Gene Regulation and Epigenetics

Many of our traits are not determined by the DNA sequence of our genome. We aspire to understand, how external and environmental factors impact on our genes and our health through epigenetic mechanisms.

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About Our Group

We are the group of Gene Regulation and Epigenetics. Our research focuses on the epigenetic inheritance of metabolic diseases such as obesity and diabetes mostly using the mouse as functional model system. We aim to understand how metabolic phenotypes that are acquired during life - for example, by malnutrition - are inherited from one generation to the next. Changes in transcripts carried by oocytes and sperms as well as chemical modifications of DNA and chromosomes contribute to this inheritance. This mode of inter-generational epigenetic inheritance was only recently discovered. With our research we want to contribute to a better understanding of its mechanisms and implications for the observed pandemic of obesity and diabetes in man. We offer our technical expertise in transcriptomics in numerous scientific collaborations, preferentially in the area of metabolic disorders.

Prof. Dr. Johannes Beckers

Prof. Dr. rer. nat. Johannes Beckers, Executive MBA (TUM) View profile

Dr. Sieglinde Hastreiter

Sandra Hoffmann

Dr. Martin Irmler

Kerstin Richter

Selected Publications

2024 Scientific Article in Thorax

Stoleriu, M.-G. ; Ansari, M. ; Strunz, M. ; Schamberger, A.C. ; Heydarian, M. ; Ding, Y. ; Voss, C. ; Schneider, J.J. ; Gerckens, M. ; Burgstaller, G. ; Castelblanco, A. ; Kauke, T. ; Fertmann, J. ; Schneider, C. ; Behr, J. ; ... ; Irmler, M. ; Beckers, J. ; Eickelberg, O. ; Schubert, B. ; Hauck, S.M. ; Schmid, O. ; Stöger, T. ; Schiller, H. ; Hilgendorff, A.

COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.

2024 Scientific Article in Respiratory Research

Upadhyay, S. ; Rahman, M. ; Rinaldi, S. ; Koelmel, J.P. ; ... ; Beckers, J. ; Irmler, M. ; Ganguly, K.

Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air-liquid interface.

2024 Scientific Article in European Respiratory Journal

Mayr, C. ; Sengupta, A. ; Asgharpour, S. ; Ansari, M. ; Pestoni, J. ; Ogar, P. ; Angelidis, I. ; Liontos, A. ; Rodriguez-Castillo, J.A. ; Lang, N.J. ; Strunz, M. ; Porras-Gonzalez, D.L. ; Gerckens, M. ; De Sadeleer, L.J. ; Oehrle, B. ; Viteri-Alvarez, V. ; Fernandez, I.E. ; Tallquist, M. ; Irmler, M. ; Beckers, J. ; ... ; Wasnick, R. ; Yildirim, A.Ö. ; Theis, F.J. ; Burgstaller, G. ; Schiller, H.

Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts.

2024 Scientific Article in Physiological reports

Sabikunnahar, B. ; Caldwell, S. ; Varnum, S. ; Hogan, T. ; ... ; Rathkolb, B. ; Gerlini, R. ; Dragano, N.R.V. ; Aguilar-Pimentel, J.A. ; Irmler, M. ; Sanz-Moreno, A. ; da Silva Buttkus, P. ; Beckers, J. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Krementsov, D.N.

LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.

2023 Scientific Article in Neuroscience Applied

Garrett, L. ; Irmler, M. ; Baljuls, A. ; Rathkolb, B. ; Dragano, N.R.V. ; Gerlini, R. ; Sanz-Moreno, A. ; Aguilar-Pimentel, J.A. ; Becker, L. ; Kraiger, M. ; Reithmeir, R. ; Beckers, J. ; Calzada-Wack, J. ; Wurst, W. ; Fuchs, H. ; Gailus-Durner, V. ; Zimmermann, T. ; Hölter, S.M. ; Hrabě de Angelis, M.

GPR101 loss promotes insulin resistance and diet-induced obesity risk.

2023 Scientific Article in The Lancet Public Health

Baksh, R.A. ; Pape, S.E. ; Chan, L.F. ; Aslam, A.A. ; ... ; GO-DS21 Consortium (Beckers, J.)

Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: A population-based cohort study using electronic health records.

2023 Scientific Article in Journal of Clinical Endocrinology & Metabolism, The

Kovác, L. ; Goj, T. ; Ouni, M. ; Irmler, M. ; Jähnert, M. ; Beckers, J. ; Hrabě de Angelis, M. ; Peter, A. ; Moller, A. ; Birkenfeld, A.L. ; Weigert, C. ; Schürmann, A.

Skeletal muscle gene expression signatures of obese high- and low- responders to endurance exercise training.

2023 Scientific Article in American Journal of Physiology - Cell Physiology

Maurer, J. ; Zhao, X. ; Irmler, M. ; Gudiksen, A. ; Pilmark, N.S. ; ... ; Beckers, J. ; Hrabě de Angelis, M. ; Birkenfeld, A.L. ; Peter, A. ; Lehmann, R. ; Weigert, C.

Gene Regulation and Epigenetics

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About Our Group

Group Members

Prof. Dr. Johannes Beckers

Dr. Sieglinde Hastreiter

Sandra Hoffmann

Dr. Martin Irmler

Kerstin Richter

Selected Publications

COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.

Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air-liquid interface.

Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts.

LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.

GPR101 loss promotes insulin resistance and diet-induced obesity risk.

Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: A population-based cohort study using electronic health records.

Skeletal muscle gene expression signatures of obese high- and low- responders to endurance exercise training.

Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes.

Contact

Prof. Dr. Johannes Beckers

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