Helmholtz Munich

IRBM, guest scientist

Email meBuilding/Room: Neuherberg/ unit 34/ room 110

Dr. Dongsheng Jiang is a research scientist in Dr. Yuval Rinkevich’s lab, in the Institute of Regenerative Biology and Medicine, Helmholtz Munich. He is interested in fundamental questions of how skin develops during embryonic development and how scar develops during wound healing. His current research focuses on fibroblast heterogeneity, subcutaneous fascia, chronic wounds, and skin scarring. The overall aim of his research is to develop therapeutic options for chronic skin wounds with reduced scarring and enhanced regeneration.
Dongsheng Jiang’s dermatological research started during his postdoc study in Prof. Karin Scharffetter-Kochanek's lab, at Ulm University, which was focused on mesenchymal stem cells, skin wound healing, and skin aging. He obtained his PhD study in Prof. Herbert Schwarz's lab at National University Singapore, where he started to be interested in stem cell biology and immunology.

Dr. Dongsheng Jiang is a research scientist in Dr. Yuval Rinkevich’s lab, in the Institute of Regenerative Biology and Medicine, Helmholtz Munich. He is interested in fundamental questions of how skin develops during embryonic development and how scar develops during wound healing. His current research focuses on fibroblast heterogeneity, subcutaneous fascia, chronic wounds, and skin scarring. The overall aim of his research is to develop therapeutic options for chronic skin wounds with reduced scarring and enhanced regeneration.

Dongsheng Jiang’s dermatological research started during his postdoc study in Prof. Karin Scharffetter-Kochanek's lab, at Ulm University, which was focused on mesenchymal stem cells, skin wound healing, and skin aging. He obtained his PhD study in Prof. Herbert Schwarz's lab at National University Singapore, where he started to be interested in stem cell biology and immunology.

Fields of Work and Expertise

mouse modelRegeneration

Key publications

2023

Correa-Gallegos D., Ye H., Dasgupta B., Sardogan A., Kadri S., Kandi R., Dai R., Lin Y., Kopplin R., Shantaram D.S., Wannemacher J., Ichijo R., Jiang D., Strunz M., Ansari M., Angelidis I., Schiller H.B., Voltz T., Machens H.-G., Rinkevich Y. (2023). CD201+ fascia progenitors choreograph injury repair. Nature 623, 792–802

Kalgudde Gopal S.#, Dai R.#, Stefanska A. M., Ansari M., Zhao J., Ramesh P., Bagnoli J. W., Correa-Gallegos D., Lin Y., Christ S., Angelidis I., Lupperger V., Marr C., Davies L. C., Enard W., Machens H.-G., Schiller H. B.*, Jiang D.*, Rinkevich Y.* (2023). Wound infiltrating adipocytes are not myofibroblasts. Nat Commun 14: 3020.

Tao Y., Zhang Y., Jin X., Hua N., Liu H., Qi R., Huang Z., Sun Y., Jiang D., Snutch T.P., Jiang X., Tao J. (2023). Epigenetic regulation of beta-1 endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model. Nat Commun. In press

Zhang Y., Wei Y., Zheng T., Tao Y., Sun Y., Jiang D., Tao J. (2023). Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice. J Headache Pain 24: 117.

Xiong Y., Feng Q., Lu L., Qiu X., Knoedler S., Panayi A.C., Jiang D., Rinkevich Y., Lin Z., Mi B., Liu G., Zhao Y. (2023). Metal–Organic Frameworks and Their Composites for Chronic Wound Healing: From Bench to Bedside. Adv Mater. In press

Knoedler S., Broichhausen S., Guo R., Dai R., Knoedler L., Kauke-Navarro M., Diatta F., Pomahac B., Machens H.-G.*, Jiang D.*, Rinkevich Y.* (2023). Fibroblasts – The Cellular Choreographers of Wound Healing. Front Immunol 14: 1233800.

Chu X., Xiong Y., Knoedler S., Lu L., Panayi A.C., Alfertshofer M., Jiang D., Rinkevich Y., Lin Z., Zhao Z., Dai G., Mi B., Liu G. (2023). Immunomodulatory Nanosystems: Advanced Delivery Tools for Treating Chronic Wounds. Research 6: 0198.

Xiong Y., Chu X., Yu T., Knoedler S., Schroeter A., Lu L., Zha K., Lin Z., Jiang D., Rinkevich Y., Panayi A.C., Mi B., Liu G., Zhao Y. (2023). Reactive Oxygen Species-Scavenging Nanosystems in the Treatment of Diabetic Wounds. Advanced Healthcare Materials e2300779. In press

Rajendran V., Ramesh P., Dai R., Kalgudde Gopal S., Ye H., Machens H.-G., Adler H., Jiang D., Rinkevich Y. (2023). Therapeutic silencing of p120 in fascia fibroblasts ameliorate tissue repair. J Invest Dermatol 143(5): 854-863.

2022

Jiang D., Guo R., Machens H.-G., Rinkevich Y. (2022). Diversity of fibroblasts and their roles in wound healing. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a041222.

2021

Jiang D*, Rinkevich Y* (2021). Converting fibroblastic fates leads to wound healing without scar. Signal Trans Target Ther. 6: 332.

Wan L, Jiang D, Correa-Gallegos D, Ramesh P, Zhao J, Ye H, Zhu S, Wannemacher J, Volz T, Rinkevich Y (2021) Connexin43 gap junction drives fascia mobilization and repair of deep skin wounds. Matrix Biol. 97: 58-71.

2020

Jiang D, Christ S, Correa-Gallegos D, Ramesh P, Kalgudde GS., Wannemacher J, Mayr CH, Lupperger V, Yu Q, Ye H, Mück-Häusl M, Rajendran V, Wan L, Liu J, Mirastschijski U, Volz T, Marr C, Schiller HB, Rinkevich Y (2020) Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin. Nat Commun. 11: 5653.

Jiang D, Singh K, Muschhammer J, Schatz S, Sindrilaru A, Makrantonaki E, Qi Y, Wlaschek M, Scharffetter-Kochanek K (2020) MSCs rescue impaired wound healing in a murine LAD1 model by adaptive responses to low TGF-b1 levels. EMBO Rep. 21(4): e49115.

Jiang D, de Vries JC, Muschhammer J, Schatz S, Ye H, Hein T, Fidan M, Romanov VS, Rinkevich Y, Scharffetter-Kochanek K (2020) Local and transient inhibition of p21 expression ameliorates age-related delayed wound healing. Wound Repair Regen. 28(1): 49-60.

2019

Correa-Gallegos D, Jiang D, Christ S, Ramesh P, Ye H, Wannemacher J, Kalgudde GS., Yu Q, Aichler M, Walch A, Mirastschijski U, Volz T, Rinkevich Y (2019) Patch repair of deep wounds by mobilized fascia. Nature 576(7786): 287-292.