Regulatory network mapping will identify transcription factors (TFs) regulating the genes and pathways that enable either regulation processes within an organism or elucidate regulation of molecular host pathways by microbes. In silico analyses will be complemented by experimental identification of TFs that regulate signature response genes and will be followed by genetic proof-of-principle experiments. Interactions between regulatory genomic DNA and transcription factors, generated by our Y1H platform, provide the first level of gene control and, therefore, the backbone of gene regulatory networks.
Identification and analysis of the Chlamydomonas reinhardtii Gene Regulatory Network
Growth-regulating factors interact with DELLAs and regulate growth in cold stress
Lantzouni et al. Plant Cell. 2020 DOI: 10.1105/tpc.19.00784
Regulatory wheat network