IDOT

The focus of the Institute for Diabetes and Organoid Technology (IDOT) is to understand and modify the mechanisms underlying pancreas development and function with the goal to improve disease progression and outcome. We utilize organoid systems derived from human pluripotent stem cells as well as mouse models to study pancreas biology, diabetes and pancreatic cancer, with the goal to prevent or reverse disease-related pathological processes.

We are interested in understanding how pancreatic islet cells form and how we can direct the differentiation of human pluripotent stem cells towards functional insulin-producing cells. Using these tools we explore the underlying causes of diabetes and unresolved questions in human beta cell biology.

We harness organoid technology to understand the origin and development of pancreatic neoplasias. Using both human stem cell and patient derived organoid models allows us to query the mechanisms of pancreatic cancer formation and interrogate potential therapeutic targets.

At the third Helmholtz Munich Expert Hour at the German Bundestag on June 4, 2024, the cutting-edge research center provided information on the potential of artificial intelligence (AI) and new technologies to improve medicine in the areas of…

Helmholtz Munich researchers receive 2.25 Mio US Dollar JDRF Grant

With a 2.25 million US dollar grant provided by the Juvenile Diabetes Research Foundation (JDRF), Prof. Matthias Hebrok, Prof. Heiko Lickert, and Prof. Carolin Daniel from the…

The biologist and medical researcher Matthias Hebrok was awarded the Bavarian Distinguished Professorship. Since 2022 Prof. Hebrok is Director at the Institute for Diabetes and Organoid Technology (IDOT)) at Helmholtz Munich. The Bavarian Ministry of…

Matthias Hebrok about his new Institute for Diabetes and Organoid Technology (IDOT) at Helmholtz Munich

Prof. Dr. Matthias Hebrok

Director, IDOT

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Dr. Laura Leonhardt

Scientific Strategist and Project Manager, IDOT

Dr. Hasna Maachi

Postdoc, IDOT

Dr. Jia Mei

Postdoc, IDOT

Dr. Kai Duan

Postdoc, IDOT

Dr. Suhail Ansari

Scientist, IDOT

Dr. Naoya Murao

Scientist, IDOT

Dr. Hossam Montaser

Postdoc, IDOT

Merve Yigin

PhD Student, IDOT

Damla Taskin

PhD Student, IDOT

Marierose Mina

Phd Student, IDOT

Helen Göhler

Phd Student, IDOT

Lars Henrik Joost

Phd Student, IDOT

Rachita Gupta

Phd Student, IDOT

Mateus Perazo

Master Student, IDOT

Diana Lochner

Assistant to the Director, IDOT

Hannes Rolbieski

Lab Technician, IDOT

Sabina Szüts

Lab Technician, IDOT

Maria Katharina Zacherl

Lab Technician, IDOT

Francisco Martin Hinojosa

Lab Technician, IDOT

Laura Leonhardt, Matthias Hebrok

KRAS degradation averts PDAC chemoresistance

Nishith R Reddy, Hasna Maachi, Yini Xiao, Milos S Simic, Wei Yu, Yurie Tonai, Daniela A Cabanillas, Ella Serrano-Wu, Philip T Pauerstein, Whitney Tamaki, Greg M Allen, Audrey V Parent, Matthias Hebrok, Wendell A Lim

Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs

Sapna Puri, Hasna Maachi, Gopika Nair, Holger A. Russ, Richard Chen, Pamela Pulimeno, Zachary Cutts, Vasilis Ntranos & Matthias Hebrok

Sox9 regulates alternative splicing and pancreatic beta cell function

Sudipta Ashe, Matthias Hebrok

Role of Cell-Based Therapies in T2D

Veronica A. Chochrane, Matthias Hebrok

Stem cell-derived islet therapy: is this the end of the beginning?

Jeeyeon Cha, Xin Tong, Emily M. Walker, Tehila Dahan, Veronica A. Cochrane, Sudipta Ashe, Ronan Russell, Anna B. Osipovich,
Alex M. Mawla, Min Guo, Jin-hua Liu, Zachary A. Loyd, Mark O. Huising, Mark A. Magnuson, Matthias Hebrok, Yuval Dor, Roland Stein

Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity

Gauree Chendke, Bhushan Kharbikar, Sudipta Ashe, Gaetano Faleo, Julie B. Sneddon, Qizhi Tang, Matthias Hebrok, Tejal Desai

Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space

Eleonora de Klerk, Yini Xiao, Christopher H. Empfinger, Mark P. Keller, David I. Berrios, Valentina Loconte, Axel A. Ekman, Kate L. White, Rebecca L. Cardone, Richard G. Kibbey, Alan D. Attie, Matthias Hebrok

Loss of ZNF148 enhances insulin secretion in human pancreatic β cells

Goswami I, de Klerk E, Carnese P, Hebrok M, Healy KE

Multiplexed microfluidic platform for stem-cell derived pancreatic islet β cells

Emfinger CH, de Klerk E, Schueler KL, Rabaglia ME, Stapleton DS, Simonett SP, Mitok KA, Wang Z, Liu X, Paulo JA, Yu Q, Cardone RL, Foster HR, Lewandowski SL, Perales JC, Kendziorski CM, Gygi SP, Kibbey RG, Keller MP, Hebrok M, Merrins MJ, Attie AD

β Cell-specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses

Chai S, Kim Y, Galivo F, Dorrell C, Wakefield L, Posey J, Ackermann AM, Kaestner KH, Hebrok M, Grompe M

Development of a Beta Cell-Specific Expression Control Element for Recombinant Adeno-Associated Virus

Parent AV, Ashe S, Nair GG, Li ML, Chavez J, Liu JS, Zhong Y, Streeter PR, Hebrok M

Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells

Kerper N, Ashe S, Hebrok M

Pancreatic β-Cell Development and Regeneration

Parent AV, Faleo G, Chavez J, Saxton M, Berrios DI, Kerper NR, Tang Q, Hebrok M

Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection

Shaheen R, Gurlin RE, Gologorsky R, Blaha C, Munnangi P, Santandreu A, Torres A, Carnese P, Nair GG, Szot G, Fissell WH, Hebrok M, Roy S

Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived β cells for intravascular bioartificial pancreas applications.

Hendley AM, Rao AA, Leonhardt L, Ashe S, Smith JA, Giacometti S, Peng XL, Jiang H, Berrios DI, Pawlak M, Li LY, Lee J, Collisson EA, Anderson MS, Fragiadakis GK, Yeh JJ, Ye CJ, Kim GE, Weaver VM, Hebrok M

Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree

de Klerk E, Hebrok M

Stem Cell-Based Clinical Trials for Diabetes Mellitus

Jacobson EF, Chen Z, Stoukides DM, Nair GG, Hebrok M, Tzanakakis ES

Non-xenogeneic expansion and definitive endoderm differentiation of human pluripotent stem cells in an automated bioreactor

Institute for Diabetes and Organoid Technology

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About our Research

Diabetes

Pancreas cancer

News from the IDOT

Award

Helmholtz Munich in the Bundestag: Artificial Intelligence and High-Tech

Advancing Stem Cell-Based Therapy for Type 1 Diabetes

Helmholtz Munich researchers receive 2.25 Mio US Dollar JDRF Grant

Research Against Cancer and Diabetes: Matthias Hebrok Receives Bavarian Distinguished Professorship

“Science must embrace invention, explore new avenues, test the unknown.”

Scientists at IDOT

Recent publications

Networks and Affiliations

Technical University Munich

University of California, San Francisco

Juvenile Diabetes Research Foundation

EASD

American Diabetes Association

German Center for Diabetes Research

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