Woman and Diabetes
Most patients and particularly women with type-2 diabetes mellitus develop cardiovascular disease with substantial loss of life expectancy. Nonfatal cardiovascular disease contributes greatly to healthcare costs and decreased quality of life in patients with diabetes. Atherogenic dyslipidemia, high blood sugar and obesity are key contributors in people with insulin resistance, metabolic syndrome, and type-2 diabetes and is one of the strongest and independent predictors for cardiovascular disease. Unfortunately, the early stages of type-2 diabetes mellitus often go unrecognized, worsening the situation. People with obesity, particularly those referred to as ‘metabolically healthy obese,’ have a substantially higher risk of developing diabetes and its complications. This highlights that the current diagnostic methods are inadequate for capturing the heterogeneity seen in patient presentations, disease course, and response to therapy.
Our mission is to close this knowledge-gap by developing precise diagnostic tools and identifying novel and non-traditional biomarkers and treatment targets to monitor and preserve cardio-metabolic health on an individual basis using a wide range of techniques spanning biophysical chemistry, molecular biology, protein biochemistry, cell biology, multiomics and animal physiology in three metabolically important tissues.
1. Skeletal muscle and intermuscular fat (IMAT): known as a critical driver for cardio-metabolic disease and diabetes, IMAT increases with aging at an accelerated rate in men and women with diabetes. We are conducting in-depth molecular metabolic profiling of skeletal muscle and IMAT using state-of-the-art techniques such as spatial multiomics, functional microscopy, and mitochondrial bioenergetics to create an individual and detailed molecular environment profile. This profile will be correlated with the novel non-invasive imaging technique MSOT and MIROM, a photoacoustic microscopy assessment of tissue composition, to develop a non-invasive diagnostic tool for accurately assessing metabolic disease states and the impact of lifestyle interventions such as diet and exercise.
2. Circulating immune cells: chronic conditions like obesity and insulin resistance induce functional changes in immune cells, especially monocytes and T-lymphocytes, increasing their pro-inflammatory profiles. We hypothesize that certain immune cell features could potentially be used to identify non-traditional biomarkers to monitor cardio-metabolic disease and treatment response on an individual basis.
3. Central Nervous System (CNS): Specific brain regions play a crucial role in regulating major metabolic processes and cardiovascular functions. We explore neuroendocrine mechanisms that may contribute to the development of cardiometabolic diseases, aiming to uncover new therapeutic targets.
4. Microplastics: Plastic consumer products are part of modern day life and have been deemed safe and non-toxic. However, subsequent plastic waste degrades into micro- and nanoplastics (MNP) and by entering the environment accumulate in the food chain and finally in the human organism. Recent studies suggest that these plastic particles can convey genotoxocity and cytotoxicity when ingested. In addition, plastic particles release plastic chemicals and additives known to interfere with hormone signaling and lipid metabolism. We investigate the impact of micro- and nanoplastics as well as plastic chemicals on the inlammatory status of human tissues employing 3D cell cultures and organoids in combination with human primary immune cells. By combining controlled MNP exposure with spatial multiomics profiling, we aim to establish an organoid-based spatial exposome model that traces particle uptake, lysosomal retention, and intracellular degradation, linking MNP and polymer-derived metabolites to spatial molecular signatures of cellular dysfunction. It is our aim to better characterize the impact of plastics on human metabolism and their contribution to metabolic dieseases and find new therapeutic ways to better treat the chronic inflammation often caused by these diseases.
By advancing our understanding in these key areas, we strive to improve the quality of life and life expectancy for individuals with type-2 diabetes mellitus, ultimately reducing the healthcare costs associated with nonfatal cardiovascular diseases.
Personal Assistant IDR-H, budget and project coordinator
Scientific Manager and Coordinator IDR-H
TA
PhD Student
TA
Post Doc
PhD Student
Postdoc
PhD Student - Woman and Diabetes
PhD (medical) student
Publications
Schrenk, M. ; Nowak, E. ; Vogel, F. ; Krüger, L. ; Stüfchen, I. ; Oettle, M. ; Apaydin, T. ; Bobrowicz, M. ; Bidlingmaier, M. ; García-Angarita, N. ; Hofmann, S.M. ; Dinges, S.M.-T. ; Reisch, N. ; Siebenbürger, G. ; Halle, M. ; Reincke, M. ; Schoser, B.
Myopathy in endogenous Cushing’s Syndrome: Type II muscle fiber atrophy and its association with age and circulating IGF-1.Chen, B. ; Prabhu, A. ; Guo, L. ; Kaltenbach, A. ; Wang, Y. ; Shakir, G. ; Natarelli, L. ; Megens, R.T.A. ; Jansen, Y. ; Ramanathan, S. ; Geiger, M. ; Faußner, A. ; Hristov, M. ; Richter, D. ; Di, X. ; Stelt, M.v.d. ; Triantafyllidou, V. ; Li, Z. ; Sachs, N. ; Paloschi, V. ; Mäegdefessel, L. ; Hofmann, S.M. ; Schifferer, M. ; Simons, M. ; Weber, C. ; Santovito, D. ; Herzig, S. ; Guillamat‐Prats, R. ; Steffens, S.
Endothelial cannabinoid CB1 receptor deficiency reduces shear stress-induced arterial inflammation and lipid uptake.Dinges, S.M.-T. ; Schwedhelm, E. ; Baldassarri, F. ; Haller, B. ; Gevaert, A.B. ; Böger, R. ; Winzer, E.B. ; Edelmann, F. ; Wisløff, U. ; Adams, V. ; Pieske, B. ; Van Craenenbroeck, E.M. ; Halle, M. ; Hofmann, S.M. ; Mueller-Stegner, S.
Circulating nitric oxide pathway metabolites in heart failure with preserved ejection fraction: A sex-stratified cross-sectional analysis.Singh, I. ; Onogi, Y. ; Cardoso Micu Menezes, F.M. ; Khasanova, D. ; Kang, L. ; Wang, C. ; Ruiz-Trave, J. ; Sharma, S. ; Khalil, A. ; Reichenbach, V.K. ; Shi, Y. ; Flatley, A. ; Yan, X. ; Israel, A. ; Dragano, N.R.V. ; Aguilar-Pimentel, J.A. ; Hoffmann, A. ; Ghosh, A. ; Noé, F. ; Wolfrum, C. ; Cucuruz, S. ; König, A.-C. ; Burtscher, I. ; Hauck, S.M. ; Lickert, H. ; Hofmann, S.M. ; Feederle, R. ; Schriever, S.C. ; Hernandez-Bautista, R. ; Sancar, G. ; Cebrian Serrano, A. ; Tetko, I.V. ; Fuchs, H. ; Gailus-Durner, V. ; Blüher, M. ; Hrabě de Angelis, M. ; Ussar, S.
NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo.Hofmann, S.M.
Geschlechtersensible Aspekte von Diabetes mellitus Typ 2.Präzisionsmedizin der Zukunft in der Diabetologie.Sachs, S. ; Götz, A. ; Finan, B. ; Feuchtinger, A. ; DiMarchi, R.D. ; Döring, Y. ; Weber, C. ; Tschöp, M.H. ; Müller, T.D. ; Hofmann, S.M.
Correction: GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease.Huang, S. ; He, H. ; Tom, R.Z. ; Glasl, S. ; Anzenhofer,P. ; Stiel, A.-C. ; Hofmann, S.M. ; Ntziachristos, V.
Non-invasive optoacoustic imaging of dermal microcirculatory revascularization in diet-induced obese mice undergoing exercise intervention.Seeland, U. ; Hofmann, S.M.
Leitbilder und Forschung in der Geschlechtersensiblen Medizin.Akindehin, S.E. ; Liskiewicz, A. ; Liskiewicz, D. ; Bernecker, M. ; García-Cáceres, C. ; Drucker, D.J. ; Finan, B. ; Grandl, G. ; Gutgesell, R.M. ; Hofmann, S.M. ; Khalil, A. ; Liu, X. ; Cota, P. ; Bakhti, M. ; Czarnecki, O. ; Bastidas-Ponce, A. ; Lickert, H. ; Kang, L. ; Maity-Kumar, G. ; Novikoff, A. ; Parlee, S. ; Pathak, E. ; Schriever, S.C. ; Sterr, M. ; Ussar, S. ; Zhang, Q. ; DiMarchi, R. ; Tschöp, M.H. ; Pfluger, P.T. ; Douros, J.D. ; Müller, T.D.
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.Liskiewicz, A. ; Khalil, A. ; Liskiewicz, D. ; Novikoff, A. ; Grandl, G. ; Maity-Kumar, G. ; Gutgesell, R.M. ; Bakhti, M. ; Bastidas-Ponce, A. ; Czarnecki, O. ; Makris, K. ; Lickert, H. ; Feuchtinger, A. ; Tost, M. ; Coupland, C. ; Ständer, L. ; Akindehin, S.E. ; Prakash, S. ; Abrar, F. ; Castelino, R.L. ; He, Y. ; Knerr, P.J. ; Yang, B. ; Hogendorf, W.F.J. ; Zhang, S. ; Hofmann, S.M. ; Finan, B. ; DiMarchi, R.D. ; Tschöp, M.H. ; Douros, J.D. ; Müller, T.D.
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.Becker, M. ; Joseph, S.S. ; Garcia-Carrizo, F. ; Tom, R.Z. ; Opaleva, D. ; Serr, I. ; Tschöp, M.H. ; Schulz, T. ; Hofmann, S.M. ; Daniel, C.
Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration.Sachs, S. ; Götz, A. ; Finan, B. ; Feuchtinger, A. ; DiMarchi, R.D. ; Döring, Y. ; Weber, C. ; Tschöp, M.H. ; Müller, T.D. ; Hofmann, S.M.
GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease.Alfaro, A.J. ; Dittner, C. ; Becker, J. ; Loft, A. ; Mhamane, A. ; Maida, A. ; Georgiadi, A. ; Tsokanos, F.-F. ; Klepac, K. ; Molocea, C.-E. ; El-Merahbi, R. ; Motzler, K. ; Geppert, J. ; Karikari, R.A. ; Szendrödi, J. ; Feuchtinger, A. ; Hofmann, S.M. ; Karaca, S. ; Urlaub, H. ; Berriel Diaz, M. ; Melchior, F. ; Herzig, S.
Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism.Lutter, D. ; Sachs, S. ; Walter, M.C. ; Kerege, A. ; Perreault, L. ; Kahn, D.E. ; Wolide, A.D. ; Kleinert, M. ; Bergman, B.C. ; Hofmann, S.M.
Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response.Fasoula, N.-A. ; Karlas, A. ; Prokopchuk, O. ; Katsouli, N. ; Bariotakis, M. ; Liapis, E. ; Götz, A. ; Kallmayer, M. ; Reber, J. ; Novotny, A. ; Friess, H. ; Ringelhan, M. ; Schmid, R. ; Eckstein, H.H. ; Hofmann, S.M. ; Ntziachristos, V.
Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis.Ali, H. ; Abu-Farha, M. ; Hofmann, S.M.
Editorial: COVID-19 and diabetes, volume II.Maity-Kumar, G. ; Ständer, L. ; de Angelis, M. ; Lee, S. ; Molenaar, A. ; Becker, L. ; Garrett, L. ; Amarie, O.V. ; Hölter, S.M. ; Wurst, W. ; Fuchs, H. ; Feuchtinger, A. ; Gailus-Durner, V. ; García-Cáceres, C. ; Othman, A.E. ; Brockmann, C. ; Schöffling, V.I. ; Beiser, K. ; Krude, H. ; Mroz, P.A. ; Hofmann, S.M. ; Tuckermann, J. ; DiMarchi, R.D. ; Hrabě de Angelis, M. ; Tschöp, M.H. ; Pfluger, P.T. ; Müller, T.D.
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome.Quarta, C. ; Stemmer, K. ; Novikoff, A. ; Yang, B. ; Klingelhuber, F. ; Harger, A. ; Bakhti, M. ; Bastidas-Ponce, A. ; Baugé, E. ; Campbell, J.E. ; Capozzi, M.E. ; Clemmensen, C. ; Collden, G. ; Cota, P. ; Douros, J. ; Drucker, D.J. ; Dubois, B. ; Feuchtinger, A. ; García-Cáceres, C. ; Grandl, G. ; Hennuyer, N. ; Herzig, S. ; Hofmann, S.M. ; Knerr, P.J. ; Kulaj, K. ; Lalloyer, F. ; Lickert, H. ; Liskiewicz, A. ; Liskiewicz, D. ; Maity-Kumar, G. ; Perez-Tilve, D. ; Prakash, S. ; Sanchez-Garrido, M.A. ; Zhang, Q. ; Staels, B. ; Krahmer, N. ; DiMarchi, R.D. ; Tschöp, M.H. ; Finan, B. ; Müller, T.D.
GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.Abu-Farha, M. ; Hofmann, S.M. ; Ali, H.
Editorial: Covid-19 and diabetes.Hofmann, S.M. ; Landgraf, R.
Research in metabolic ageing - a tale of mice versus humans?Contact