Publications of Johannes Beckers
2024 Scientific Article in Thorax Thorax 79, 524-537 (2024)
COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.
2024 Scientific Article in Respiratory Research Respir. Res. 25:49 (2024)
Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air-liquid interface.
2024 Scientific Article in European Respiratory Journal Eur. Respir. J. 63:2301326 (2024)
Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts.
2024 Scientific Article in Physiological reports Physiol. Rep. 12:e15901 (2024)
LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.
2023 Scientific Article in Neuroscience Applied Neurosci. App. 2:101126 (2023)
GPR101 loss promotes insulin resistance and diet-induced obesity risk.
2023 Scientific Article in The Lancet Public Health Lancet Public Health 8, e453-e462 (2023)
Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: A population-based cohort study using electronic health records.
2023 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 109, 1318-1327 (2023)
Skeletal muscle gene expression signatures of obese high- and low- responders to endurance exercise training.
2023 Scientific Article in American Journal of Physiology - Cell Physiology Am. J. Physiol.-Cell Physiol. 325, C1131-C1143 (2023)
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes.
2023 Scientific Article in ACS Nano ACS Nano 17, 21056-21072 (2023)
Nanoparticle-exposure-triggered virus reactivation induces lung emphysema in mice.
2023 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 32, 2717-2734 (2023)
Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria.
2023 Scientific Article in Molecular Metabolism Mol. Metab. 75:101774 (2023)
Differences in DNA methylation of HAMP in blood cells predicts the development of type 2 diabetes.
2023 Scientific Article in International Journal of Obesity Int. J. Obes. 47, 313-324 (2023)
Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: A matched transcriptomics approach after 8-week training-intervention.
2022 Scientific Article in Diabetes Care Diabetes Care 45, 2892–2899 (2022)
Diabetes and obesity in down syndrome across the lifespan: A retrospective cohort study using U.K. electronic health records.
2022 Scientific Article in Scientific Reports Sci. Rep. 12:16396 (2022)
Insight into the pulmonary molecular toxicity of heated tobacco products using human bronchial and alveolar mucosa models at air-liquid interface.
2022 Scientific Article in Cells Cells 11:3289 (2022)
Dendritic cells or macrophages? The microenvironment of human clear cell renal cell carcinoma imprints a mosaic myeloid subtype associated with patient survival.
2022 Scientific Article in EMBO Reports EMBO Rep.:e54078 (2022)
A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis.
2022 Scientific Article in Cells Cells 11:520 (2022)
Innate immune pathways promote oligodendrocyte progenitor cell recruitment to the injury site in adult Zebrafish brain.
2022 Scientific Reports Sci. Rep. 12:6793 (2022)
Author Correction: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin (Scientific Reports, (2018), 8, 1, (1366), 10.1038/s41598-018-19200-9).
2022 Scientific Article in Biomedicines Biomedicines 10:616 (2022)
Bezafibrate reduces elevated hepatic fumarate in insulin-deficient mice.
2022 Nature Genetics Nat. Genet. 54, 358-360 (2022)
EMPReSS: Standardized phenotype screens for functional annotation of the mouse genome (vol 37, pg 1155, 2005).
2021 Scientific Article in Science Advances Sci. Adv. 7:eabb3673 (2021)
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.
2021 Scientific Article in Viruses Viruses 13:2537 (2021)
Differential effect of SARS-CoV-2 spike glycoprotein 1 on human bronchial and alveolar lung mucosa models: Implications for pathogenicity.
2021 Scientific Article in Cells Cells 10:3443 (2021)
Tgf-β induction of mir-143/145 is associated to exercise response by influencing differentiation and insulin signaling molecules in human skeletal muscle.
2021 Scientific Article in Molecular Metabolism Mol. Metab. 54:101359 (2021)
Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability.
2021 Scientific Article in Nature metabolism Nat. Metab. 3, 1202-1216 (2021)
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice.
2021 Nature Cell Biology Nat. Cell Biol., DOI: 10.1038/s41556-021-00735-5 (2021)
Publisher Correction: Epithelial cell plasticity drives endoderm formation during gastrulation.
2021 Scientific Article in Molecular Metabolism Mol. Metab. 53, 101295 (2021)
Correlation guided Network Integration (CoNI) reveals novel genes affecting hepatic metabolism.
2021 Scientific Article in Nature Cell Biology Nat. Cell Biol. 23, 692-703 (2021)
Epithelial cell plasticity drives endoderm formation during gastrulation.
2021 Scientific Article in Diabetes Aktuell Diabetes akt. 19, 62-65 (2021)
Einfluss von Genetik und Epigenetik auf die Entstehung von Diabetes.
2021 Scientific Article in Diabetologia Diabetologia 64, 1850-1865 (2021)
HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling.
2021 Nature Cell Biology Nat. Cell Biol. 23, 566-576 (2021)
Author Correction: Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates.
2021 Nature Nature 592:E1 (2021)
Author Correction: Inceptor counteracts insulin signalling in β-cells to control glycaemia.
2021 Nature Nature 589, E6 (2021)
Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung (Nature, (2020), 588, 7836, (151-156), 10.1038/s41586-020-2882-8).
2021 Scientific Article in Nature Nature 590, 326–331 (2021)
Inceptor counteracts insulin signalling in β-cells to control glycaemia.
2021 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med.:e12461 (2021)
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.
2021 Scientific Article in Cell Reports Cell Rep. 34:108748 (2021)
Dynamic adoption of anergy by antigen-exhausted CD4+ T cells.
2021 Scientific Article in Nature Cell Biology Nat. Cell Biol. 23, 23-31 (2021)
Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates.
2021 Scientific Article in PLoS Genetics PLoS Genet. 16:e1009190 (2021)
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
2020 Scientific Article in Frontiers in Immunology Front. Immunol. 11:606338 (2020)
Specific induction of double negative B cells during protective and pathogenic immune responses.
2020 Scientific Article in Nature Nature 588, 151–156 (2020)
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
2020 Scientific Article in Advanced materials Adv. Mater. 32:e2003913 (2020)
Prediction of chronic inflammation for inhaled particles: The impact of material cycling and quarantining in the lung epithelium.
2020 Scientific Article in Frontiers in cell and developmental biology Front. Cell Dev. Biol. 8:587778 (2020)
Dose-dependent and subset-specific regulation of midbrain dopaminergic neuron differentiation by LEF1-mediated WNT1/b-catenin signaling.
2020 Scientific Article in Communications Biology Comm. Biol. 3:628 (2020)
PAX6 mutation alters circadian rhythm and beta cell function in mice without affecting glucose tolerance.
2020 Scientific Article in International Journal of Cancer Int. J. Cancer 147, 3523-3538 (2020)
miR-34a is upregulated in AIP-mutated somatotropinomas and promotes octreotide resistance.
2020 Scientific Article in Royal Society Open Science R. Soc. Open Sci. 7:200701 (2020)
Ectopic fat accumulation in human astrocytes impairs insulin action.
2020 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 130, 6093-6108 (2020)
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
2020 Editorial in Mammalian Genome Mamm. Genome, DOI: 10.1007/s00335-020-09843-3 (2020)
Introduction to mammalian genome special issue: Epigenetics.
2020 Scientific Article in Particle and Fibre Toxicology Part. Fibre Toxicol. 17:27 (2020)
Influence of wood species on toxicity of log-wood stove combustion aerosols: A parallel animal and air-liquid interface cell exposure study on spruce and pine smoke.
2020 Scientific Article in Nature Biotechnology Nat. Biotechnol. 38, 1061–1072 (2020)
Generation of pancreatic β cells from CD177+ anterior definitive endoderm.
2020 Review in Mammalian Genome Mamm. Genome 31, 119–133 (2020)
Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations.
2020 Scientific Article in Mammalian Genome Mamm. Genome 31, 30-48 (2020)
A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.
In: Beyond Our Genes. 2020. 175-208
The (not so) controversial role of DNA methylation in epigenetic inheritance across generations.
2019Poster: Intestinal organoids - from stem cells to metabolism and microbiome interactions, 29 September 2019, Kopenhagen. (2019)
Gradual pioneer factor expression resolves enteroendocrine lineage recruitment from intestinal stem cells.
2019 Scientific Article in Haematologica - The Hematology Journal Haematologica 105, 2484-2495 (2019)
Murine tissue actor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality.
2019 Scientific Article in Fluids and barriers of the CNS Fluids barriers CNS 16:30 (2019)
Claudin-12 is not required for blood-brain barrier tight junction function.
2019 Scientific Article in Stem cell research & therapy Stem Cell Res. Ther. 10:218 (2019)
Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability.
2019 Scientific Article in Bioinformatics Bioinformatics 35, 4834-4836 (2019)
DEUS: An R package for accurate small RNA profiling based on differential expression of unique sequences.
2019 Scientific Article in EBioMedicine EBioMedicine 43, 562-575 (2019)
The Notch ligand DNER regulates macrophage IFN gamma release in chronic obstructive pulmonary disease.
2019 Scientific Article in Experimental Eye Research Exp. Eye Res. 188:107632 (2019)
Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.
2019 Scientific Article in Molecular Metabolism Mol. Metab. 24, 80-97 (2019)
Point mutations in the PDX1 transactivation domain impair human beta-cell development and function.
2018 Scientific Article in Cell Reports Cell Rep. 25, 3241-3251.e5 (2018)
The aryl hydrocarbon receptor pathway defines the time frame for restorative neurogenesis.
2018 Meeting abstract in Diabetologia Diabetologia 61, S259-S259 (2018)
Interindividual susceptibility to type 2 diabetes in mice: Hepatic transcriptome and DNA methylome profiling.
2018 Scientific Article in Nutrients Nutrients 10:547 (2018)
A vitamin E-enriched antioxidant diet interferes with the acute adaptation of the liver to physical exercise in mice.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:7547 (2018)
Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner.
2018 Scientific Article in Molecular Metabolism Mol. Metab. 9, 57-68 (2018)
Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.
2018 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 10:e8349 (2018)
Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.
2018 Review in Environment International Environ. Int. 114, 77-86 (2018)
Epigenetics as a mechanism linking developmental exposures to long-term toxicity.
2018 Scientific Article in Nature Communications Nat. Commun. 9:288 (2018)
Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
2018 Scientific Article in Scientific Reports Sci. Rep. 8:1366 (2018)
Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin.
2018 Review in Nature Reviews - Endocrinology Nat. Rev. Endocrinol. 14, 140-162 (2018)
Animal models of obesity and diabetes mellitus.
2018 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 25, 145-162 (2018)
Characterization of neuroendocrine tumors in heterozygous mutant MENX rats: A novel model of invasive medullary thyroid carcinoma.
2018 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 138, 141-149 (2018)
MSX1-induced neural crest-like reprogramming promotes melanoma progression.
2018 Scientific Article in International Journal of Obesity Int. J. Obes. 42, 507-517 (2018)
A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue.
2018 Scientific Article in Journal of Investigative Dermatology, The J. Invest. Dermatol. 138, 179-188 (2018)
The role of Fibroblast growth factor binding protein 1 in skin carcinogenesis and inflammation.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:15453 (2017)
Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.
2017 Scientific Article in Nature Communications Nat. Commun. 8:886 (2017)
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
2017 Scientific Article in Behavioural Brain Research Behav. Brain Res. 352, 187-196 (2017)
Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.
2017 Scientific Article in Journal of Biomedical Science J. Biomed. Sci. 24:57 (2017)
Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1I27N mutant mice.
2017 Scientific Article in Thorax Thorax 72, 1007-1020 (2017)
Pulmonary CCR2+CD4+ T cells are immune regulatory and attenuate lung fibrosis development.
2017 Scientific Article in Respiratory Research Respir. Res. 18:152 (2017)
Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function.
2017 Scientific Article in Diabetes Aktuell Diabetes akt. 15, 104-107 (2017)
Ernährungsgewohnheiten schlagen sich im Erbgut nieder.
2017 Scientific Article in Nature Communications Nat. Commun. 8:15475 (2017)
Prevalence of sexual dimorphism in mammalian phenotypic traits.
2017 Scientific Article in Immunology Immunology 152, 402-413 (2017)
microRNA cluster 106a~363 is involved in T-Helper 17 (Th17) cell differentiation.
2017 Scientific Article in Journal of Theoretical Biology J. Theor. Biol. 430, 32-44 (2017)
Modeling coexistence of oscillation and Delta/Notch-mediated lateral inhibition in pancreas development and neurogenesis.
2017 Meeting abstract in Glia Glia 65, E401-E401 (2017)
Proliferation and neural stem cell potential of diencephalic astrocytes revealed by genome-wide expression analysis is Smad4-dependent.
2017 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 195 (2017)
2d cross-omics integrated enrichment analysis of human and mice COPD lungs reveal novel pathological mechanisms of disease progression.
2017 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 195 (2017)
Deficiency of immunoproteasome subunits increases alternative polarization of alveolar macrophages.
2017 Meeting abstract in Molecular and Cellular Pediatrics Mol. Cell. Pediatr. 4, 1:5 (2017)
Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.
2017 Scientific Article in Scientific Reports Sci. Rep. 7:2397 (2017)
Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.
2017 Scientific Article in Particle and Fibre Toxicology Part. Fibre Toxicol. 14:2 (2017)
Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection.
2017 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 127, 695-708 (2017)
Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance.
2017 Scientific Article in PLoS ONE PLoS ONE 12:e0169223 (2017)
Maternal pre-pregnancy obesity is associated with altered placental transcriptome.
2017 Scientific Article in Disease Models and Mechanisms Dis. Model. Mech. 10, 163-171 (2017)
Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology.
2017 Scientific Article in Endocrine-Related Cancer Endocr. Relat. Cancer 24, 1-15 (2017)
Targeting PI3K/mTOR signaling exerts potent antitumor activity in pheochromocytoma in vivo.
2017 Scientific Article in Nature Chemical Biology Nat. Chem. Biol. 13, 91-98 (2017)
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.
2016 Meeting abstract in Diabetologia Diabetologia 59, S259-S259 (2016)
Systemic metabolic effects exerted by a point mutation in the RED subdomain of PAX6.
2016 Meeting abstract in Diabetologia Diabetologia 59, S188-S188 (2016)
Dll1-and Dll4-mediated Notch signalling in adult pancreatic beta cells is essential for the structural integrity of islets and maintenance of glucose homeostasis.
2016 Meeting abstract in Diabetologia Diabetologia 59, S47-S47 (2016)
miRNA signatures in maternal whole blood cells of women with gestational diabetes.
2016 Letter to the Editor in Obstetrical & gynecological survey Obstet. Gynecol. Surv. 71, 719-720 (2016)
Epigenetic germline inheritance of diet-induced obesity and insulin resistance.
2016 Meeting abstract in American Journal of Respiratory and Critical Care Medicine Am. J. Respir. Crit. Care Med. 193 (2016)
Mouse lung developmental gene expression profiling study identifies novel candidate genes for pulmonary function.
2016 Scientific Article in Nature medicine Nat. Med. 22, 1428-1438 (2016)
Cardioprotection and lifespan extension by the natural polyamine spermidine.
2016 Scientific Article in Genes Genomes Genetics G3 Genes Genomes Genetics G3 6, 4035-4046 (2016)
The first Scube3 mutant mouse line with pleiotropic phenotypic alterations.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0164298 (2016)
Sphingomyelin synthase 1 is essential for male fertility in mice.
2016 Scientific Article in Gut (eGut) Gut 67, 146-156 (2016)
Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy.
2016 Scientific Article in Archives of Physiology and Biochemistry Arch. Physiol. Biochem. 122, 281-288 (2016)
Impact of fibroblast growth factor 21 on the secretome of human perivascular preadipocytes and adipocytes: A targeted proteomics approach.
2016 Scientific Article in Nature Nature 535, 430-434 (2016)
Identification of proliferative and mature β-cells in the islets of Langerhans.
2016 Scientific Article in Diabetes Diabetes 65, 2849-2861 (2016)
TGFβ contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle.
2016 Meeting abstract in Cancer Research Cancer Res. 76:P1-06-02 (2016)
A force-sensitive organoid assay to quantify regenerative potential of single primary human mammary cells.
2016 Scientific Article in Diabetes Diabetes 65, 2540-2552 (2016)
Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice.
2016 Nature Communications Nat. Commun. 7:11835 (2016)
Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0152996 (2016)
CIP2A promotes T-cell activation and immune response to Listeria monocytogenes infection.
2016 Scientific Article in Nature Communications Nat. Commun. 7:11317 (2016)
Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
2016 Scientific Article in PLoS ONE PLoS ONE 11:e0150472 (2016)
Generation and standardized, systemic phenotypic analysis of Pou3f3L423P mutant mice.
2016 Scientific Article in Cell Death and Differentiation Cell Death Differ. 23, 1026-1037 (2016)
Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages.
2016 Scientific Article in Nature Genetics Nat. Genet. 48, 497-499 (2016)
Epigenetic germline inheritance of diet-induced obesity and insulin resistance.
2016 Scientific Article in Journal of Inherited Metabolic Disease J. Inherit. Metab. Dis. 39, 309-319 (2016)
Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
2016 Scientific Article in Cell Stem Cell Cell Stem Cell 18, 396-409 (2016)
Identification and successful negotiation of a metabolic checkpoint in direct neuronal repogramming.
2016 Scientific Article in Mechanisms of Development Mech. Dev. 139, 51-64 (2016)
The global gene expression profile of the secondary transition during pancreatic development.
2016 Scientific Article in Gut (eGut) Gut 65, 647-657 (2016)
A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling.
2015 Scientific Article in Mammalian Genome Mamm. Genome 27, 17-28 (2015)
Dexamethasone treatment alters insulin, leptin, and adiponectin levels in male mice as observed in DIO but does not lead to alterations of metabolic phenotypes in the offspring.
2015 Scientific Article in Journal of Neuroscience J. Neurosci. 35, 13385-13401 (2015)
Dickkopf3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse.
2015 Scientific Article in Archives of Biochemistry and Biophysics Arch. Biochem. Biophys. 589, 93-107 (2015)
Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis.
2015 Scientific Article in PLoS ONE PLoS ONE 10:e0134503 (2015)
Cox4i2, Ifit2, and Prdm11 mutant mice: Effective selection of genes predisposing to an altered airway inflammatory response from a large compendium of mutant mouse lines.
2015 Scientific Article in Glia Glia 63, 2340-2361 (2015)
Astrocyte reactivity after brain injury - the role of galectins 1 and 3.
2015 Scientific Article in PLoS Genetics PLoS Genet. 11:e1005423 (2015)
SLIRP regulates the rate of mitochondrial protein synthesis and protects LRPPRC from degradation.
2015 Scientific Article in Scientific Reports Sci. Rep. 5:12673 (2015)
Validated prediction of pro-invasive growth factors using a transcriptome-wide invasion signature derived from a complex 3D invasion assay.
2015 Scientific Article in Genome Research Genome Res. 25, 1295-1308 (2015)
Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers.
2015 Scientific Article in Cell Stem Cell Cell Stem Cell 17, 74-88 (2015)
Transcriptional mechanisms of proneural factors and REST in regulating neuronal reprogramming of astrocytes.
2015 Scientific Article in Diabetologia Diabetologia 58, 1845-1854 (2015)
Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery.
2015 Scientific Article in Development / Company of Biologists Development 142, 3239-3251 (2015)
Quantification of regenerative potential in primary human mammary epithelial cells.
2015 Scientific Article in Diabetes Aktuell Diabetes akt. 13, 72-74 (2015)
Epigenetische Vererbung - ist die Zukunft diabetisch?
2015 Review in Glia Glia 63, 1452-1468 (2015)
Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and genome-wide expression analysis.
2015 Meeting abstract in Journal of Investigative Dermatology, The J. Invest. Dermatol. 135, S111 (2015)
MSX1-induced neural crest-like reprograming promotes melanoma progression.
2015 Scientific Article in Molecular Metabolism Mol. Metab. 4, 519-527 (2015)
Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes.
2015 Scientific Article in Circulation Circulation 131, 1191-1201 (2015)
ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling via cleavage of thrombospondin-1.
2015 Editorial in BioSpektrum BioSpektrum 21, 20-21 (2015)
Vererbung von Merkmalen außerhalb der primären Sequenz der DNA.
2015 Scientific Article in Cell Reports Cell Rep. 10, 131-139 (2015)
Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation.
2015 Scientific Article in Diabetologia Diabetologia 58, 374-383 (2015)
Nutritional strategy to prevent fatty liver and insulin resistance independent from obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice.
2015 Scientific Article in Mammalian Genome Mamm. Genome 26, 33-42 (2015)
Generation of mice lacking DUF1220 protein domains: Effects on fecundity and hyperactivity.
2015 Scientific Article in Diabetes Diabetes 64, 284-290 (2015)
Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice.
2015 Scientific Article in Neuropsychopharmacology Neuropsychopharmacology 40, 338-349 (2015)
Differential and converging molecular mechanisms of antidepressants' action in the hippocampal dentate gyrus.
2014 Meeting abstract in Experimental and Clinical Endocrinology & Diabetes Exp. Clin. Endocrinol. Diabet. 122:OP4_11 (2014)
FGF21 inhibits adiponectin secretion in human adipocytes.
2014 Scientific Article in PLoS ONE PLoS ONE 9:e113125 (2014)
Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: Renal transcriptome studies in mouse models of uromodulin-associated kidney disease.
2014 Scientific Article in Cell Reports Cell Rep. 9, 1292-1305 (2014)
Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.
2014 Scientific Article in International Journal of Cancer Int. J. Cancer 136, 2293-2303 (2014)
MiR-34a deficiency accelerates medulloblastoma formation in vivo.
2014 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 10:e1003843 (2014)
Fast synchronization of ultradian oscillators controlled by Delta-Notch signaling with Cis-inhibition.
2014 Meeting abstract in Allergy Allergy 69, 365 (2014)
In utero cigarette smoke exposure affects foetal pulmonary signalling networks in a murine model.
2014 Scientific Article in American Journal of Physiology - Lung Cellular and Molecular Physiology Am. J. Physiol. Lung Cell Mol. Physiol. 307, L692-L706 (2014)
Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD.
2014 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 23, 5597-5614 (2014)
Peroxidasin is essential for eye development in the mouse.
2014 Scientific Article in Journal of Immunology J. Immunol. 192, 3507-3517 (2014)
Differential kinetics of antigen dependency of CD4+ and CD8+ T cells.
2014 Scientific Article in Molecular Biotechnology : MB Online Mol. Biotechnol. 56, 697-713 (2014)
Simple derivation of transgene-free iPS cells by a dual recombinase approach.
2014 Scientific Article in Genome Research Genome Res. 24, 592-603 (2014)
Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.
2014 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 289, 10769-10784 (2014)
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
2014 Scientific Article in Journal of Hepatology J. Hepatol. 60, 816-823 (2014)
Liver adapts mitochondrial function to insulin resistant and diabetic states in mice.
2013 Meeting abstract in Pancreas Pancreas 42, 1360-1361 (2013)
Identification and characterization of an Aldh1a3-positive subtype of pancreatic ductal adenocarcinoma mediated by oncogenic Krasg12d/Erk-Mtor axis.
2013 Meeting abstract in Diabetologia Diabetologia 56, S267 (2013)
High glycaemic index (GI) diet induced hepatic fat accumulation and insulin resistance is associated with high glucose-dependent insulinotropic polypeptide (GIP) secretion.
2013 Scientific Article in International Journal of Developmental Biology Int. J. Dev. Biol. 57, 741-751 (2013)
Pitx3 directly regulates Foxe3 during early lens development.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e81833 (2013)
Prdm6 is essential for cardiovascular development in vivo.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e78337 (2013)
Standardized, systemic phenotypic analysis of UmodC93F and UmodA227T mutant mice.
2013 Scientific Article in American Journal of Physiology - Cell Physiology Am. J. Physiol.-Cell Physiol. 305, C877-C886 (2013)
Cytokine response of primary human myotubes in an in vitro exercise model.
2013 Scientific Article in Biochimica et Biophysica Acta - Proteins and Proteomics Biochim. Biophys. Acta-Proteins Proteom. 1844, 1011-1017 (2013)
Secretome profiling of primary human skeletal muscle cells.
2013 Scientific Article in Molecular Metabolism Mol. Metab. 2, 435-446 (2013)
Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis.
2013 Scientific Article in Cell Stem Cell Cell Stem Cell 13, 403-418 (2013)
The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network.
2013 Scientific Article in Journal of Clinical Investigation J. Clin. Invest. 123, 3272-3291 (2013)
Rapamycin extends murine lifespan but has limited effects on aging.
2013 Scientific Article in PLoS ONE PLoS ONE 8:e64544 (2013)
Identification of C/EBPβ target genes in ALK+ Anaplastic Large Cell Lymphoma (ALCL) by gene expression profiling and chromatin immunoprecipitation.
2013 Scientific Article in Acta Neuropathologica Acta Neuropathol. 126, 137-150 (2013)
Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas.
2013 Scientific Article in EMBO Molecular Medicine EMBO Mol. Med. 5, 919-934 (2013)
The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival.
2013 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The J. Clin. Endocrinol. Metab. 98, E1137-E1142 (2013)
Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors.
2013 Scientific Article in Cell Cell 153, 535-549 (2013)
Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate.
2013 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 288, 16690-16703 (2013)
High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.
2013 Scientific Article in Translational Psychiatry Transl. Psychiatry 3:e229 (2013)
A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults.
2013 Scientific Article in Systembiologie.de Systembiologie.de 6, 16-19 (2013)
Wer hat an der Uhr gedreht? Regulationsmechanismen der Segmentierung im Wirbeltierembryo.
2013 Scientific Article in DNA Repair DNA Repair 12, 356-366 (2013)
SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.
2013 Scientific Article in Development / Company of Biologists Development 140, 1123-1136 (2013)
Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation.
2013 Scientific Article in Cellular and Molecular Life Sciences - CMLS Cell. Mol. Life Sci. 70, 1637-1651 (2013)
Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells.
2013 Scientific Article in Development / Company of Biologists Development 140, 1055-1066 (2013)
The transcription factor Otx2 regulates choroid plexus development and function.
2012 Scientific Article in Journal of natural medicines J. Nat. Med. 18, 1847-1856 (2012)
Targeted estrogen delivery reverses the metabolic syndrome.
2012 Scientific Article in FASEB Journal FASEB J. 26, 5081-5091 (2012)
The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis.
2012 Scientific Article in Mammalian Genome Mamm. Genome 23, 611-622 (2012)
Innovations in phenotyping of mouse models in the German Mouse Clinic.
2012 Scientific Article in PLoS ONE PLoS ONE 7:e44609 (2012)
In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis.
In: Suhre, K.* [Eds.]: Genetics Meets Metabolomics: from Experiment to Systems Biology. Springer, 2012. 85-106
Mouse genetics and metabolic mouse phenotyping.
2012 Scientific Article in Human Molecular Genetics Hum. Mol. Genet. 21, 3535-3545 (2012)
Cardiopulmonary dysfunction in the osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms.
2012 Scientific Article in Acta Neuropathologica Acta Neuropathol. 124, 187-197 (2012)
Long-term proteasomal inhibition in transgenic mice by UBB+1 expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients.
2012 Scientific Article in PLoS Computational Biology PLoS Comput. Biol. 8:e1002586 (2012)
From dynamic expression patterns to boundary formation in the presomitic mesoderm.
2012 Scientific Article in Cancer Genetics Cancer Genet. 205, 212-219 (2012)
MicroRNA profiling with correlation to gene expression revealed the oncogenic miR-17-92 cluster to be up-regulated in osteosarcoma.
2012 Scientific Article in Cellular Reprogramming Cell. Reprogramm. 14, 68-78 (2012)
Comparative analysis of nuclear transfer embryo-derived mouse embryonic stem cells. Part II: Gene regulation.
2011 Scientific Article in Respiratory Research Respir. Res. 12, 94 (2011)
Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation.
2011 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 286, 18614-18622 (2011)
Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice.
2011 Scientific Article in PLoS ONE PLoS ONE 6:e18195 (2011)
Integration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner ear.
2011 Scientific Article in FASEB Journal FASEB J. 25, 937-947 (2011)
Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling.
2011 Scientific Article in Glia Glia 59, 821-832 (2011)
GDNF-induced osteopontin from Müller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration.
2011 Scientific Article in Blood Blood 117, 519-529 (2011)
Immune modulation by Fas ligand reverse signaling: Lymphocyte proliferation is attenuated by the intracellular Fas ligand domain.
2011 Review in Methods Methods 53, 120-135 (2011)
Mouse phenotyping.
2010Vortrag: 8th ERS Lung Science Conference 2010, 26-28 March 2010, Estoril, Portugal. (2010)
Comparison of pulmonary response among two mouse strains with divergent lung function following carbon nanoparticle instillation.
2010 Scientific Article in Cell Stem Cell Cell Stem Cell 7, 744-758 (2010)
In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells.
2010 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 107, 18493-18498 (2010)
Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma.
2010 Scientific Article in Gene Expression Patterns Gene Expr. Patterns 10, 265-273 (2010)
Combination of in silico and in situ hybridisation approaches to identify potential Dll1 associated miRNAs during mouse embryogenesis.
2010 Scientific Article in Molecular Pharmaceutics Mol. Pharm. 7, 727-737 (2010)
Toxicity pathway focused gene expression profiling of PEI-based polymers for pulmonary applications.
2010 Scientific Article in PLoS ONE PLoS ONE 5:e9468 (2010)
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
2010 Scientific Article in Nature Genetics Nat. Genet. 42, 24-26 (2010)
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.
2010 Scientific Article in Mammalian Genome Mamm. Genome 21, 13-27 (2010)
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3(416insG ) mice.
In: Proceedings (Strengthening Radiation Protection Worldwide, IRPA 12 - 12th International Congress of the International Radiation Protection Association; 19-24 October 2008; Buenos Aires). Vienna: International Atomic Energy Agency, 2009. 1-10
Organ doses from environmental exposures calculated using the ICRP Reference Male and Reference Female voxel phantoms.
2009 Scientific Article in Molecular and Cellular Endocrinology Mol. Cell. Endocrinol. 301, (Sp. Iss. SI), 109-116 (2009)
Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms.
2009 Scientific Article in Particle and Fibre Toxicology Part. Fibre Toxicol. 6:31 (2009)
Pathway focused protein profiling indicates differential function for IL-1B,-18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice.
2009Vortrag: Herbsttagung der Sektion Zellbiologie, 06-07 November 2009, Borstel, Germany. (2009)
Indications of IL1B, IL18 and VEGF cascade in maintenance of homeostasis following transient pulmonary inflammation due to carbon nanoparticle (CNP) challenge in mice .
2009 Scientific Article in Journal of Biological Chemistry, The J. Biol. Chem. 284, 31260-31269 (2009)
Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells.
2009 Scientific Article in Nature Neuroscience Nat. Neurosci. 12, 1229-1237 (2009)
AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.
2009 Scientific Article in PLoS ONE PLoS ONE 4:e6054 (2009)
Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.
2009 Scientific Article in British Journal of Cancer BJC Br. J. Cancer 100, 656-662 (2009)
Overexpressed vs mutated Kras in murine fibroblasts: A molecular phenotyping study.
2009 Review in Nature Reviews - Genetics Nat. Rev. Genet. 10, 371-380 (2009)
Towards better mouse models: Enhanced genotypes, systemic phenotyping and envirotype modelling.
2009 Review in Current Pharmaceutical Biotechnology Curr. Pharm. Biotechnol. 10, 236-243 (2009)
The German Mouse Clinic: A platform for systemic phenotype analysis of mouse models.
2008 Scientific Article in BMC Developmental Biology BMC Dev. Biol. 8:118 (2008)
Pleiotropic effects in Eya3 knockout mice.
2008 Scientific Article in Neurobiology of Aging Neurobiol. Aging 29, 1404-1411 (2008)
Creatine improves health and survival of mice.
2008 Scientific Article in Molecular and Cellular Neuroscience Mol. Cell. Neurosci. 38, 15-42 (2008)
Prospective isolation of functionally distinct radial glial subtypes--lineage and transcriptome analysis.
2008 Scientific Article in Frontiers in Bioscience Front. Biosci. 13, 5810-5823 (2008)
'Sighted C3H' mice - a tool for analysing the influence of vision on mouse behaviour?
2008 Scientific Article in Investigative Ophthalmology & Visual Science, IOVS Invest. Ophthalmol. Vis. Sci. 49, 1533-1541 (2008)
Novel allele of crybb2 in the mouse and its expression in the brain.
2008 Scientific Article in Proteomics Proteomics 8, 1248-1256 (2008)
Systematic gene expression profiling of mouse model series reveals coexpressed genes.
2008 Scientific Article in Proteomics Proteomics 8, 1257-1265 (2008)
Transcriptome and proteome analysis of early embryonic mouse brain development.
2008 Scientific Article in Proteomics Proteomics 8, 1162-1164 (2008)
BrainProfileDB - a platform for integration of functional genomics data.
2008 Scientific Article in Proteomics Proteomics 8, 1165-1169 (2008)
An approach to handling and interpretation of ambiguous data in transcriptome and proteome comparisons.
2008 Scientific Article in Proteomics Proteomics 8, 1170-1178 (2008)
Interlocking transcriptomics, proteomics and toponomics technologies for brain tissue analysis in murine hippocampus.
2008 Scientific Article in Inhalation Toxicology Inhal. Toxicol. 20, 319-337 (2008)
Health effects of ambient particulate matter - biological mechanisms and inflammatory responses to in vitro and in vivo particle exposures.
2007Vortrag: NGFN-Projektleiter-Treffen, 10-11 November 2007, Heidelberg, Germany. (2007)
Systemic analysis of mouse mutants at the German Mouse Clinic.
2007Vortrag: 6th NGFN Meeting 2007, 10-11 November 2007, Heidelberg, Germany. (2007)
German Mouse Clinic: Systematic gene expression profiling of mouse models reveals co-expressed genes.
2007Vortrag: 19th Mouse Molecular Genetics Meeting, 5-9 September 2007, Hinxton/Cambridge, UK. (2007)
A genetic screen for modifiers of the delta1-dependent notch signalling function in the mouse.
2007Vortrag: HUPO Brain Proteome Project, 8th March 2007, Hinxton, England. (2007)
Deciphering genotype-phenotype correlation : The German Mouse Clinic and more.
2007 Scientific Article in BioSpektrum BioSpektrum 13, 504-506 (2007)
Von der funktionellen Genomforschung zur systemischen Krankheitsanalyse.
2007 Scientific Article in Proteomics Proteomics 7, 2490-2496 (2007)
High Performance Proteomics: 7th HUPO Brain Proteome Project Workshop.
2007 Scientific Article in Journal of Theoretical Biology J. Theor. Biol. 248, 120-129 (2007)
Cell-based simulation of dynamic expression patterns in the presomitic mesoderm.
2007 Scientific Article in BMC Developmental Biology BMC Dev. Biol. 7:68 (2007)
Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints.
In: Fox, J.* [Eds.]: The Mouse in Biomedical Research. Amsterdam: Elsevier, 2007. 225-260
Chemical mutagenesis in mice.
2007 Scientific Article in Physiological Genomics Physiol. Genomics 28, 301-310 (2007)
Profiling at mRNA, protein, and metabolite levels reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2–/– mice.
2007 Scientific Article in Genetics Genetics 175, 1451-1463 (2007)
A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse.
2006 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 329, 397-407 (2006)
Use of chemical mutagenesis in mouse embryonic stem cells.
In: Fox, J.G.* ; Barthold, S.W.* ; Davisson, M.T.* ; Newcomer, C.E.* ; Quimby, F.W.* ; Smith, A.L.* [Eds.]: The Mouse in Biomedical Research, 2nd Edition. Amsterdam: Elsevier Press, 2006. 225-260 ( ; 1)
Chemical mutagenesis in mice.
In: Hrabě de Angelis, M.* ; Chambon, P.* ; Brown, S.* [Eds.]: Standards of Mouse Model Phenotyping. Weinheim: Wiley-VCH, 2006. 15-34
Molecular phenotyping: Gene expression profiling.
München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2006, 107 S.
Gene expression profiling and gene regulation for functional genomics in mouse models.
2006Vortrag: International Mouse Genome Congress (IMGC), 12-16 November 2006, Charleston, USA. (2006)
Open access mouse phenotyping platform: The German Mouse Clinic.
2006Vortrag: Entwicklungsbiologischer Sino-German Workshop über Mesodermbildung und -differenzierung, 0.-03 September 2006, Beijing, China. (2006)
The Notch gene regulatory network during somitogenesis.
2006Vortrag: ICMSB, 2nd August 2006, München, Germany. (2006)
The Notch gene regulatory network during somitogenesis.
2006Vortrag: Mouse Molecular Genetics Meeting, 28th. August - 3rd September 2006, Cold Spring Harbor, USA. (2006)
A new standard: Phenotyping in the German Mouse Clinic.
2005 Scientific Article in Gene Expression Patterns Gene Expr. Patterns 6, 94-101 (2005)
Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling.
2005 Scientific Article in GenomXPress GenomXPress 2, 7-10 (2005)
Mäuse als Modelle für menschliche Erkrankungen.
2005 Scientific Article in Nature Genetics Nat. Genet. 37, 1155 (2005)
EMPReSS: Standardized phenotype screens for functional annotation of the mouse genome.
2005 Scientific Article in Nature Methods Nat. Methods 2, 403-404 (2005)
Introducing the German Mouse Clinic: Open access platform for standardized phenotyping.
2005 Scientific Article in Journal of Molecular Biology J. Mol. Biol. 349, 487-500 (2005)
Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells.
2005 Scientific Article in Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. 102, 8621-8626 (2005)
Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues.
2005 Scientific Article in Mammalian Genome Mamm. Genome 16, 1-10 (2005)
Assessment of a systematic expression profiling approach in ENU-induced mouse mutant lines.
2005 Scientific Article in International Journal of Cancer Int. J. Cancer 114, 590-597 (2005)
Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis.
In: Hedrich, H.J.* ; Bullock, G.* [Eds.]: The Laboratory Mouse. Amsterdam: Elsevier, 2004. 47-84
Mouse genomics.
2003 Scientific Article in Current Genomics Curr. Genomics 4, 615-621 (2003)
Artefacts and Reliability of DNA Microarray Expression Profiling Data.
2003 Scientific Article in Journal of Molecular Biology J. Mol. Biol. 333, 229-235 (2003)
Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the notch ligand Delta1.
2003 Scientific Article in Nucleic Acids Research Nucleic Acids Res. 31, 2-10 (2003)
Specificity assessment from fractionation experiments (SAFE) : a novel method to evaluate microarray probe specificity based on hybridisation strinencies.
2003 Scientific Article in Development / Company of Biologists Development 130, 3-13 (2003)
Node and midline defects are associated with left-right development in Delta1 mutant embryos.
2002 Scientific Article in Current Genomics Curr. Genomics 3, 121-129 (2002)
Molecular Phenotyping of Mouse Mutant Resources by RNA Expression Profiling.
2001 Scientific Article in Current Opinion in Chemical Biology Curr. Opin. Chem. Biol. 6, 17-23 (2001)
Large-scale mutational analysis for the annotation of the mouse genome.
2000 Scientific Article in Mechanisms of Development Mech. Dev. 95, 23-34 (2000)
Distinct regulatory elements direct Delta1 expression in the nervous system and paraxial mesoderm of transgenic mice.
2000 Scientific Article in Mechanisms of Development Mech. Dev. 95, 35-46 (2000)
The mouse rib-vertebrae mutation disrupts anterior-posterior somite patterning and genetically interacts with a Delta1 null allele.
2000 Scientific Article in Development / Company of Biologists Development 127, 1421-1429 (2000)
Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm.
1999 Scientific Article in Mechanisms of Development Mech. Dev. 84, 165-168 (1999)
Expression of the mouse Delta1 gene during organogenesis and fetal development.
1999 Scientific Article in Developmental Biology Dev. Biol. 208, 157-165 (1999)