REGULOMICS

Regulatory network mapping will identify transcription factors (TFs) regulating the genes and pathways that enable either regulation processes within an organism or elucidate regulation of molecular host pathways by microbes. In silico analyses will be complemented by experimental identification of TFs that regulate signature response genes and will be followed by genetic proof-of-principle experiments. Interactions between regulatory genomic DNA and transcription factors, generated by our Y1H platform, provide the first level of gene control and, therefore, the backbone of gene regulatory networks.

Research

• Identification and analysis of the Chlamydomonas reinhardtii Gene
  Regulatory Network
• Growth-regulating factors interact with DELLAs and regulate growth
  in cold stress. Lantzouni et al. Plant Cell. 2020. DOI: 10.1105/tpc.19.00784
• Regulatory wheat network