Gene Regulation and Epigenetics
Many of our traits are not determined by the DNA sequence of our genome. We aspire to understand, how external and environmental factors impact on our genes and our health through epigenetic mechanisms.
Many of our traits are not determined by the DNA sequence of our genome. We aspire to understand, how external and environmental factors impact on our genes and our health through epigenetic mechanisms.
About Our Group
We are the group of Gene Regulation and Epigenetics. Our research focuses on the epigenetic inheritance of metabolic diseases such as obesity and diabetes mostly using the mouse as functional model system. We aim to understand how metabolic phenotypes that are acquired during life - for example, by malnutrition - are inherited from one generation to the next. Changes in transcripts carried by oocytes and sperms as well as chemical modifications of DNA and chromosomes contribute to this inheritance. This mode of inter-generational epigenetic inheritance was only recently discovered. With our research we want to contribute to a better understanding of its mechanisms and implications for the observed pandemic of obesity and diabetes in man. We offer our technical expertise in transcriptomics in numerous scientific collaborations, preferentially in the area of metabolic disorders.
Group Members
Selected Publications
Read more2022 Scientific Article in Diabetes Care
Diabetes and obesity in down syndrome across the lifespan: A retrospective cohort study using U.K. electronic health records.
2022 Scientific Article in Scientific Reports
Insight into the pulmonary molecular toxicity of heated tobacco products using human bronchial and alveolar mucosa models at air-liquid interface.
2022 Scientific Article in Cells
Dendritic cells or macrophages? The microenvironment of human clear cell renal cell carcinoma imprints a mosaic myeloid subtype associated with patient survival.
2022 Scientific Article in EMBO Reports
A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis.
2022 Scientific Article in Cells
Innate immune pathways promote oligodendrocyte progenitor cell recruitment to the injury site in adult Zebrafish brain.
2022 Scientific Reports
Author Correction: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin (Scientific Reports, (2018), 8, 1, (1366), 10.1038/s41598-018-19200-9).
