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Helmholtz Munich | ©Michael Haggenmueller

Dr. Natalie Krahmer

Emmy Noether Research Group Leader Cellular Proteomics and Metabolic Signaling, Institute of Diabetes and Obesity
+49 89 3187 43359Email meBuilding/Room: 3620

“Together with my junior research group, I want to identify still unknown proteins involved in the signaling pathway of the satiety hormone leptin and factors for developing resistance to it.”

“Together with my junior research group, I want to identify still unknown proteins involved in the signaling pathway of the satiety hormone leptin and factors for developing resistance to it.”

Academic Career and Research Areas

Natalie is intrigued by the question how chronic overnutritiuon affects the organization and functions of cells and how this contributes to obesity and metabolic disease. Natalie’s lab develops spatial proteomic tools to map the localization and modifications of proteins at large scale and to generate systematic organellar atlases of organs and tissues. Their aim is to combine these unbiased proteomics tools with cell biological and biochemical methods to characterize the reprogramming of signaling, cellular metabolism and organelle functions in metabolic diseases to identify novel drug targets. A particular interest of her lab is to discover factors that drive progression of fatty liver disease and to elucidate how genetic risk factors influence the cellular processes in order to develop pharmaceutical intervention strategies.

Natalie Krahmer entered the metabolic field during her PhD when she focused on the cell biology of lipid storage.  With her work at the Max-Planck Institute of Biochemistry in Munich and during research stays in the US at Yale Medical School and at UCSF, San Francisco, she elucidated the mechanisms of how lipid droplets, the cellular lipid storage depots, expand and regulate their proteome. During her postdoc at the Max-Planck Institute of Biochemistry, she was then trained in proteomics and developed spatial proteomic tools to investigate the changes of cellular organization and metabolic signaling in fatty liver disease.

In 2019, Natalie was awarded the DFG Emmy-Noether fellowship to start an independent research group and she joined the Helmholtz Diabetes center as group leader. Together with her team, Natalie moves state of the art proteomics into the collaborative environment of the Helmholtz Diabetes Center and has established collaborations with the pharmaceutical industry.

Fields of Work and Expertise

Organelle proteomicsMetabolic signalingNAFLDSystems biologyDiabetesCell biologylipid droplets

Professional Background


PhD, Max-Planck Institute of Biochemistry

2013 - 2018

Postdoc, Max-Planck Institute of Biochemistry


Group leader at the Helmholtz Diabetes Center

Honors and Awards

EFSD/Novo Nordisk Future Leader Award
German research foundation (DFG) Emmy-Noether Fellow


Read more

2022 Scientific Article in Cell

Bhatia, H.S. ; Brunner, A.D. ; Öztürk, F. ; Kapoor, S. ; Rong, Z. ; Mai, H. ; Thielert, M. ; Ali, M. ; Al-Maskari, R. ; Paetzold, J.C. ; Kofler, F. ; Todorov, M.I. ; Molbay, M. ; Kolabas, Z.I. ; Negwer, M. ; Höher, L. ; Steinke, H. ; Dima, A. ; Gupta, B. ; Kaltenecker, D. ; Caliskan, Ö.S. ; Brandt, D. ; Krahmer, N. ; Müller, S. ; Lichtenthaler, S.F. ; Hellal, F. ; Bechmann, I. ; Menze, B. ; Theis, F.J. ; Mann, M. ; Ertürk, A.

Spatial proteomics in three-dimensional intact specimens.

2020 Scientific Article in EMBO Journal, The

Cinque, L. ; De Leonibus, C. ; Iavazzo, M. ; Krahmer, N. ; Intartaglia, D. ; Salierno, F.G. ; De Cegli, R. ; Di Malta, C. ; Svelto, M. ; Lanzara, C. ; Maddaluno, M. ; Wanderlingh, L.G. ; Huebner, A.K. ; Cesana, M. ; Bonn, F. ; Polishchuk, E. ; Hübner, C.A. ; Conte, I. ; Dikic, I. ; Mann, M. ; Ballabio, A. ; Sacco, F. ; Grumati, P. ; Settembre, C.

MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.

Networks and Affiliations


DZD Deutsches Zentrum für Diabetesforschung