©Barth-Jan van Rossum
Calcium Sensor for Photoacoustics (CaSPA)
We have synthesized a calcium sensor for photoacoustics, which changes its absorbance and thus photoacoustic spectrum upon selective binding to Ca2+ for future use in organoids or in vivo models.
In its esterified form, CaSPA is cell-permeable such that we could use it to image intracellular calcium changes in cells, organoids and in vivo in zebrafish larvae with photoacoustic tomography.
manuscript: https://doi.org/10.1021/jacs.8b01874
cover: https://pubs.acs.org/pb-assets/images/_journalCovers/jacsat/jacsat_v140i008.jpg?0.7467585368755068
press release: https://www.tum.de/en/news-and-events/all-news/press-releases/details/34326