Stem Cell Center Institute of Developmental Genetics
The Institute of Developmental Genetics (IDG) develops novel genetic tools and gene therapies. Using preclinical mouse and human cell models, it investigates the molecular causes of Parkinson’s disease to advance therapies like somatic cell reprogramming into neurons.
The Institute of Developmental Genetics (IDG) develops novel genetic tools and gene therapies. Using preclinical mouse and human cell models, it investigates the molecular causes of Parkinson’s disease to advance therapies like somatic cell reprogramming into neurons.
Highlight Publications
See all2024 Cell Discov. 2024 Apr 12;10(1):42
Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting.
2023 Nat Commun. 2023 Nov 23;14(1):7674.
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease.
2022 Nat Commun. 2022 Aug 16;13(1):4819.
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.
2022 EMBO Mol Med. 2022 May 9;14(5):e14797.
2021 Cell Stem Cell. 2021 Mar 4;28(3):524-534.e7.
2020 Nat Med. 2020 Feb;26(2):207-214.