2017)
Long-term management of resistant acromegaly with pasireotide LAR in 2 cases with a familial AIP mutation.
2017 Meeting abstract in Molecular Biology of the Cell Mol. Biol. Cell 28 (2017)
Proteomics identifies organelle specific phosphorylation and reveals major subcellular reorganization in the progression of NAFLD.
2017 Review in International Journal of Molecular Sciences Int. J. Mol. Sci. 18:2578 (2017)
Long non-coding RNAs in metabolic organs and energy homeostasis.
2017 Scientific Article in Frontiers in Physiology Front. Physiol. 8:968 (2017)
Comparative analysis of muscle hypertrophy models reveals divergent gene transcription profiles and points to translational regulation of muscle growth through increased mTOR signaling.
2017 Scientific Article in Journal of Visualized Experiments J. Vis. Exp. 2017:e56538 (2017)
Analysis of immune cells in single sciatic nerves and dorsal root ganglion from a single mouse using flow cytometry.
2017 Scientific Article in Journal of the American Society of Nephrology J. Am. Soc. Nephrol. 28, 3182-3189 (2017)
Farnesoid X receptor agonism protects against diabetic tubulopathy: Potential add-on therapy for diabetic nephropathy.
2017 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 45, 10595-10613 (2017)
Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair.
2017 Scientific Article in Cell Metabolism Cell Metab. 26, 1–14.e1–e5 (2017)
Acetyl-CoA carboxylase 1-dependent protein acetylation controls breast cancer metastasis and recurrence.
2017 Review in Hormone molecular biology and clinical investigation Horm. Mol. Biol. Clin. Investig. 31:0043 (2017)
Endocrine and autocrine/paracrine modulators of brown adipose tissue mass and activity as novel therapeutic strategies against obesity and type 2 diabetes.
2017 Meeting abstract in Diabetologia Diabetologia 60, S507-S508 (2017)
Loss of glyoxalase 1 in various mammalian cells is associated with an increased resistance against environmental stressors.
2017 Scientific Article in Neuroscience Neuroscience, DOI: 10.1016/j.neuroscience.2017.09.023 (2017)
The quest for more research on painful diabetic neuropathy.
2017 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 45, 11121-11130 (2017)
DNA residence time is a regulatory factor of transcription repression.
2017 Scientific Article in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 126, 141-147 (2017)
Purification and Characterization of the Soluble form of the Receptor for Advanced Glycation End-Products (sRAGE): A Novel Fast, Economical and Convenient Method.
2017 Scientific Article in Development / Company of Biologists Development 144, 3917-3931 (2017)
The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development.
2017 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 137, S311-S311 (2017)
Blocking negative effects of senescence in human skin fibroblasts with a plant extract.
2017 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 137, S250-S250 (2017)
Senescent human fibroblasts selectively secrete miRNAs in extracellular vesicles and modulate keratinocyte functionality during skin aging.
2017 Scientific Article in Redox Biology Redox Biol. 13, 674-686 (2017)
Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux.
2017 Letter to the Editor in Journal of Biological Chemistry, The J. Biol. Chem. 292, 12784-12785 (2017)
Reply to Richarme: Evidence against a role of DJ-1 in methylglyoxal detoxification.
2017 Review in Frontiers in Neuroscience Front. Neurosci. 11:369 (2017)
Circadian metabolomics in time and space.
2017 Scientific Article in Cell Reports Cell Rep. 20, 1422-1434 (2017)
A hepatic GAbp-AMPK axis links inflammatory signaling to systemic vascular damage.
2017 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 24, T161-T177 (2017)
Animal models of MEN1.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 873-881 (2017)
Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution.
2017 Review in EMBO Journal, The EMBO J. 36, 1999-2017 (2017)
Adipose tissue: Between the extremes.
2017 Other: News Item in EMBO Reports EMBO Rep. 18, 1039-1040 (2017)
Let's burn whatever you have: Mitofusin 2 metabolically re-wires brown adipose tissue.
2017 Scientific Article in Clinical therapeutics Clin. Ther. 39, 1132-1144.e2 (2017)
Electrical muscle stimulation induces an increase of VEGFR2 on circulating hematopoietic stem cells in patients with diabetes.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:4023 (2017)
Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis.
2017 Scientific Article in Cell Reports Cell Rep. 19, 643-654 (2017)
Rapid genome-wide recruitment of RNA polymerase II drives transcription, splicing, and translation events during T cell responses.
2017 Review in International Journal of Molecular Sciences Int. J. Mol. Sci. 18:984 (2017)
Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention.
2017 Scientific Article in Journal of Neuroimmunology J. Neuroimmunol. 306, 76-82 (2017)
STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes.
2017 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 114, 5265-5270 (2017)
Lsd1 prevents age-programed loss of beige adipocytes.
2017 Scientific Article in Journal of Diabetes and its Complications J. Diab. Complic. 31, 1058-1065 (2017)
ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy.
2017 Scientific Article in Molecular and Cellular Endocrinology Mol. Cell. Endocrinol. 456, 87-94 (2017)
Small non coding RNAs in adipocyte biology and obesity.
2017 Scientific Article in Nature medicine Nat. Med. 23, 623-630 (2017)
Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis.
2017 Scientific Article in Chemico-Biological Interactions Chem. Biol. Interact. 276, 182-193 (2017)
Characterization of AKR1B16, a novel mouse aldo-keto reductase.
2017 Scientific Article in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 26, 90-94 (2017)
Diabetes mellitus and bone metabolism.
2017 Scientific Article in Biochimica et Biophysica Acta Biochim. Biophys. Acta 1863, 654-662 (2017)
A scavenger peptide prevents methylglyoxal induced pain in mice.
2017 Scientific Article in Stem Cell Reports Stem Cell Rep. 8, 21-29 (2017)
SNEVhPrp19/hPso4 regulates adipogenesis of human adipose stromal cells.
2017 Review in Trends in Endocrinology and Metabolism Trends Endocrinol. Metab. 28, 104-120 (2017)
Genome-wide insights into the development and function of thermogenic adipocytes.
2017 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 292, 685-690 (2017)
Evidence against a role for the parkinsonism-associated protein DJ-1 in methylglyoxal detoxification.
2017 Scientific Article in Experimental Cell Research Exp. Cell Res. 350, 242-252 (2017)
Functional properties of hepatocytes in vitro are correlated with cell polarity maintenance.
2017 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 24, 1-15 (2017)
Targeting PI3K/mTOR signaling exerts potent antitumor activity in pheochromocytoma in vivo.
2017 Scientific Article in Journal of Diabetes and its Complications J. Diab. Complic. 31, 304-310 (2017)
Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.
2017 Scientific Article in Journal of Magnetic Resonance Imaging J. Magn. Reson. Imaging 45, 369-380 (2017)
In vivo assessment of cold stimulation effects on the fat fraction of brown adipose tissue using DIXON MRI.
2017 Scientific Article in Endocrine Endocrine 55, 386-397 (2017)
Loss of p27 expression is associated with MEN1 gene mutations in sporadic parathyroid adenomas.
2016 Meeting abstract in Diabetologia Diabetologia 59, S521-S521 (2016)
Impaired lung function as a diabetes related complication.
2016 Meeting abstract in Diabetologia Diabetologia 59, S234-S234 (2016)
Transforming growth factor beta-like stimulated clone 22 D4 promotes diabetic hyperglycaemia and insulin resistance.
2016 Meeting abstract in Atherosclerosis Atherosclerosis 252, E131-E131 (2016)
Liposomes for microRNA delivery to human adipocytes.
2016 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 292, 3224-3238 (2016)
Loss of glyoxalase 1 induces compensatory mechanism to achieve dicarbonyl detoxification in mammalian Schwann cells.
2016 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 17:2011 (2016)
Comprehensive analysis of miRNome alterations in response to sorafenib treatment in colorectal cancer cells.
2016 Scientific Article in Recent Results in Cancer Research Recent Results Cancer Res. 208, 219-242 (2016)
Biological mechanisms for the effect of obesity on cancer risk: Experimental evidence.
2016 Scientific Article in Best Practice and Research Clinical Endocrinology and Metabolism Best Pract. Res. Clin. Endocrinol. Metab. 30, 653-664 (2016)
MicroRNAs in adipocyte formation and obesity.
2016 Scientific Article in Nature Communications Nat. Commun. 7:13267 (2016)
Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.
2016 Meeting abstract in Neuroendocrinology Neuroendocrinology 103, 8-8 (2016)
The Role of p27 in Pheochromocytoma Development.
2016 Scientific Article in BMC Endocrine Disorders BMC Endocr. Disord. 16:56 (2016)
The effect of lifestyle intervention in obesity on the soluble form of activated leukocyte cell adhesion molecule.
2016 Review in Skeletal muscle Skelet. Muscle 6:33 (2016)
The functional significance of the skeletal muscle clock: Lessons from Bmal1 knockout models.
2016 Meeting abstract in European Journal of Immunology Eur. J. Immunol. 46, 189-189 (2016)
System-level effects of ectopic galectin-7 reconstitution in cervical cancer and their microenvironment.
2016 Scientific Article in Molecular Metabolism Mol. Metab. 5, 615-25 (2016)
miR-125b affects mitochondrial biogenesis and impairs brite adipocyte formation and function.
2016 Scientific Article in BioTechniques / Protocol Guide BioTechniques 61, 137-148 (2016)
Characterization of aggregate load and pattern in living yeast cells by flow cytometry.
2016 Scientific Article in BMC Cancer BMC Cancer 16:680 (2016)
Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment.
2016 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 126, 3263-3278 (2016)
A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.
2016 Scientific Article in Journal of natural medicines J. Nat. Med. 22, 1120-1130 (2016)
An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice.
2016 Scientific Article in Nature Communications Nat. Commun. 7:12397 (2016)
MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity.
2016 Scientific Article in Journal of vascular surgery J. Vasc. Surg. 64, 990-994 (2016)
Reduced glyoxalase 1 activity in carotid artery plaques of nondiabetic patients with increased hemoglobin A1c level.
2016 Letter to the Editor in Journal of Physiology - Paris J. Physiol. 594, 3161-3162 (2016)
Inactivation of the intrinsic muscle clock does not cause sarcopenia.
2016 Scientific Article in Scientific Reports Sci. Rep. 6:28613 (2016)
Let-7i-5p represses brite adipocyte function in mice and humans.
2016 Review in Journal of Biotechnology J. Biotechnol. 235, 150-161 (2016)
A signature of 12 microRNAs is robustly associated with growth rate in a variety of CHO cell lines.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11869 (2016)
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance.
2016 Scientific Article in Thyroid Thyroid 26, 1131-1140 (2016)
Primary cell culture systems for human thyroid studies.
2016 Scientific Article in Endocrinology Endocrinology 157, 3157-3166 (2016)
Morphology, biochemistry and pathophysiology of MENX-related pheochromocytoma recapitulate the clinical features.
2016 Scientific Article in Cancer Research Cancer Res. 76, 3644-3654 (2016)
Increased expression of miR-23a mediates a loss of expression in the RAF kinase inhibitor protein RKIP.
2016 Scientific Article in Steroids Steroids 114, 7-15 (2016)
There goes the neighborhood: Assembly of transcriptional complexes during the regulation of metabolism and inflammation by the glucocorticoid receptor.
2016 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 8, 654-669 (2016)
Fasting-induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health.
2016 Scientific Article in Cell Reports Cell Rep. 15, 360-371 (2016)
An essential role for liver ERα in coupling hepatic metabolism to the reproductive cycle.
2016 Scientific Article in Science Signaling Sci. Signal. 9:rs1 (2016)
Mouse redox histology using genetically encoded probes.
2016 Scientific Article in Nature Communications Nat. Commun. 7:10782 (2016)
Hypothalamic leptin action is mediated by histone deacetylase 5.
2016 Scientific Article in Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1861, 285-293 (2016)
IP-receptor and PPARs trigger the conversion of human white to brite adipocyte induced by carbaprostacyclin.
2016 Scientific Article in Molecular Metabolism Mol. Metab. 5, 67-78 (2016)
Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia.
2015 Meeting abstract in Oncology Research and Treatment Oncol. Res. Treat. 38, 99 (2015)
Loss of the tumor- and metastasis suppressor RAF kinase inhibitor protein is caused by the overexpression of miRNA-23a.
2015 Scientific Article in Molecular Metabolism Mol. Metab. 4, 406-417 (2015)
Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control.
2015 Scientific Article in Journal of Diabetes Research J. Diabetes Res.:842584 (2015)
A glyoxalase-1 knockdown does not have major short term effects on energy expenditure and atherosclerosis in mice.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005561 (2015)
PPP2R5C couples hepatic glucose and lipid homeostasis.
2015 Scientific Article in Molecular Metabolism Mol. Metab. 4, 823-833 (2015)
The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle.
2015 Meeting abstract in Alcohol and Alcoholism Alcohol Alcohol. 50:SY14-4 (2015)
Primary hepatocellular damage and suppressed fat mobilization in heavy drinkers with PNPLA3 G genotype.
2015 Scientific Article in Frontiers in Endocrinology Front. Endocrin. 6:129 (2015)
Transcriptional pathways in cPGI2-induced adipocyte progenitor activation for browning.
2015 Scientific Article in Molecular Metabolism Mol. Metab. 4, 732-740 (2015)
Molecular regulation of urea cycle function by the liver glucocorticoid receptor.
2015 Scientific Article in Nature Communications Nat. Commun. 6:7796 (2015)
Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1.
2015 Scientific Article in International Journal of Obesity Int. J. Obes. 39, 1733-1741 (2015)
Mesoderm Specific Transcript (MEST) is a negative regulator of human adipocyte differentiation.
2015 Meeting abstract in Diabetologie und Stoffwechsel Diabetol. Stoffwechs. 10:P62 (2015)
Mind the Ga(b)p! – a novel hepatic gatekeeper at the switch point of metabolic homeostasis and diabetic late complications controlled by reactive metabolites.
2015 Meeting abstract in Diabetologie und Stoffwechsel Diabetol. Stoffwechs. 10:P311 (2015)
Hepatic heat shock proteins in diabetes and long term diabetic complications.
2015 Meeting abstract in Diabetologie und Stoffwechsel Diabetol. Stoffwechs. 10:FV12 (2015)
Transforming growth factor beta-like stimulated clone 22 D4 promotes diabetic hyperglycemia and insulin resistance.
2015 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 7, 1048-1062 (2015)
Transcriptional co-factor Transducin Beta-Like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.
2015 Scientific Article in Frontiers in Endocrinology Front. Endocrin. 6:81 (2015)
Oxytocin reverses osteoporosis in a sex-dependent manner.
2015 Scientific Article in Genome Research Genome Res. 25, 836-844 (2015)
Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo.
2015 Scientific Article in Cell Metabolism Cell Metab. 21, 678-691 (2015)
Hematopoietic Kit deficiency, rather than lack of mast cells, protects mice from obesity and insulin resistance.
2015 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 1296, 161-171 (2015)
Microarray analysis of small non-coding RNAs.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0118534 (2015)
Brown adipose tissue harbors a distinct sub-population of regulatory T cells.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0118534 (2015)
Brown adipose tissue harbors a distinct sub-population of regulatory T cells.
2015 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 1296, 161-171 (2015)
Microarray analysis of small non-coding RNAs.
2015 Scientific Article in EMBO Journal, The EMBO J. 34, 344-360 (2015)
microRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis.
In: Molecular Exercise Physiology. 2022. 25 S. ( ; 11)
Altitude, temperature, circadian rhythms and exercise.
2022 Scientific Article in Cell Cell 185, 5040-5058.e19 (2022)
Spatial proteomics in three-dimensional intact specimens.
2022 Scientific Article in Cancers Cancers 14:5481 (2022)
Combined targeting of pathogenetic mechanisms in pancreatic neuroendocrine tumors elicits synergistic antitumor effects.
2022 Scientific Article in Nature Communications Nat. Commun. 13:6754 (2022)
Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.
2022 Review in Cancer and Metastasis Reviews Cancer Metastasis Rev. 41, 517–547 (2022)
Obesity and cancer-extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases.
2022 Editorial in Frontiers in Pharmacology Front. Pharmacol. 13:975812 (2022)
Editorial: Ion channels and transporters in diabetes and metabolic diseases.
2022 Nature Reviews - Endocrinology Nat. Rev. Endocrinol. 19:62 (2022)
Author Correction: Endosomal trafficking in metabolic homeostasis and diseases (Nature Reviews Endocrinology, (2022), 10.1038/s41574-022-00737-9).
2022 Review in Antioxidants Antioxidants 11:1541 (2022)
The prognostic value of derivatives-reactive oxygen metabolites (d-ROMs) for cardiovascular disease events and mortality: A review.
2022 Scientific Article in Toxicology Letters Toxicol. Lett. 368, 33-46 (2022)
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay.
2022 Scientific Article in Molecular Metabolism Mol. Metab. 64:101556 (2022)
Tryptophan metabolism is a physiological integrator regulating circadian rhythms.
2022 Editorial in Diabetologie und Stoffwechsel Diabetol. Stoffwechs. 17, 357-358 (2022)
Hunger metabolism - from molecular basis to therapeutic use Werner Creutzfeldt prize 2022-a brief overview of the award winner Stephan Herzig.
2022 Editorial in Molecular Metabolism Mol. Metab. 63:101547 (2022)
10 years of molecular metabolism.
2022 Scientific Article in Nature metabolism Nat. Metab. 4, 1071-1083 (2022)
GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.
2022 Scientific Article in Science Advances Sci. Adv. 8:eabo5555 (2022)
TSC22D4 interacts with Akt1 to regulate glucose metabolism.
2022 Scientific Article in Cell Metabolism Cell Metab. 34, 1824-1842.e9 (2022)
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.
2022 Scientific Article in Advanced science Adv. Sci. 9:e2104291 (2022)
Trip13 depletion in liver cancer induces a lipogenic response contributing to plin2-dependent mitotic cell death.
2022 Review in Advances in Experimental Medicine and Biology Adv. Exp. Med. Biol. 1390, 61-82 (2022)
Nuclear receptors in energy metabolism.
Methods in Molecular Biology In: Circadian Regulation. 2022. 311-327 (Methods Mol. Biol. ; 2482)
Untargeted and targeted circadian metabolomics using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and flow injection-electrospray ionization-tandem mass spectrometry (FIA-ESI-MS/MS).
2022 Scientific Article in Life Sciences Life Sci. 303:120601 (2022)
Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain.
2022 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 29, 285-306 (2022)
Personalized drug testing in human pheochromocytoma/paraganglioma primary cultures.
2022 Scientific Article in Molecular Metabolism Mol. Metab. 60:101487 (2022)
Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function.
2022 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 107, 2167-2181 (2022)
Six-month periodic fasting in patients with type 2 diabetes and diabetic nephropathy: A proof-of-concept study.
2022 Scientific Article in Biochemical and Biophysical Research Communications Biochem. Biophys. Res. Commun. 618, 46-53 (2022)
TSC22D4 promotes TGFβ1-induced activation of hepatic stellate cells.
2022 Scientific Article in Metabolites Metabolites 12:99 (2022)
Analogues of natural chalcones as efficient inhibitors of AKR1C3.
2022 Scientific Article in Metabolites Metabolites 12:445 (2022)
Effects of acute and chronic resistance exercise on the skeletal muscle metabolome.
2022 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e14364 (2022)
Angpt2/Tie2 autostimulatory loop controls tumorigenesis.
2022 Scientific Article in Cell Metabolism Cell Metab. 34, 473-486.e9 (2022)
A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis.
2022 Review in Lancet Diabetes and Endocrinology Lancet Diabet. Endocrinol. 10, 221-230 (2022)
Sexual dimorphism in COVID-19: Potential clinical and public health implications.
2022 Scientific Article in Cell Metabolism Cell Metab. 34, 329-345.e8 (2022)
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis.
2022 Scientific Article in Molecular Metabolism Mol. Metab. 56:101412 (2022)
Adipocyte-specific tribbles pseudokinase 1 regulates plasma adiponectin and plasma lipids in mice.
2022 Scientific Article in Cancers Cancers 14:90 (2022)
Aging aggravates cachexia in tumor-bearing mice.
2022 Scientific Article in Clinical Cancer Research Clin. Cancer Res. 28, 1038-1052 (2022)
Therapy-related transcriptional subtypes in matched primary and recurrent head and neck cancer.
2022 Diabetologia Diabetologia 65:257 (2022)
Correction to: Neuron-specific biomarkers predict hypo- and hyperalgesia in individuals with diabetic peripheral neuropathy.
In: Endocrine Surgery Comprehensive Board Exam Guide. 2021. 935–950
Multiple endocrine neoplasia type 4 (MEN 4).
In: Gigantism and Acromegaly. 2021. 157-172
CDKN1B (p27) defects leading to pituitary tumors.
Endocrinology In: Polyendocrine Disorders and Endocrine Neoplastic Syndromes. 2021. 245-274 (Endocrinology)
Multiple endocrine neoplasia-type 4 (MEN4) and other MEN1-like syndromes.
2021 Review in Frontiers in Endocrinology Front. Endocrin. 12:765201 (2021)
Diabetic pneumopathy-a new diabetes-associated complication: Mechanisms, consequences and treatment considerations.
2021 Review in EJNMMI Research EJNMMI Res. 11:121 (2021)
Imaging pheochromocytoma in small animals: Preclinical models to improve diagnosis and treatment.
2021 Scientific Article in Cell Reports Medicine Cell Rep. Med. 2:100434 (2021)
Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice.
2021 Review in EJNMMI Research EJNMMI Res. 11:94 (2021)
Imaging modalities for diagnosis and monitoring of cancer cachexia.
2021 Scientific Article in STAR Protocols STAR Protoc. 2:100805 (2021)
Purification of GFP-tagged nuclei from frozen livers of INTACT mice for RNA- and ATAC-sequencing.
2021 Scientific Article in Cancers Cancers 13:4433 (2021)
Mri‐determined psoas muscle fat infiltration correlates with severity of weight loss during cancer cachexia.
2021 Scientific Article in Diabetologia Diabetologia, DOI: 10.1007/s00125-021-05557-6 (2021)
Neuron-specific biomarkers predict hypo- and hyperalgesia in individuals with diabetic peripheral neuropathy.
2021 Scientific Article in Science Advances Sci. Adv. 7:eabi7828 (2021)
Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms.
2021 Scientific Article in Life Science Alliance Life Sci. All. 4:e202101037 (2021)
RNA sequencing reveals niche gene expression effects of beta-hydroxybutyrate in primary myotubes.
2021 Scientific Article in Journal of Cachexia, Sarcopenia and Muscle J. Cachexia Sarcopenia Muscle, DOI: 10.1002/jcsm.12758 (2021)
Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy.
2021 Scientific Article in Nature Communications Nat. Commun. 12:5068 (2021)
O-GlcNAcylated p53 in the liver modulates hepatic glucose production.
2021 Nature Communications Nat. Commun. 12:4796 (2021)
Author Correction: Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing.
2021 Scientific Article in International Journal of Molecular Sciences Int. J. Mol. Sci. 22:7958 (2021)
Common muscle metabolic signatures highlight arginine and lysine metabolism as potential therapeutic targets to combat unhealthy aging.
2021 Review in Advanced science Adv. Sci., e2100275 (2021)
Emerging targets in type 2 diabetes and diabetic complications.
2021 Scientific Article in Cell Metabolism Cell Metab. 33, 1685-1700.e9 (2021)
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication.
2021 Journal of Nutritional Biochemistry, The J. Nutr. Biochem. 97:108807 (2021)
Corrigendum to "Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance" [The Journal of Nutritional Biochemistry 57 (2018) 189-196].
2021 Editorial in Frontiers in Endocrinology Front. Endocrin. 12:722790 (2021)
Editorial: Stem cells in endocrine tumors.
2021 Scientific Article in Cancers Cancers 13:3097 (2021)
Gender-specific efficacy revealed by head-to-head comparison of pasireotide and octreotide in a representative in vivo model of nonfunctioning pituitary tumors.
2021 Editorial in Molecular Metabolism Mol. Metab. 50:101274 (2021)
NAFLD - A rising metabolic disease.
2021 Scientific Article in Cancers Cancers 13:2843 (2021)
Elevated expression of the rage variant-v in sclc mitigates the effect of chemotherapeutic drugs.
2021 Scientific Article in Diabetes Aktuell Diabetes akt. 19, 82-85 (2021)
Folgeerkrankungen des Diabetes mellitus.
2021 Scientific Article in Nature Communications Nat. Commun. 12:2999 (2021)
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
2021 Scientific Article in Diabetologia Diabetologia 64, 1850-1865 (2021)
HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling.
2021 Scientific Article in Comprehensive Physiology Compr. Physiol. 11, 1759-1783 (2021)
Glucagon's metabolic action in health and disease.
2021 Scientific Article in Thrombosis and Haemostasis Thromb. Haemost. 121, 1464-1475 (2021)
Methylglyoxal drives a distinct, nonclassical macrophage activation status.
2021 Scientific Article in Molecular Metabolism Mol. Metab. 49:101181 (2021)
Spatiotemporal GLP-1 and GIPR receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists.
2021 Scientific Article in Cancers Cancers 13:126 (2021)
Mutation of the cell cycle regulator p27kip1 drives pseudohypoxic pheochromocytoma development.
2021 Scientific Article in Nature metabolism Nat. Metab. 3, 394–409 (2021)
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
2021 Scientific Article in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 9:641410 (2021)
TBL1XR1 ensures balanced neural development through NCOR complex-mediated regulation of the MAPK pathway.
2021 Scientific Article in Life Science Alliance Life Sci. All. 4:e202000898 (2021)
Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control.
2021 Scientific Article in Cell Metabolism Cell Metab. 33, 833-844.e5 (2021)
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.
2021 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e12461 (2021)
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.
2020Vortrag: ASCB/EMBO Cell Bio Vitrual, 07.-12.12.2020, online. (2020)
Endosomal sorting complex protein Vps37a regulates hepatic glucose production via regulating glucagon receptor trafficking.
2020 Meeting abstract in Diabetologia Diabetologia 63, 1, S384-S385 (2020)
Urinary cathepsin levels are predictive of the improvement of albuminuria and are associated with elevated excretion of free glucosepane.
2020 Molecular Metabolism Mol. Metab. 41:101068 (2020)
Molecular regulation of urea cycle function by the liver glucocorticoid receptor (vol 4, pg 732, 2015).
2020 Scientific Article in Journal of Cachexia, Sarcopenia and Muscle J. Cachexia Sarcopenia Muscle 11, 1459-1475 (2020)
High levels of modified ceramides are a defining feature of murine and human cancer cachexia.
2020 Review in Current opinion in pharmacology Curr. Opin. Pharmacol. 53, 101-116 (2020)
Exploiting common aspects of obesity and cancer cachexia for future therapeutic strategies.
2020 Scientific Article in International Journal of Cancer Int. J. Cancer 147, 3523-3538 (2020)
miR-34a is upregulated in AIP-mutated somatotropinomas and promotes octreotide resistance.
2020 Scientific Article in Liver International Liver Int. 40, 2982-2997 (2020)
High-protein diet more effectively reduces hepatic fat than low-protein diet despite lower autophagy and FGF21 levels.
2020 Other: Opinion in Cell Metabolism Cell Metab. 32, 331-333 (2020)
An antibody attack against body wasting in cancer.
2020 Scientific Article in Molecular Metabolism Mol. Metab. 40:101026 (2020)
STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue.
2020 Scientific Article in Journal of Diabetes and its Complications J. Diab. Complic. 34:107648 (2020)
Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study.
2020 Review in Seminars in cell & developmental biology Semin. Cell Dev. Biol. 108, 72-81 (2020)
Hepatic lipid droplet homeostasis and fatty liver disease.
2020 Scientific Article in Molecular Metabolism Mol. Metab. 36:100953 (2020)
De novo discovery of metabolic heterogeneity with immunophenotype-guided imaging mass spectrometry.
2020 Scientific Article in Nature Communications Nat. Commun. 11:2306 (2020)
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.
2020 Scientific Article in Acta Physiologica Acta Physiol. 230:e13496 (2020)
Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling.
2020 Review in Cell Cell 181, 1189-1193 (2020)
Biomedical research goes viral: Dangers and opportunities.
2020 Scientific Article in EMBO Journal, The EMBO J. 39:e103477 (2020)
Compromised DNA repair is responsible for diabetes-associated fibrosis.
2020 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 12:e09271 (2020)
Endothelial Notch signaling controls insulin transport in muscle.
2020 Scientific Article in Nature Biotechnology Nat. Biotechnol. 38, 293-296 (2020)
Label-free metabolic imaging by mid-infrared optoacoustic microscopy in living cells.
2019 Meeting abstract in Journal of Cachexia, Sarcopenia and Muscle J. Cachexia Sarcopenia Muscle, 1387 (2019)
Exploring the contribution of the liver to cancer cachexia development.
2019 Scientific Article in Nature Communications Nat. Commun. 10:5686 (2019)
Glucose homeostasis is regulated by pancreatic beta-cell cilia via endosomal EphA-processing.
2019 Scientific Article in Molecular Cell Mol. Cell 76, 531-545.e5 (2019)
Cistromic reprogramming of the diurnal glucocorticoid hormone response by high-fat diet.
2019 Scientific Article in Nature metabolism Nat. Metab. 1, 1009-1026 (2019)
Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity.
2019 Scientific Article in EMBO Reports EMBO Rep. 20:e48552 (2019)
The glucocorticoid receptor in brown adipocytes is dispensable for control of energy homeostasis.
2019 Scientific Article in Molecular Metabolism Mol. Metab. 28, 91-106 (2019)
alpha-Calcitonin gene-related peptide inhibits autophagy and calpain systems and maintains the stability of neuromuscular junction in denervated muscles.
2019 Review in Molecular Aspects of Medicine Mol. Aspects Med. 68, 90-100 (2019)
The role of brown and beige adipose tissue in glycaemic control.
2019 Scientific Article in Archives of Toxicology Arch. Toxicol. 93, 1609-1637 (2019)
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.
2019 Scientific Article in Nature Communications Nat. Commun. 10:2474 (2019)
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic beta-cells.
2019 Review in Traffic Traffic 20, 552-570 (2019)
Metabolic regulation through the endosomal system.
Handbook of Experimental Pharmacology In: Brown Adipose Tissue. 2019. (Handb. Exp. Pharmacol. ; 251)
Preface.
2019 Review in Thrombosis and Haemostasis Thromb. Haemost. 119, 567-575 (2019)
Endocannabinoid signalling in atherosclerosis and related metabolic complications.
2019 Scientific Article in Endocrine Connections Endocr. Connect. 8, 367–377 (2019)
Aip-mutated acromegaly resistant to first-generation somatostatin analogs: Long-term control with pasireotide lar in two patients.
2019 Review in EMBO Reports EMBO Rep. 20:e47258 (2019)
Energy metabolism in cachexia.
2019 Scientific Article in Cellular Signalling Cell. Signal. 57, 45-57 (2019)
Chemical genetic screen identifies Gapex-5/GAPVDI and STBD1 as novel AMPK substrates.
2019 Scientific Article in FASEB Journal FASEB J. 33, 5924-5941 (2019)
A miR-29a-driven negative feedback loop regulates peripheral glucocorticoid receptor signaling.
2019 Scientific Article in Molecular Metabolism Mol. Metab. 19, 97-106 (2019)
Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis.
2019 Review in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 127, 203-214 (2019)
Effects of the reactive metabolite methylglyoxal on cellular signalling, insulin action and metabolism – What we know in mammals and what we can learn from yeast.
2018 Diabetes Diabetes 67, 343-344 (2018)
Erratum. Adipocyte glucocorticoid Receptor deficiency attenuates aging- and HFD-induced obesity and impairs the feeding-fasting transition. Diabetes 2017;66:272-286.
2018 Scientific Article in BMC Genomics BMC Genomics 19:794 (2018)
Norepinephrine triggers an immediate-early regulatory network response in primary human white adipocytes.
2018 Review in Trends in cancer Trends Cancer 4, 849-860 (2018)
Cancer cachexia: More than skeletal muscle wasting.
2018 Scientific Article in Developmental Cell Dev. Cell 47, 205-221.e7 (2018)
Organellar proteomics and phospho-proteomics reveal subcellular teorganization in diet-induced hepatic steatosis.
2018 Scientific Article in World Journal of Gastroenterology World J. Gastroenterol. 24, 4028-4035 (2018)
Adiponectin affects the mechanical responses in strips from the mouse gastric fundus.
2018 Scientific Article in Molecular and Cellular Proteomics Mol. Cell. Proteomics 17, 2358-2370 (2018)
Comparative secretome analyses of primary murine white and brown adipocytes reveal novel adipokines.
2018 Scientific Article in Cell Cell 174, 1571-1585.e11 (2018)
Atlas of circadian metabolism reveals system-wide coordination and communication between clocks.
2018 Scientific Article in PLoS Biology PLoS Biol. 16:e2005886 (2018)
Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock.
2018 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 10:e8613 (2018)
Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.
2018 Scientific Article in Science Signaling Sci. Signal. 11:eaai7838 (2018)
Jak-TGF beta cross-talk links transient adipose tissue inflammation to beige adipogenesis.
2018 Scientific Article in Journal of Nutritional Biochemistry, The J. Nutr. Biochem. 57, 189-196 (2018)
Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance.
2018 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 293, 4845-4859 (2018)
High-glucose toxicity is mediated by AICAR-transformylase/ IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans.
2018 Scientific Article in Circulation Circulation 137, 2592-2608 (2018)
Inhibition of endothelial notch signaling impairs fatty acid transport and leads to metabolic and vascular remodeling of the adult heart.
2018 Review in Current Opinion in Clinical Nutrition & Metabolic Care Curr. Opin. Clin. Nutr. Metab. Care 21, 164-167 (2018)
Skeletal muscle mass is controlled by the MRF4-MEF2 axis.
2018 Scientific Article in Nature medicine Nat. Med. 24, 62-72 (2018)
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.
2018 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 25, 145-162 (2018)
Characterization of neuroendocrine tumors in heterozygous mutant MENX rats: A novel model of invasive medullary thyroid carcinoma.
2017 Meeting abstract in Acta clinica Belgica Acta Clin. Belg. 72, 16-17 (2017)
Long-term management of resistant acromegaly with pasireotide LAR in 2 cases with a familial AIP mutation.
2017 Meeting abstract in Molecular Biology of the Cell Mol. Biol. Cell 28 (2017)
Proteomics identifies organelle specific phosphorylation and reveals major subcellular reorganization in the progression of NAFLD.
2017 Scientific Article in Frontiers in Physiology Front. Physiol. 8:968 (2017)
Comparative analysis of muscle hypertrophy models reveals divergent gene transcription profiles and points to translational regulation of muscle growth through increased mTOR signaling.
2017 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 45, 10595-10613 (2017)
Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair.
2017 Scientific Article in Cell Metabolism Cell Metab. 26, 1–14.e1–e5 (2017)
Acetyl-CoA carboxylase 1-dependent protein acetylation controls breast cancer metastasis and recurrence.
2017 Review in Hormone molecular biology and clinical investigation Horm. Mol. Biol. Clin. Investig. 31:0043 (2017)
Endocrine and autocrine/paracrine modulators of brown adipose tissue mass and activity as novel therapeutic strategies against obesity and type 2 diabetes.
2017 Meeting abstract in Diabetologia Diabetologia 60, S507-S508 (2017)
Loss of glyoxalase 1 in various mammalian cells is associated with an increased resistance against environmental stressors.
2017 Scientific Article in Redox Biology Redox Biol. 13, 674-686 (2017)
Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux.
2017 Review in Frontiers in Neuroscience Front. Neurosci. 11:369 (2017)
Circadian metabolomics in time and space.
2017 Scientific Article in Cell Reports Cell Rep. 20, 1422-1434 (2017)
A hepatic GAbp-AMPK axis links inflammatory signaling to systemic vascular damage.
2017 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 24, T161-T177 (2017)
Animal models of MEN1.
2017 Scientific Article in Molecular Metabolism Mol. Metab. 6, 873-881 (2017)
Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution.
2017 Review in EMBO Journal, The EMBO J. 36, 1999-2017 (2017)
Adipose tissue: Between the extremes.
2017 Other: News Item in EMBO Reports EMBO Rep. 18, 1039-1040 (2017)
Let's burn whatever you have: Mitofusin 2 metabolically re-wires brown adipose tissue.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:4023 (2017)
Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis.
2017 Review in International Journal of Molecular Sciences Int. J. Mol. Sci. 18:984 (2017)
Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention.
2017 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 114, 5265-5270 (2017)
Lsd1 prevents age-programed loss of beige adipocytes.
2017 Scientific Article in Journal of Diabetes and its Complications J. Diab. Complic. 31, 1058-1065 (2017)
ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy.
2017 Scientific Article in Nature medicine Nat. Med. 23, 623-630 (2017)
Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis.
2017 Scientific Article in Experimental Cell Research Exp. Cell Res. 350, 242-252 (2017)
Functional properties of hepatocytes in vitro are correlated with cell polarity maintenance.
2017 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 24, 1-15 (2017)
Targeting PI3K/mTOR signaling exerts potent antitumor activity in pheochromocytoma in vivo.
2017 Scientific Article in Journal of Diabetes and its Complications J. Diab. Complic. 31, 304-310 (2017)
Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.
2017 Scientific Article in Journal of Magnetic Resonance Imaging J. Magn. Reson. Imaging 45, 369-380 (2017)
In vivo assessment of cold stimulation effects on the fat fraction of brown adipose tissue using DIXON MRI.
2017 Scientific Article in Endocrine Endocrine 55, 386-397 (2017)
Loss of p27 expression is associated with MEN1 gene mutations in sporadic parathyroid adenomas.
2016 Meeting abstract in Diabetologia Diabetologia 59, S521-S521 (2016)
Impaired lung function as a diabetes related complication.
2016 Meeting abstract in Diabetologia Diabetologia 59, S234-S234 (2016)
Transforming growth factor beta-like stimulated clone 22 D4 promotes diabetic hyperglycaemia and insulin resistance.
2016 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 292, 3224-3238 (2016)
Loss of glyoxalase 1 induces compensatory mechanism to achieve dicarbonyl detoxification in mammalian Schwann cells.
2016 Scientific Article in Recent Results in Cancer Research Recent Results Cancer Res. 208, 219-242 (2016)
Biological mechanisms for the effect of obesity on cancer risk: Experimental evidence.
2016 Scientific Article in Nature Communications Nat. Commun. 7:13267 (2016)
Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.
2016 Meeting abstract in Neuroendocrinology Neuroendocrinology 103, 8-8 (2016)
The Role of p27 in Pheochromocytoma Development.
2016 Review in Skeletal muscle Skelet. Muscle 6:33 (2016)
The functional significance of the skeletal muscle clock: Lessons from Bmal1 knockout models.
2016 Scientific Article in Diabetes Diabetes 66, 272-286:db160381 (2016)
Adipocyte glucocorticoid receptor deficiency attenuates aging and HFDinduced obesity, and impairs the feedingfasting transition.
2016 Scientific Article in Molecular Metabolism Mol. Metab. 5, 615-25 (2016)
miR-125b affects mitochondrial biogenesis and impairs brite adipocyte formation and function.
2016 Scientific Article in BioTechniques / Protocol Guide BioTechniques 61, 137-148 (2016)
Characterization of aggregate load and pattern in living yeast cells by flow cytometry.
2016 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 126, 3263-3278 (2016)
A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.
2016 Scientific Article in Journal of natural medicines J. Nat. Med. 22, 1120-1130 (2016)
An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice.
2016 Scientific Article in Nature Communications Nat. Commun. 7:12397 (2016)
MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity.
2016 Letter to the Editor in Journal of Physiology - Paris J. Physiol. 594, 3161-3162 (2016)
Inactivation of the intrinsic muscle clock does not cause sarcopenia.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11869 (2016)
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance.
2016 Scientific Article in Thyroid Thyroid 26, 1131-1140 (2016)
Primary cell culture systems for human thyroid studies.
2016 Scientific Article in Endocrinology Endocrinology 157, 3157-3166 (2016)
Morphology, biochemistry and pathophysiology of MENX-related pheochromocytoma recapitulate the clinical features.
2016 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 8, 654-669 (2016)
Fasting-induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health.
2016 Scientific Article in Science Signaling Sci. Signal. 9:rs1 (2016)
Mouse redox histology using genetically encoded probes.
2016 Scientific Article in Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1861, 285-293 (2016)
IP-receptor and PPARs trigger the conversion of human white to brite adipocyte induced by carbaprostacyclin.
2016 Scientific Article in Molecular Metabolism Mol. Metab. 5, 67-78 (2016)
Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia.
2015 Scientific Article in Endocrine Endocrine 51, 236-244 (2015)
Aggressive tumor growth and clinical evolution in a patient with X-linked acro-gigantism syndrome.
2015 Scientific Article in Molecular Metabolism Mol. Metab. 4, 406-417 (2015)
Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control.
2015 Scientific Article in Journal of Diabetes Research J. Diabetes Res.:842584 (2015)
A glyoxalase-1 knockdown does not have major short term effects on energy expenditure and atherosclerosis in mice.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005561 (2015)
PPP2R5C couples hepatic glucose and lipid homeostasis.
2015 Scientific Article in Molecular Metabolism Mol. Metab. 4, 823-833 (2015)
The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle.
2015 Scientific Article in Diabetes Diabetes 65, 406-420 (2015)
Obesity in MENX rats is accompanied by high circulating levels of ghrelin and improved insulin sensitivity.
2015 Meeting abstract in Alcohol and Alcoholism Alcohol Alcohol. 50:SY14-4 (2015)
Primary hepatocellular damage and suppressed fat mobilization in heavy drinkers with PNPLA3 G genotype.
2015 Scientific Article in Frontiers in Endocrinology Front. Endocrin. 6:129 (2015)
Transcriptional pathways in cPGI2-induced adipocyte progenitor activation for browning.
2015 Scientific Article in OncoTarget Oncotarget 6, 39111-39126 (2015)
Oncogenic features of the Bone Morphogenic Protein 7 (BMP7) in pheochromocytoma.
2015 Scientific Article in Molecular Metabolism Mol. Metab. 4, 732-740 (2015)
Molecular regulation of urea cycle function by the liver glucocorticoid receptor.
2015 Scientific Article in Nature Genetics Nat. Genet. 47, 969-978 (2015)
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
2015 Scientific Article in Molecular and Cellular Endocrinology Mol. Cell. Endocrinol. 421, 49-59 (2015)
Animal models of multiple endocrine neoplasia.
2015 Scientific Article in International Journal of Obesity Int. J. Obes. 39, 1733-1741 (2015)
Mesoderm Specific Transcript (MEST) is a negative regulator of human adipocyte differentiation.
2015 Meeting abstract in Diabetologie und Stoffwechsel Diabetol. Stoffwechs. 10:P62 (2015)
Mind the Ga(b)p! – a novel hepatic gatekeeper at the switch point of metabolic homeostasis and diabetic late complications controlled by reactive metabolites.
2015 Meeting abstract in Diabetologie und Stoffwechsel Diabetol. Stoffwechs. 10:P311 (2015)
Hepatic heat shock proteins in diabetes and long term diabetic complications.
2015 Meeting abstract in Diabetologie und Stoffwechsel Diabetol. Stoffwechs. 10:FV12 (2015)
Transforming growth factor beta-like stimulated clone 22 D4 promotes diabetic hyperglycemia and insulin resistance.
2015 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 7, 1048-1062 (2015)
Transcriptional co-factor Transducin Beta-Like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.
2015 Scientific Article in Cell Metabolism Cell Metab. 21, 678-691 (2015)
Hematopoietic Kit deficiency, rather than lack of mast cells, protects mice from obesity and insulin resistance.
2015 Scientific Article in Journal of Nuclear Medicine J. Nucl. Med. 56, 839-846 (2015)
Semi-quantitative 123I-metaiodobenzylguanidine scintigraphy to distinguish pheochromocytoma and paraganglioma from physiological adrenal uptake and its correlation with genotype-dependent expression of catecholamine transporters.
2015 Scientific Article in Clinical Cancer Research Clin. Cancer Res. 21, 3204-3215 (2015)
Targeting PI3K/mTOR signaling displays potent antitumor efficacy against nonfunctioning pituitary adenomas.
2015 Scientific Article in Theranostics Theranostics 5, 618-630 (2015)
Disclosing the CXCR4 expression in lymphoproliferative diseases by targeted molecular imaging.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0118534 (2015)
Brown adipose tissue harbors a distinct sub-population of regulatory T cells.
2015 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 22, 353-367 (2015)
X-Linked Acrogigantism (X-LAG) syndrome: Clinical profile and therapeutic responses.
2015 Scientific Article in Endocrine Endocrine 49, 58-64 (2015)
Early onset acromegaly associated with a novel deletion in CDKN1B 5'UTR region.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0118534 (2015)
Brown adipose tissue harbors a distinct sub-population of regulatory T cells.
2015 Scientific Article in Molecular and Cellular Endocrinology Mol. Cell. Endocrinol. 408, 178-184 (2015)
Adrenomedullary progenitor cells: Isolation and characterization of a multi-potent progenitor cell population.
2015 Scientific Article in Lancet, The Lancet 385, 392 (2015)
Ovarian hyperstimulation from ectopic hypersecretion of follicle stimulating hormone.
2015 Scientific Article in Endocrinology and Metabolism Endocrinol. Metab. 30, 389-394 (2015)
Acromegaly due to a macroinvasive plurihormonal pituitary adenoma and a rectal carcinoid tumor.
2015 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 22, 111-119 (2015)
SSTR3 is a putative target for the medical treatment of gonadotroph adenomas of the pituitary.
2015 Scientific Article in EMBO Journal, The EMBO J. 34, 344-360 (2015)