Environmental Epigenetics
About our Group
Diabetes and Obesity affect almost 400 million people worldwide and forecasts anticipate an increase of at least 20% by 2030.
Epidemiological studies have shown a high degree of genetic predisposition and familial aggregation in both diabetes and obesity. Nevertheless, lifestyle interventions have proven valuable in disease prevention and management.
Our group of Environmental Epigenetics focuses on the interface between metabolism, genetics and disease. We study physiological and pathological aspects of gene-environment interaction and epigenetic control of inheritance and aim to find novel targets and/or mechanisms towards effective strategies for disease prevention.
Publications
2024 Scientific Article in Reproduction, Fertility and Development Reprod. Fertil. Dev. 36:RD24079 (2024)
ShinySperm: Navigating the sperm proteome landscape.
2024 Scientific Article in Molecular and Cellular Proteomics Mol. Cell. Proteomics 23:100811 (2024)
Enhanced in situ spatial proteomics by effective combination of MALDI imaging and LC-MS/MS.
2024 Scientific Article in Nature Nature, 27 (2024)
Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs.
2022 Nature Cardiovascular Research Nat. Cardio. Res. 1, 529-531 (2022)
Publisher Correction: Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy (Nature Cardiovascular Research, (2022), 1, 2, (157-173), 10.1038/s44161-022-00018-8).
2022 Review in Biomedicines Biomedicines 10:2461 (2022)
The legacy of parental obesity: Mechanisms of non-genetic transmission and reversibility.
2022 Scientific Article in Nature Cardiovascular Research Nat. Cardio. Res. 1, 157-173 (2022)
Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy.
2022 Scientific Article in Basic Research in Cardiology Basic Res. Cardiol. 117:11 (2022)
Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing.
2021 Scientific Article in Nature Communications Nat. Commun. 12:2999 (2021)
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
2021 Scientific Article in Science Advances Sci. Adv. 7:eabg6424 (2021)
Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors.
2021 Scientific Article in PLoS Genetics PLoS Genet. 16:e1009190 (2021)
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
2020 Scientific Article in Scientific Reports Sci. Rep. 10:18334 (2020)
Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice.
2020 Scientific Article in Communications Biology Comm. Biol. 3:628 (2020)
PAX6 mutation alters circadian rhythm and beta cell function in mice without affecting glucose tolerance.
2020 Scientific Article in Genome Medicine Genome Med. 12:87 (2020)
The aging mouse microbiome has obesogenic characteristics.
2020 Editorial in Mammalian Genome Mamm. Genome, DOI: 10.1007/s00335-020-09843-3 (2020)
Introduction to mammalian genome special issue: Epigenetics.
2020 Review in Mammalian Genome Mamm. Genome 31, 146–156 (2020)
Genetic control of non-genetic inheritance in mammals: state-of-the-art and perspectives.
In: Beyond Our Genes. 2020. 159-173
Introduction to epigenetic inheritance: Definition, mechanisms, implications and relevance.
Springer International Publishing, 2020.:doi.org/10.1007/978-3-030-35213-
Pathophyiology of gene and environment interaction and epigenetic inheritance.
2020 Scientific Article in Cell Reports Cell Rep. 30, 3183-3194.e4 (2020)
iTAG-RNA isolates cell-specific transcriptional responses to environmental stimuli and identifies an RNA-based endocrine axis.
2019 Scientific Article in Journal of Hepatology J. Hepatol. 70, 1192-1202 (2019)
Tick-tock hedgehog-mutual crosstalk with liver circadian clock promotes liver steatosis.
2018 Meeting abstract in Wiener medizinische Wochenschrift Wien. Med. Wochenschr. 130, 353-354 (2018)
Paternal circadian arrhythmia affects offspring health and feeding behaviour.
2018 Scientific Article in Molecular Metabolism Mol. Metab. 18, 42-50 (2018)
Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity.
2018 Scientific Article in Cell Metabolism Cell Metab. 27, 1294-1308.e7 (2018)
The polycomb-dependent epigenome controls beta cell dysfunction, dedifferentiation, and diabetes.
2017 Scientific Article in Nature Structural & Molecular Biology Nat. Struct. Mol. Biol. 24, 902-910 (2017)
MacroH2A1.1 regulates mitochondrial respiration by limiting nucleas NAD+ consumption.
2017 Other: Opinion in Molecular Metabolism Mol. Metab. 6, 1079-1080 (2017)
Anti-hypertensive treatment in pregnancy impacts offspring growth and metabolism: Q&A.
2016 Meeting abstract in Diabetologia Diabetologia 59, S307-S307 (2016)
Polycomb controls metabolic homeostasis through a novel liver-to-adipose axis.
2016 Scientific Article in Cell Cell 164, 353-364 (2016)
Trim28 haploinsufficiency triggers bi-stable epigenetic obesity.
2015 Scientific Article in Methods in Molecular Biology Methods Mol. Biol. 1322, 187-198 (2015)