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Damla Taskin

PhD student

    Building 3620, Room 109

    Hannes Rolbieski

    Lab Technician

    Building 3620, Room 106

    Prof. Dr. Matthias Hebrok

    Director

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    Building 3620, Room 315b

    Academic Education and Degrees

    10/1999            Postdoctorial Training, Harvard University, Department of Molecular & Cell Biology, and Howard Hughes Medical Institute, Cambridge, MA, Develop.  Biology

    07/1995            Ph.D., Max-Planck-Institute for Immunobiology and Albert-Ludwigs University, Freiburg, Germany, Developmental Biology

    02/1992            Diploma/Master, Albert-Ludwigs University, Freiburg, Germany, Cell & Molecular Biology

    09/1985            Diploma Biological-Technical Assistant (BTA) School, Bückeburg, Germany

    Employment

    2022 -              Chair for Applied Stem Cell and Organoid Systems, Technical University Munich (TUM)

    2022 -              Director, Center for Organoid Systems, TUM

    2022 -              Director, Institute for Diabetes and Organoid Technology, Helmholtz Center Munich

    2021                Visiting Professor, Technische Universität Dresden

    2010 - 2020      Director, UCSF Diabetes Center

    2009 - 2022      Professor, UCSF Diabetes Center, Department of Medicine

    2009 - 2022      Hurlbut-Johnson Distinguished Professorship in Diabetes Research

    2009 - 2010      Associate Director, Research, UCSF Diabetes Center

    2008                Interim Director, UCSF Diabetes Center

    2007 - 2022      Hurlbut-Johnson Endowed Chair in Diabetes Research

    2005 - 2009      Associate Professor, UCSF Diabetes Center, Department of Medicine

    1999 - 2005      Assistant Professor, UCSF Diabetes Center, Department of Medicine

    1996 - 1999      Post-doctoral Research Fellow, Howard Hughes Medical Institute and Dept. of Molecular and Cellular Biology, Harvard University, Dr. Douglas A. Melton,                                   advisor

    1995                 Post-doctoral Research Fellow, Max-Planck-Institute for Immunobiology in Freiburg, Dept. of Developmental Biology

    1992 - 1995      Graduate student, Max-Planck-Institute for Immunobiology, Freiburg, Dept. of Developmental Biology, Dr. Ernst-Martin Füchtbauer, advisor; Dr. Davor Solter,                            Head of Department

    1991 - 1992      Diploma thesis, Institute for Immunobiology, Dept. of Tumorbiology, Dr. W. Bessler, advisor

     

    Scholarships / Awards /Honors

    2021                Global Visiting Professorship, Technical University Munich

    2021                Senior Fellow, Technical University Dresden

    2021                 Sixth annual Carolyn Clifford Distinguished Lecture on Nutrition and Cancer, UC Davis

    2020                JDRF Greater Bay Area Chapter Innovation Award

    2019                Plenary lecture, AIBIS, Korean Society for Endocrinology, Seoul, Korea

    2019 -              Honorary Professor, Technical University, Dresden, Germany

    2015                Frank Brooks State of the Art Lecture, American Pancreatic Association

    2015                Gerold & Kayla Grodsky Award, Juvenile Diabetes Research Foundation

    2013 -  2015     Chair, NIH Study section, Cellular Aspects of Diabetes and Obesity (CADO)

    2006                Scholar Award, Juvenile Diabetes Research Foundation

    2004                 Guest-Professor, University of Ulm, Germany

    2000                Career Development Award, Juvenile Diabetes Foundation

    2000                Sandler Award in Basic Sciences

    1999                Sandler Program in Basic Sciences Junior Faculty Start-up Award

    1997 - 1999      Howard Hughes Medical Institute Postdoctoral Fellowship

    1996                Post-doctoral Fellowship from the German Research Society (DFG)

    1995                Post-doctoral Fellowship from the Max-Planck Society

    1994                Graduate Student Research Award of the Hoechst AG, Frankfurt

    Publications of Prof. Dr. Matthias Hebrok

    1. Biology, 2019 Feb;21(2):263-274. doi: 10.1038/s41556-018-0271-4. Epub 2019 Feb 1. PMID: 30710150. PMCID 6746427. Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M (2011): Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol. 2011 Sep;9(9):e1001143. PMCID: PMC3167782. 2. Landsman, L., Parent, A., and M. Hebrok (2011). Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. PNAS. 2011 Oct 11;108(41):17010-5. PMCID: PMC3193206. 3. Parent, A., Russ, H. A., Kahn, I., Laflam, T. N., Metzger, T. C. Anderson, M. S., and M. Hebrok (2013): Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development. Cell Stem Cell, 2013 Aug 1;13(2):219-29. doi: 10.1016/j.stem.2013.04.004. Epub 2013 May 16. PMCID: PMC3869399. 4. Puri, S., Akiyama, H., and M. Hebrok (2013): VHL-mediated disruption of Sox9 activity compromises ß-cell Identity and Results in Diabetes. Genes & Development. 2013 Dec 1;27(23):2563-75. doi: 10.1101/gad.227785.113. PMCID: PMC3861670. 5. Li, K., Zhu, S., Russ,H. A., Xu, S., Xu, T., Zhang, Y., Ma, T., Hebrok,M., and S. Ding (2014): Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell, 2014 Feb 6;14(2):228-36. doi: 10.1016/j.stem.2014.01.006. PMCID: PMC4747235. 6. Russ, H. A., Parent, A. V., Ringler, J. J., Hennings, T. G., Nair, G. G., Shveygert, M., Guo, G., Puri, S., Haataja, L., Cirulli, V., Szot, G., Arvan, P. and M. Hebrok (2015): Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro. Embo J., PMCID: PMC4516429 [Available on 2016-07-02]. 7. Puri, S., Roy, N., Russ, H. A., Leonhardt, L., Karslioglu, E., French, E. K.,Roy, R., Bengsston, H., Scott, D. K., Stewart, A. F., and M. Hebrok (2018): Replication confers ß cell immaturity. Nature Communications. Nat Commun. 2018 Feb 2;9(1):485. doi: 10.1038/s41467-018-02939-0. PMCID: PMC5797102 8. Nair, G. G., Liu, J., Russ, H. A., Tran, S., Saxton, M., Chen, R., Juang, C., Lan, M. L., Puri, S., Xing, Y., Wang, Y., Nguyen, V. Q., Szot, G., Oberholzer, J., Bhushan, A., and M. Hebrok (2019): Recapitulating endocrine cell clustering in culture promotes maturation of human stem cell-derived beta cells. Nature Cell 9. Russell, R., Carnese, P. P., Hennings, T. G., Walker, E. M., Russ, H. A., Liu, J. S., Giacometti, S., Stein, S., and M. Hebrok (2020): Loss of the transcription factor MAFB limits β-cell derivation from human PSCs. Nature Communications. 2020 Jun 2;11(1):2742. doi: 10.1038/s41467-020-16550-9. PMID: 32488111. 10. Hendley, A.M., Rao, A.A., Leonhardt, L., Ashe, S., Smith, J.A., Giacometti, S., Peng, X.L., Jiang, H., Berrios, D.I., Pawlak, M., Li, L.Y., Lee, J., Collisson, E.A., Anderson, M., Fragiadakis, G.K., Yeh, J.J., Chun, J.Y., Kim, G.E., Weaver, V.M., and M. Hebrok (2021): Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree Elife. 2021 May 19;10:e67776. doi: 10.7554/eLife.67776. PMID: 34009124. 11. Parent, A. V., Faleo, G., Jessica Chavez, J., Saxton, M., Berrios, D.I., Kerper, N.R., Qizhi Tang, Q., and M. Hebrok (2021): Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection. Cell Reports, 2021 Aug 17;36(7):109538. doi: 10.1016/j.celrep.2021.109538. PMID: 34407395. 12. Parent*, A. V., Ashe S., Nair, G. G., Li, M-L., Chavez, J., Liu, J. S., Zhong, Y., Streeter, P. R., and M. Hebrok* (2022): Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2022.02.001. PMID: 35245441. * co-corresponding authors. A list of all my PubMed publications can be found under: http://www.ncbi.nlm.nih.gov/sites/myncbi/matthias.hebrok.1/bibliography/41053582/public/?sort=date&direction=ascending

    Diana Lochner

    Assistant to the Director

    Building 3620

    Dr. Laura Leonhardt

    Scientific Strategist and Project Manager

    Building 3620, Room 109a