Institute: Stage (Staff of the Institute)
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Damla Taskin
PhD student

Prof. Dr. Matthias Hebrok
Director
- Telephone: +49 89 3187-43646
- Mobile phone: 01522-3256819
- E-mail: Email me
- Go to website: Visit
Academic Education and Degrees
10/1999 Postdoctorial Training, Harvard University, Department of Molecular & Cell Biology, and Howard Hughes Medical Institute, Cambridge, MA, Develop. Biology
07/1995 Ph.D., Max-Planck-Institute for Immunobiology and Albert-Ludwigs University, Freiburg, Germany, Developmental Biology
02/1992 Diploma/Master, Albert-Ludwigs University, Freiburg, Germany, Cell & Molecular Biology
09/1985 Diploma Biological-Technical Assistant (BTA) School, Bückeburg, Germany
Employment
2022 - Chair for Applied Stem Cell and Organoid Systems, Technical University Munich (TUM)
2022 - Director, Center for Organoid Systems, TUM
2022 - Director, Institute for Diabetes and Organoid Technology, Helmholtz Center Munich
2021 Visiting Professor, Technische Universität Dresden
2010 - 2020 Director, UCSF Diabetes Center
2009 - 2022 Professor, UCSF Diabetes Center, Department of Medicine
2009 - 2022 Hurlbut-Johnson Distinguished Professorship in Diabetes Research
2009 - 2010 Associate Director, Research, UCSF Diabetes Center
2008 Interim Director, UCSF Diabetes Center
2007 - 2022 Hurlbut-Johnson Endowed Chair in Diabetes Research
2005 - 2009 Associate Professor, UCSF Diabetes Center, Department of Medicine
1999 - 2005 Assistant Professor, UCSF Diabetes Center, Department of Medicine
1996 - 1999 Post-doctoral Research Fellow, Howard Hughes Medical Institute and Dept. of Molecular and Cellular Biology, Harvard University, Dr. Douglas A. Melton, advisor
1995 Post-doctoral Research Fellow, Max-Planck-Institute for Immunobiology in Freiburg, Dept. of Developmental Biology
1992 - 1995 Graduate student, Max-Planck-Institute for Immunobiology, Freiburg, Dept. of Developmental Biology, Dr. Ernst-Martin Füchtbauer, advisor; Dr. Davor Solter, Head of Department
1991 - 1992 Diploma thesis, Institute for Immunobiology, Dept. of Tumorbiology, Dr. W. Bessler, advisor
Scholarships / Awards /Honors
2021 Global Visiting Professorship, Technical University Munich
2021 Senior Fellow, Technical University Dresden
2021 Sixth annual Carolyn Clifford Distinguished Lecture on Nutrition and Cancer, UC Davis
2020 JDRF Greater Bay Area Chapter Innovation Award
2019 Plenary lecture, AIBIS, Korean Society for Endocrinology, Seoul, Korea
2019 - Honorary Professor, Technical University, Dresden, Germany
2015 Frank Brooks State of the Art Lecture, American Pancreatic Association
2015 Gerold & Kayla Grodsky Award, Juvenile Diabetes Research Foundation
2013 - 2015 Chair, NIH Study section, Cellular Aspects of Diabetes and Obesity (CADO)
2006 Scholar Award, Juvenile Diabetes Research Foundation
2004 Guest-Professor, University of Ulm, Germany
2000 Career Development Award, Juvenile Diabetes Foundation
2000 Sandler Award in Basic Sciences
1999 Sandler Program in Basic Sciences Junior Faculty Start-up Award
1997 - 1999 Howard Hughes Medical Institute Postdoctoral Fellowship
1996 Post-doctoral Fellowship from the German Research Society (DFG)
1995 Post-doctoral Fellowship from the Max-Planck Society
1994 Graduate Student Research Award of the Hoechst AG, Frankfurt
Publications of Prof. Dr. Matthias Hebrok
1. Biology, 2019 Feb;21(2):263-274. doi: 10.1038/s41556-018-0271-4. Epub 2019 Feb 1. PMID: 30710150. PMCID 6746427. Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M (2011): Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol. 2011 Sep;9(9):e1001143. PMCID: PMC3167782. 2. Landsman, L., Parent, A., and M. Hebrok (2011). Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. PNAS. 2011 Oct 11;108(41):17010-5. PMCID: PMC3193206. 3. Parent, A., Russ, H. A., Kahn, I., Laflam, T. N., Metzger, T. C. Anderson, M. S., and M. Hebrok (2013): Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development. Cell Stem Cell, 2013 Aug 1;13(2):219-29. doi: 10.1016/j.stem.2013.04.004. Epub 2013 May 16. PMCID: PMC3869399. 4. Puri, S., Akiyama, H., and M. Hebrok (2013): VHL-mediated disruption of Sox9 activity compromises ß-cell Identity and Results in Diabetes. Genes & Development. 2013 Dec 1;27(23):2563-75. doi: 10.1101/gad.227785.113. PMCID: PMC3861670. 5. Li, K., Zhu, S., Russ,H. A., Xu, S., Xu, T., Zhang, Y., Ma, T., Hebrok,M., and S. Ding (2014): Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell, 2014 Feb 6;14(2):228-36. doi: 10.1016/j.stem.2014.01.006. PMCID: PMC4747235. 6. Russ, H. A., Parent, A. V., Ringler, J. J., Hennings, T. G., Nair, G. G., Shveygert, M., Guo, G., Puri, S., Haataja, L., Cirulli, V., Szot, G., Arvan, P. and M. Hebrok (2015): Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro. Embo J., PMCID: PMC4516429 [Available on 2016-07-02]. 7. Puri, S., Roy, N., Russ, H. A., Leonhardt, L., Karslioglu, E., French, E. K.,Roy, R., Bengsston, H., Scott, D. K., Stewart, A. F., and M. Hebrok (2018): Replication confers ß cell immaturity. Nature Communications. Nat Commun. 2018 Feb 2;9(1):485. doi: 10.1038/s41467-018-02939-0. PMCID: PMC5797102 8. Nair, G. G., Liu, J., Russ, H. A., Tran, S., Saxton, M., Chen, R., Juang, C., Lan, M. L., Puri, S., Xing, Y., Wang, Y., Nguyen, V. Q., Szot, G., Oberholzer, J., Bhushan, A., and M. Hebrok (2019): Recapitulating endocrine cell clustering in culture promotes maturation of human stem cell-derived beta cells. Nature Cell 9. Russell, R., Carnese, P. P., Hennings, T. G., Walker, E. M., Russ, H. A., Liu, J. S., Giacometti, S., Stein, S., and M. Hebrok (2020): Loss of the transcription factor MAFB limits β-cell derivation from human PSCs. Nature Communications. 2020 Jun 2;11(1):2742. doi: 10.1038/s41467-020-16550-9. PMID: 32488111. 10. Hendley, A.M., Rao, A.A., Leonhardt, L., Ashe, S., Smith, J.A., Giacometti, S., Peng, X.L., Jiang, H., Berrios, D.I., Pawlak, M., Li, L.Y., Lee, J., Collisson, E.A., Anderson, M., Fragiadakis, G.K., Yeh, J.J., Chun, J.Y., Kim, G.E., Weaver, V.M., and M. Hebrok (2021): Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree Elife. 2021 May 19;10:e67776. doi: 10.7554/eLife.67776. PMID: 34009124. 11. Parent, A. V., Faleo, G., Jessica Chavez, J., Saxton, M., Berrios, D.I., Kerper, N.R., Qizhi Tang, Q., and M. Hebrok (2021): Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection. Cell Reports, 2021 Aug 17;36(7):109538. doi: 10.1016/j.celrep.2021.109538. PMID: 34407395. 12. Parent*, A. V., Ashe S., Nair, G. G., Li, M-L., Chavez, J., Liu, J. S., Zhong, Y., Streeter, P. R., and M. Hebrok* (2022): Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2022.02.001. PMID: 35245441. * co-corresponding authors. A list of all my PubMed publications can be found under: http://www.ncbi.nlm.nih.gov/sites/myncbi/matthias.hebrok.1/bibliography/41053582/public/?sort=date&direction=ascendingDr. Laura Leonhardt
Scientific Strategist and Project Manager
- Telephone: +49 89 3187-49707
- E-mail: Email me