Helmholtz Munich

IRBM, deputy institute director

Email meBuilding/Room: Neuherberg/ unit 34/ room 110

Dr. Dongsheng Jiang is a research scientist in Dr. Yuval Rinkevich’s lab, in the Institute of Regenerative Biology and Medicine, Helmholtz Munich. He is interested in fundamental questions of how skin develops during embryonic development and how scar develops during wound healing. His current research focuses on fibroblast heterogeneity, subcutaneous fascia, chronic wounds, and skin scarring. The overall aim of his research is to develop therapeutic options for chronic skin wounds with reduced scarring and enhanced regeneration.
Dongsheng Jiang’s dermatological research started during his postdoc study in Prof. Karin Scharffetter-Kochanek's lab, at Ulm University, which was focused on mesenchymal stem cells, skin wound healing, and skin aging. He obtained his PhD study in Prof. Herbert Schwarz's lab at National University Singapore, where he started to be interested in stem cell biology and immunology.

Dr. Dongsheng Jiang is a research scientist in Dr. Yuval Rinkevich’s lab, in the Institute of Regenerative Biology and Medicine, Helmholtz Munich. He is interested in fundamental questions of how skin develops during embryonic development and how scar develops during wound healing. His current research focuses on fibroblast heterogeneity, subcutaneous fascia, chronic wounds, and skin scarring. The overall aim of his research is to develop therapeutic options for chronic skin wounds with reduced scarring and enhanced regeneration.

Dongsheng Jiang’s dermatological research started during his postdoc study in Prof. Karin Scharffetter-Kochanek's lab, at Ulm University, which was focused on mesenchymal stem cells, skin wound healing, and skin aging. He obtained his PhD study in Prof. Herbert Schwarz's lab at National University Singapore, where he started to be interested in stem cell biology and immunology.

Fields of Work and Expertise

mouse modelRegeneration

Key publications

2023

Kalgudde GS, Dai R, Stefanska AM, Ansari M, Zhao J, Ramesh P, Bagnoli JW, Correa-Gallegos D, Lin Y, Christ S, Angelidis I, Lupperger V, Marr C, Davies LC, Enard W, Machens HG, Schiller HB, Jiang D, Rinkevich Y (2023). Wound infiltrating adipocytes are not myofibroblasts. Nat Commun In press.

2022

Jiang D., Guo R., Machens H.-G., Rinkevich Y. (2022). Diversity of fibroblasts and their roles in wound healing. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a041222.

2021

Jiang D*, Rinkevich Y* (2021). Converting fibroblastic fates leads to wound healing without scar. Signal Trans Target Ther. 6: 332.

Wan L, Jiang D, Correa-Gallegos D, Ramesh P, Zhao J, Ye H, Zhu S, Wannemacher J, Volz T, Rinkevich Y (2021) Connexin43 gap junction drives fascia mobilization and repair of deep skin wounds. Matrix Biol. 97: 58-71.

2020

Jiang D, Christ S, Correa-Gallegos D, Ramesh P, Kalgudde GS., Wannemacher J, Mayr CH, Lupperger V, Yu Q, Ye H, Mück-Häusl M, Rajendran V, Wan L, Liu J, Mirastschijski U, Volz T, Marr C, Schiller HB, Rinkevich Y (2020) Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin. Nat Commun. 11: 5653.

Jiang D, Singh K, Muschhammer J, Schatz S, Sindrilaru A, Makrantonaki E, Qi Y, Wlaschek M, Scharffetter-Kochanek K (2020) MSCs rescue impaired wound healing in a murine LAD1 model by adaptive responses to low TGF-b1 levels. EMBO Rep. 21(4): e49115.

Jiang D, de Vries JC, Muschhammer J, Schatz S, Ye H, Hein T, Fidan M, Romanov VS, Rinkevich Y, Scharffetter-Kochanek K (2020) Local and transient inhibition of p21 expression ameliorates age-related delayed wound healing. Wound Repair Regen. 28(1): 49-60.

2019

Correa-Gallegos D, Jiang D, Christ S, Ramesh P, Ye H, Wannemacher J, Kalgudde GS., Yu Q, Aichler M, Walch A, Mirastschijski U, Volz T, Rinkevich Y (2019) Patch repair of deep wounds by mobilized fascia. Nature 576(7786): 287-292.

2018

Jiang D, Correa-Gallegos D, Christ S, Stefanska A, Liu J, Ramesh P, Rajendran V, De Santis MM, Wagner DE, Rinkevich Y (2018) Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring. Nat Cell Biol. 20(4): 422-431.

2016

Jiang D, Muschhammer J, Qi Y, Kügler A, de Vries JC, Saffarzadeh M, Sindrilaru A, Vander Beken S, Wlaschek M, Kluth AM, Ganss C, Frank NY, Frank MH, Preissner KT, Scharffetter-Kochanek K (2016) Suppression of neutrophil-mediated tissue damage – a novel skill of mesenchymal stem cells. Stem Cells 34(9): 2393-2406.

2013

Jiang D, Qi Y, Walker NG, Sindrilaru A, Hainzl A, Wlaschek M, MacNeil S, Scharffetter-Kochanek K (2013) Adipose tissue derived mesenchymal stem cells delivered by a chemically defined carrier accelerate mouse acute cutaneous wound healing. Biomaterials 34(10): 2501-2515.

Full list of publications

Link to ORCID 0000-0003-0961-2671