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Pathophysiology of Prediabetes

About our research

Our goal is to understand the causes and consequences of impaired metabolic health in obesity and normal weight and the role of metabolic dysfunction-associated steatotic liver disease (MASLD) in the pathogenesis of prediabetes, type 2 diabetes and cardiovascular diseases.

In this respect, in 2008, we published the first large cohort study addressing precise phenotyping in metabolically healthy obesity (MHO) and then extended our research to subphenotypes of impaired metabolic in normal weight. To address the mechanisms how MASLD impacts on cardiometabolic diseases, in 2008, we were the first to introduce the concept of hepatokines and are studying their cardiometabolic role in the organ cross-talk.

Scientists at Pathophysiology of Prediabetes

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Tobias Haueise

PhD student

Dr. Konstantinos Kantartzis

Physician Scientist
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Dr. Angela Lehn-Stefan

Physician Scientist

Dr. Sebastian Schuth

Physician Scientist

Karin Waneck


Highlight Publications


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Prof. Dr. Norbert Stefan

Head of Section