Our research group uses cell culture systems to investigate signalling processes regulated by phosphorylation. The methods used include the yeast-2-hybrid system, expression cloning, transfection, confocal immunofluorescence and the analysis of physiological parameters such as glucose transport or cellular transformation.
Ongoing projects (selection):
Tyrosine phosphatases: PTPalpha and its role in insulin signalling and transformation by Src kinases.
aPKC and Akt kinases: Modulation of insulin signalling by binding proteins and phosphorylated substrates.
Kinesins: effects of intracellular organelle transport on metabolic functions
CDCP1: a Src-binding transmembrane adaptor protein and its role in cellular transformation
Transcription factors Transcription ChIP-Sequencing Genomics Gene Expression Epigenetics Circadian Clocks