CONTACTOMICS

The contactome, the sum of physical contacts between viral and host macromolecules, affects cellular perturbations that enable viral replication and cause disease manifestations. Because co-complex assays predominantly detect indirect protein-associations, the virus–host contactome remains largely unexplored and unknown. To address this fundamental research gap, we systematically identified protein–protein contacts between SARS-CoV-2 and the human proteome.

Research

• EU-RIA: RiPCoN- Rapid interaction profiling of 2019-nCoV for network-based deep drug-repurpose learning (DDRL)
• A map of direct SARS-CoV-2 protein interactions implicates specific human host processes. Kim, DK., Weller, B., Lin, CW. et al. A proteome-scale map of the SARS-CoV-2–human contactome. Nat Biotechnol 41, 140–149 (2023). doi.org/10.1038/s41587-022-01475-z
• Global BioID-based SARS-CoV-2 proteins proximal interactome unveils novel ties between viral polypeptides and host factors involved in multiple COVID19-associated mechanisms. Estelle et al. bioRxiv 2020.08.28.272955
• CLARITY - New EU project @ INET: EU-RIA: CLARITY - Causative Link between respiratory syncytial virus and chronic lung diseases: Identifying targets for therapy
• ALS Association: Understanding and preventing virus-triggered ALS
• Swedish Research Council: Infections in the risk and prognosis of amyotrophic lateral sclerosis (co-PI, main PI Prof. Fang Fang, Karolinska Institute)