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Dr. Dominik Lutter, PhD

Head of the Computational Discovery Research Group

"My research is driven by the vision to enable a systemic understanding of health and metabolism that leads to personalized prevention, predictions and treatments of metabolic diseases."

"My research is driven by the vision to enable a systemic understanding of health and metabolism that leads to personalized prevention, predictions and treatments of metabolic diseases."

Academic Pathway

Dominik Lutter’s research focusses on the intersection between applied data science and systemic metabolism. The primary and long-term objective of his research is to advance a systemic view on the development of insulin resistance and Type 2 Diabetes Mellitus (T2DM). In close collaboration with his experimental partners he follows a systems biology approach to unravel regulatory interactions from genes to metabolism to environment leading to a better understanding of metabolic diseases and enabling novel diagnostic approaches and personalized intervention strategies.

Dominik studied Biology at the University of Regensburg. In 2007, he joined Helmholtz Munich to finish his PhD following a Postdoc position in the group of Fabian Theis at the Institute for Bioinformatics and Systems Biology (IBIS) and in 2013 the Institute for Diabtes and Obesity (IDO). From 2015 on he is heading the group Computational Discovery Research (CDR) with the IDO and the Helmholtz Ciabtes Center (HDC).

Expertise

Computational Biology  Multi Omics Systems biology Obesity Diabetes   Metabolism

Professional Career

2015

Head of Computational Discovery Research

Institute for Diabetes and Obesity, Helmholtz Center Munich, Germany

2013 - 2015

Postdoctoral Fellow

Institute for Diabetes and Obesity, Helmholtz Center Munich, Germany

2009 - 2013

Postdoctoral Fellow

Computational Modeling in Biology Group, Institute for Bioinformatics and Systems Biology, Helmholtz Center Munich, Germany

Publications

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2021 Scientific Article in Science Advances

Greco, C.M. ; Koronowski, K.B. ; Smith, J.G. ; Shi, J. ; Kunderfranco, P. ; Carriero, R. ; Chen, S. ; Samad, M. ; Welz, P.S. ; Zinna, V.M. ; Mortimer, T. ; Chun, S.K. ; Shimaji, K. ; Sato, T. ; Petrus, P. ; Kumar, A. ; Vaca-Dempere, M. ; Deryagian, O. ; Van, C. ; Monroy Kuhn, J.M. ; Lutter, D. ; Seldin, M.M. ; Masri, S. ; Li, W. ; Baldi, P. ; Dyar, K.A. ; Muñoz-Cánoves, P. ; Benitah, S.A. ; Sassone-Corsi, P.

Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms.

2021 Scientific Article in EMBO Molecular Medicine

Hartleben, G. ; Schorpp, K.K. ; Kwon, Y. ; Betz, B. ; Tsokanos, F.-F. ; Dantes, Z. ; Schäfer, A. ; Rothenaigner, I. ; Monroy Kuhn, J.M. ; Morigny, P. ; Mehr, L. ; Lin, S. ; Seitz, S. ; Tokarz, J. ; Artati, A. ; Adamski, J. ; Plettenburg, O. ; Lutter, D. ; Irmler, M. ; Beckers, J. ; Reichert, M. ; Hadian, K. ; Zeigerer, A. ; Herzig, S. ; Berriel Diaz, M.

Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.

Networks and Affiliations

Helmholtz Munich

HDC

DZD