The contactome, the sum of physical contacts between viral and host macromolecules, affects cellular perturbations that enable viral replication and cause disease manifestations. Because co-complex assays predominantly detect indirect protein-associations, the virus–host contactome remains largely unexplored and unknown. To address this fundamental research gap, we systematically identified protein–protein contacts between SARS-CoV-2 and the human proteome.
EU-RIA: RiPCoN- mRapid interaction profiling of 2019-nCoV for network-based deep drug-repurpose learning (DDRL)
A map of direct SARS-CoV-2 protein interactions implicates specific human host processes. Kim et al. bioRxiv 2021 doi: doi.org/10.1101/2021.03.15.433877
Global BioID-based SARS-CoV-2 proteins proximal interactome unveils novel ties between viral polypeptides and host factors involved in multiple COVID19-associated mechanisms. Estelle et al. bioRxiv 2020.08.28.272955