ALS Research @INET

ALS-Virome human Interactome
Epidemiologically several viruses are associated with diseases other than infectious diseases including neurodegenerative and autoimmune diseases. While the causality direction of these associations remains unknown, viral replication and persistence require expression of proteins that modulate host processes. During the course of a viral infection, virus–host protein–protein interactions (PPIs) are crucial for viral replication and therefore survival in the host. These molecular interactions can lead to viral-mediated perturbations of the human interactome adding to the generation of various disease usually seen as non communicable. Viruses also can interact with host genetic variation to trigger symptoms pointing to a chronic disease. As several viruses are suspected to play an important role in the development of ALS we perform the experimental interaction mapping of the proteins from 10 “ALS related” viruses with the human proteome (18k ORFs) combined with subsequent deep neural network-based analysis of viral pathogenicity and high level edgetics analysis based on multi-level molecular data very promising in order to find good intervention and/or drug repurposing strategies.