Gene Regulation and Epigenetics
Many of our traits are not determined by the DNA sequence of our genome. We aspire to understand, how external and environmental factors impact on our genes and our health through epigenetic mechanisms.
Many of our traits are not determined by the DNA sequence of our genome. We aspire to understand, how external and environmental factors impact on our genes and our health through epigenetic mechanisms.
About Our Group
We are the group of Gene Regulation and Epigenetics. Our research focuses on the epigenetic inheritance of metabolic diseases such as obesity and diabetes mostly using the mouse as functional model system. We aim to understand how metabolic phenotypes that are acquired during life - for example, by malnutrition - are inherited from one generation to the next. Changes in transcripts carried by oocytes and sperms as well as chemical modifications of DNA and chromosomes contribute to this inheritance. This mode of inter-generational epigenetic inheritance was only recently discovered. With our research we want to contribute to a better understanding of its mechanisms and implications for the observed pandemic of obesity and diabetes in man. We offer our technical expertise in transcriptomics in numerous scientific collaborations, preferentially in the area of metabolic disorders.
Selected Publications
Ehlich, H. ; Blease, A. ; Biju, R. ; Gustems, M. ; Song, F. ; Fessele, S. ; Massimi, M. ; Bozonelos, K. ; Ntafis, V. ; Hiltunen, A.E. ; Marschall, S. ; Stoeger, C. ; Khorshidi, Z. ; Ziadi, A. ; Jambou, K. ; Armagno, A. ; Scavizzi, F. ; Raspa, M. ; Fernández, J. ; del Hierro, M.J. ; Ayadi, A. ; Pensavalle, J. ; Prevost, G. ; Dufkova, L. ; Krupkova, M. ; Nickl, P. ; Krimpenfort, P. ; Jonkers, J. ; Valera Vazquez, G. ; Raess, M. ; Beckers, J. ; Moles, A. ; Dahlhoff, M. ; Montoliu, L. ; Herault, Y. ; Hinttala, R. ; Kontoyiannis, D.L. ; Sedlacek, R. ; Hrabě de Angelis, M. ; Boersma, A.A. ; Matteoni, R.
A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution.Bhattacharya, D. ; da Silva Buttkus, P. ; Nalbach, K. ; Cheng, L. ; Garrett, L. ; Irmler, M. ; Kislinger, G. ; Werner, G. ; Rodde, R. ; Lengger, C. ; Beckers, J. ; Zimprich, A. ; Hölter, S.M. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Wefers, B. ; Wurst, W. ; Brill, M.S. ; Schifferer, M. ; Lichtenthaler, S.F. ; Behrends, C.
Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia.Beckers, J. ; Valera, G. ; Raess, M.
INFRAFRONTIER – the European Research Infrastructure for In Vivo and In Vitro Diseases Modelling.Gillet, J.P. ; Gerard, L. ; Vieira, W. ; Fourrez, M. ; Gaudray, F. ; Rathkolb, B. ; Rozman, J. ; Klein-Rodewald, T. ; Becker, L. ; Aguilar-Pimentel, J.A. ; Horsch, M. ; Spielmann, N. ; Prehn, C. ; Bihin, B. ; Beckers, J. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Southon, E. ; Tessarollo, L. ; Xia, D. ; Gottesman, M.M.
Abcb5-deficient mice show a subtle, pleiotropic phenotype indicating a role for this transporter in intermediary metabolism.Skerrett-Byrne, D.A. ; Pepin, A.-S. ; Laurent, K. ; Beckers, J. ; Schneider, R. ; Hrabě de Angelis, M. ; Teperino, R.
Dad's diet shapes the future: How paternal nutrition impacts placental development and childhood metabolic health.Dreher, S.I. ; Goj, T. ; von Toerne, C. ; Hoene, M. ; Irmler, M. ; Ouni, M. ; Jähnert, M. ; Beckers, J. ; Hrabě de Angelis, M. ; Peter, A. ; Moller, A. ; Birkenfeld, A.L. ; Schürmann, A. ; Hauck, S.M. ; Weigert, C.
Sex differences in resting skeletal muscle and the acute and long-term response to endurance exercise in individuals with overweight and obesity.Stoleriu, M.-G. ; Ansari, M. ; Strunz, M. ; Schamberger, A.C. ; Heydarian, M. ; Gabriel, C. ; Najak, A. ; Disovic, A. ; Schneider, J. ; Gerckens, M. ; Burgstaller, G. ; Ding, Y. ; Doryab, A. ; Voss, C. ; Ketscher, C. ; Sienel, W. ; Kauke, T. ; Fertmann, J. ; Schneider, C. ; Behr, J. ; Irmler, M. ; Beckers, J. ; Eickelberg, O. ; Schubert, B. ; Hauck, S.M. ; Hatz, R. ; Schmid, O. ; Stöger, T. ; Schiller, H. B. ; Hilgendorff, A.
Development of advanced in-vitro human bronchial epithelial models and lung cell atlas in COPD enabled by thoracic surgery translational research.Stoleriu, M.-G. ; Ansari, M. ; Strunz, M. ; Schamberger, A.C. ; Heydarian, M. ; Ding, Y. ; Voss, C. ; Schneider, J.J. ; Gerckens, M. ; Burgstaller, G. ; Castelblanco, A. ; Kauke, T. ; Fertmann, J. ; Schneider, C. ; Behr, J. ; Lindner, M. ; Stacher-Priehse, E. ; Irmler, M. ; Beckers, J. ; Eickelberg, O. ; Schubert, B. ; Hauck, S.M. ; Schmid, O. ; Hatz, R.A. ; Stöger, T. ; Schiller, H. B. ; Hilgendorff, A.
COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.Contact
